Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 25, Issue 5, Pages 598-605Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2013.08.005
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Funding
- NAID Autoimmunity Centers of Excellence [U19 AUIO82715]
- Human Immunology Project Consortium [5U19AI089987]
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Systemic autoimmune diseases result from interactions between genes and environmental triggers that lead to dysregulation of both innate and adaptive immunity. Systems biology approaches enable the global characterization of complex systems at the DNA, RNA and protein levels. Recent technological breakthroughs such as deep sequencing or high-throughput proteomics are revealing novel inflammatory pathways involved in autoimmunity. Herein, we review recent developments, challenges and promising avenues in the use of systems approaches to understand human systemic autoimmune and autoinflammatory diseases.
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