Article
Medicine, General & Internal
Jimmy Z. Yu, Tobias Granberg, Roya Shams, Sven Petersson, Magnus Skold, Sven Nyren, Johan Lundberg
Summary: This study used DCE-MRI to detect pulmonary perfusion disturbances in individuals with persistent dyspnea after COVID-19. The results showed that the post-COVID group had longer pulmonary perfusion time compared to the control group. There was a correlation between dyspnea and perfusion parameters in male patients, but not in female patients. These findings suggest sex differences in the mechanisms underlying post-COVID dyspnea.
JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Paul D. Griffiths, Mariasavina Severino, Deborah Jarvis, Laura Mandefield, Cecilia Parazzini, Lorenzo Pinelli, Marco Di Maurizio, Fabio Triulzi, Elisa Scola, Giorgio Conte, Giovanni Palumbo, Maurilio Genovese, Andrea Rossi, Renzo Guerrini, Andrea Righini
Summary: The study included 64 foetuses with cortical formation abnormalities (CFA) who underwent two in utero magnetic resonance (iuMR) exams, with 62% showing consistent CFA description between the two studies. In 38% of cases, there was a category change, including cases without CFA initially detected, changes in laterality/symmetry, and re-classification within the same group. Brain abnormalities other than CFA were present in around half of the cases on both first and second studies. Prognosis was predicted to have changed in 8% of cases based on the second study, with all indicating a worse prognosis.
EUROPEAN RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Feifei Qu, Taotao Sun, Yongsheng Chen, Brijesh Kumar Yadav, Ling Jiang, Zhaoxia Qian, E. Mark Haacke
Summary: The study utilized STAGE imaging to estimate tissue properties in the fetal brain, finding that the ratios of T-1app and PDapp in different regions varied, indicating the potential utility of STAGE imaging for assessing fetal brain properties.
EUROPEAN RADIOLOGY
(2021)
Article
Neurosciences
Pauline Mouches, Matthias Wilms, Deepthi Rajashekar, Sonke Langner, Nils D. Forkert
Summary: This study aimed to develop deep learning models to predict biological brain age using multimodal imaging data. The results showed that combining T1-weighted and angiography MRI data significantly improved prediction accuracy, while also identifying the most contributing brain regions and arteries.
HUMAN BRAIN MAPPING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Caohui Duan, Yongqin Xiong, Kun Cheng, Sa Xiao, Jinhao Lyu, Cheng Wang, Xiangbing Bian, Jing Zhang, Dekang Zhang, Ling Chen, Xin Zhou, Xin Lou
Summary: A complex-valued convolutional neural network (ComplexNet) was developed to accelerate susceptibility-weighted imaging (SWI) and showed superior performance compared to conventional methods, providing high-quality images for clinical brain imaging.
EUROPEAN RADIOLOGY
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Weizhao Lu, Yuanyuan Sun, Hui Gao, Jianfeng Qiu
Summary: The increasing number of women in the perimenopausal phase due to global population ageing highlights the importance of studying the perimenopausal brain. Magnetic resonance imaging (MRI) has been widely used to reveal brain alterations associated with perimenopausal symptoms. This review collects literature on perimenopausal brain using MRI techniques, describes the changes in brain structure, function, perfusion, and metabolic compounds, and provides a perspective on future multi-modal MRI studies in the perimenopausal brain. Further research is needed to address the neural heterogeneity in the perimenopausal brain for precise diagnosis and personalized treatment of perimenopausal symptoms.
EUROPEAN RADIOLOGY
(2023)
Review
Clinical Neurology
Pierre Seners, Anke Wouters, Benjamin Maier, William Boisseau, Benjamin J. Gory, Jeremy Heit, Christophe Cognard, Mikael Mazighi, Brice Gaudilliere, Robin Lemmens, Greg W. Zaharchuk, Gregory Albers, Richard Leigh, Jean-Marc Olivot, PRECISE STROKE NETWORK
Summary: Currently, endovascular therapy (EVT) is widely used for large vessel occlusion in acute ischemic stroke patients, but the occurrence of post-EVT intracerebral hemorrhage still leads to disability in more than half of EVT-treated patients. Predicting this complication is important for personalized treatment strategies and selecting suitable candidates for clinical trials. Brain and vascular imaging biomarkers show promise in providing insights into acute stroke pathophysiology and predicting post-EVT intracerebral hemorrhage. This review summarizes the current literature on the role of cerebrovascular imaging biomarkers in predicting this complication to guide future observational or therapeutic studies.
Article
Radiology, Nuclear Medicine & Medical Imaging
Tom Finck, Jens Gempt, Claus Zimmer, Jan S. Kirschke, Nico Sollmann
Summary: The study suggests that CE BB imaging can significantly improve the delineation of therapy-naive HGGs compared to traditional TFE imaging, indicating a potential supplementary role for CE BB sequences in MRI protocols for brain tumors.
EUROPEAN RADIOLOGY
(2021)
Article
Clinical Neurology
Bin Jiang, Nancy K. Hills, Rob Forsyth, Lori C. Jordan, Mahmoud Slim, Steven G. Pavlakis, Neil Freidman, Nomazulu Dlamini, Osman Farooq, Ying Li, Guangming Zhu, Heather Fullerton, Max Wintermark, Warren D. Lo
Summary: In childhood arterial ischemic stroke patients, larger infarct volume and younger age at stroke onset are associated with poorer outcomes, but the strength of these relationships is weak. Specific infarct locations are significantly associated with poorer outcomes, but lose significance when adjusted for infarct volume.
Article
Immunology
May A. Beydoun, Hind A. Beydoun, Yi-Han Hu, Zhiguang Li, Claudia Wolf, Osorio Meirelles, Nicole Noren Hooten, Lenore J. Launer, Michele K. Evans, Alan B. Zonderman
Summary: This study found that infection burden is associated with neurite orientation, dispersion, and density imaging measures, which can reflect brain health. Both total and hospital-treated infection burdens are associated with poorer white matter microstructure. These effects are heterogeneous across cardiovascular health and AD risk.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jacob Ellison, Kisoo Kim, Yi Li, Xin Mu, Orit Glenn, Eugene Ozhinsky, Shabnam Peyvandi, Duan Xu
Summary: This study evaluated the safety of T2-weighted Single Shot Fast Spin Echo (SSFSE) scans at 3 Tesla (3T) for fetal brains using magnetic resonance (MR) thermometry. The results showed that the relative temperature changes in fetal brains compared to the mother's gluteal tissue were minimal, indicating that fetal brain imaging at 3T is safe.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Thomas Leclerc, Raphael Levy, Arnault Tauziede-Espariat, Charles-Joris Roux, Kevin Beccaria, Thomas Blauwblomme, Stephanie Puget, Jacques Grill, Christelle Dufour, Lea Guerrini-Rousseau, Samuel Abbou, Stephanie Bolle, Alexandre Roux, Johan Pallud, Corentin Provost, Catherine Oppenheim, Pascale Varlet, Nathalie Boddaert, Volodia Dangouloff-Ros
Summary: The MRI characteristics of posterior fossa ependymoma subtypes, EPN_PFA and EPN_PFB, can be distinguished. EPN_PFA is commonly seen in young children and appears as median or lateral tissular calcified masses with incomplete enhancement, pronounced hydrocephalus, and invasion of the posterior fossa foramina. EPN_PFB is commonly seen in adolescents and adults as median non-calcified masses, predominantly cystic, minimally invasive, with total and homogeneous enhancement.
EUROPEAN RADIOLOGY
(2023)
Article
Clinical Neurology
Pauline Mouches, Matthias Wilms, Agampreet Aulakh, Soenke Langner, Nils D. D. Forkert
Summary: This study compared the accuracy of brain age prediction using T1-weighted MRI and magnetic resonance angiography (MRA) data, showing that a combined model achieved a mean absolute error of 4 years. The results also revealed diverging associations between cardiovascular risk factors when evaluating the brain age gap (BAG) obtained from different approaches and imaging modalities.
FRONTIERS IN NEUROLOGY
(2022)
Article
Engineering, Biomedical
Irteza Enan Kabir, Diego A. Caban-Rivera, Juvenal Ormachea, Kevin J. Parker, Curtis L. Johnson, Marvin M. Doyley
Summary: In this study, it is found that reverberant elastography can accurately produce elastograms of the brain using a single mechanical driver, as demonstrated in experiments on healthy volunteers and a brain phantom. Compared to the established subzone inversion method, reverberant elastography has smaller errors and higher contrast-to-noise ratio, showing great potential for clinical applications in neuroimaging.
PHYSICS IN MEDICINE AND BIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hongxi Zhang, Xingwang Yong, Xiaohui Ma, Jianjiang Zhao, Zhipeng Shen, Xinchun Chen, Fengyu Tian, Weibo Chen, Dan Wu, Yi Zhang
Summary: APT imaging can differentiate high-grade and low-grade gliomas in pediatric patients, and provides additional value beyond quantitative relaxation times.
EUROPEAN RADIOLOGY
(2021)
Article
Neurosciences
Maxi Becker, Tobias Sommer, Simone Kuehn
HUMAN BRAIN MAPPING
(2020)
Article
Multidisciplinary Sciences
Matthias Zunhammer, Tamas Spisak, Tor D. Wager, Ulrike Bingel
Summary: Placebo analgesia influences pain-related activity in multiple brain areas, with activity increases mainly in frontoparietal regions, and reductions in regions belonging to ventral attention and somatomotor networks. The findings suggest that the neural mechanisms of placebo analgesia are complex and involve multiple cerebral mechanisms that differ across studies.
NATURE COMMUNICATIONS
(2021)
Article
Biochemical Research Methods
Julien Cohen-Adad, Eva Alonso-Ortiz, Mihael Abramovic, Carina Arneitz, Nicole Atcheson, Laura Barlow, Robert L. Barry, Markus Barth, Marco Battiston, Christian Buechel, Matthew Budde, Virginie Callot, Anna J. E. Combes, Benjamin De Leener, Maxime Descoteaux, Paulo Loureiro de Sousa, Marek Dostal, Julien Doyon, Adam Dvorak, Falk Eippert, Karla R. Epperson, Kevin S. Epperson, Patrick Freund, Juergen Finsterbusch, Alexandru Foias, Michela Fratini, Issei Fukunaga, Claudia A. M. Gandini Wheeler-Kingshott, Giancarlo Germani, Guillaume Gilbert, Federico Giove, Charley Gros, Francesco Grussu, Akifumi Hagiwara, Pierre-Gilles Henry, Tomas Horak, Masaaki Hori, James Joers, Kouhei Kamiya, Haleh Karbasforoushan, Milos Kerkovsky, Ali Khatibi, Joo-Won Kim, Nawal Kinany, Hagen Kitzler, Shannon Kolind, Yazhuo Kong, Petr Kudlicka, Paul Kuntke, Nyoman D. Kurniawan, Slawomir Kusmia, Rene Labounek, Maria Marcella Lagana, Cornelia Laule, Christine S. Law, Christophe Lenglet, Tobias Leutritz, Yaou Liu, Sara Llufriu, Sean Mackey, Eloy Martinez-Heras, Loan Mattera, Igor Nestrasil, Kristin P. O'Grady, Nico Papinutto, Daniel Papp, Deborah Pareto, Todd B. Parrish, Anna Pichiecchio, Ferran Prados, Alex Rovira, Marc J. Ruitenberg, Rebecca S. Samson, Giovanni Savini, Maryam Seif, Alan C. Seifert, Alex K. Smith, Seth A. Smith, Zachary A. Smith, Elisabeth Solana, Yuichi Suzuki, George Tackley, Alexandra Tinnermann, Jan Valosek, Dimitri Van De Ville, Marios C. Yiannakas, Kenneth A. Weber, Nikolaus Weiskopf, Richard G. Wise, Patrik O. Wyss, Junqian Xu
Summary: The study introduces a harmonized quantitative MRI protocol called the spine generic protocol to address challenges in quantitative spinal cord imaging. The protocol provides guidance for assessing spinal cord structure and has been validated in 260 healthy subjects.
Article
Multidisciplinary Sciences
Julien Cohen-Adad, Eva Alonso-Ortiz, Mihael Abramovic, Carina Arneitz, Nicole Atcheson, Laura Barlow, Robert L. Barry, Markus Barth, Marco Battiston, Christian Buchel, Matthew Budde, Virginie Callot, Anna J. E. Combes, Benjamin De Leener, Maxime Descoteaux, Paulo Loureiro de Sousa, Marek Dostal, Julien Doyon, Adam Dvorak, Falk Eippert, Karla R. Epperson, Kevin S. Epperson, Patrick Freund, Jurgen Finsterbusch, Alexandru Foias, Michela Fratini, Issei Fukunaga, Claudia A. M. Gandini Wheeler-Kingshott, Giancarlo Germani, Guillaume Gilbert, Federico Giove, Charley Gros, Francesco Grussu, Akifumi Hagiwara, Pierre-Gilles Henry, Tomas Horak, Masaaki Hori, James Joers, Kouhei Kamiya, Haleh Karbasforoushan, Milos Kerkovsky, Ali Khatibi, Joo-Won Kim, Nawal Kinany, Hagen H. Kitzler, Shannon Kolind, Yazhuo Kong, Petr Kudlicka, Paul Kuntke, Nyoman D. Kurniawan, Slawomir Kusmia, Rene Labounek, Maria Marcella Lagana, Cornelia Laule, Christine S. Law, Christophe Lenglet, Tobias Leutritz, Yaou Liu, Sara Llufriu, Sean Mackey, Eloy Martinez-Heras, Loan Mattera, Igor Nestrasil, Kristin P. O'Grady, Nico Papinutto, Daniel Papp, Deborah Pareto, Todd B. Parrish, Anna Pichiecchio, Ferran Prados, Alex Rovira, Marc J. Ruitenberg, Rebecca S. Samson, Giovanni Savini, Maryam Seif, Alan C. Seifert, Alex K. Smith, Seth A. Smith, Zachary A. Smith, Elisabeth Solana, Y. Suzuki, George Tackley, Alexandra Tinnermann, Jan Valosek, Dimitri van de Ville, Marios C. Yiannakas, Kenneth A. . Weber, Nikolaus Weiskopf, Richard G. Wise, Patrik O. Wyss, Junqian Xu
Summary: The paper introduces a spine generic quantitative MRI protocol and presents normative values and statistics generated from datasets across multiple centers, demonstrating high reproducibility of the protocol. This will support the development of accessible and reproducible quantitative MRI in the spinal cord.
Article
Neurosciences
Gina Joue, Karima Chakroun, Janine Bayer, Jan Glaescher, Lei Zhang, Johannes Fuss, Nora Hennies, Tobias Sommer
Summary: The study found that women showed enhanced brain activity related to reward prediction error compared to men, and this effect was further amplified when estrogen levels were elevated in both sexes. However, both female sex and estrogen slowed adaptation to reward prediction errors, resulting in a smaller learning rate.
Article
Clinical Neurology
Katja Wiech, Falk Eippert, Joachim Vandekerckhove, Jonas Zaman, Katerina Placek, Francis Tuerlinckx, Johan W. S. Vlaeyen, Irene Tracey
Summary: This study investigated the neural basis of how prior expectations can bias pain perception. The results showed that changes in perceptual decision-making and altered information processing contribute to the expectancy effect on pain. The dorsolateral prefrontal cortex, amygdala, and periaqueductal gray were found to be involved in these processes.
Article
Multidisciplinary Sciences
Moritz M. Nickel, Laura Tiemann, Vanessa D. Hohn, Elisabeth S. May, Cristina Gil Avila, Falk Eippert, Markus Ploner
Summary: The perception of pain is influenced by both somatosensory information and expectations, but the brain mechanisms involved in conveying these influences differ.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Valentina Krenz, Tobias Sommer, Arjen Alink, Benno Roozendaal, Lars Schwabe
Summary: Memories are believed to undergo a time-dependent system consolidation, during which hippocampal activity decreases and neocortical activity increases. However, noradrenergic arousal after encoding can reverse this process and maintain the vividness of memories over time.
NATURE COMMUNICATIONS
(2021)
Article
Endocrinology & Metabolism
Sawis Nouri, Sarah Biedermann, Gina Joue, Matthias K. Auer, Tobias Sommer, Johannes Fuss
Summary: There is a sex difference in anxiety-related behaviors and disorders, with estradiol potentially having an anxiolytic effect. This study investigated the effects of elevated estradiol levels on anxiety in men and women. The results showed that estradiol treatment reduced physiological stress response, but had no effect on behavioral measures and subjective anxiety levels.
PSYCHONEUROENDOCRINOLOGY
(2022)
Article
Neurosciences
Merve Kaptan, S. Johanna Vannesjo, Toralf Mildner, Ulrike Horn, Ronald Hartley-Davies, Valeria Oliva, Jonathan C. W. Brooks, Nikolaus Weiskopf, Juergen Finsterbusch, Falk Eippert
Summary: Functional magnetic resonance imaging (fMRI) of the human spinal cord faces challenges due to signal loss caused by local magnetic field inhomogeneities. This study proposes a slice-specific z-shimming technique to address this issue. The effects of z-shimming on various aspects of spinal fMRI are evaluated, and two automated procedures are developed to improve upon the time-consuming and subjective manual selection of z-shims. The results demonstrate the beneficial effects of z-shimming across different echo times and for both the dorsal and ventral horn. The automated approaches are faster than the manual one, leading to significant improvements in gray matter tSNR compared to no z-shimming. While the field-map-based approach performed slightly worse than the manual one, the EPI-based approach performed as well as the manual one and was validated on an external dataset. Overall, automated z-shimming may enhance data quality and reproducibility in future spinal fMRI studies.
HUMAN BRAIN MAPPING
(2022)
Article
Neurosciences
T. Stephani, B. Nierula, A. Villringer, F. Eippert, V. V. Nikulin
Summary: Identical sensory stimuli can lead to different neural responses depending on the instantaneous brain state. Our study reveals spatially distinct excitability dynamics within the primary somatosensory cortex, with different frequencies showing different spatial specificity.
Article
Neurosciences
Merve Kaptan, Ulrike Horn, S. Johanna Vannesjo, Toralf Mildner, Nikolaus Weiskopf, Juergen Finsterbusch, Jonathan C. W. Brooks, Falk Eippert
Summary: The investigation of spontaneous fluctuations of BOLD signal in the spinal cord has attracted clinical interest. Resting-state fMRI studies have shown functional connectivity in dorsal and ventral horns of the spinal cord. This study evaluated the reliability of resting-state signals in the cervical spinal cord, finding fair to good reliability for dorsal-dorsal and ventral-ventral connectivity, but poor reliability for within-and between-hemicord dorsal-ventral connectivity. The impact of noise sources on connectivity was also investigated, showing that removal of physiological noise reduces connectivity strength and reliability, while removal of thermal noise increases detectability of connectivity without clear influence on reliability.
Article
Endocrinology & Metabolism
Gabriele M. Rune, Gina Joue, Tobias Sommer
Summary: To translate findings on the effects of 178-estradiol (E2) from animal studies to humans, a placebo-controlled pharmacological enhancement of E2 levels for at least 24 hours was administered. The exogenous increase in E2 levels had an impact on the secretion of other hormones and neuroactive hormones. Overall, the E2V regimen resulted in similar E2 levels, down-regulation of FSH and LH levels, decreased P4 concentration, dropped TST and DHT levels in men, and decreased levels of IGF-1 in both sexes.
PSYCHONEUROENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
Valentina Krenz, Arjen Alink, Tobias Sommer, Benno Roozendaal, Lars Schwabe
Summary: Memories undergo a time-dependent neural reorganization, with a transformation characterized by a semantic nature and reflected in pattern reinstatement in the hippocampus and event representations in the neocortex.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Karima Chakroun, Antonius Wiehler, Ben Wagner, David Mathar, Florian Ganzer, Thilo van Eimeren, Tobias Sommer, Jan Peters
Summary: This study investigates the impact of dopaminergic mechanisms on reinforcement learning and action selection using a combined pharmacological neuroimaging approach. The results suggest that there is little difference in the effects of L-dopa and Haloperidol on learning from gains, and lower dosages of D2 receptor antagonists may increase striatal dopamine release, leading to reduced decision thresholds.
NATURE COMMUNICATIONS
(2023)