Review
Medicine, General & Internal
Elodie Bousquet, Pierre Duraffour, Louis Debillon, Swathi Somisetty, Dominique Monnet, Antoine P. Brezin
Summary: Birdshot chorioretinopathy is a bilateral chronic inflammation of the eye, primarily affecting middle-aged individuals of European descent. Recent advances have highlighted the role of Endoplasmic Reticulum Aminopeptidase 2 in disease pathogenesis. Multimodal imaging and visual field testing are valuable tools for diagnosis and monitoring. There is no consensus on optimal treatment, with long-term management often requiring immunosuppressive or biological therapies.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Ophthalmology
Hossein Ameri, Maryam Naser, Farzana Choudhury, Narsing A. Rao
Summary: In this study, a strong positive correlation was found between the largest isopter of Glodmann visual field and all standard ERG amplitudes in birdshot choriorctinopathy (BCR) patients. This novel finding highlights the role of ERG as an objective visual function test in monitoring disease activity.
ASIA-PACIFIC JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Medicine, General & Internal
Dino Ferracci, Thibaud Mathis, Antoine Gavoille, Mathieu Gerfaud-Valentin, Arthur Bert, Meriem Hafidi, Philippe Denis, Olivier Loria, Laurent Kodjikian, Pascal Seve
Summary: The purpose of this study was to report the progression of patients initially treated with corticosteroids for birdshot chorioretinopathy (BSCR). A total of 39 BSCR patients were included in the study and followed up for =1 year. The study found that prolonged corticosteroid therapy resulted in inflammation control in 50% of BSCR patients, with low doses of cortisone (<5 mg/day) being sufficient to maintain this control.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
Frauke Stascheit, Anne Ruebsam, Carolin Otto, Andreas Meisel, Klemens Ruprecht, Uwe Pleyer
Summary: The study suggests that anti-CD20 therapy may be a valuable treatment option for MS-associated uveitis. It improves ophthalmological outcomes, reduces relapse rates of uveitis and MS, and has no severe adverse events.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Review
Ophthalmology
Ghazala A. Datoo O'Keefe, Narsing Rao
Summary: Retinal vasculitis, involving inflammation or ischemia of the retinal vessel wall, can be associated with systemic processes or isolated to the retina. Due to limited ability for histopathological studies and lack of a gold standard for diagnosis, creating a classification system and improving diagnostic strategies are essential. This framework based on size, location, and etiology aims to provide diagnostic strategies for this complex condition.
SURVEY OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Amde Selassie Shifera, Gloria H. Hong, Irfan R. Khan, Chinwenwa Okeagu, Jennifer E. Thorne
Summary: The study found that the relapse rate of MMP patients after drug-free remission is relatively low, and patients treated with cyclophosphamide or rituximab have a lower risk of relapse.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2021)
Review
Pharmacology & Pharmacy
Sean Teabagy, Emma Wood, Evan Bilsbury, Sean Doherty, Priya Janardhana, Darren J. Lee
Summary: Ocular immune privilege refers to the ability of foreign tissue grafts placed in the eye to survive indefinitely. This privilege is maintained by various mechanisms, including the blood-ocular barrier, lack of lymphatics in the eye, production of immune-suppressing molecules in the ocular microenvironment, and induction of systemic regulatory immunity. Failure of ocular immune privilege can lead to uveitis, which is a group of inflammatory disorders that can cause vision loss. Current treatments for uveitis involve immunosuppressive and anti-inflammatory medications. Research on ocular immune privilege mechanisms and the development of novel uveitis treatments is ongoing.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Article
Ophthalmology
Jared E. Knickelbein, Brett G. Jeffrey, Maggie M. Wei, Shuk Kei Cheng, Natasha Kesav, Susan Vitale, H. Nida Sen
Summary: The study investigated the variability of ffERG measurements in stable birdshot chorioretinopathy patients, finding that intra-visit variability was lower than inter-visit variability. It was suggested that a 40% reduction in ERG amplitude and/or a delay of >2 msec in the photopic single flash response may be suitable criteria for determining meaningful change in BCR patients.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2021)
Article
Ophthalmology
M. Servant, C. Couret, O. Lebreton, H. Masse, M. Weber
Summary: The study identified significant correlations between visual acuity and retinal thickness in patients with birdshot chorioretinopathy. The peripheral hypo-autofluorescent zones corresponded to visual field defects, and there were correlations between retinal sensitivity and capillary density.
JOURNAL FRANCAIS D OPHTALMOLOGIE
(2021)
Article
Ophthalmology
Ashley Li, Atitaya Apivatthakakul, George N. N. Papaliodis, Lucia Sobrin
Summary: A contiguous, perineural retinal vascular leakage fluorescein angiography pattern can help identify potential Birdshot chorioretinopathy patients, especially in the early stages of the disease.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2022)
Article
Ophthalmology
John H. Kempen, Maxwell Pistilli, Hosne Begum, Tonetta D. Fitzgerald, Teresa L. Liesegang, Abhishek Payal, Nazlee Zebardast, Nirali P. Bhatt, C. Stephen Foster, Douglas A. Jabs, Grace A. Levy-Clarke, Robert B. Nussenblatt, James T. Rosenbaum, H. Nida Sen, Eric B. Suhler, Jennifer E. Thorne
Summary: This study aimed to assess the remission rate and predictive factors of non-infectious anterior scleritis. Results showed that bilateral scleritis and comorbid systemic inflammatory diseases were associated with lower remission rates, while statin treatment within a certain period was linked to higher remission incidence. Confirmation studies on the efficacy of adjunctive statin therapy in enhancing scleritis remission are needed.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Lucas Furnon, Jose Labarere, Emanuele Trucco, Stephen Hogg, Tom MacGillivray, Christophe Chiquet
Summary: This study aimed to identify the retinal vessel vasculature parameters associated with birdshot chorioretinopathy (BSCR). The results showed that BSCR was associated with lower fractal dimension (FD) of retinal vessels. Among BSCR patients, retinal vein vasculitis was associated with higher central retinal artery equivalent (CRAE), venous tortuosity, and FD. Resolution of retinal vein vasculitis was accompanied by changes in retinal vascular parameters. These findings suggest that retinal vascular parameters could be useful for assessing patients with BSCR.
ACTA OPHTHALMOLOGICA
(2023)
Article
Ophthalmology
Edmund Tsui, Jaskirat S. Takhar, Ashlin Joye, Tessnim R. Ahmad, Nisha R. Acharya, John A. Gonzales
Summary: This study describes high-resolution DNA typing of HLA-A29 in two families with familial birdshot chorioretinopathy (BSCR), including clinical outcomes of multigenerational BSCR, with positive results for the HLA-A29*02 allele in all affected individuals.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2021)
Article
Ophthalmology
Arash Maleki, Sydney Look-Why, Ambika Manhapra, Soheila Asgari, Cristina M. Garcia, Alaa Al-Dabbagh, Catherine Tsang, Peter Y. Chang, Stephen D. Anesi, C. Stephen Foster
Summary: This study found that small vessel leakage in the macular area and/or optic nerve head leakage may be risk factors for resistant birdshot chorioretinopathy.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Review
Pharmacology & Pharmacy
Christopher D. Conrady, Steven Yeh
Summary: Uveitis is a group of inflammatory disorders of the eye that require medical and surgical management, with challenges in drug delivery due to absorption barriers. New drugs and drug delivery platforms are being developed to reduce intraocular inflammation and its complications.
Article
Ophthalmology
Ahmed Al-Janabi, Amgad El Nokrashy, Lazha Sharief, Vivekka Nagendran, Sue Lightman, Oren Tomkins-Netzer
Article
Ophthalmology
Haya H. Al-Ani, Joanne L. Sims, Oren Tomkins-Netzer, Susan Lightman, Rachael L. Niederer
BRITISH JOURNAL OF OPHTHALMOLOGY
(2020)
Article
Ophthalmology
Lazha Sharief, Yi-Hsing Chen, Sue Lightman, Oren Tomkins-Netzer
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2020)
Editorial Material
Ophthalmology
Michal Kramer, Oren Tomkins-Netzer
Article
Ophthalmology
Yi-Hsing Chen, Raz Gepstein, Lazha Sharief, Hsiao-Jung Tseng, Ruoxin Wei, Xiaozhe Zhang, Sue Lightman, Oren Tomkins-Netzer
INTERNATIONAL OPHTHALMOLOGY
(2020)
Article
Ophthalmology
Malgorzata Woronkowicz, Sue Lightman, Oren Tomkins-Netzer
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2020)
Article
Ophthalmology
Oren Tomkins-Netzer, Susan L. Lightman, Alyce E. Burke, Elizabeth A. Sugar, Lyndell L. Lim, Glenn J. Jaffe, Michael M. Altaweel, John H. Kempen, Janet T. Holbrook, Douglas A. Jabs
Summary: The study found that nearly all uveitic macular edema can resolve with sufficient time and treatment, but relapse is common. Eyes with resolved macular edema had better visual acuity results, suggesting that controlling inflammation and resolving edema may be important treatment targets.
Article
Ophthalmology
Rachael Louise Niederer, Shirley P. Ma, Margaret L. Wilsher, Noor Q. Ali, Joanne L. Sims, Oren Tomkins-Netzer, Sue L. Lightman, Lyndell L. Lim
Summary: This retrospective study examined 362 patients with sarcoid uveitis and found various systemic associations with sarcoidosis. Differences in uveitis phenotype and age at onset were observed among different ethnicities, highlighting the need for further investigation.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Malgorzata Woronkowicz, Rachael Niederer, Sue Lightman, Oren Tomkins-Netzer
Summary: This study compared the visual outcomes and recurrence rates of eyes with noninfectious inflammatory choroidal neovascularization (CNV) treated with or without anti-vascular endothelial growth factor (VEGF) injections and immunosuppression. The study found that eyes receiving early anti-VEGF injections achieved better visual outcomes and had a reduced risk of CNV recurrence.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Amgad El Nokrashy, Sue Lightman, Oren Tomkins-Netzer
Summary: Infliximab shows value in controlling and reducing relapse rates of orbital myositis, making it a potential treatment option for refractory orbital myositis.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Review
Ophthalmology
Didar Abdulla, Yasser Ali, Victor Menezo, Simon R. J. Taylor
Summary: The development of sustained-release corticosteroid implants has revolutionized the treatment of non-infectious uveitis affecting the posterior segment of the eye. Their use is now supported by healthcare systems based on high-quality randomized controlled trials, providing clinicians with information on their benefits and risks.
OPHTHALMOLOGY AND THERAPY
(2022)
Article
Ophthalmology
Rachael L. Niederer, Lazha Sharief, Oren Tomkins-Netzer, Sue L. Lightman
Summary: Compared to other non-infectious uveitis, sarcoid uveitis has better visual acuity outcomes and is less likely to require second-line immunosuppression.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2022)
Article
Ophthalmology
Oren Tomkins-Netzer, Shaul Sar, Ofra Barnett-Griness, Binyamin Friedman, Hana Shyriaieva, Walid Saliba
Summary: This study suggests an association between the BNT162b2 mRNA COVID-19 vaccine and an increased risk of active noninfectious uveitis (NIU). However, due to the small effect size and study limitations, this study does not provide proof for a cause-and-effect relationship. The small estimated attributable risks suggest that the impact on public health is relatively minor.
Article
Ophthalmology
Ahmed Al-Janabi, Lazha Sharief, Noura Al Qassimi, Yi-Hsing Chen, Tao Ding, Gareth Ambler, Dimitris Ladas, Sue Lightman, Oren Tomkins-Netzer
Summary: A randomized controlled trial found no significant difference in efficacy between 80 mg/day simvastatin and placebo in noninfectious nonanterior uveitis patients. The study suggests that simvastatin does not have a corticosteroid-sparing effect but may extend the time to disease relapse for patients achieving disease quiescence.
OPHTHALMOLOGY SCIENCE
(2023)
Article
Ophthalmology
Yoav Vardizer, Tamer Sobeh, Daphna Landau Prat, Guy J. Ben Simon, Oren Tomkins-Netzer
Summary: The study aimed to identify factors related to successful cosmetic results in patients using ocular prostheses, finding that good eyelid position and symmetry, orbital fullness, and prosthesis motility were associated with better cosmetic outcomes. Results showed no correlation between patients' perceptions and those of examiners.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2021)