Article
Pediatrics
Anne Kotaniemi-Syrjanen, Timo Klemola, Petri Koponen, Outi Jauhola, Henrikka Aito, Kristiina Malmstrom, L. Pekka Malmberg, Eero Rahiala, Seppo Sarna, Anna S. Pelkonen, Mika J. Makela
Summary: Intermittent tiotropium bromide treatment may be an effective alternative for episodic wheezing, with a higher proportion of episode-free days.
Article
Physiology
Min Cao, Robert A. Calmelat, Peter Kierstead, Nicolo Carraro, William W. Stringer, Janos Porszasz, Richard Casaburi, Harry B. Rossiter
Summary: Exercise intolerance in COPD is associated with dyspnea and reduced inspiratory capacity. Combination bronchodilator therapy did not improve neuromuscular performance or increase exercise tolerance in COPD patients.
JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Article
Respiratory System
Daniel Sebastian Majorski, Friederike Sophie Magnet, Saadia Thilemann, Claudia Schmoor, Wolfram Windisch, Sarah Bettina Schwarz
Summary: The use of portable NIV device during walking can improve dyspnea and walking distance in patients with moderate to severe COPD. Patients who do not already receive long-term NIV therapy are more likely to benefit compared to those undergoing long-term NIV. Careful patient selection is mandatory.
RESPIRATORY RESEARCH
(2021)
Article
Sport Sciences
Christos Chalitsios, Thomas Nikodelis, Vasileios Konstantakos, Iraklis Kollias
Summary: This study examined the sensitivity of several movement variables during running to exhaustion using a machine learning approach. The most important variables identified were related to angular range, loading rate, and ground reaction force. The results provide insights into the interconnections between kinetics and kinematics of the torso to maintain a coordinated running pattern under fatigue conditions.
EUROPEAN JOURNAL OF SPORT SCIENCE
(2022)
Article
Gastroenterology & Hepatology
Bertha A. Marin-Alejandre, Irene Cantero, Nuria Perez-Diaz-del-Campo, Jose I. Monreal, Mariana Elorz, Jose I. Herrero, Alberto Benito-Boillos, Jorge Quiroga, Ana Martinez-Echeverria, Juan I. Uriz-Otano, Maria P. Huarte-Muniesa, Josep A. Tur, Jose A. Martinez, Itziar Abete, Maria A. Zulet
Summary: The study found that both AHA and FLiO diets were effective in improving weight, body composition, metabolism, and liver status in NAFLD patients over a 2-year period. The FLiO diet showed greater improvements in liver enzymes, liver stiffness, and Fatty Liver Index, as well as a significant increase in adiponectin compared to the AHA diet.
LIVER INTERNATIONAL
(2021)
Article
Multidisciplinary Sciences
Msolli Mohamed Amine, Messous Selma, Sekma Adel, Bel Haj Ali Khaoula, Khalil Mohamed Hassene, Trabelsi Imen, Abdelghani Ahmed, Ben Brahim Nadia, Ben Dhaya Yosra, Razgallah Rabie, Grissa Mohamed Habib, Beltaief Kaouthar, Methamem Mehdi, Belguith Asma, Bouida Wahid, Boukef Riadh, Boubaker Hamdi, Nouira Semir
Summary: This study showed that a 2-day course of levofloxacin had similar efficacy compared to CRP-guided treatment in patients with acute exacerbation of COPD. Both treatment strategies did not significantly differ in cure rate, need for additional antibiotics, ICU admission rates, and exacerbation rates, indicating that the short course treatment can decrease antibiotic consumption without compromising efficacy.
Article
Physiology
Ritva S. Taipale-Mikkonen, Anna Raitanen, Anthony C. Hackney, Guro Strom Solli, Maarit Valtonen, Heikki Peltonen, Kerry McGawley, Heikki Kyrolainen, Johanna K. Ihalainen
Summary: The study found that fluctuations in menstrual cycle and hormonal contraceptive cycle do not systematically affect physiological variables monitored during incremental treadmill testing. However, differences in heart rate at AerT and AnaT between EUM and CHC groups suggest that heart rate-based training should be individually prescribed, and recording of MC or HC use during testing is important to explain potential minor changes in variables such as lactate concentrations or HR response.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Medicine, Research & Experimental
Francois Maltais, Alberto de la Hoz, Richard Casaburi, Denis O'Donnell
Summary: For COPD patients, treatment with inhaled long-acting muscarinic antagonist (LAMA) and long-acting beta(2)-agonist (LABA) combination therapy can improve airflow limitation, reduce breathlessness, and enhance quality of life. Optimizing therapy with dual bronchodilation using tiotropium/olodaterol can improve inspiratory capacity and exercise endurance time.
ADVANCES IN THERAPY
(2021)
Article
Sport Sciences
Ingrid Demmelmaier, Hannah L. Brooke, Anna Henriksson, Anne-Sophie Mazzoni, Ann Christin Helgesen Bjorke, Helena Igelstrom, Anna-Karin Ax, Katarina Sjovall, Maria Hellbom, Ronnie Pingel, Henrik Lindman, Silvia Johansson, Galina Velikova, Truls Raastad, Laurien M. Buffart, Pernilla Asenlof, Neil K. Aaronson, Bengt Glimelius, Peter Nygren, Birgitta Johansson, Sussanne Borjeson, Sveinung Berntsen, Karin Nordin
Summary: This study compared high- vs low-to-moderate-intensity exercise on CRF in cancer patients undergoing treatment, and found that high intensity exercise can lower physical fatigue, but the difference was not clinically significant. Additional behavior change support did not provide extra benefits for CRF in supervised exercise interventions.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Sherrie Khadanga, Patrick D. Savage, Anton Pecha, Jason Rengo, Philip A. Ades
Summary: In this randomized clinical trial, a combination of HIIT and intensive lower extremity RT showed enhanced exercise training response for women in cardiac rehabilitation compared to standard exercise training, with significantly greater improvements in both peak Vo(2) and leg strength in the HIIT group.
Article
Physiology
Almudena Montalvo-Perez, Lidia B. Alejo, Pedro L. Valenzuela, Jaime Gil-Cabrera, Eduardo Talavera, Alejandro Luia, David Barranco-Gil
Summary: In competitive female cyclists, short-term velocity-based resistance training (VBRT) and traditional resistance training (TRT) both led to significant improvements in muscle strength/power, with VBRT potentially resulting in greater gains in maximum strength/power.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Medicine, General & Internal
Linette Marie Kofod, Elisabeth Westerdahl, Morten Tange Kristensen, Barbara Cristina Brocki, Thomas Ringbaek, Ejvind Frausing Hansen
Summary: This study found that COPD patients using automated oxygen titration during walking experienced lower levels of dyspnea and greater endurance, making it more effective than using usual fixed-dose oxygen treatment.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Hospitality, Leisure, Sport & Tourism
Anne Krause, Ivo da Mota de Moreira, Nicolas Walser, Daniel Memmert, Ramona Ritzmann
Summary: The aim of this study was to evaluate the physiological and metabolic responses to running with whole-body electromyostimulation (wbEMS) compared to running without electromyostimulation (control, CG). The results showed that wbEMS induced earlier fatigue and a shift in energy metabolism toward fat utilization. Therefore, wbEMS can be considered as an alternative training stimulus that is easy-to-apply and effective during endurance training.
RESEARCH QUARTERLY FOR EXERCISE AND SPORT
(2023)
Article
Orthopedics
Felix Rohrer, Malte Wendt, Hubert Noetzli, Lorenz Risch, Thomas Bodmer, Philippe Cottagnoud, Tanja Hermann, Andreas Limacher, Brigitta Gahl, Jan Bruegger
Summary: This study investigated the impact of preoperative decolonization on delayed onset of periprosthetic joint infection (PJI) and found no cases of PJI in either the carrier or noncarrier group after a two-year follow-up. While a definite conclusion on the efficacy of preoperative decolonization to reduce PJI could not be drawn, the results may be helpful for future meta-analyses.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2021)
Article
Physiology
Christopher C. F. Howe, Nicola Swann, Owen Spendiff, Anna Kosciuk, Elizabeth K. L. Pummell, Hannah J. Moir
Summary: This study aimed to investigate the changes in metabolic variables, running energetics, and spatiotemporal gait parameters during an 80.5 km treadmill ultramarathon, with a focus on key predictive variables for performance. The results showed that fractional utilisation of (V) over dotO(2max) (F) and energy cost of running (Cr) accounted for 61% of the variance in finish time, highlighting their importance in ultramarathon performance optimization.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Letter
Critical Care Medicine
David A. Lipson, MeiLan K. Han, Robert Wise, Fernando J. Martinez
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Medicine, Research & Experimental
Robert A. Wise, Benjamin M. Scirica, Deepak L. Bhatt, Sami Z. Daoud, Ferran Chuecos, Esther Garcia Gil, Kenneth R. Chapman
Summary: This study found that aclidinium bromide did not increase the risk of MACE or all-cause mortality, regardless of baseline maintenance treatment. Aclidinium reduced moderate-to-severe COPD exacerbation rates in all subgroups and improved morning trough FEV1 and CAT total scores at multiple time points, providing additional benefits when added to maintenance therapy with LABA or LABA + ICS.
ADVANCES IN THERAPY
(2021)
Article
Critical Care Medicine
Nadia N. Hansel, Nirupama Putcha, Han Woo, Roger Peng, Gregory B. Diette, Ashraf Fawzy, Robert A. Wise, Karina Romero, Meghan F. Davis, Ana M. Rule, Michelle N. Eakin, Patrick N. Breysse, Meredith C. McCormack, Kirsten Koehler
Summary: This is the first environmental intervention study conducted among former smokers with COPD, showing potential health benefits of portable high-efficiency particulate absolute air cleaners in improving respiratory morbidity.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Review
Medicine, General & Internal
Ian M. Adcock, Surya P. Bhatt, Ronald Balkissoon, Robert A. Wise
Summary: Inhaled corticosteroids (ICS) in combination with bronchodilators are commonly used in primary care settings for patients with chronic obstructive pulmonary disease (COPD). However, ICS-containing therapies may be less effective in COPD patients, especially in those who continue to smoke. Studies have shown that the inflammation in COPD is different from asthma, and exposure to cigarette smoke alters the functioning of glucocorticoid receptors and other anti-inflammatory mechanisms. Therefore, ICS treatment may be relatively ineffective in COPD patients, particularly in smokers. Inappropriate use of ICS therapies in COPD patients can increase the risk of side effects such as pneumonia and bone fractures. Careful evaluation and selection of anti-inflammatory/bronchodilatory strategies based on individual patient characteristics and current guidelines are crucial for the treatment of COPD.
AMERICAN JOURNAL OF MEDICINE
(2022)
Article
Critical Care Medicine
Nirupama Putcha, Han Woo, Meredith C. McCormack, Ashraf Fawzy, Karina Romero, Meghan F. Davis, Robert A. Wise, Gregory B. Diette, Kirsten Koehler, Elizabeth C. Matsui, Nadia N. Hansel
Summary: This study investigated the sensitivity of COPD patients to common indoor allergens and its association with symptoms and exacerbation risk. The results showed a significant correlation between sensitization and exposure with lower lung function, higher respiratory questionnaire scores, and higher exacerbation risk. Allergens are identified as an important home exposure in COPD, which could potentially be addressed through comprehensive home environmental modification strategies to improve outcomes.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Letter
Critical Care Medicine
Meredith C. McCormack, Aparna Balasubramanian, Elizabeth C. Matsui, Roger D. Peng, Robert A. Wise, Corinne A. Keet
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Review
Respiratory System
Robert A. Wise, Mona Bafadhel, Courtney Crim, Gerard J. Criner, Nicola C. Day, David M. G. Halpin, MeiLan K. Han, Peter Lange, David A. Lipson, Fernando J. Martinez, Diego J. Maselli, Dawn Midwinter, Dave Singh, Maeva Zysman, Mark T. Dransfield, Richard E. K. Russell
Summary: This review discusses methodological differences in defining and recording pneumonia events in clinical trials of ICS use in COPD, as well as factors contributing to varying pneumonia incidence. Variations in diagnosis criteria and reporting methods across trials were found to influence the reported pneumonia rates.
EUROPEAN RESPIRATORY REVIEW
(2021)
Article
Critical Care Medicine
Robert A. Wise, Janet T. Holbrook, Robert H. Brown, Gerard J. Criner, Mark T. Dransfield, Jiaxian He, Robert J. Henderson, David A. Kaminsky, Robert J. Kaner, Stephen C. Lazarus, Barry J. Make, Meredith C. McCormack, Enid R. Neptune, Loretta G. Que
Summary: This study aimed to evaluate the efficacy of losartan in reducing emphysema progression in COPD patients, and the results showed that losartan did not prevent emphysema progression.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Critical Care Medicine
Peter M. A. Calverley, Fernando J. Martinez, Jorgen Vestbo, Christine R. Jenkins, Robert Wise, David A. Lipson, Nicholas J. Cowans, Julie Yates, Courtney Crim, Bartolome R. Celli
Summary: Countries participating in COPD trials consistently differ in reporting exacerbations, which may explain why large studies are needed to show differences in exacerbation risk reduction between treatments.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Letter
Critical Care Medicine
Robert A. Wise, Janet T. Holbrook
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Respiratory System
Andrea Gabrio, Necdet B. Gunsoy, Gianluca Baio, Alan Martin, Victoria F. Paly, Nancy Risebrough, David M. G. Halpin, Dave Singh, Robert A. Wise, MeiLan K. Han, Fernando J. Martinez, Gerard J. Criner, Neil Martin, David A. Lipson, Afisi S. Ismaila
Summary: Triple therapy with fluticasone furoate/umeclidinium/vilanterol (FF/UMEC/VI) showed better clinical benefits compared to dual therapy in the treatment of COPD, and also resulted in lower healthcare resource utilization costs related to COPD.
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2022)
Article
Allergy
Joan Reibman, Bradley E. Chipps, Robert S. Zeiger, David A. Beuther, Robert A. Wise, William McCann, Ileen Gilbert, James M. Eudicone, Hitesh N. Gandhi, Gale Harding, Katelyn Cutts, Karin S. Coyne, Kevin R. Murphy, Maureen George
Summary: Purpose of this study was to assess the construct validity of the Asthma Impairment and Risk Questionnaire (AIRQ) by comparing it with patient self-perception of asthma status and validated disease-specific patient-reported outcome measures. The results showed significant correlations between AIRQ score and patient self-perception, as well as scores from other validated measures. As the AIRQ control category worsened, scores from other measures also worsened. This study demonstrates that AIRQ can be a useful instrument to raise awareness of the impacts of asthma on patients' lives.
JOURNAL OF ASTHMA AND ALLERGY
(2023)
Article
Allergy
Anne M. Mathews, Isaretta Riley, Robert Henderson, Janet T. Holbrook, Jason E. Lang, Anne E. Dixon, Robert A. Wise, Loretta G. Que
Summary: Obesity is an important factor associated with asthma outcomes and may modify the effects of drug treatment. This study aimed to evaluate obesity as a potential treatment effect modifier of enhanced drug messaging or placebos on subjective asthma outcomes.
JOURNAL OF ASTHMA AND ALLERGY
(2022)
Article
Cardiac & Cardiovascular Systems
David A. Kaminsky, Jiaxian He, Robert Henderson, Anne E. Dixon, Charles G. Irvin, John Mastronarde, Lewis J. Smith, Elizabeth A. Sugar, Robert A. Wise, Janet T. Holbrook
Summary: The purpose of this study was to determine the relationship between four different definitions of bronchodilator response (BDR) and asthma control and symptom burden in participants with poorly controlled asthma. The study found that there was no association between BDR and asthma control or symptoms, regardless of the definition used. These findings question the clinical utility of BDR in assessing asthma control and symptoms.
RESPIRATORY MEDICINE
(2023)
Article
Respiratory System
Nirupama Putcha, Antonio R. Anzueto, Peter M. A. Calverley, Bartolome R. Celli, Donald P. Tashkin, Norbert Metzdorf, Achim Mueller, Robert A. Wise
Summary: There is an association between body mass index (BMI) and adverse outcomes in COPD, with underweight individuals having higher mortality and exacerbation risk. Overweight and obese individuals are at lower risk or no additional risk. A holistic management approach is needed to improve the general well-being of COPD patients.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2022)