Article
Radiology, Nuclear Medicine & Medical Imaging
Carlos H. Martinez, Yuka Okajima, Andrew Yen, Diego J. Maselli, Pietro Nardelli, Farbord Rahaghi, Kendra Young, Gregory Kinney, Charles Hatt, Craig Galban, George R. Washko, MeiLan Han, Raul San Jose Estepar, Alejandro A. Diaz
Summary: This study assessed the relationship between chronic obstructive pulmonary disease (COPD) and bronchiectasis in smokers, revealing that smokers with radiographic bronchiectasis have an increased burden of emphysema and lower airflow and exercise capacity.
ACADEMIC RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Josalyn L. Cho, Raul Villacreses, Prashant Nagpal, Junfeng Guo, Alejandro A. Pezzulo, Andrew L. Thurman, Nabeel Y. Hamzeh, Robert J. Blount, Spyridon Fortis, Eric A. Hoffman, Joseph Zabner, Alejandro P. Comellas
Summary: This study found that survivors of COVID-19 may experience small airways disease independently of the severity of their initial infection. The degree of air trapping in patients was correlated with the residual volume-to-total lung capacity ratio. The long-term consequences of these findings remain unknown.
Article
Radiology, Nuclear Medicine & Medical Imaging
Alan A. Peters, Oliver Weinheimer, Oyunbileg von Stackelberg, Jonas Kroschke, Lars Piskorski, Manuel Debic, Kai Schlamp, Linn Welzel, Moritz Pohl, Andreas Christe, Lukas Ebner, Hans-Ulrich Kauczor, Claus Peter Heussel, Mark O. Wielpuetz
Summary: Quantitative computed tomography (QCT) of the whole lung and nodule-bearing lobe can be valuable in assessing the malignancy risk of pulmonary nodules. The study shows that nodules in subjects with higher emphysema levels and less fibrosis in the lungs are more likely to be malignant.
EUROPEAN RADIOLOGY
(2023)
Article
Multidisciplinary Sciences
Thuy D. Do, Stephan Skornitzke, Uta Merle, Maximilian Kittel, Stefan Hofbaur, Claudius Melzig, Hans-Ulrich Kauczor, Mark O. Wielpuetz, Oliver Weinheimer
Summary: Fully automatic lung quantification based on spectral CT and laboratory parameters can be used for prognostic prediction in COVID-19 pneumonia, and it can predict the need for invasive ventilation in patients.
Article
Multidisciplinary Sciences
Babak Haghighi, Hannah Horng, Peter B. B. Noel, Eric A. A. Cohen, Lauren Pantalone, Anil Vachani, Katharine A. A. Rendle, Jocelyn Wainwright, Chelsea Saia, Russel T. T. Shinohara, Eduardo Mortani Barbosa Jr, Despina Kontos
Summary: High-throughput extraction of radiomic features from low-dose CT scans can characterize the heterogeneity of the lung parenchyma and potentially aid in identifying subpopulations that may have higher risk of lung diseases. We aim to determine the feasibility of a lung radiomics phenotyping approach in a lung cancer screening cohort, while quantifying the effect of different CT reconstruction algorithms on phenotype robustness.
SCIENTIFIC REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Dimitrios Toumpanakis, Omar S. Usmani
Summary: Alpha-1 antitrypsin deficiency (AATD) is a genetic disorder that leads to panacinar emphysema and increases the risk of chronic obstructive pulmonary disease (COPD), especially in smokers. AATD is caused by mutations in the SERPINA1 gene, which affects the production of alpha-1 antitrypsin (AAT) protein. AAT not only acts as a protease inhibitor, but also has anti-inflammatory and antioxidative effects. Imbalance in protease/antiprotease levels not only affects the lung parenchyma, but also the small airways.
RESPIRATORY MEDICINE
(2023)
Article
Medicine, General & Internal
Panagiotis K. Panagopoulos, Andreas V. Goules, Vasiliki E. Georgakopoulou, Anastasios Kallianos, Eirini Chatzinikita, Vasileios C. Pezoulas, Katerina Malagari, Dimitrios I. Fotiadis, Panayiotis Vlachoyiannopoulos, Theodoros Vassilakopoulos, Athanasios G. Tzioufas
Summary: This study evaluated small airways function in SSc patients with ILD and explored the effect of treatment on small airways function. The results showed that phase III slope(N2SBW) and R5-R20 may have high diagnostic accuracy in detecting early small airways dysfunction in SSc-associated ILD, and there may be partial improvement in some patients after treatment.
FRONTIERS IN MEDICINE
(2022)
Article
Critical Care Medicine
Brianna P. Matthew, Amir M. Hasani, Yun-Ching Chen, Mehdi Pirooznia, Mario Stylianou, Shirley F. Rollison, Tania R. Machado, Nora M. Quade, Amanda M. Jones, Patricia Julien-Williams, Angelo Taveira-DaSilva, Marcus Y. Chen, Joel Moss, Han Wen
Summary: The study examined the impact of ultra-small cysts on pulmonary function in patients with LAM, finding that ultra-small cysts primarily contribute to a reduction in DLCO, with minimal effects on FEV1 and FEV1/FVC.
Article
Radiology, Nuclear Medicine & Medical Imaging
Diana Penha, Erique Pinto, Bruno Hochhegger, Colin Monaghan, Edson Marchiori, Luis Taborda-Barata, Klaus Irion
Summary: This study found that the likelihood of good segmentation for lung nodules with diameters of 5-8 mm decreases with increasing attenuation of the adjacent parenchyma. There was good interobserver and intersoftware agreement on segmentation, though one software package performed better and measurements consistently differed between packages.
INSIGHTS INTO IMAGING
(2021)
Article
Genetics & Heredity
Maxim Avanesov, Lennart Well, Azien Laqmani, Thorsten Derlin, Vincent M. Riccardi, Gerhard Adam, Victor-Felix Mautner, Johannes Salamon
Summary: Diffuse interstitial lung disease has been described in Neurofibromatosis type 1 (NF1), but the prevalence and characteristics of NF1-associated lung manifestations remain unclear. This study evaluated lung pathologies in NF1 patients, finding that smoking history, age, and presence of MPNST could influence pulmonary findings. Different lung pathologies occurred independently of specific NF1 mutations, emphasizing the importance of smoking cessation in preventing pulmonary metastases, MPNST, and centrilobular emphysema.
ORPHANET JOURNAL OF RARE DISEASES
(2021)
Article
Surgery
Daniel T. Dugger, Monica Fung, Steven R. Hays, Jonathan P. Singer, Mary E. Kleinhenz, Lorriana E. Leard, Jeffrey A. Golden, Rupal J. Shah, Joyce S. Lee, Fred Deiter, Nancy Y. Greenland, Kirk D. Jones, Chaz R. Langelier, John R. Greenland
Summary: In patients with chronic lung allograft dysfunction (CLAD) following lung transplantation, research indicated that small airway gene expression changes were associated with CLAD, and molecular analysis conducted on airway brushings showed potential for diagnosing CLAD.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jong Eun Lee, Kum Ju Chae, Young Ju Suh, Won Gi Jeong, Taebum Lee, Yun-Hyeon Kim, Gong Yong Jin, Yeon Joo Jeong
Summary: This study investigated the prevalence of interstitial lung abnormalities (ILAs) in an Asian health screening cohort and found that fibrotic ILA was associated with increased risks of ILA progression, lung cancer development, and mortality over a 10-year follow-up period.
Article
Radiology, Nuclear Medicine & Medical Imaging
Lin Zhang, Beibei Jiang, Hendrik Joost Wisselink, Rozemarijn Vliegenthart, Xueqian Xie
Summary: By utilizing chest CT images, a deep convolutional neural network model was established to accurately infer lung function and diagnose COPD, showing significantly higher accuracy compared to traditional quantitative CT methods.
BRITISH JOURNAL OF RADIOLOGY
(2022)
Article
Respiratory System
Victor Manuel Mora-Cuesta, Laura Sanchez-Moreno, David Iturbe-Fernandez, Elena Perez-Barquin, Sandra Tello-Mena, Pilar Alonso-Lecue, Sheila Izquierdo-Cuervo, Sara Naranjo-Gozalo, Jose Manuel Cifrian-Martinez, Jose Javier Gomez-Roman
Summary: This study reviewed the histopathology of lung transplant recipients and found that significant additional histological diagnoses were more frequent in these patients compared to those with other chronic respiratory diseases, and these findings were not related to tobacco use.
JOURNAL OF THORACIC DISEASE
(2023)
Article
Pharmacology & Pharmacy
Ping Wei, Ru-Jia Tao, Hai-wen Lu, Jin-Fu Xu, Yi-han Liu, Hai Wang, Ling-Ling Li, Ye Gu, Wei-Jun Cao
Summary: Bronchoscopic lung volume reduction (BLVR) is a feasible, safe, effective, and minimally invasive technique that significantly improves the quality of life of advanced severe chronic obstructive pulmonary disease (COPD) patients. This study evaluated the postoperative efficacy of BLVR patients using three-dimensional computed tomography (3D-CT) automatic analysis software and pulmonary function test (PFT). The results confirmed the accurate evaluation of lung volume, ventilation, and perfusion changes with 3D-CT analysis.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2023)
