Article
Immunology
Mingming Deng, Yan Yin, Qin Zhang, Xiaoming Zhou, Gang Hou
Summary: This study aimed to identify effective biomarkers for COPD through differential expressed genes analysis and weighted co-expression network analysis. The results suggest that Lp-PLA2 may be a potential biomarker for assessing exercise tolerance in COPD patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Flavia Rossi Caruso, Cassia da Luz Goulart, Jose Carlos Bonjorno Jr, Claudio Ricardo de Oliveira, Renata Goncalves Mendes, Ross Arena, Audrey Borghi-Silva
Summary: Weber classification can be used to stratify cardiorespiratory fitness in COPD patients. Patients in Weber D group had lower exercise capacity and higher dyspnea compared to Weber A and B groups. Heart rate and forced expiratory volume in one second were significant predictors of peak oxygen consumption.
Article
Respiratory System
Felipe V. C. Machado, Martijn A. Spruit, Miriam T. J. Groenen, Sarah Houben-Wilke, Paula P. van Melick, Nidia A. Hernandes, Annemie M. W. J. Schols, Fabio Pitta, Emiel F. M. Wouters, Frits M. E. Franssen
Summary: This study analyzed data from 469 COPD patients and found that over half of overweight and obese patients have low muscle mass when using age-gender-BMI-specific cut-offs. Low muscle mass is associated with worse functional outcomes in overweight and obese COPD patients.
RESPIRATORY RESEARCH
(2021)
Article
Sport Sciences
Nicholas B. Tiller, Janos Porszasz, Richard Casaburi, Harry B. Rossiter, Carrie Ferguson
Summary: Several studies suggest that pulmonary oxygen uptake (V?O-2) at the respiratory compensation point (RCP) is equivalent to the V?O-2 at critical power (CP), which indicates that these variables can be used interchangeably. This study aimed to compare V?O-2 at CP with V?O-2 at RCP in patients with chronic obstructive pulmonary disease (COPD).
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2023)
Article
Cardiac & Cardiovascular Systems
Francisco Garcia-Rio, Marc Miravitlles, Joan B. Soriano, Borja G. Cosio, Juan Jose Soler-Cataluna, Ciro Casanova, Pilar de Lucas, Inmaculada Alfageme, Jose Miguel Rodriguez Gonzalez-Moro, Maria Guadalupe Sanchez Herrero, Julio Ancochea
Summary: A study on COPD patients and subjects without airflow limitation found that almost half of them maintain a sedentary lifestyle, with different risk factors for sedentarism between the two groups.
RESPIRATORY MEDICINE
(2023)
Review
Nutrition & Dietetics
Angela Tramontano, Paolo Palange
Summary: Chronic Obstructive Pulmonary Disease (COPD) is a global epidemic causing numerous deaths annually. It is characterized by progressive and often irreversible airflow obstruction with varying clinical manifestations. Malnutrition is commonly observed in COPD patients and can worsen respiratory function and prognosis. Nutritional impairment is associated with reduced exercise tolerance and impact on patient-perceived quality of life. However, there is limited data on the best strategies to manage malnutrition in COPD patients. This review highlights the importance of COPD-related malnutrition on muscle function, exercise tolerance, and dyspnea.
Article
Critical Care Medicine
Elena Crescioli, Thomas Lass Klitgaard, Anders Perner, Olav Lilleholt Schjorring, Bodil Steen Rasmussen
Summary: This study compared the effects of lower versus higher oxygenation targets in adult ICU patients with hypoxaemic respiratory failure after cardiac arrest. The findings showed that the lower-oxygenation group had a higher mortality rate, but fewer serious adverse events.
Article
Respiratory System
David H. Au, Emily Gleason, Rachel Hunter-Merrill, Anna E. Baron, Margaret Collins, Corina Ronneberg, Nan Lv, Peter Rise, Travis Hee Wai, Robert Plumley, Stephen R. Wisniewski, Frank C. Sciurba, Dong-Yun Kim, Paul Simonelli, Jerry A. Krishnan, Christine H. Wendt, Laura C. Feemster, Gerard J. Criner, Veeranna Maddipati, Arjun Mohan, Jun Ma
Summary: Among overweight or obese patients with COPD, a self-guided low-intensity video-based lifestyle intervention led to modest weight loss but did not lead to clinically important improvements in physical functional status and dyspnea.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2023)
Article
Respiratory System
Rainer Gloeckl, Tessa Schneeberger, Daniela Leitl, Tobias Reinold, Christoph Nell, Inga Jarosch, Klaus Kenn, Andreas R. Koczulla
Summary: The study found that whole-body vibration training on a vibration platform can significantly improve balance performance and muscular power in patients with chronic obstructive pulmonary disease, with better results than conventional balance training. Additionally, patients showed improvements in 6-minute walk distance and 4-meter gait speed test after whole-body vibration training.
RESPIRATORY RESEARCH
(2021)
Article
Rehabilitation
Hugo L. Pereira, Danielle S. Vieira, Raquel R. Britto, Lailane S. Da Silva, Giane A. Ribeiro-Samora, Bianca L. Carmona, Guilherme A. Fregonezi, Veronica F. Parreira
Summary: The study showed that in patients with COPD, the use of 7.5 cmH(2)O EPAP was associated with reduced exercise tolerance and increased dyspnea during a constant cycle ergometer exercise test.
PHYSIOTHERAPY THEORY AND PRACTICE
(2022)
Review
Biochemistry & Molecular Biology
Andreea-Bianca Uzun, Madalina Gabriela Iliescu, Liliana-Elena Stanciu, Elena-Valentina Ionescu, Rodica Ana Ungur, Viorela Mihaela Ciortea, Laszlo Irsay, Irina Motoasca, Marius Nicolae Popescu, Florina Ligia Popa, Loredana Pazara, Doina-Ecaterina Tofolean
Summary: Intermittent oxygen therapy (IHT) has shown effectiveness in preventing and treating various diseases by combining hypoxic and hyperoxic periods. This therapy has gained attention in sports medicine due to its potential to enhance adaptive response. By upregulating reactive oxygen species and hypoxia-inducible genes, moderate hyperoxia may increase the benefits of intermittent hypoxic stimulus.
Article
Critical Care Medicine
L. Imeen van der Wal, Chloe C. A. Grim, Michael R. del Prado, David J. van Westerloo, E. Christiaan Boerma, Hilda G. Rijnhart-de Jong, Auke C. Reidinga, Bert G. Loef, Pim L. J. van der Heiden, Marnix J. Sigtermans, Frederique Paulus, Alexander D. Cornet, Maurizio Loconte, F. Jeannette Schoonderbeek, Nicolette F. de Keizer, Ferishta Bakhshi-Raiez, Saskia Le Cessie, Ary Serpa Neto, Paolo Pelosi, Marcus J. Schultz, Hendrik J. F. Helmerhorst, Evert de Jonge
Summary: A low-oxygenation strategy did not result in a reduction of 28-day mortality compared with a high-oxygenation strategy in mechanically ventilated ICU patients.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Health Care Sciences & Services
Nour Baalbaki, Christopher Giuliano, Carrie L. Hartner, Pramodini Kale-Pradhan, Leonard Johnson
Summary: The study compared treatment failure in patients with acute exacerbations of chronic obstructive pulmonary disease (AECOPD) receiving azithromycin or beta-lactams. Results showed that azithromycin was associated with less treatment failure, driven by lower readmission rates and prescription of new antimicrobials.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2022)
Review
Medicine, General & Internal
Erwin Grasmuk-Siegl, Arschang Valipour
Summary: According to current guidelines, minimal invasive strategies should be used as the primary management for spontaneous pneumothorax. However, in clinical practice, oxygen supplementation is frequently applied regardless of hypoxemia to enhance air resorption from the pleural cavity. This review discusses the scientific origin of this practice in animal models and its clinical use in adult and pediatric patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Emily S. Wan, Rebekah L. Goldstein, Eric Garshick, Dawn L. DeMeo, Marilyn L. Moy
Summary: The study suggests that epigenetic measures of biological age are independent predictors of exercise capacity and physical activity in COPD patients, but not associated with acute exacerbations. Adjusted models show that changes in biological age are gradually associated with exercise capacity and physical activity.
RESPIRATORY MEDICINE
(2021)
Article
Public, Environmental & Occupational Health
Raissa M. da Coelho, Marco A. P. Nunes, Cristiane V. C. Gomes, Ilma S. dos Viana, Angela M. da Silva
Article
Multidisciplinary Sciences
Marcela Sampaio Lima, Erika de Abreu Costa Brito, Hianga Fayssa Fernandes Siqueira, Marceli de Oliveira Santos, Angela Maria da Silva, Marco Antonio Prado Nunes, Hugo Leite de Farias Britoi, Marcia Maria Macedo Lima, Rosana Cipolotti, Carlos Anselmo Lima
Article
Health Care Sciences & Services
Marcus Valerius da Silva Peixoto, Andrezza Marques Duque, Allan Dantas dos Santos, Shirley Veronica Almeida Melo Lima, Tarsilla Pereira Goncalves, Ana Paula de Souza Novais, Susana de Carvalho, Silvia Maria Voci, Karina Conceicao Gomes Machado de Araujo, Marco Antonio Prado Nunes
Article
Pharmacology & Pharmacy
Cristina G. M. Pereira, Erely R. S. Santana, Joane E. R. Ramos, Heloisa M. B. S. da Silva, Marco A. P. Nunes, Scott C. Forbes, Heitor O. Santos
Summary: The study aimed to assess the impact of hospitalization and feeding strategy on the risk of hypozincemia and related factors. It found that levels of serum zinc were significantly lower in inpatients receiving enteral nutrition compared to those receiving oral nutrition, and that hospitalization and old age were independent predictors of zinc deficiency. Additionally, factors such as age, noninvasive mechanical ventilatory support, critical care, low hemoglobin levels, and low iron levels were associated with increased risk of hypozincemia in patients.
CLINICAL THERAPEUTICS
(2021)
Article
Health Care Sciences & Services
Gessyca Cavalcante de Melo, Emilia Carolle Azevedo de Oliveira, Iane Brito Leal, Carolina Piedade Morais de Freitas Soares Silva, Roberta Andrade Beltrao, Allan Dantas dos Santos, Renata Karina Reis, Marco Antonio Prado Nunes, Karina Conceicao Gomes Machado de Araujo
Review
Medicine, General & Internal
Marcela Larissa Costa, Carlos Adriano Santos Souza, Ana Caroline Cardoso Silva, Dayane Franciely Conceicao Santos, Edilene Fernandes Nonato, Francismayne Batista Santana, Giselle dos Santos Dias, Jessyca Teles Barreto, Lais Santos Costa, Maria Carolina Barros Costa, Tamila das Neves Ferreira, Jeniffer Santos Santana, Raquel Simoes Mendes-Netto, Tereza Virginia Silva Bezerra do Nascimento, Marco Antonio Prado Nunes, Marcia Ferreira Candido de Souza
Summary: This review aims to synthesize the evidence on the association between COVID-19 and the severity of clinical outcomes in infected obese patients, in order to advance treatment directions and optimization.
SYSTEMATIC REVIEWS
(2021)
Article
Multidisciplinary Sciences
Carlos Anselmo Lima, Brenda Evelin Barreto da Silva, Evania Curvelo Hora, Marcela Sampaio Lima, Erika de Abreu Costa Brito, Marceli de Oliveira Santos, Angela Maria da Silva, Marco Antonio Prado Nunes, Hugo Leite de Farias Brito, Marcia Maria Macedo Lima
Summary: Prostate cancer incidence rates in Sergipe state of Brazil sharply increased until the mid-2000s for all age groups before declining, while mortality rates increased until 2005 and then stabilized. The changes in incidence rates were associated with screening recommendations, while the increase in mortality rates appeared to be linked to age and improvements in cause of death identification. A PSA screening program may not benefit the population studied.
Article
Health Care Sciences & Services
Fellipe Amatuzzi, Alexandra Correa Gervazoni Balbuena de Lima, Marianne Lucena Da Silva, Graziella Franca Bernardelli Cipriano, Aparecida Maria Catai, Lawrence Patrick Cahalin, Gaspar Chiappa, Gerson Cipriano Jr
Summary: The study demonstrated that osteopathic manipulative treatment had a positive effect on vascular dilation and heart rate variability in patients with heart failure, with the most significant effects observed 15 minutes after the intervention. This suggests that OMT is effective in increasing brachial blood flow and stimulating the vagal system in these patients.
JOURNAL OF MANIPULATIVE AND PHYSIOLOGICAL THERAPEUTICS
(2021)
Article
Medicine, General & Internal
Robson F. Borges, Gaspar R. Chiappa, Paulo T. Muller, Alexandra Correa Gervazoni Balbuena de Lima, Lawrence Patrick Cahalin, Graziella Franca Bernardelli Cipriano, Gerson Cipriano
Summary: Moderate-intensity BFR training prior to a high-intensity exercise did not accelerate subsequent VO2P and Q(T) kinetics, but significantly improved exercise tolerance and work efficiency, resulting in lower oxygen cost.
Letter
Cardiac & Cardiovascular Systems
Alexandra C. G. B. Lima, Magno F. Formiga, Luiz T. Giollo, Marianne L. da Silva, Vinicius Z. M. da Silva, Maria E. B. Otto, Gaspar R. Chiappa, Gerson Cipriano
JOURNAL OF CARDIOVASCULAR MEDICINE
(2022)
Article
Environmental Sciences
Amanda Vale-Lira, Natalia Turri-Silva, Kenneth Verboven, Joao Luiz Quagliotti Durigan, Alexandra Correa G. B. de Lima, Martim Bottaro, Gaspar R. Chiappa, Dominique Hansen, Gerson Cipriano Jr
Summary: Exercise intolerance is a common issue in heart failure patients, and it is associated with muscle weakness. This study aimed to compare the microcirculatory and muscle characteristics between heart failure patients with HFpEF and HFrEF phenotypes. The researchers found that HFpEF patients showed more pronounced impairments in local microcirculatory dynamics during muscle strength exercise, combined with muscle-skeletal abnormalities detected via ultrasound imaging. These findings may help explain the exercise intolerance observed in HFpEF patients.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Review
Physiology
William R. Pedon, Francisco V. Lima, Gerson Cipriano, Weder A. da Silva, Marcos V. S. Fernandes, Natalia S. Gomes, Adriana M. G. Chiappa, Rafael Pena de Sousa, Maria Eduarda Pereira da Silva, Gaspar R. Chiappa
Summary: This study summarizes the existing evidence on the acute response of low-load resistance exercise with blood flow restriction on hemodynamic parameters. The results indicate that low-load resistance exercise with blood flow restriction has similar effects on all hemodynamic parameters compared to conventional resistance exercise. Younger individuals show slightly higher chronotropic responses compared to older individuals.
CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING
(2022)
Letter
Cardiac & Cardiovascular Systems
Marcos V. S. Fernandes, Paulo de Tarso Muller, Mariah Castilho dos Santos, Weder Alves da Silva, Adriana M. Guntzel Chiappa, Gaspar R. Chiappa
JOURNAL OF CARDIOVASCULAR MEDICINE
(2022)
Article
Medicine, General & Internal
Victor Hugo De Melol, Ricardo Augusto Leoni de Sousa, Alex Cleber Improta-Caria, Marco Antonio Prado Nunes
Summary: Elderly individuals with lower limb amputation are more likely to have negative health outcomes compared to adults with lower limb amputation. In the elderly group, there were higher levels of low functional independency and lower physical activity levels. Positive correlations were found between low metabolic equivalent task, time since amputation, and family income in the elderly group, while only a correlation with low family income was found in the adult group.
REVISTA DA ASSOCIACAO MEDICA BRASILEIRA
(2021)
Article
Multidisciplinary Sciences
Shirley Veronica Melo Almeida Lima, Karina Conceicao Gomes Machado de Araujo, Marco Antonio Prado Nunes, Carla Nunes
Summary: A study conducted in Sergipe, Brazil from 2015 to 2018 identified various individual and ecological factors contributing to loss to follow-up in tuberculosis treatment. Findings revealed that males, individuals with black skin, those aged 20-39, with 4-7 years of schooling, alcohol users, drug users, smokers, and homeless individuals were more likely to abandon treatment. Additionally, living in municipalities with high human development index and income inequality increased the likelihood of not completing treatment. These factors were shown to be predictive in a generalised hierarchical model with a precision of 0.771 and accuracy of 84.0% according to the receiver operating characteristic curve.