Article
Critical Care Medicine
Spyridon Fortis, Pedro M. Quibrera, Alejandro P. Comellas, Surya P. Bhatt, Donald P. Tashkin, Eric A. Hoffman, Gerard J. Criner, MeiLan K. Han, R. Graham Barr, Mehrdad Arjomandi, Mark B. Dransfield, Stephen P. Peters, Brett A. Dolezal, Victor Kim, Nirupama Putcha, Stephen I. Rennard, Robert Paine, Richard E. Kanner, Jeffrey L. Curtis, Russell P. Bowler, Fernando J. Martinez, Nadia N. Hansel, Jerry A. Krishnan, Prescott G. Woodruff, Igor Z. Barjaktarevic, David Couper, Wayne H. Anderson, Christopher B. Cooper
Summary: This study found that consistent bronchodilator responsiveness (BDR) is associated with specific features of obstructive lung disease, such as asthma history and small airways disease, in tobacco-exposed individuals with or without COPD. Additionally, consistent BDR is also associated with lung function decline and increased risk of COPD progression in patients with GOLD stage 0 disease.
Article
Physiology
Devin B. Phillips, Matthew D. James, Conor D. O'Donnell, Sandra G. Vincent, Katherine A. Webb, Juan P. de-Torres, J. Alberto Neder, Denis E. O'Donnell
Summary: Low resting inspiratory capacity (IC) is closely associated with exertional dyspnea, exercise limitation, and poor survival in COPD. Meanwhile, maximal inspiratory pressure (MIP) has no significant impact on these variables. Resting IC is a stronger predictor of peak oxygen uptake (VO2peak) compared to MIP. Low resting IC remains independently associated with worse survival in COPD after accounting for airway obstruction, inspiratory muscle strength, and diffusing capacity.
JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Article
Medicine, General & Internal
Ming-Lung Chuang
Summary: This study examined the factors influencing exertional dyspnoea (ED) and exercise intolerance (EI) in COPD patients. It found that lung and non-lung variables had the strongest impact on ED, while ED had a significant influence on EI.
ANNALS OF MEDICINE
(2022)
Article
Otorhinolaryngology
Emeline Drapier, Esteban Brenet, Marie-Anne Louges, Jean-Claude Merol, Marc Labrousse, Xavier Dubernard
Summary: Peak inspiratory flow (PIF) measurement can help determine the need for upper airway release surgery in patients with acute inspiratory dyspnoea, serving as a useful tool in emergency decision making for healthcare providers.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Article
Respiratory System
Shiyi Gong, Hao Hu, Kun Zhao, Ting Yang
Summary: This study assessed the cost-effectiveness of IND/GLY compared with SAL/FLU and tiotropium in the long-term treatment of stable COPD from the perspective of payers in China. The results showed that IND/GLY was cost-effective in terms of gaining life years and quality-adjusted life years when compared with SAL/FLU and tiotropium.
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2021)
Review
Nutrition & Dietetics
Angela Tramontano, Paolo Palange
Summary: Chronic Obstructive Pulmonary Disease (COPD) is a global epidemic causing numerous deaths annually. It is characterized by progressive and often irreversible airflow obstruction with varying clinical manifestations. Malnutrition is commonly observed in COPD patients and can worsen respiratory function and prognosis. Nutritional impairment is associated with reduced exercise tolerance and impact on patient-perceived quality of life. However, there is limited data on the best strategies to manage malnutrition in COPD patients. This review highlights the importance of COPD-related malnutrition on muscle function, exercise tolerance, and dyspnea.
Review
Medicine, General & Internal
Peter M. A. Calverley, Paul Phillip Walker
Summary: This review examines the overlap between asthma and COPD, known as ACO, and how it is defined and managed. It discusses the challenges in diagnosing and treating ACO patients, highlighting various phenotypes that could be part of ACO and suggesting ways for clinicians to manage patients with features of both asthma and COPD.
Article
Cardiac & Cardiovascular Systems
Chien-Tzu Lee, Jung-Yien Chien, Miao-Ju Hsu, Huey-Dong Wu, Li-Ying Wang
Summary: IMT increases diaphragm and SCM activation significantly in COPD patients, with SCM being activated to a greater extent regardless of the level of diaphragm activation.
RESPIRATORY MEDICINE
(2021)
Article
Virology
Mikael Skurnik, Salla Jaakkola, Laura Mattinen, Lotta von Ossowski, Ayesha Nawaz, Maria Pajunen, Lotta J. Happonen
Summary: This study describes the isolation of two bacteriophages from sewage water samples in Turku, Finland. These phages are a novel type of dwarf myovirus and a T4-like myovirus, with different host ranges including Yersinia pestis and other Enterobacterales. The genomes, proteomes, and life cycles of these Yersinia myoviruses, fEV-1 and fD1, were examined.
Article
Critical Care Medicine
Donald A. Mahler, David M. G. Halpin
Summary: Peak inspiratory flow, a biological plausible measure with good test characteristics, is considered as a predictive therapeutic biomarker to optimize therapy for COPD patients, both in outpatient and hospitalized settings, aligning with the principles of precision medicine.
Review
Medicine, General & Internal
Marc Miravitlles, Tomotaka Kawayama, Michael Dreher
Summary: Inhaled bronchodilators, particularly long-acting muscarinic antagonists (LAMA) and long-acting beta(2)-agonists (LABA), are recommended as the primary treatment for symptomatic COPD patients. The use of LABA/LAMA combination therapy is strongly recommended in patients with more severe symptoms, regardless of exacerbation history. However, real-world prescribing data show that LABA and/or LAMA without an inhaled corticosteroid are not commonly prescribed for COPD.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Shih-Yu Chen, Chun-Kai Huang, Hui-Chuan Peng, Hsing-Chen Tsai, Szu-Ying Huang, Chong-Jen Yu, Jung-Yien Chien
Summary: PIFR-guided inhalation therapy significantly reduces the incidence of severe acute exacerbation in COPD patients compared to conventional inhaler education, especially benefiting patients with older age, short stature, early COPD stage, frequent exacerbations, and use of multiple inhalers. Careful assessment and education of PIFR are crucial in the management of COPD.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Respiratory System
Dave Singh, Jim M. Wild, Dinesh Saralaya, Rod Lawson, Helen Marshall, Jonathan Goldin, Matthew S. Brown, Konstantinos Kostikas, Kristin Belmore, Robert Fogel, Francesco Patalano, Anton Drollmann, Surendra Machineni, Ieuan Jones, Denise Yates, Hanns-Christian Tillmann
Summary: This study evaluated the effects of IND/GLY on lung function and pulmonary perfusion in COPD patients. The results showed that IND/GLY treatment improved global ventilated lung volume and the ratio of ventilation volume to perfusion volume. Additionally, there was a trend of improvement in diffusing capacity for carbon monoxide and forced expiratory volume in 1 s (FEV1).
RESPIRATORY RESEARCH
(2022)
Review
Medicine, General & Internal
Francesco Nucera, Andrea Bianco, Teresa David, Ilaria Salvato, Ian M. Adcock, Gaetano Caramori
Summary: Current management of patients with chronic obstructive pulmonary disease is effective in reducing symptoms, improving exercise capacity, enhancing quality of life, preventing exacerbations, and decreasing mortality.
Article
Respiratory System
Yasemin Buran Cirak, Gul Deniz Yilmaz Yelvar, Nurgul Durustkan Elbasi
Summary: This study aimed to investigate the effects of manual therapy (MT) in addition to inspiratory muscle training (IMT) on severe COPD patients. The results showed that the MT group had significantly greater improvements in various aspects compared to the IMT group, including functional capacity, respiratory muscle strength, pulmonary function, dyspnea, fatigue perception, and quality of life.
CLINICAL RESPIRATORY JOURNAL
(2022)