Oxidative Stress Induced by Pt(IV) Pro-drugs Based on the Cisplatin Scaffold and Indole Carboxylic Acids in Axial Position

The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs

(2016) Timothy C. Johnstone et al.   CHEMICAL REVIEWS

Potentiation of mitochondrial dysfunction in tumor cells by conjugates of metabolic modulator dichloroacetate with a Pt(IV) derivative of oxaliplatin

(2016) Juraj Zajac et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Pt(iv) derivatives of cisplatin and oxaliplatin with phenylbutyrate axial ligands are potent cytotoxic agents that act by several mechanisms of action

(2016) Raji Raveendran et al.   Chemical Science

New insights into the molecular and epigenetic effects of antitumor Pt(IV)-valproic acid conjugates in human ovarian cancer cells

(2015) Vojtech Novohradsky et al.   BIOCHEMICAL PHARMACOLOGY

Tetracarboxylatoplatinum(IV) complexes featuring monodentate leaving groups — A rational approach toward exploiting the platinum(IV) prodrug strategy

(2015) Doris Höfer et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Influence of reducing agents on the cytotoxic activity of platinum(iv) complexes: induction of G2/M arrest, apoptosis and oxidative stress in A2780 and cisplatin resistant A2780cis cell lines

(2015) Verena Pichler et al.   Metallomics

A simple, sensitive analytical method for platinum trace determination in human urine

(2015) M. Crespo Alonso et al.   MICROCHEMICAL JOURNAL

Immuno-Chemotherapeutic Platinum(IV) Prodrugs of Cisplatin as Multimodal Anticancer Agents

(2014) Daniel Yuan Qiang Wong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Prodrug Platin-A: Simultaneous Release of Cisplatin and Aspirin

(2014) Rakesh K. Pathak et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Conjugates of Cisplatin and Cyclooxygenase Inhibitors as Potent Antitumor Agents Overcoming Cisplatin Resistance

(2014) Wilma Neumann et al.   ChemMedChem

Conjugation of Cisplatin Analogues and Cyclooxygenase Inhibitors to Overcome Cisplatin Resistance

(2014) Wilma Neumann et al.   ChemMedChem

Conjugation of vitamin E analog α-TOS to Pt(iv) complexes for dual-targeting anticancer therapy

(2013) Kogularamanan Suntharalingam et al.   CHEMICAL COMMUNICATIONS

Monofunctional and Higher-Valent Platinum Anticancer Agents

(2013) Timothy C. Johnstone et al.   INORGANIC CHEMISTRY

Influence of Equatorial and Axial Carboxylato Ligands on the Kinetic Inertness of Platinum(IV) Complexes in the Presence of Ascorbate and Cysteine and within DLD-1 Cancer Cells

(2013) Catherine K. J. Chen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Modulation of oxidative stress as an anticancer strategy

(2013) Chiara Gorrini et al.   NATURE REVIEWS DRUG DISCOVERY

Facile Preparation of Mono-, Di- and Mixed-Carboxylato Platinum(IV) Complexes for Versatile Anticancer Prodrug Design

(2012) Jenny Z. Zhang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Novel tetracarboxylatoplatinum(iv) complexes as carboplatin prodrugs

(2012) Hristo P. Varbanov et al.   DALTON TRANSACTIONS

Synthesis, characterization and antiproliferative activity on mesothelioma cell lines of bis(carboxylato)platinum(iv) complexes based on picoplatin

(2012) Mauro Ravera et al.   DALTON TRANSACTIONS

What do we know about the reduction of Pt(IV) pro-drugs?

(2012) Ezequiel Wexselblatt et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Theoretical Investigations and Density Functional Theory Based Quantitative Structure–Activity Relationships Model for Novel Cytotoxic Platinum(IV) Complexes

(2012) Hristo P. Varbanov et al.   JOURNAL OF MEDICINAL CHEMISTRY

Tuning the Activity of Platinum(IV) Anticancer Complexes through Asymmetric Acylation

(2012) Chee Fei Chin et al.   JOURNAL OF MEDICINAL CHEMISTRY

Platinum(ii/iv) complexes containing ethylenediamine-N,N′-di-2/3-propionate ester ligands induced caspase-dependent apoptosis in cisplatin-resistant colon cancer cells

(2012) Goran N. Kaluđerović et al.   Metallomics

Pt(iv) analogs of oxaliplatin that do not follow the expected correlation between electrochemical reduction potential and rate of reduction by ascorbate

(2011) Jenny Z. Zhang et al.   CHEMICAL COMMUNICATIONS

New reduction pathways for ctc-[PtCl2(CH3CO2)2(NH3)(Am)] anticancer prodrugs

(2010) Alina Nemirovski et al.   CHEMICAL COMMUNICATIONS

Advances in Platinum Chemotherapeutics

(2010) Benjamin W. Harper et al.   CHEMISTRY-A EUROPEAN JOURNAL

The status of platinum anticancer drugs in the clinic and in clinical trials

(2010) Nial J. Wheate et al.   DALTON TRANSACTIONS

Synthesis, antioxidant and DNA cleavage activities of novel indole derivatives

(2010) J.S. Biradar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The mechanism of action of platinum anticancer agents—what do we really know about it?

(2009) Dan Gibson   DALTON TRANSACTIONS

Mitaplatin, a potent fusion of cisplatin and the orphan drug dichloroacetate

(2009) Shanta Dhar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel Endothall-Containing Platinum(IV) Complexes: Synthesis, Characterization, and Cytotoxic Activity

(2008) Michael R. Reithofer et al.   CHEMISTRY & BIODIVERSITY

Conjugated Platinum(IV)−Peptide Complexes for Targeting Angiogenic Tumor Vasculature

(2007) Sumitra Mukhopadhyay et al.   BIOCONJUGATE CHEMISTRY