Lung hyperinflation in chronic obstructive pulmonary disease: mechanisms, clinical implications and treatment

Can bronchodilators improve exercise tolerance in COPD patients without dynamic hyperinflation?

(2014) Maria Enedina Aquino Scuarcialupi et al.   Jornal Brasileiro de Pneumologia

The Continuum of Physiological Impairment during Treadmill Walking in Patients with Mild-to-Moderate COPD: Patient Characterization Phase of a Randomized Clinical Trial

(2014) Denis E. O’Donnell et al.   PLoS One

Effect of QVA149 on lung volumes and exercise tolerance in COPD patients: The BRIGHT study

(2014) Kai-Michael Beeh et al.   RESPIRATORY MEDICINE

Extrafine Beclomethasone/formoterol compared to Fluticasone/salmeterol Combination Therapy in COPD

(2014) Dave Singh et al.   BMC Pulmonary Medicine

Limits to Ventilation (For Sure!) and Exercise (Maybe?) in Mild Chronic Obstructive Pulmonary Disease

(2013) Jerome A. Dempsey   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

An Official American Thoracic Society/European Respiratory Society Statement: Key Concepts and Advances in Pulmonary Rehabilitation

(2013) Martijn A. Spruit et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Does the Respiratory System Limit Exercise in Mild Chronic Obstructive Pulmonary Disease?

(2013) Roberto C. Chin et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Impaired Left Ventricular Filling in COPD and Emphysema: Is It the Heart or the Lungs?

(2013) Benjamin M. Smith et al.   CHEST

Treadmill Endurance During 2-Year Treatment With Tiotropium in Patients With COPD

(2013) Christopher B. Cooper et al.   CHEST

Small Airway Obstruction in COPD

(2013) James C. Hogg et al.   CHEST

Breathlessness, fatigue and the respiratory muscles

(2013) J. Moxham et al.   CLINICAL MEDICINE

Impact of Pulmonary Rehabilitation on the Major Dimensions of Dyspnea in COPD

(2013) Karin Wadell et al.   COPD-Journal of Chronic Obstructive Pulmonary Disease

Inspiratory resistance decreases limb blood flow in COPD patients with heart failure

(2013) G. R. Chiappa et al.   EUROPEAN RESPIRATORY JOURNAL

Intensity of daily physical activity is associated with central hemodynamic and leg muscle oxygen availability in COPD

(2013) Zafeiris Louvaris et al.   JOURNAL OF APPLIED PHYSIOLOGY

Efficacy and Tolerability of Yoga Breathing in Patients With Chronic Obstructive Pulmonary Disease

(2013) Luca Pomidori et al.   Journal of Cardiopulmonary Rehabilitation and Prevention

CT and physiologic determinants of dyspnea and exercise capacity during the six-minute walk test in mild COPD

(2013) Alejandro A. Díaz et al.   RESPIRATORY MEDICINE

Defining hyperinflation as ‘dynamic’: Moving toward the slope

(2013) Thomas E. Dolmage et al.   RESPIRATORY MEDICINE

Resting and ADL-induced dynamic hyperinflation explain physical inactivity in COPD better than FEV1

(2013) Anke J.M.C. Lahaije et al.   RESPIRATORY MEDICINE

Activity monitoring reflects cardiovascular and metabolic variations in COPD patients across GOLD stages II to IV

(2013) E.A. Kortianou et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Influences of Spinal Anesthesia on Exercise Tolerance in Patients with Chronic Obstructive Pulmonary Disease

(2012) Philippe Gagnon et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

An Official American Thoracic Society Statement: Update on the Mechanisms, Assessment, and Management of Dyspnea

(2012) Mark B. Parshall et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease

(2012) Jørgen Vestbo et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Diagnostic accuracy of metronome-paced tachypnea to detect dynamic hyperinflation

(2012) Anke J. M. C. Lahaije et al.   CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING

Aerobic Exercise Training Improves Right- and Left Ventricular Systolic Function in Patients with COPD

(2012) Eivind Brønstad et al.   COPD-Journal of Chronic Obstructive Pulmonary Disease

Tough at the top: must end-expiratory lung volume make way for end-inspiratory lung volume?

(2012) Yuan Ming Luo et al.   EUROPEAN RESPIRATORY JOURNAL

Exercise tolerance with helium-hyperoxiaversushyperoxia in hypoxaemic patients with COPD

(2012) Fernando Queiroga et al.   EUROPEAN RESPIRATORY JOURNAL

Heliox increases quadriceps muscle oxygen delivery during exercise in COPD patients with and without dynamic hyperinflation

(2012) Zafeiris Louvaris et al.   JOURNAL OF APPLIED PHYSIOLOGY

On- and off-exercise kinetics of cardiac output in response to cycling and walking in COPD patients with GOLD Stages I–IV

(2012) M.K. Vasilopoulou et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Once-daily NVA237 improves exercise tolerance from the first dose in patients with COPD: the GLOW3 trial

(2012) Kai Michael Beeh et al.   International Journal of Chronic Obstructive Pulmonary Disease

Effects of inspiratory muscle training on dynamic hyperinflation in patients with COPD

(2012) Milos Petrovic et al.   International Journal of Chronic Obstructive Pulmonary Disease

Computational Analysis of Thoracic Multidetector Row HRCT for Segmentation and Quantification of Small Airway Air Trapping and Emphysema in Obstructive Pulmonary Disease

(2011) Eduardo Mortani Barbosa et al.   ACADEMIC RADIOLOGY

Evolution of Dyspnea during Exercise in Chronic Obstructive Pulmonary Disease

(2011) Pierantonio Laveneziana et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Effects of BMI on Static Lung Volumes in Patients With Airway Obstruction

(2011) Denis E. O'Donnell et al.   CHEST

Six-Minute Walk Distance Predictors, Including CT Scan Measures, in the COPDGene Cohort

(2011) Mehdi Rambod et al.   CHEST

Decline of Resting Inspiratory Capacity in COPD

(2011) Denis E. O'Donnell et al.   CHEST

Effect of Indacaterol on Dynamic Lung Hyperinflation and Breathlessness in Hyperinflated Patients with COPD

(2011) Kai-Michael Beeh et al.   COPD-Journal of Chronic Obstructive Pulmonary Disease

Impact of inspiratory muscle training in patients with COPD: what is the evidence?

(2011) R. Gosselink et al.   EUROPEAN RESPIRATORY JOURNAL

Does dynamic hyperinflation contribute to dyspnoea during exercise in patients with COPD?

(2011) Jordan A. Guenette et al.   EUROPEAN RESPIRATORY JOURNAL

Emphysema — A Disease of Small Airways or Lung Parenchyma?

(2011) Wayne Mitzner   NEW ENGLAND JOURNAL OF MEDICINE

Small-Airway Obstruction and Emphysema in Chronic Obstructive Pulmonary Disease

(2011) John E. McDonough et al.   NEW ENGLAND JOURNAL OF MEDICINE

Structural Brain Changes Related to Disease Duration in Patients with Asthma

(2011) Andreas von Leupoldt et al.   PLoS One

Effect of indacaterol on exercise endurance and lung hyperinflation in COPD

(2011) Denis E. O’Donnell et al.   RESPIRATORY MEDICINE

Sex differences in exertional dyspnea in patients with mild COPD: Physiological mechanisms

(2011) Jordan A. Guenette et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Impact of pulmonary system limitations on locomotor muscle fatigue in patients with COPD

(2010) Markus Amann et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Low Inspiratory Capacity to Total Lung Capacity Ratio Is a Risk Factor for Chronic Obstructive Pulmonary Disease Exacerbation

(2010) Mumtaz Zaman et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Decreasing Cardiac Chamber Sizes and Associated Heart Dysfunction in COPD

(2010) Henrik Watz et al.   CHEST

Lung Hyperinflation and Its Reversibility in Patients with Airway Obstruction of Varying Severity

(2010) Athavudh Deesomchok et al.   COPD-Journal of Chronic Obstructive Pulmonary Disease

Factors Discriminating Spontaneous Pursed-Lips Breathing Use in Patients with COPD

(2010) Jadranka Spahija et al.   COPD-Journal of Chronic Obstructive Pulmonary Disease

Therapeutic implications of the pathophysiology of COPD

(2010) P. T. Macklem   EUROPEAN RESPIRATORY JOURNAL

Lung Deposition of BDP/Formoterol HFA pMDI in Healthy Volunteers, Asthmatic, and COPD Patients

(2010) Wilfried De Backer et al.   Journal of Aerosol Medicine and Pulmonary Drug Delivery

Percent Emphysema, Airflow Obstruction, and Impaired Left Ventricular Filling

(2010) R. Graham Barr et al.   NEW ENGLAND JOURNAL OF MEDICINE

Budesonide added to formoterol contributes to improved exercise tolerance in patients with COPD

(2010) Heinrich Worth et al.   RESPIRATORY MEDICINE

Beclomethasone/formoterol in the management of COPD: A randomised controlled trial

(2010) P.M.A. Calverley et al.   RESPIRATORY MEDICINE

Contrasting pressure-support ventilation and helium–oxygen during exercise in severe COPD

(2010) Omar Hussain et al.   RESPIRATORY MEDICINE

Aclidinium bromide improves exercise endurance and lung hyperinflation in patients with moderate to severe COPD

(2010) François Maltais et al.   RESPIRATORY MEDICINE

Bronchodilators accelerate the dynamics of muscle O2 delivery and utilisation during exercise in COPD

(2010) D. C. Berton et al.   THORAX

Heliox Improves Oxygen Delivery and Utilization during Dynamic Exercise in Patients with Chronic Obstructive Pulmonary Disease

(2009) Gaspar R. Chiappa et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Down-Regulation of Insular Cortex Responses to Dyspnea and Pain in Asthma

(2009) Andreas von Leupoldt et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Daily Physical Activity in Patients with Chronic Obstructive Pulmonary Disease Is Mainly Associated with Dynamic Hyperinflation

(2009) Francisco Garcia-Rio et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Reliability of ventilatory parameters during cycle ergometry in multicentre trials in COPD

(2009) D. E. O'Donnell et al.   EUROPEAN RESPIRATORY JOURNAL

The prevalence of quadriceps weakness in COPD and the relationship with disease severity

(2009) J. M. Seymour et al.   EUROPEAN RESPIRATORY JOURNAL

Respiratory muscle fiber remodeling in chronic hyperinflation: dysfunction or adaptation?

(2009) Thomas L. Clanton et al.   JOURNAL OF APPLIED PHYSIOLOGY

Airway wall attenuation: a biomarker of airway disease in subjects with COPD

(2009) George R. Washko et al.   JOURNAL OF APPLIED PHYSIOLOGY

Pulmonary characteristics in COPD and mechanisms of increased work of breathing

(2009) Stephen H. Loring et al.   JOURNAL OF APPLIED PHYSIOLOGY

Ventilation-perfusion imbalance and chronic obstructive pulmonary disease staging severity

(2009) Roberto Rodríguez-Roisin et al.   JOURNAL OF APPLIED PHYSIOLOGY

Respiratory muscle function and activation in chronic obstructive pulmonary disease

(2009) David K. McKenzie et al.   JOURNAL OF APPLIED PHYSIOLOGY

Response of the respiratory muscles to rehabilitation in COPD

(2009) Marc Decramer   JOURNAL OF APPLIED PHYSIOLOGY

Effect of acute inflation on the mechanics of the inspiratory muscles

(2009) André De Troyer et al.   JOURNAL OF APPLIED PHYSIOLOGY

Pulmonary Rehabilitation for Management of Chronic Obstructive Pulmonary Disease

(2009) Richard Casaburi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mechanisms of activity-related dyspnea in pulmonary diseases

(2009) Denis E. O’Donnell et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Prediction of the rate of decline in FEV1 in smokers using quantitative computed tomography

(2009) R Yuan et al.   THORAX

Effects of respiratory muscle unloading on leg muscle oxygenation and blood volume during high-intensity exercise in chronic heart failure

(2008) Audrey Borghi-Silva et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Can Ventilation–Feedback Training Augment Exercise Tolerance in Patients with Chronic Obstructive Pulmonary Disease?

(2008) Eileen G. Collins et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The Unpleasantness of Perceived Dyspnea Is Processed in the Anterior Insula and Amygdala

(2008) Andreas von Leupoldt et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The Affective Dimension of Laboratory Dyspnea

(2008) Robert B. Banzett et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Effects of hyperinflation on the oxygen pulse as a marker of cardiac performance in COPD

(2008) C. Vassaux et al.   EUROPEAN RESPIRATORY JOURNAL

Kinetics of muscle deoxygenation are accelerated at the onset of heavy-intensity exercise in patients with COPD: relationship to central cardiovascular dynamics

(2008) Gaspar R. Chiappa et al.   JOURNAL OF APPLIED PHYSIOLOGY

Cortical and subcortical central neural pathways in respiratory sensations

(2008) Paul W. Davenport et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Respiratory muscle unloading improves leg muscle oxygenation during exercise in patients with COPD

(2008) A Borghi-Silva et al.   THORAX

Mechanisms of Dyspnea during Cycle Exercise in Symptomatic Patients with GOLD Stage I Chronic Obstructive Pulmonary Disease

(2007) Dror Ofir et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE