A ruthenium(ii) based photosensitizer and transferrin complexes enhance photo-physical properties, cell uptake, and photodynamic therapy safety and efficacy

Perfusion CT Estimates Photosensitizer Uptake and Biodistribution in a Rabbit Orthotopic Pancreatic Cancer Model

(2015) Jonathan T. Elliott et al.   ACADEMIC RADIOLOGY

Lipophilic Tetranuclear Ruthenium(II) Complexes as Two-Photon Luminescent Tracking Non-Viral Gene Vectors

(2015) Bole Yu et al.   CHEMISTRY-A EUROPEAN JOURNAL

Ru(II) dyads derived from α -oligothiophenes: A new class of potent and versatile photosensitizers for PDT

(2015) Ge Shi et al.   COORDINATION CHEMISTRY REVIEWS

Impact of low- and high-molecular-mass components of human serum on NAMI-A binding to transferrin

(2015) K. Śpiewak et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

A novel class of ruthenium-based photosensitizers effectively kills in vitro cancer cells and in vivo tumors

(2015) Jamie Fong et al.   PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

Combination of Ru(ii) complexes and light: new frontiers in cancer therapy

(2015) Cristina Mari et al.   Chemical Science

Binding of [Cr(phen)3]3+ to transferrin at extracellular and endosomal pHs: Potential application in photodynamic therapy

(2014) Pablo F. Garcia et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

DNA Intercalating RuIIPolypyridyl Complexes as Effective Photosensitizers in Photodynamic Therapy

(2014) Cristina Mari et al.   CHEMISTRY-A EUROPEAN JOURNAL

Mixed-ligand ruthenium polypyridyl complexes as apoptosis inducers in cancer cells, the cellular translocation and the important role of ROS-mediated signaling

(2014) Zhennan Zhao et al.   DALTON TRANSACTIONS

New method for the speciation of ruthenium-based chemotherapeutics in human serum by conjoint liquid chromatography on affinity and anion-exchange monolithic disks

(2014) Anže Martinčič et al.   JOURNAL OF CHROMATOGRAPHY A

Transferrin Receptor-Mediated Endocytosis: A Useful Target for Cancer Therapy

(2014) Stephanie Tortorella et al.   JOURNAL OF MEMBRANE BIOLOGY

The Significance of Transferrin Receptors in Oncology: the Development of Functional Nano-based Drug Delivery Systems

(2014) Stephanie Tortorella et al.   Current Drug Delivery

Ligand-mediated endocytosis of nanoparticles in neural stem cells: implications for cellular magnetic resonance imaging

(2013) Yesen Zhang et al.   BIOTECHNOLOGY LETTERS

Protein binding by dinuclear polypyridyl ruthenium(ii) complexes and the effect of cucurbit[10]uril encapsulation

(2013) Fangfei Li et al.   DALTON TRANSACTIONS

Transferrin Serves As a Mediator to Deliver Organometallic Ruthenium(II) Anticancer Complexes into Cells

(2013) Wei Guo et al.   INORGANIC CHEMISTRY

Light-Activated Metal Complexes that Covalently Modify DNA

(2013) Edith C. Glazer   ISRAEL JOURNAL OF CHEMISTRY

Targetting cancer with Ru(III/II)-phosphodiesterase inhibitor adducts: A novel approach in the treatment of cancer

(2013) Raj Kumar Koiri et al.   MEDICAL HYPOTHESES

Photodynamic inactivation of Staphylococcus aureus and methicillin-resistant Staphylococcus aureus with Ru(II)-based type I/type II photosensitizers

(2013) Yaxal Arenas et al.   Photodiagnosis and Photodynamic Therapy

Epidermal growth factor receptor-targeted photosensitizer selectively inhibits EGFR signaling and induces targeted phototoxicity in ovarian cancer cells

(2012) Adnan O. Abu-Yousif et al.   CANCER LETTERS

Light-activated ruthenium complexes photobind DNA and are cytotoxic in the photodynamic therapy window

(2012) Erin Wachter et al.   CHEMICAL COMMUNICATIONS

Transferrin conjugation does not increase the efficiency of liposomal Foscan during in vitro photodynamic therapy of oesophageal cancer

(2012) Edyta Paszko et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Characterization of the binding sites of the anticancer ruthenium(III) complexes KP1019 and KP1339 on human serum albumin via competition studies

(2012) Orsolya Dömötör et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Interaction of apo-transferrin with anticancer ruthenium complexes NAMI-A and its reduced form

(2012) Olga Mazuryk et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Phosphate inhibits in vitro Fe3+ loading into transferrin by forming a soluble Fe(III)–phosphate complex: A potential non-transferrin bound iron species

(2012) Robert J. Hilton et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Strained Ruthenium Complexes Are Potent Light-Activated Anticancer Agents

(2012) Brock S. Howerton et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Distinct cellular fates for KP1019 and NAMI-A determined by X-ray fluorescence imaging of single cells

(2012) Jade B. Aitken et al.   Metallomics

Mitochondrial Localization of ABC Transporter ABCG2 and Its Function in 5-Aminolevulinic Acid-Mediated Protoporphyrin IX Accumulation

(2012) Hirotsugu Kobuchi et al.   PLoS One

Insights into the mechanism of cell death induced by saporin delivered into cancer cells by an antibody fusion protein targeting the transferrin receptor 1

(2012) Tracy R. Daniels-Wells et al.   TOXICOLOGY IN VITRO

The binding and transport of alternative metals by transferrin

(2011) John B. Vincent et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

An Antibody-based Multifaceted Approach Targeting the Human Transferrin Receptor for the Treatment of B-cell Malignancies

(2011) Tracy R. Daniels et al.   JOURNAL OF IMMUNOTHERAPY

Advances on the interaction of polypyridyl Cr(III) complexes with transporting proteins and its potential relevance in photodynamic therapy

(2011) Judith Toneatto et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Metal retention in human transferrin: Consequences of solvent composition in analytical sample preparation methods

(2011) C. Derrick Quarles Jr. et al.   Metallomics

Biological Effects of a De Novo Designed Myxoma Virus Peptide Analogue: Evaluation of Cytotoxicity on Tumor Cells

(2011) Taghrid S. Istivan et al.   PLoS One

DNA photocleavage by an osmium(ii) complex in the PDT window

(2010) Yujie Sun et al.   CHEMICAL COMMUNICATIONS

Efficient DNA photocleavage by [Ru(bpy)2(dppn)]2+ with visible light

(2010) Yujie Sun et al.   CHEMICAL COMMUNICATIONS

The role of porphyrin chemistry in tumor imaging and photodynamic therapy

(2010) Manivannan Ethirajan et al.   CHEMICAL SOCIETY REVIEWS

[Ru(bpy)3−n(dpb)n]2+: Unusual Photophysical Property and Efficient DNA Photocleavage Activity

(2010) Qian-Xiong Zhou et al.   INORGANIC CHEMISTRY

Photobiological Activity of Ru(II) Dyads Based on (Pyren-1-yl)ethynyl Derivatives of 1,10-Phenanthroline

(2010) Susan Monro et al.   INORGANIC CHEMISTRY

Tuning heavy metal compounds for anti-tumor activity: is diversity the key to ruthenium’s success?

(2009) Simon M Page et al.   Future Medicinal Chemistry

Recent developments in ruthenium anticancer drugs

(2009) Aviva Levina et al.   Metallomics

Simultaneous multiple element detection by particle beam/hollow cathode-optical emission spectroscopy as a tool for metallomic studies: Determinations of metal binding with apo-transferrin

(2009) C. Derrick Quarles et al.   Metallomics

Regulation of 5-Aminolevulinic Acid-Mediated Protoporphyrin IX Accumulation in Human Urothelial Carcinomas

(2009) Keiji Inoue et al.   PATHOBIOLOGY

Ru(II) Complexes of New Tridentate Ligands: Unexpected High Yield of Sensitized1O2

(2008) Yao Liu et al.   INORGANIC CHEMISTRY

Pulsed diode laser-based singlet oxygen monitor for photodynamic therapy: in vivo studies of tumor-laden rats

(2008) Seonkyung Lee et al.   JOURNAL OF BIOMEDICAL OPTICS

Photoreactions of 1,4-naphthoquinone with lysozyme studied by laser flash photolysis and steady-state analysis

(2008) Zhaoxia Zhang et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Enzymatic, but not non-enzymatic,1O2-mediated peroxidation of polyunsaturated fatty acids forms part of the EXECUTER1-dependent stress response program in the flu mutant of Arabidopsis thaliana

(2008) Dominika Przybyla et al.   PLANT JOURNAL