Autoimmune and autoinflammatory mechanisms in uveitis

Pro-inflammatory human Th17 cells selectively express P-glycoprotein and are refractory to glucocorticoids

(2014) Radha Ramesh et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Gene Expression Profiling in Autoimmune Noninfectious Uveitis Disease

(2014) Z. Li et al.   JOURNAL OF IMMUNOLOGY

The bone marrow niche for haematopoietic stem cells

(2014) Sean J. Morrison et al.   NATURE

Interleukin 21, Interleukin 23, and Transforming Growth Factor β1 in HLA-A29-Associated Birdshot Retinochoroidopathy

(2013) Paul Yang et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

Infectious causes of posterior uveitis

(2013) Efrem D. Mandelcorn   CANADIAN JOURNAL OF OPHTHALMOLOGY-JOURNAL CANADIEN D OPHTALMOLOGIE

Systems approaches to human autoimmune diseases

(2013) Romain Banchereau et al.   CURRENT OPINION IN IMMUNOLOGY

Ocular manifestations of emerging infectious diseases

(2013) Moncef Khairallah et al.   CURRENT OPINION IN OPHTHALMOLOGY

Environmental Cues Dictate the Fate of Individual CD8+ T Cells Responding to Infection

(2013) Courtney R. Plumlee et al.   IMMUNITY

Uveitis in Mouse and Man

(2013) John V Forrester et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Role of IL-22- and TNF- -Producing Th22 Cells in Uveitis Patients with Behcet's Disease

(2013) S. Sugita et al.   JOURNAL OF IMMUNOLOGY

The complement anaphylatoxin receptors are not required for the development of experimental autoimmune uveitis

(2013) Russell W. Read et al.   JOURNAL OF NEUROIMMUNOLOGY

High-throughput sequencing for biology and medicine

(2013) W. W. Soon et al.   Molecular Systems Biology

Dynamic regulatory network controlling TH17 cell differentiation

(2013) Nir Yosef et al.   NATURE

Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1

(2013) Yohei Kirino et al.   NATURE GENETICS

Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci

(2013) Adrian Cortes et al.   NATURE GENETICS

Enhanced survival of lung tissue-resident memory CD8+ T cells during infection with influenza virus due to selective expression of IFITM3

(2013) Linda M Wakim et al.   NATURE IMMUNOLOGY

Bringing genome-wide association findings into clinical use

(2013) Teri A. Manolio   NATURE REVIEWS GENETICS

Systematic Review of Anti-Tumor Necrosis Factor-alpha Therapy for Treatment of Immune-mediated Uveitis

(2013) Miguel Cordero-Coma et al.   OCULAR IMMUNOLOGY AND INFLAMMATION

Elevated Serum Levels of Interleukin-17A in Uveitis Patients

(2013) Shayma Jawad et al.   OCULAR IMMUNOLOGY AND INFLAMMATION

Can Rituximab Induce Long-Term Disease Remission in Patients with Intra-Ocular Non-Infectious Inflammation?

(2013) Oren Tomkins-Netzer et al.   OPHTHALMOLOGICA

Secukinumab in the Treatment of Noninfectious Uveitis: Results of Three Randomized, Controlled Clinical Trials

(2013) Andrew D. Dick et al.   OPHTHALMOLOGY

Association Study of Polymorphisms rs4552569 and rs17095830 and the Risk of Ankylosing Spondylitis in a Taiwanese Population

(2013) James Cheng-Chung Wei et al.   PLoS One

Assessment and In Vivo Scoring of Murine Experimental Autoimmune Uveoretinitis Using Optical Coherence Tomography

(2013) Colin J. Chu et al.   PLoS One

Comparative Analysis of Induced vs. Spontaneous Models of Autoimmune Uveitis Targeting the Interphotoreceptor Retinoid Binding Protein

(2013) Jun Chen et al.   PLoS One

CD200R signaling inhibits pro-angiogenic gene expression by macrophages and suppresses choroidal neovascularization

(2013) Shintaro Horie et al.   Scientific Reports

From Cellular Characteristics to Disease Diagnosis: Uncovering Phenotypes with Supercells

(2013) Julián Candia et al.   PLoS Computational Biology

Identification of a susceptibility locus inSTAT4for Behçet's disease in Han Chinese in a genome-wide association study

(2012) Shengping Hou et al.   ARTHRITIS AND RHEUMATISM

Two-stage association study in Chinese Han identifies two independent associations in CCR1/CCR3 locus as candidate for Behçet’s disease susceptibility

(2012) Shengping Hou et al.   HUMAN GENETICS

Morphologic and immunohistochemical characterization of granulomas in the nucleotide oligomerization domain 2–related disorders Blau syndrome and Crohn disease

(2012) Carl E.I. Janssen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The adaptive immune system in diseases of the central nervous system

(2012) David C. Wraith et al.   JOURNAL OF CLINICAL INVESTIGATION

Cutting Edge: Intravascular Staining Redefines Lung CD8 T Cell Responses

(2012) K. G. Anderson et al.   JOURNAL OF IMMUNOLOGY

Maintenance of T Cell Function in the Face of Chronic Antigen Stimulation and Repeated Reactivation for a Latent Virus Infection

(2012) L. K. Mackay et al.   JOURNAL OF IMMUNOLOGY

The Living Eye "Disarms" Uncommitted Autoreactive T Cells by Converting Them to Foxp3+ Regulatory Cells following Local Antigen Recognition

(2012) R. Zhou et al.   JOURNAL OF IMMUNOLOGY

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

(2012) Luke Jostins et al.   NATURE

IL-23 induces spondyloarthropathy by acting on ROR-γt+ CD3+CD4−CD8− entheseal resident T cells

(2012) Jonathan P Sherlock et al.   NATURE MEDICINE

Gene Therapy for Noninfectious Uveitis

(2012) C. J. Chu et al.   OCULAR IMMUNOLOGY AND INFLAMMATION

Dynamics of Intraocular IFN-γ, IL-17 and IL-10-Producing Cell Populations during Relapsing and Monophasic Rat Experimental Autoimmune Uveitis

(2012) Ulrike Kaufmann et al.   PLoS One

Adalimumab for the treatment of Behcet's disease: experience in 19 patients

(2012) D. Perra et al.   RHEUMATOLOGY

Inhibition of Th17 differentiation by anti-TNF-alpha therapy in uveitis patients with Behçet's disease

(2012) Sunao Sugita et al.   ARTHRITIS RESEARCH & THERAPY

Environmental conditioning in the control of macrophage thrombospondin-1 production

(2012) Jezrom B. Fordham et al.   Scientific Reports

Espondilite anquilosante e uveíte: revisão

(2012) Enéias Bezerra Gouveia et al.   Revista Brasileira De Reumatologia

Intraocular Interleukin-17 and Proinflammatory Cytokines in HLA-A29–Associated Birdshot Chorioretinopathy

(2011) Jonas J.W. Kuiper et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

Persistent Inflammation Subverts Thrombospondin-1–Induced Regulation of Retinal Angiogenesis and Is Driven by CCR2 Ligation

(2011) Mei Chen et al.   AMERICAN JOURNAL OF PATHOLOGY

Therapeutic Dosing of Fingolimod (FTY720) Prevents Cell Infiltration, Rapidly Suppresses Ocular Inflammation, and Maintains the Blood-Ocular Barrier

(2011) David A. Copland et al.   AMERICAN JOURNAL OF PATHOLOGY

Systems biology approaches to new vaccine development

(2011) Ann L Oberg et al.   CURRENT OPINION IN IMMUNOLOGY

NLRs in immune privileged sites

(2011) Holly L Rosenzweig et al.   CURRENT OPINION IN PHARMACOLOGY

Th17 Cells Induce Ectopic Lymphoid Follicles in Central Nervous System Tissue Inflammation

(2011) Anneli Peters et al.   IMMUNITY

Critical role of IL-21 in modulating TH17 and regulatory T cells in Behçet disease

(2011) Guillaume Geri et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Uveitis-Associated Epitopes of Retinal Antigens Are Pathogenic in the Humanized Mouse Model of Uveitis and Identify Autoaggressive T Cells

(2011) M. J. Mattapallil et al.   JOURNAL OF IMMUNOLOGY

Defining the Herpes Simplex Virus-Specific CD8 + T Cell Repertoire in C57BL/6 Mice

(2011) Anthony J. St. Leger et al.   JOURNAL OF IMMUNOLOGY

Genome-wide pathway analysis of a genome-wide association study on psoriasis and Behcet’s disease

(2011) Young Ho Lee et al.   MOLECULAR BIOLOGY REPORTS

Regional and mucosal memory T cells

(2011) Brian S Sheridan et al.   NATURE IMMUNOLOGY

Immunodeficiency and Genetic Defects of Pattern-Recognition Receptors

(2011) Mihai G. Netea et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genetics in Ocular Inflammation—Basic Principles

(2011) G.R. Wallace et al.   OCULAR IMMUNOLOGY AND INFLAMMATION

Label-Free Proteomics Reveals Decreased Expression of CD18 and AKNA in Peripheral CD4+ T Cells from Patients with Vogt-Koyanagi-Harada Syndrome

(2011) Liming Mao et al.   PLoS One

CD40 gene polymorphisms confer risk of Behcet's disease but not of Vogt-Koyanagi-Harada syndrome in a Han Chinese population

(2011) F. Chen et al.   RHEUMATOLOGY

Single-Cell Mass Cytometry of Differential Immune and Drug Responses Across a Human Hematopoietic Continuum

(2011) S. C. Bendall et al.   SCIENCE

Treat early and embrace the evidence in favour of anti-TNF-  therapy for Behcet's uveitis

(2010) R. W J Lee et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

A systems biology approach to understanding atherosclerosis

(2010) Stephen A. Ramsey et al.   EMBO Molecular Medicine

Dendritic cell physiology and function in the eye

(2010) John V. Forrester et al.   IMMUNOLOGICAL REVIEWS

TNFR1 signalling is a critical checkpoint for developing macrophages that control of T-cell proliferation

(2010) Ben J. E. Raveney et al.   IMMUNOLOGY

Endogenous Cortisol and TGF-  in Human Aqueous Humor Contribute to Ocular Immune Privilege by Regulating Dendritic Cell Function

(2010) A. K. Denniston et al.   JOURNAL OF IMMUNOLOGY

Proteomic surveillance of autoantigens in patients with Behcet's disease by a proteomic approach

(2010) Seido Ooka et al.   MICROBIOLOGY AND IMMUNOLOGY

Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behçet's disease susceptibility loci

(2010) Nobuhisa Mizuki et al.   NATURE GENETICS

Genome-wide association study identifies variants in the MHC class I, IL10 and IL23R-IL12RB2 regions associated with Behçet's disease

(2010) Elaine F Remmers et al.   NATURE GENETICS

Effector T cell plasticity: flexibility in the face of changing circumstances

(2010) Kenneth M Murphy et al.   NATURE IMMUNOLOGY

Memory T cells persisting within the brain after local infection show functional adaptations to their tissue of residence

(2010) L. M. Wakim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anti-TNF Agents for Behçet's Disease: Analysis of Published Data on 369 Patients

(2010) Aikaterini Arida et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

Horror Autoinflammaticus: The Molecular Pathophysiology of Autoinflammatory Disease

(2009) Seth L. Masters et al.   Annual Review of Immunology

Rituximab is effective in the treatment of refractory ophthalmic Wegener's granulomatosis

(2009) Simon R. J. Taylor et al.   ARTHRITIS AND RHEUMATISM

TheNOD2defect in Blau syndrome does not result in excess interleukin-1 activity

(2009) Tammy M. Martin et al.   ARTHRITIS AND RHEUMATISM

Rituximab for treatment of ocular inflammatory disease: a series of four cases

(2009) P A Kurz et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Systemic and local anti-C5 therapy reduces the disease severity in experimental autoimmune uveoretinitis

(2009) D. A. Copland et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Suppression of Experimental Autoimmune Uveoretinitis by Anti-IL-17 Antibody

(2009) Rui Zhang et al.   CURRENT EYE RESEARCH

TNFR1-Dependent Regulation of Myeloid Cell Function in Experimental Autoimmune Uveoretinitis

(2009) B. J. E. Raveney et al.   JOURNAL OF IMMUNOLOGY

Th1, Th17, and Th9 Effector Cells Induce Experimental Autoimmune Encephalomyelitis with Different Pathological Phenotypes

(2009) A. Jager et al.   JOURNAL OF IMMUNOLOGY

Genome-wide scan reveals association of psoriasis with IL-23 and NF-κB pathways

(2009) Rajan P Nair et al.   NATURE GENETICS

Different routes of bacterial infection induce long-lived TH1 memory cells and short-lived TH17 cells

(2009) Marion Pepper et al.   NATURE IMMUNOLOGY

Clinical Review: Anti-TNFα Therapies in Uveitis: Perspective on 5 Years of Clinical Experience

(2009) Srilakshmi M. Sharma et al.   OCULAR IMMUNOLOGY AND INFLAMMATION

Identification of novel genetic susceptibility loci for Behçet's disease using a genome-wide association study

(2009) Yiping Fei et al.   ARTHRITIS RESEARCH & THERAPY

Fingolimod (FTY720) as an Acute Rescue Therapy for Intraocular Inflammatory Disease

(2008) B. J. E. Raveney et al.   ARCHIVES OF OPHTHALMOLOGY

Glucocorticoids and the emerging importance of T cell subsets in steroid refractory diseases

(2008) Lauren P. Schewitz et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

High-dose humanized anti-IL-2 receptor alpha antibody (daclizumab) for the treatment of active, non-infectious uveitis

(2008) Steven Yeh et al.   JOURNAL OF AUTOIMMUNITY

Analysis of retinal cellular infiltrate in experimental autoimmune uveoretinitis reveals multiple regulatory cell populations

(2008) Emma C. Kerr et al.   JOURNAL OF AUTOIMMUNITY

Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category

(2008) Dror Luger et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Activation of NOD2 in vivo induces IL-1β production in the eye via caspase-1 but results in ocular inflammation independently of IL-1 signaling

(2008) H. L. Rosenzweig et al.   JOURNAL OF LEUKOCYTE BIOLOGY

A critical function for CD200 in lung immune homeostasis and the severity of influenza infection

(2008) Robert J Snelgrove et al.   NATURE IMMUNOLOGY

The dynamics of leukocyte infiltration in experimental autoimmune uveoretinitis

(2008) Emma C. Kerr et al.   PROGRESS IN RETINAL AND EYE RESEARCH