A dinuclear cyclometalated gold(iii)–phosphine complex targeting thioredoxin reductase inhibits hepatocellular carcinoma in vivo

Latest Insights into the Anticancer Activity of Gold(III)-Dithiocarbamato Complexes

(2012) Luca Ronconi et al.   Anti-Cancer Agents in Medicinal Chemistry

Targeting the ubiquitin–proteasome pathway with inorganic compounds to fight cancer: a challenge for the future

(2012) Lisa Dalla Via et al.   Future Medicinal Chemistry

Synthesis, Structural Characterization, Solution Behavior, and in Vitro Antiproliferative Properties of a Series of Gold Complexes with 2-(2′-Pyridyl)benzimidazole as Ligand: Comparisons of Gold(III) versus Gold(I) and Mononuclear versus Binuclear Derivatives

(2012) Maria Serratrice et al.   INORGANIC CHEMISTRY

Proteomic analysis of ovarian cancer cell responses to cytotoxic gold compounds

(2012) Francesca Guidi et al.   Metallomics

Rottlerin and Cancer: Novel Evidence and Mechanisms

(2012) E. Maioli et al.   TheScientificWorldJOURNAL

Therapeutic applications of gold complexes: lipophilic gold(iii) cations and gold(i) complexes for anti-cancer treatment

(2011) Chi-Ming Che et al.   CHEMICAL COMMUNICATIONS

Gold(i) complexes of water-soluble diphos-type ligands: Synthesis, anticancer activity, apoptosis and thioredoxin reductase inhibition

(2011) Corinna Wetzel et al.   DALTON TRANSACTIONS

Inhibition of thioredoxin reductase 1 by porphyrins and other small molecules identified by a high-throughput screening assay

(2011) Stefanie Prast-Nielsen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Gold compounds as therapeutic agents for human diseases

(2011) Susan J. Berners-Price et al.   Metallomics

Gold(i) complex of N,N′-disubstituted cyclic thiourea with in vitro and in vivo anticancer properties—potent tight-binding inhibition of thioredoxin reductase

(2010) Kun Yan et al.   CHEMICAL COMMUNICATIONS

Stable Anticancer Gold(III)-Porphyrin Complexes: Effects of Porphyrin Structure

(2010) Raymond Wai-Yin Sun et al.   CHEMISTRY-A EUROPEAN JOURNAL

The status of platinum anticancer drugs in the clinic and in clinical trials

(2010) Nial J. Wheate et al.   DALTON TRANSACTIONS

Gold(III)-dithiocarbamato anticancer agents: Activity, toxicology and histopathological studies in rodents

(2010) Cristina Marzano et al.   INTERNATIONAL JOURNAL OF CANCER

Antitumor activity of gold(III)-dithiocarbamato derivatives on prostate cancer cells and xenografts

(2010) Lara Cattaruzza et al.   INTERNATIONAL JOURNAL OF CANCER

Cysteine proteases as targets for metal-based drugs

(2010) Simon P. Fricker   Metallomics

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Design of Gold-Based, Mitochondria-Targeted Chemotherapeutics

(2009) Susan J. Berners-Price et al.   AUSTRALIAN JOURNAL OF CHEMISTRY

Chemical Genomics Identifies the Unfolded Protein Response as a Target for Selective Cancer Cell Killing during Glucose Deprivation

(2009) S. Saito et al.   CANCER RESEARCH

A Gold(III) Porphyrin Complex with Antitumor Properties Targets the Wnt/ -catenin Pathway

(2009) K. H.-M. Chow et al.   CANCER RESEARCH

Targeting proteins with metal complexes

(2009) Eric Meggers   CHEMICAL COMMUNICATIONS

On the medicinal chemistry of gold complexes as anticancer drugs

(2009) Ingo Ott   COORDINATION CHEMISTRY REVIEWS

Thioredoxin reductase: A target for gold compounds acting as potential anticancer drugs

(2009) Alberto Bindoli et al.   COORDINATION CHEMISTRY REVIEWS

The anti-cancer properties of gold(III) compounds with dianionic porphyrin and tetradentate ligands

(2009) Raymond Wai-Yin Sun et al.   COORDINATION CHEMISTRY REVIEWS

Metal complexes in medicine with a focus on enzyme inhibition

(2009) Chi-Ming Che et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Current applications and future potential for bioinorganic chemistry in the development of anticancer drugs

(2009) Sabine H. van Rijt et al.   DRUG DISCOVERY TODAY

Screen for Chemical Modulators of Autophagy Reveals Novel Therapeutic Inhibitors of mTORC1 Signaling

(2009) Aruna D. Balgi et al.   PLoS One

Coupling of Endoplasmic Reticulum Stress to CDDO-Me-Induced Up-regulation of Death Receptor 5 via a CHOP-Dependent Mechanism Involving JNK Activation

(2008) W. Zou et al.   CANCER RESEARCH

Rottlerin induces apoptosis via death receptor 5 (DR5) upregulation through CHOP-dependent and PKC  -independent mechanism in human malignant tumor cells

(2008) J. H. Lim et al.   CARCINOGENESIS

A Gene Signature-Based Approach Identifies mTOR as a Regulator of p73

(2008) J. M. Rosenbluth et al.   MOLECULAR AND CELLULAR BIOLOGY

15-deoxy-Δ12,14-prostaglandin J2 up-regulates death receptor 5 gene expression in HCT116 cells: involvement of reactive oxygen species and C/EBP homologous transcription factor gene transcription

(2008) Rong-Ying Su et al.   MOLECULAR CANCER THERAPEUTICS

Thioredoxin system inhibitors as mediators of apoptosis for cancer therapy

(2008) Kathryn F. Tonissen et al.   MOLECULAR NUTRITION & FOOD RESEARCH

The promise of cancer therapeutics targeting the TNF-related apoptosis-inducing ligand and TRAIL receptor pathway

(2008) S Wang   ONCOGENE

Antitumour metal compounds: more than theme and variations

(2007) Michael A. Jakupec et al.   DALTON TRANSACTIONS

Gold(III) compounds as anticancer agents: Relevance of gold–protein interactions for their mechanism of action

(2007) Angela Casini et al.   JOURNAL OF INORGANIC BIOCHEMISTRY