Metal-based antitumor compounds: beyond cisplatin

Tailoring Platinum(IV) Amphiphiles for Self-Targeting All-in-One Assemblies as Precise Multimodal Theranostic Nanomedicine

(2018) Shasha He et al.   ACS Nano

The multifaceted allosteric regulation of Aurora kinase A

(2018) Nicholas Mark Levinson   BIOCHEMICAL JOURNAL

Identification of a rhodium(iii) complex as a Wee1 inhibitor against TP53-mutated triple-negative breast cancer cells

(2018) Guan-Jun Yang et al.   CHEMICAL COMMUNICATIONS

Targeted photodynamic therapy in visible light using BODIPY-appended copper(ii) complexes of a vitamin B6 Schiff base

(2018) Nandini Mukherjee et al.   DALTON TRANSACTIONS

Anticancer activity of complexes of the third row transition metals, rhenium, osmium, and iridium

(2018) Chilaluck C. Konkankit et al.   DALTON TRANSACTIONS

Multiply Intercalator-Substituted Cu(II) Cyclen Complexes as DNA Condensers and DNA/RNA Synthesis Inhibitors

(2018) Jan Hormann et al.   INORGANIC CHEMISTRY

Photoactivated in Vitro Anticancer Activity of Rhenium(I) Tricarbonyl Complexes Bearing Water-Soluble Phosphines

(2018) Sierra C. Marker et al.   INORGANIC CHEMISTRY

Gold-Based Medicine: A Paradigm Shift in Anti-Cancer Therapy?

(2018) Chien Yeo et al.   MOLECULES

Platinum, palladium, gold and ruthenium complexes as anticancer agents: Current clinical uses, cytotoxicity studies and future perspectives

(2017) Tatjana Lazarević et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A comprehensive review on Aurora kinase: Small molecule inhibitors and clinical trial studies

(2017) Ankit C. Borisa et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A New Series of Succinimido-ferrociphenols and Related Heterocyclic Species Induce Strong Antiproliferative Effects, Especially against Ovarian Cancer Cells Resistant to Cisplatin

(2017) Pascal Pigeon et al.   JOURNAL OF MEDICINAL CHEMISTRY

Advances in the design of organometallic anticancer complexes

(2017) Pingyu Zhang et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

In Vitro Anticancer Activity and in Vivo Biodistribution of Rhenium(I) Tricarbonyl Aqua Complexes

(2017) Kevin M. Knopf et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A subset of platinum-containing chemotherapeutic agents kills cells by inducing ribosome biogenesis stress

(2017) Peter M Bruno et al.   NATURE MEDICINE

Aurora A Kinase Is a Priority Pharmaceutical Target for the Treatment of Cancers

(2017) Arun Prasath Damodaran et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Metal complexes in cancer therapy – an update from drug design perspective

(2017) Umar Ndagi et al.   Drug Design Development and Therapy

Direct inhibition of STAT signaling by platinum drugs contributes to their anti-cancer activity

(2017) Stanleyson V. Hato et al.   Oncotarget

Breast Cancer Stem Cell Potent Copper(II)-Non-Steroidal Anti-Inflammatory Drug Complexes

(2016) Janine N. Boodram et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Targeting Iron in Colon Cancer via Glycoconjugation of Thiosemicarbazone Prochelators

(2016) Eman A. Akam et al.   BIOCONJUGATE CHEMISTRY

Platinum-based drugs: past, present and future

(2016) Shahana Dilruba et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs

(2016) Timothy C. Johnstone et al.   CHEMICAL REVIEWS

Platinum(iv) anticancer prodrugs – hypotheses and facts

(2016) Dan Gibson   DALTON TRANSACTIONS

Metal-based drugs that break the rules

(2016) Claire S. Allardyce et al.   DALTON TRANSACTIONS

Thirty Years of the Drug Candidate NAMI-A and the Myths in the Field of Ruthenium Anticancer Compounds: A Personal Perspective

(2016) Enzo Alessio   EUROPEAN JOURNAL OF INORGANIC CHEMISTRY

Evaluation of Perylene Bisimide-Based RuIIand IrIIIComplexes as Photosensitizers for Photodynamic Therapy

(2016) Cristina Mari et al.   EUROPEAN JOURNAL OF INORGANIC CHEMISTRY

Metal-Containing Pharmacophores in Molecularly Targeted Anticancer Therapies and Diagnostics

(2016) Mu Yang et al.   EUROPEAN JOURNAL OF INORGANIC CHEMISTRY

Histidine availability is decisive in ROS-mediated cytotoxicity of copper complexes of Aβ1–16 peptide

(2016) Yamini P. Ginotra et al.   FREE RADICAL RESEARCH

Water-Soluble Dinitrosyl Iron Complex (DNIC): a Nitric Oxide Vehicle Triggering Cancer Cell Death via Apoptosis

(2016) Shou-Cheng Wu et al.   INORGANIC CHEMISTRY

Novel copper complexes as potential proteasome inhibitors for cancer treatment

(2016) Zhen Zhang et al.   Molecular Medicine Reports

A ruthenium(ii) based photosensitizer and transferrin complexes enhance photo-physical properties, cell uptake, and photodynamic therapy safety and efficacy

(2016) Pavel Kaspler et al.   PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

Oxidative Stress Induced by Pt(IV) Pro-drugs Based on the Cisplatin Scaffold and Indole Carboxylic Acids in Axial Position

(2016) Dina Tolan et al.   Scientific Reports

Self-assembled nanoscale coordination polymers carrying siRNAs and cisplatin for effective treatment of resistant ovarian cancer

(2015) Chunbai He et al.   BIOMATERIALS

Near infrared activation of an anticancer PtIV complex by Tm-doped upconversion nanoparticles

(2015) Emmanuel Ruggiero et al.   CHEMICAL COMMUNICATIONS

Chemical biology of anticancer gold(iii) and gold(i) complexes

(2015) Taotao Zou et al.   CHEMICAL SOCIETY REVIEWS

Ferrocifen type anti cancer drugs

(2015) Gérard Jaouen et al.   CHEMICAL SOCIETY REVIEWS

Influence of the binding of reduced NAMI-A to human serum albumin on the pharmacokinetics and biological activity

(2015) V. Novohradský et al.   DALTON TRANSACTIONS

Recent Advances in Platinum (IV) Complex-Based Delivery Systems to Improve Platinum (II) Anticancer Therapy

(2015) Xiaopeng Han et al.   MEDICINAL RESEARCH REVIEWS

A novel class of ruthenium-based photosensitizers effectively kills in vitro cancer cells and in vivo tumors

(2015) Jamie Fong et al.   PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

Clinically used antirheumatic agent auranofin is a proteasomal deubiquitinase inhibitor and inhibits tumor growth

(2015) Ningning Liu et al.   Oncotarget

Organoiridium Complexes: Anticancer Agents and Catalysts

(2014) Zhe Liu et al.   ACCOUNTS OF CHEMICAL RESEARCH

Underestimated Potential of Organometallic Rhenium Complexes as Anticancer Agents

(2014) Anna Leonidova et al.   ACS Chemical Biology

A Binuclear Gold(I) Complex with Mixed Bridging Diphosphine and Bis(N-Heterocyclic Carbene) Ligands Shows Favorable Thiol Reactivity and Inhibits Tumor Growth and Angiogenesis In Vivo

(2014) Taotao Zou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

How copper traverses cellular membranes through the mammalian copper transporter 1, Ctr1

(2014) Helena Öhrvik et al.   Annals of the New York Academy of Sciences

Organometallic Compounds in Cancer Therapy: Past Lessons and Future Directions

(2014) Pedro Martins et al.   Anti-Cancer Agents in Medicinal Chemistry

N-heterocyclic carbene metal complexes: photoluminescence and applications

(2014) Renso Visbal et al.   CHEMICAL SOCIETY REVIEWS

Anticancer Profile of a Series of Gold(III) (2-phenyl)pyridine Complexes

(2014) Riccardo Rubbiani et al.   ChemMedChem

Molecular Pathways: The Immunogenic Effects of Platinum-Based Chemotherapeutics

(2014) S. V. Hato et al.   CLINICAL CANCER RESEARCH

The Combined Therapeutical Effect of Metal-based Drugs and Radiation Therapy: The Present Status of Research

(2014) C. Ceresa et al.   CURRENT MEDICINAL CHEMISTRY

Cisplatin in cancer therapy: Molecular mechanisms of action

(2014) Shaloam Dasari et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Target selective micelles for bombesin receptors incorporating Au(III)-dithiocarbamato complexes

(2014) Paola Ringhieri et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Ferrocifen derivatives that induce senescence in cancer cells: selected examples

(2014) Céline Bruyère et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Evidence for Targeting Thioredoxin Reductases with Ferrocenyl Quinone Methides. A Possible Molecular Basis for the Antiproliferative Effect of Hydroxyferrocifens on Cancer Cells

(2014) Anna Citta et al.   JOURNAL OF MEDICINAL CHEMISTRY

Nanoscale Metal–Organic Frameworks for the Co-Delivery of Cisplatin and Pooled siRNAs to Enhance Therapeutic Efficacy in Drug-Resistant Ovarian Cancer Cells

(2014) Chunbai He et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

NKP-1339, the first ruthenium-based anticancer drug on the edge to clinical application

(2014) Robert Trondl et al.   Chemical Science

Enhanced Cytotoxicity through Conjugation of a “Clickable” Luminescent Re(I) Complex to a Cell-Penetrating Lipopeptide

(2014) Anna Leonidova et al.   ACS Medicinal Chemistry Letters

Multifunctional polymeric micelles for delivery of drugs and siRNA

(2014) Aditi M. Jhaveri et al.   Frontiers in Pharmacology

Metal/N-Heterocyclic Carbene Complexes: Opportunities for the Development of Anticancer Metallodrugs

(2013) Federico Cisnetti et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Near-Infrared Light-Mediated Photoactivation of a Platinum Antitumor Prodrug and Simultaneous Cellular Apoptosis Imaging by Upconversion-Luminescent Nanoparticles

(2013) Yuanzeng Min et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Taxanes as radiosensitizers

(2013) Encouse B. Golden et al.   ANTI-CANCER DRUGS

Advances in Copper Complexes as Anticancer Agents

(2013) Carlo Santini et al.   CHEMICAL REVIEWS

Synthetic Methods for the Preparation of Platinum Anticancer Complexes

(2013) Justin J. Wilson et al.   CHEMICAL REVIEWS

A golden future in medicinal inorganic chemistry: the promise of anticancer gold organometallic compounds

(2013) Benoît Bertrand et al.   DALTON TRANSACTIONS

A dinuclear cyclometalated gold(iii)–phosphine complex targeting thioredoxin reductase inhibits hepatocellular carcinoma in vivo

(2013) Raymond Wai-Yin Sun et al.   Chemical Science

Influence of an anti-metastatic ruthenium(iii) prodrug on extracellular protein–protein interactions: studies by bio-layer interferometry

(2013) Aviva Levina et al.   Inorganic Chemistry Frontiers

N-Heterocyclic carbene metal complexes in medicinal chemistry

(2012) Luciano Oehninger et al.   DALTON TRANSACTIONS

A Luminescent and Biocompatible PhotoCORM

(2012) Agustin E. Pierri et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Copper coordination to the putative cell binding site of angiogenin: a DFT investigation

(2012) Luca Bertini et al.   THEORETICAL CHEMISTRY ACCOUNTS

Nitric Oxide: A Guardian for Vascular Grafts?

(2011) Achala de Mel et al.   CHEMICAL REVIEWS

Ruthenium anticancer compounds: myths and realities of the emerging metal-based drugs

(2011) Alberta Bergamo et al.   DALTON TRANSACTIONS

PhotoCORMs: Light-triggered release of carbon monoxide from the coordination sphere of transition metal complexes for biological applications

(2011) Ulrich Schatzschneider   INORGANICA CHIMICA ACTA

Platinum-based drugs disrupt STAT6-mediated suppression of immune responses against cancer in humans and mice

(2011) W. Joost Lesterhuis et al.   JOURNAL OF CLINICAL INVESTIGATION

Comparative in Vitro Evaluation of N-Heterocyclic Carbene Gold(I) Complexes of the Benzimidazolylidene Type

(2011) Riccardo Rubbiani et al.   JOURNAL OF MEDICINAL CHEMISTRY

Opportunities and Challenges in the Development of Experimental Drug Combinations for Cancer

(2011) R. W. Humphrey et al.   JNCI-Journal of the National Cancer Institute

Molecular mechanisms of cisplatin resistance

(2011) L Galluzzi et al.   ONCOGENE

Characterization of a Ruthenium(III)/NAMI-A Adduct with Bovine Serum Albumin that Exhibits a High Anti-Metastatic Activity

(2010) Mimi Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Metal–organic frameworks as potential drug carriers

(2010) Rachel C Huxford et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Encapsulation of dual cytotoxic and anti-angiogenic gold(iii) complexes by gelatin-acacia microcapsules: In vitro and in vivo studies

(2010) Jessie Jing Yan et al.   DALTON TRANSACTIONS

Copper(ii) complex formation with a linear peptide encompassing the putative cell binding site of angiogenin

(2010) Diego La Mendola et al.   DALTON TRANSACTIONS

The status of platinum anticancer drugs in the clinic and in clinical trials

(2010) Nial J. Wheate et al.   DALTON TRANSACTIONS

Copper ions potentiate organic hydroperoxide and hydrogen peroxide toxicity through different mechanisms in Xanthomonas campestris pv. campestris

(2010) Nisa Patikarnmonthon et al.   FEMS MICROBIOLOGY LETTERS

A ferrocenyl derivative of hydroxytamoxifen elicits an estrogen receptor-independent mechanism of action in breast cancer cell lines

(2010) Anne Vessières et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Radical production by hydrogen peroxide/bicarbonate and copper uptake in mammalian cells: Modulation by Cu(II) complexes

(2010) Larissa C. Carvalho do Lago et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Prolonged Drug Selection of Breast Cancer Cells and Enrichment of Cancer Stem Cell Characteristics

(2010) Anna Maria Calcagno et al.   JNCI-Journal of the National Cancer Institute

Cancer Chemotherapy: An Annotated History

(2010) W.B. Morrison   JOURNAL OF VETERINARY INTERNAL MEDICINE

Efficacy of carboplatin-taxane combinations in the management of castration-resistant prostate cancer: a pooled analysis of seven prospective clinical trials

(2009) M. M. Regan et al.   ANNALS OF ONCOLOGY

Organometallic compounds in oncology: implications of novel organotins as antitumor agents

(2009) Angela Alama et al.   DRUG DISCOVERY TODAY

A History of Cancer Chemotherapy

(2008) Vincent T. DeVita et al.   CANCER RESEARCH

COPPER AND ANGIOGENESIS: UNRAVELLING A RELATIONSHIP KEY TO CANCER PROGRESSION

(2008) Lydia Finney et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

New trends for metal complexes with anticancer activity

(2008) Pieter CA Bruijnincx et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Phase III Study Comparing Cisplatin Plus Gemcitabine With Cisplatin Plus Pemetrexed in Chemotherapy-Naive Patients With Advanced-Stage Non–Small-Cell Lung Cancer

(2008) Giorgio Vittorio Scagliotti et al.   JOURNAL OF CLINICAL ONCOLOGY

Mitochondria-Targeted Chemotherapeutics: The Rational Design of Gold(I)N-Heterocyclic Carbene Complexes That Are Selectively Toxic to Cancer Cells and Target Protein Selenols in Preference to Thiols

(2008) James L. Hickey et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY