Article
Multidisciplinary Sciences
Kathleen E. Hupfeld, Sutton B. Richmond, Heather R. McGregor, Daniel L. Schwartz, Madison N. Luther, Nichole E. Beltran, Igor S. Kofman, Yiri E. De Dios, Roy F. Riascos, Scott J. Wood, Jacob J. Bloomberg, Ajitkumar P. Mulavara, Lisa C. Silbert, Jeffrey J. Iliff, Rachael D. Seidler, Juan Piantino
Summary: The study found that spaceflight can lead to changes in perivascular spaces (PVSs) in the brain, with novice astronauts showing an increase in total PVS volume post-flight while experienced crewmembers did not. The findings suggest that prior spaceflight experience may play a role in determining PVS characteristics.
SCIENTIFIC REPORTS
(2022)
Review
Neurosciences
Kolsoum Dehdar, Mohammad Reza Raoufy
Summary: Psychiatric disorders are common in patients with allergic asthma, and recent studies suggest that immune-brain communication mechanisms may contribute to the alterations in brain structure and function that lead to anxiety in these patients. This paper comprehensively reviews the research on asthma-induced brain alterations and highlights the importance of addressing neuropsychiatric disorders in asthma clinical guidelines for improved patient quality of life. Understanding the mechanisms underlying psychiatric comorbidities in asthma could lead to more effective treatments.
BRAIN RESEARCH BULLETIN
(2023)
Article
Geriatrics & Gerontology
Song E. Kim, Soriul Kim, Hyeon Jin Kim, Regina E. Y. Kim, Sol Ah Kim, Chol Shin, Hyang Woon Lee
Summary: This study investigated the association between CLOCK genetic variation, changes in sleep duration, and volumetric brain alterations. The results showed that specific CLOCK SNP variations were associated with decreased sleep duration and alterations in brain volume, particularly in frontal and parietal regions. Less common CLOCK haplotypes were also linked to shorter sleep duration and more significant decreases in sleep duration over 8 years, leading to smaller total and gray matter volumes in specific regions of the brain.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Clinical Neurology
Amy S. Garrett, Wei Zhang, Larry R. Price, Jeremyra Cross, Natalia Gomez-Giuliani, Marie-Jose van Hoof, Victor Carrion, Judith A. Cohen
Summary: This study investigates the treatment-related changes in effective connectivity in youth with PTSD undergoing Trauma-Focused Cognitive Behavioral Therapy. The results indicate that the PTSD group had greater connectivity in certain paths at baseline compared to the healthy control group, and that this connectivity decreased significantly after treatment. The study also highlights the central role of the dorsal cingulate cortex in PTSD symptoms.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Anesthesiology
Paolo Pedersini, Massimiliano Gobbo, Mark D. Bishop, Lars Arendt-Nielsen, Jorge H. Villafane
Summary: The systematic review summarized functional and structural brain changes associated with sensitivity proxies in patients with OA-related pain, showing conflicting evidence on the relationship between these changes and sensitivity proxies.
Article
Oncology
Da-Fu Zhang, Huan Ma, Guang-Jun Yang, Zhi-Ping Zhang, Yin-Fu He, Mao-Yang Feng, Bao-Ci Shan, Xiu-Feng Xu, Ying-Ying Ding, Yu-Qi Cheng
Summary: This study found that non-brain metastasis lung cancer patients showed increased blood-brain barrier permeability, which was associated with thinner cortical thickness and smaller subcortical structure volumes. As lung cancer staging progressed, blood-brain barrier showed higher permeability and may be more likely to develop into brain metastasis.
FRONTIERS IN ONCOLOGY
(2022)
Review
Anatomy & Morphology
Hanani Abdul Manan, Noorazrul Yahya, Pengfei Han, Thomas Hummel
Summary: The brain structural features of healthy individuals are associated with olfactory functions. Different structural characteristics may be exhibited in congenital and acquired anosmia due to pathophysiological differences. A systematic review compared brain structural features between patients with congenital and acquired anosmia, finding consistent associations between olfactory bulb volume and olfactory function across etiologies, but inconsistent associations with olfactory sulcus depth. The review observed morphological variations in grey matter and white matter volume in congenital and acquired anosmia, suggesting that the structural characteristics in these two conditions are altered differently, likely due to multifactorial mechanisms and interactions with the environment.
BRAIN STRUCTURE & FUNCTION
(2022)
Article
Neurosciences
Tong Lu, Zan Wang, Ying Cui, Jiaying Zhou, Yuancheng Wang, Shenghong Ju
Summary: Ischemic leukoaraiosis (ILA) is associated with cognitive impairment and vascular dementia in the elderly, possibly due to disruptions in white matter integrity and topological disorganization of structural networks. Research indicates that ILA patients exhibit widespread white matter integrity disruptions, increased characteristic path length, and decreased global network efficiency compared to healthy controls.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Article
Geriatrics & Gerontology
Jinyoung Youn, Mansu Kim, Suyeon Park, Ji Sun Kim, Hyunjin Park, Jin Whan Cho
Summary: This study investigates the structural changes in the basal ganglia related to levodopa-induced dyskinesia (LID) in Parkinson's disease (PD). The results demonstrate distinct shape alterations, especially in the globus pallidus interna (GPi), in the LID group compared to the non-LID group. These findings suggest the crucial role of the basal ganglia pathway in the development of LID.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Environmental Sciences
Brendan Bos, Ben Barratt, Dafnis Batalle, Oliver Gale-Grant, Emer J. Hughes, Sean Beevers, Lucilio Cordero-Grande, Anthony N. Price, Jana Hutter, Joseph V. Hajnal, Frank J. Kelly, David Edwards, Serena J. Counsell
Summary: The study suggests that prenatal exposure to air pollution is associated with altered brain development in newborns. Specifically, higher exposure to PM10 and lower exposure to NO2 are linked to changes in ventricular volume and cerebellum size. These findings highlight the importance of reducing maternal exposure to particulate matter during pregnancy.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Allergy
Brandy M. Byrwa-Hill, Tricia L. Morphew, Albert A. Presto, James P. Fabisiak, Sally E. Wenzel
Summary: Living in an environmentally just tract increases the likelihood of severe and uncontrolled asthma, which is influenced by age at onset, disease duration, and traffic-related air pollution.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Barbara Bonnesen, Pradeesh Sivapalan, Alexander Jordan, Johannes Wirenfeldt Pedersen, Christina Marisa Bergsoe, Josefin Eklof, Louise Lindhardt Toennesen, Sidse Graff Jensen, Matiullah Naqibullah, Zaigham Saghir, Jens-Ulrik Staehr Jensen
Summary: The aim of this study was to evaluate if patients with asthma-COPD overlap have a higher risk of malignancy than patients with COPD without asthma. The study found that asthma-COPD overlap was not associated with an increased risk of cancer events within 2 years as compared to patients with COPD without asthma.
Article
Radiology, Nuclear Medicine & Medical Imaging
Francesca Inglese, Ilse M. J. Kant, Rory C. Monahan, Gerda M. Steup-Beekman, Tom W. J. Huizinga, Mark A. van Buchem, Cesar Magro-Checa, Itamar Ronen, Jeroen de Bresser
Summary: This study investigated the structural brain correlates of neuropsychiatric involvement in systemic lupus erythematosus (NPSLE) and found that different phenotypes of NPSLE were associated with distinct patterns of underlying structural brain MRI changes. The inflammatory phenotype of NPSLE showed the most pronounced brain volume changes, which could help facilitate diagnosis in SLE patients with neuropsychiatric symptoms.
EUROPEAN RADIOLOGY
(2021)
Article
Multidisciplinary Sciences
Yosri Akl, Eman Kamal Ibrahim, Tareq Muhammad Algarf, Rasha R. Mostafa, Hoda M. Abdel-Hamid, Asmaa Ibrahim Muhammed
Summary: The purpose of this study was to investigate nasal histopathological changes in HP patients and identify any shared pathological features between the upper airways and HP. The study included 40 HP patients who underwent thorough evaluations and nasal mucosal biopsy. The results showed that 87.5% of HP patients had chronic inflammation of the nasal mucosa, with predominant lymphocytic infiltration in 72.5% of patients. Additionally, 77.5% of patients had a high burden of sinonasal symptoms, which was positively associated with cough severity.
SCIENTIFIC REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Nazar Azahar, Yuichiro Yano, Aya Kadota, Akihiko H. Shiino, Ali Syaifullah, Naoko Miyagawa, Keiko Kondo, Mohammad Moniruzzaman, Sayuki Torii, Hiroyoshi Segawa, Takashi Hisamatsu, Akira Fujiyoshi, Kazuhiko Nozaki, Ikuo Tooyama, Hirotsugu Ueshima, Katsuyuki Miura
Summary: This study found that arterial stiffness and atherosclerotic burden may independently be associated with brain structural changes. Higher arterial stiffness was associated with lower volumes of Alzheimer disease signature, while higher atherosclerotic burden was associated with brain vascular damage.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Psychology, Biological
J. Haaker, T. B. Lonsdorf, D. Schuemann, M. Menz, S. Brassen, N. Bunzeck, M. Gamer, R. Kalisch
BIOLOGICAL PSYCHOLOGY
(2015)
Article
Neurosciences
Laura K. Sasse, Jan Peters, Christian Buechel, Stefanie Brassen
HUMAN BRAIN MAPPING
(2015)
Article
Behavioral Sciences
Michael J. Tobia, Rong Guo, Jan Glaescher, Ulrike Schwarze, Stefanie Brassen, Christian Buechel, Klaus Obermayer, Tobias Sommer
COGNITIVE AFFECTIVE & BEHAVIORAL NEUROSCIENCE
(2016)
Article
Clinical Neurology
Nathalie Wrobel, Tahmine Fadai, Stefanie Brassen, Ulrike Bingel
Article
Neurosciences
Marco Lawrenz, Stefanie Brassen, Juergen Finsterbusch
Article
Geriatrics & Gerontology
Sophia Schneider, Stefanie Brassen
FRONTIERS IN AGING NEUROSCIENCE
(2016)
Article
Multidisciplinary Sciences
Lena J. Tiedemann, Sebastian M. Schmid, Judith Hettel, Katrin Giesen, Paul Francke, Christian Buechel, Stefanie Brassen
NATURE COMMUNICATIONS
(2017)
Article
Geriatrics & Gerontology
Laura K. Sasse, Jan Peters, Stefanie Brassen
FRONTIERS IN AGING NEUROSCIENCE
(2017)
Article
Public, Environmental & Occupational Health
Annika Jagodzinski, Christoffer Johansen, Uwe Koch-Gromus, Ghazal Aarabi, Gerhard Adam, Sven Anders, Matthias Augustin, Ramona B. der Kellen, Thomas Beikler, Christian-Alexander Behrendt, Christian S. Betz, Carsten Bokemeyer, Katrin Borof, Peer Briken, Chia-Jung Busch, Christian Buechel, Stefanie Brassen, Eike S. Debus, Larissa Eggers, Jens Fiehler, Juergen Gallinat, Simone Gellissen, Christian Gerloff, Evaldas Girdauskas, Martin Gosau, Markus Graefen, Martin Haerter, Volker Harth, Christoph Heidemann, Guido Heydecke, Tobias B. Huber, Yassin Hussein, Marvin O. Kampf, Olaf von dem Knesebeck, Alexander Konnopka, Hans-Helmut Koenig, Robert Kromer, Christian Kubisch, Simone Kuehn, Sonja Loges, Bernd Loewe, Gunnar Lund, Christian Meyer, Lina Nagel, Albert Nienhaus, Klaus Pantel, Elina Petersen, Klaus Pueschel, Hermann Reichenspurner, Guido Sauter, Martin Scherer, Katharina Scherschel, Ulrich Schiffner, Renate B. Schnabel, Holger Schulz, Ralf Smeets, Vladislavs Sokalskis, Martin S. Spitzer, Claudia Terschueren, Imke Thederan, Tom Thoma, Goetz Thomalla, Benjamin Waschki, Karl Wegscheider, Jan-Per Wenzel, Susanne Wiese, Birgit-Christiane Zyriax, Tanja Zeller, Stefan Blankenberg
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2020)
Article
Neurosciences
Lena J. Tiedemann, Arjen Alink, Judith Beck, Christian Buechel, Stefanie Brassen
JOURNAL OF NEUROSCIENCE
(2020)
Article
Multidisciplinary Sciences
Joshua Baker, Matthias Gamer, Jonas Rauh, Stefanie Brassen
Summary: A perceptual bias towards negative emotions is common in mood disorders and is a target of therapeutic interventions. This study investigated how placebo-induced positive expectations can shape perception of emotional stimuli in healthy individuals. The results showed that positive expectations lowered the threshold for identifying happy emotions and decreased sensitivity to subtle emotional expressions. These findings suggest that expectations can induce a positive perceptual bias and improve mood state.
SCIENTIFIC REPORTS
(2022)
Article
Biology
Lena J. Tiedemann, Sebastian M. Meyhoefer, Paul Francke, Judith Beck, Christian Buechel, Stefanie Brassen
Summary: Central insulin plays a critical role in weight management, and the neural insulin function can be improved by weight loss even in older age. The study found that baseline measures of individual intranasal insulin inhibition and peripheral insulin sensitivity are predictors of treatment outcome in dieters. The results highlight the importance of central insulin function in mesolimbic systems for weight management in humans and its role in preventing metabolic disorders in later life.
Review
Biology
Friederike Thams, Stefanie Brassen
Summary: Although late-life depression is a common health problem in older adults, it is often undiagnosed and undertreated. The underlying cognitive-emotional causes of this depression are poorly understood, contrasting with the extensive research on emotionally healthy aging. The deficits in emotional, cognitive, and prefrontal functions associated with late-life depression are similar to those necessary for successful adaptation in midlife.
Article
Medicine, General & Internal
Ingmar Schaefer, Jan Hendrik Oltrogge, Yvonne Nestoriuc, Claire V. Warren, Stefanie Brassen, Maximilian Blattner, Dagmar Luehmann, Alexandra Tinnermann, Martin Scherer, Christian Buechel
Summary: Concerns about adverse effects can affect the uptake of COVID-19 vaccination. Research suggests that positive and negative expectations prior to vaccination are associated with systemic adverse effects. Understanding these associations can improve clinician-patient interactions and public vaccine campaigns.
Article
Multidisciplinary Sciences
Paul Francke, Lena J. Tiedemann, Mareike M. Menz, Judith Beck, Christian Buechel, Stefanie Brassen
SCIENTIFIC REPORTS
(2019)