Pro-inflammatory human Th17 cells selectively express P-glycoprotein and are refractory to glucocorticoids

TH17 Cells Mediate Steroid-Resistant Airway Inflammation and Airway Hyperresponsiveness in Mice

(2014) L. McKinley et al.   JOURNAL OF IMMUNOLOGY

Fluorescent substrates for flow cytometric evaluation of efflux inhibition in ABCB1, ABCC1, and ABCG2 transporters

(2013) J. Jacob Strouse et al.   ANALYTICAL BIOCHEMISTRY

T helper cells plasticity in inflammation

(2013) Lorenzo Cosmi et al.   CYTOMETRY PART A

CD161 expression characterizes a subpopulation of human regulatory T cells that produces IL-17 in a STAT3-dependent manner

(2013) Behdad Afzali et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Transcription Factors GATA-3 and ROR t Are Important for Determining the Phenotype of Allergic Airway Inflammation in a Murine Model of Asthma

(2013) S. Ano et al.   JOURNAL OF IMMUNOLOGY

Distinct Profiles of Effector Cytokines Mark the Different Phases of Crohn’s Disease

(2013) Francesca Zorzi et al.   PLoS One

Distinctive features of classic and nonclassic (Th17 derived) human Th1 cells

(2012) Laura Maggi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Human Th17 subsets

(2012) Federica Sallusto et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

IL-23: One cytokine in control of autoimmunity

(2012) Andrew L. Croxford et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial

(2012) Wolfgang Hueber et al.   GUT

Induction and molecular signature of pathogenic TH17 cells

(2012) Youjin Lee et al.   NATURE IMMUNOLOGY

Oral and inhaled corticosteroids: Differences in P-glycoprotein (ABCB1) mediated efflux

(2012) Andrew Crowe et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

TOR in the immune system

(2011) Koichi Araki et al.   CURRENT OPINION IN CELL BIOLOGY

Th17 Cells Are Long Lived and Retain a Stem Cell-like Molecular Signature

(2011) Pawel Muranski et al.   IMMUNITY

Cytokine signals through PI-3 kinase pathway modulate Th17 cytokine production by CCR6+human memory T cells

(2011) Qi Wan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Human Th1 and Th17 Cells Exhibit Epigenetic Stability at Signature Cytokine and Transcription Factor Loci

(2011) C. J. Cohen et al.   JOURNAL OF IMMUNOLOGY

Minireview: Glucocorticoids in Autoimmunity: Unexpected Targets and Mechanisms

(2011) Jamie R. Flammer et al.   MOLECULAR ENDOCRINOLOGY

Control of TH17 cells occurs in the small intestine

(2011) Enric Esplugues et al.   NATURE

Fate mapping of IL-17-producing T cells in inflammatory responses

(2011) Keiji Hirota et al.   NATURE IMMUNOLOGY

RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation

(2011) Laura Codarri et al.   NATURE IMMUNOLOGY

Human TH17 Cells Are Long-Lived Effector Memory Cells

(2011) I. Kryczek et al.   Science Translational Medicine

TH17 Cells in Asthma and COPD

(2010) John F. Alcorn et al.   Annual Review of Physiology

Interleukin-23 Drives Intestinal Inflammation through Direct Activity on T Cells

(2010) Philip P. Ahern et al.   IMMUNITY

Identification of a novel subset of human circulating memory CD4+ T cells that produce both IL-17A and IL-4

(2010) Lorenzo Cosmi et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Generation of pathogenic TH17 cells in the absence of TGF-β signalling

(2010) Kamran Ghoreschi et al.   NATURE

Th17 plasticity in human autoimmune arthritis is driven by the inflammatory environment

(2010) K. Nistala et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Preferential recruitment of interferon-γ-expressing TH17 cells in multiple sclerosis

(2009) Hania Kebir et al.   ANNALS OF NEUROLOGY

A Distinct Subset of Self-Renewing Human Memory CD8+ T Cells Survives Cytotoxic Chemotherapy

(2009) Cameron J. Turtle et al.   IMMUNITY

Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodeling

(2009) Stefanie Eyerich et al.   JOURNAL OF CLINICAL INVESTIGATION

Circulating and gut-resident human Th17 cells express CD161 and promote intestinal inflammation

(2009) Melanie A. Kleinschek et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Glucocorticoid resistance in inflammatory diseases

(2009) Peter J Barnes et al.   LANCET

The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17–producing effector T helper cells in vivo

(2009) Mandy J McGeachy et al.   NATURE IMMUNOLOGY

Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from TH-17, TH1 and TH2 cells

(2009) Sara Trifari et al.   NATURE IMMUNOLOGY

Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells

(2009) Thomas Duhen et al.   NATURE IMMUNOLOGY

Interleukin-17 and Type 17 Helper T Cells

(2009) Pierre Miossec et al.   NEW ENGLAND JOURNAL OF MEDICINE

Halofuginone Inhibits TH17 Cell Differentiation by Activating the Amino Acid Starvation Response

(2009) M. S. Sundrud et al.   SCIENCE

Structure of P-Glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding

(2009) S. G. Aller et al.   SCIENCE

Immune regulation and control of regulatory T cells by OX40 and 4-1BB

(2008) Takanori So et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Human interleukin 17–producing cells originate from a CD161+CD4+T cell precursor

(2008) Lorenzo Cosmi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The differentiation of human TH-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt

(2008) Nicolas Manel et al.   NATURE IMMUNOLOGY

Regulatory T Cells: Mechanisms of Differentiation and Function

(2007) Steven Z. Josefowicz et al.   Annual Review of Immunology