Article
Immunology
Moussa Labsi, Imene Soufli, Houda Belguendouz, Sara Djebbara, Leila Hannachi, Zine-Charaf Amir, Chafia Touil-Boukoffa
Summary: The study found that DMF treatment significantly reduced levels of nitric oxide and TNF-alpha in experimental autoimmune uveoretinitis, while improving the histological structure of the eyes, demonstrating potential therapeutic effects.
INFLAMMOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Emrah Ipek, Gamze Sevri Ekren Asici, Erkmen Tugrul Epikmen, Muruvvet Abbak, Busra Kibar Kurt, Sule Yurdagul Ozsoy, Recai Tunca
Summary: The aim of this study was to investigate the healing effect of propionyl-L-carnitine (PLC) on chronic gastric ulcers and its underlying mechanisms. Treatment with PLC resulted in a reduction of the gastric ulcer area, a faster rate of ulcer healing, stimulated mucosal restoration, and affected the populations of macrophages, microvessels, and myofibroblasts. Additionally, PLC treatment upregulated the expression of certain genes involved in healing processes. These findings suggest that PLC may accelerate gastric ulcer healing through various mechanisms.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Immunology
Juan Pablo Medina, Ismael Bermejo-Alvarez, Sandra Perez-Baos, Rosa Yanez, Maria Fernandez-Garcia, Damian Garcia-Olmo, Aranzazu Mediero, Gabriel Herrero-Beaumont, Raquel Largo
Summary: This study investigated the effect of Adipose-Derived Mesenchymal Stem Cells (Ad-MSC) on acute joint inflammation in rabbits with gouty arthritis. The results showed that Ad-MSC accelerated the resolution of inflammation, promoted the formation of M2 macrophages, inhibited NLRP3 and NF-kB activity, and increased the production of anti-inflammatory cytokines IL-10 and TGF-β. Therefore, Ad-MSC could be a pharmacological alternative for patients who cannot undergo conventional treatment.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Shevanuja Theivendran, Zhengying Gu, Jie Tang, Yannan Yang, Hao Song, Yang Yang, Min Zhang, Dan Cheng, Chengzhong Yu
Summary: This study reports the synthesis of a nanoparticle-based NO delivery platform that utilizes tetrasulfide-modified organosilica nanoparticles for effective NO delivery and macrophage activation. The enhanced intracellular delivery of NO resulted in macrophage activation and delayed tumor growth in a breast cancer model.
Article
Immunology
Cristian R. Falcon, Nicolas Fernandez Hurst, Ana Laura Vivinetto, Pablo Hector Horacio Lopez, Adolfo Zurita, Gerardo Gatti, Laura Cervi, Clara G. Monferran, German A. Roth
Summary: DZ has immunomodulatory effects by reducing pro-inflammatory cytokine secretion and shifting immune responses towards an anti-inflammatory profile. It can be used preventively to treat experimental autoimmune encephalomyelitis (EAE) and therapeutically to ameliorate clinical signs and prevent axonal damage.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Philip McMillan, Thomas Dexhiemer, Richard R. Neubig, Bruce D. Uhal
Summary: The COVID-19 pandemic has caused a significant loss of lives worldwide, with doctors facing an unusual pattern of organ damage when treating affected patients. Recent research suggests that autoimmunity may play a role in the organ damage seen in COVID-19, offering new insights for further study.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Ophthalmology
Yasuhiko Sato, Hiroshi Keino, Makiko Nakayama, Mirai Kano, Annabelle A. Okada
Summary: The injection of IL-2 complex and IL-2 complex/rapamycin was found to increase regulatory T cells and delay the onset of EAU in mice. However, there were limitations in using IL-2 complex or IL-2 complex/rapamycin at different stages of the experiment.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2021)
Article
Cell Biology
Jeongtae Kim, Meejung Ahn, Yuna Choi, Jiyoon Chun, Kyungsook Jung, Akane Tanaka, Hiroshi Matsuda, Taekyun Shin
Summary: This study investigated the involvement of osteopontin (OPN) in an experimental autoimmune uveoretinitis (EAU) model. The results showed that OPN was significantly upregulated in the eyes of EAU rats, suggesting its potential as an early biomarker for ocular autoimmune diseases.
NEURAL REGENERATION RESEARCH
(2022)
Article
Clinical Neurology
Wesley H. H. Godfrey, Soonmyung Hwang, Kaho Cho, Shruthi Shanmukha, Payam Gharibani, Efrat Abramson, Michael Davin Kornberg
Summary: Multiple sclerosis (MS) is a neuroinflammatory disease characterized by neuroaxonal injury. This study reveals that glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is nitrosylated in the central nervous system during MS. Inhibition of nitrosylated GAPDH (SNO-GAPDH) with CGP3466b reduces neurologic disability and axonal injury in an MS mouse model. These findings suggest that SNO-GAPDH contributes to neuroaxonal injury in MS and identify CGP3466b as a potential neuroprotective therapy.
FRONTIERS IN NEUROLOGY
(2023)
Article
Pharmacology & Pharmacy
Nicholas Dopkins, William Becker, Kathryn Miranda, Mike Walla, Prakash Nagarkatti, Mitzi Nagarkatti
Summary: Tryptamine, a microbiota-derived AHR agonist, attenuates symptoms of experimental autoimmune encephalomyelitis (EAE) by reducing inflammation cell infiltration and increasing regulatory T cells, while also altering gut microbiota and promoting butyrate production.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Alessio Gerussi, Ambra Natalini, Fabrizio Antonangeli, Clara Mancuso, Elisa Agostinetto, Donatella Barisani, Francesca Di Rosa, Raul Andrade, Pietro Invernizzi
Summary: Drug-induced liver injury (DILI) is a challenging clinical event with various phenotypes and limited diagnostic and therapeutic tools. Recent advancements in genomics and immunology offer insights into the molecular aspects of DILI, helping to improve understanding and research in this field.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Rheumatology
Eileen W. Stalman, Luuk Wieske, Koos P. J. van Dam, Laura Y. Kummer, Zoe L. E. van Kempen, Joep Killestein, Adriaan G. Volkers, Sander W. Tas, Laura Boekel, Gertjan J. Wolbink, Anneke J. Van der Kooi, Joost Raaphorst, Mark Lowenberg, R. Bart Takkenberg, Geert R. A. M. D'Haens, Phyllis Spuls, Marcel W. Bekkenk, Annelie H. Musters, Nicoline F. Post, Angela L. Bosma, Marc L. Hilhorst, Yosta Vegting, Frederique J. Bemelman, Alexandre E. Voskuyl, Bo Broens, Agner Parra Sanchez, Cecile A. C. M. van Els, Jelle De Wit, Abraham Rutgers, Karina de Leeuw, Barbara Horvath, Jan J. G. M. Verschuuren, Annabel M. Ruiter, Lotte van Ouwerkerk, Diane van der Woude, C. F. Allaart, Onno Y. K. Teng, Pieter van Paassen, Matthias H. Busch, Papay B. P. Jallah, Esther Brusse, Pieter A. van Doorn, Adaja Elisabeth Baars, Dirk Jan Hijnen, Corine R. G. Schreurs, W. Ludo Van der Pol, H. Stephan Goedee, Maurice Steenhuis, Sofie Keijzer, Jim B. D. Keijser, Arend Boogaard, Olvi Cristianawati, Anja ten Brinke, Niels J. M. Verstegen, Koos A. H. Zwinderman, Theo Rispens, S. Marieke van Ham, Taco W. Kuijpers, Filip Eftimov
Summary: This study compared the cumulative incidence and disease severity of reported SARS-CoV-2 omicron breakthrough infections between patients with immune-mediated inflammatory diseases (IMID) on immunosuppressants and controls. The results showed that the cumulative incidence of breakthrough infections was high but similar between the two groups, and the disease severity was mostly mild. Additional vaccinations and prior SARS-CoV-2 infections were associated with a decreased risk of breakthrough infections.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Immunology
Ruyi Qu, Mengxian Zhou, Yan Qiu, Yuan Peng, Xuewei Yin, Bin Liu, Hongsheng Bi, Yan'e Gao, Dadong Guo
Summary: Research has shown that glucocorticoids can modulate the balance of M1/M2 macrophage polarization through the p38MAPK-MEF2C axis in experimental autoimmune uveitis, leading to the suppression of ocular inflammation. This study elucidates the mechanism of glucocorticoids in treating uveitis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Microbiology
Laura Hobbs, Leah Allen, Megan Bias, Stephanie Johnson, Hannah DeRespiris, Chantal Diallo, Loan Bui, Yvonne Sun
Summary: The study found that propionate pretreatment significantly enhanced L. monocytogenes intracellular infections while inhibiting nitrite production by macrophages. Additionally, propionate treatment altered the morphology of macrophages and affected their responses to infection.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Immunology
Hiroshi Horiuchi, Bijay Parajuli, Hiroyasu Komiya, Yuki Ogawa, Shijie Jin, Keita Takahashi, Yasu-Taka Azuma, Fumiaki Tanaka, Akio Suzumura, Hideyuki Takeuchi
Summary: IL-19 deficiency exacerbates multiple sclerosis by promoting Th17 cell infiltration and increasing expression of antigen presentation and Th17 cell differentiation factors. IL-19 suppresses MS pathogenesis by inhibiting macrophage antigen presentation and Th17 cell expansion. Treatment with IL-19 shows significant therapeutic benefits in experimental autoimmune encephalomyelitis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Rehabilitation
Bonnie B. Y. Cheng, Brooke Ryan, David A. Copland, Sarah J. Wallace
Summary: Speech pathologists face challenges in prognosticating aphasia, with shared but unvoiced difficulties. Realistic conversations about aphasia recovery, focusing on holistic approaches and the power of words, may enhance prognosis outcomes. Future research should explore the preferences of individuals with aphasia and their caregivers for improved therapeutic potential.
DISABILITY AND REHABILITATION
(2022)
Article
Audiology & Speech-Language Pathology
Myzoon Ali, Efstathia Soroli, Luis M. T. Jesus, Madeline Cruice, Jytte Isaksen, Evy Visch-Brink, Kleanthes K. Grohmann, C. Jagoe, Tarja Kukkonen, Spyridoula Varlokosta, Carlos Hernandez-Sacristan, Vicente Rosell-Clari, Rebecca Palmer, Silvia Martinez-Ferreiro, Erin Godecke, Sarah J. Wallace, Ruth McMenamin, David Copland, Caterina Breitenstein, Audrey Bowen, Ann-Charlotte Laska, Katerina Hilari, Marian C. Brady
Summary: The coordination and collaboration of international aphasia research aim to improve the quality and transparency of research. The research agenda developed by CATs is based on global cooperation and multidisciplinary collaboration to support the advancement and implementation of aphasia research.
Article
Clinical Neurology
Nadeeka N. Dissanayaka, Elana J. Forbes, Ji Hyun J. Yang, Dana Pourzinal, John D. O'Sullivan, Leander K. Mitchell, David A. Copland, Katie L. McMahon, Gerard J. Byrne
Summary: This study found that anxiety disorders in patients with Parkinson's disease are associated with immediate and delayed verbal memory impairments, providing implications for anxiety management and treatment in this population.
JOURNAL OF NEUROLOGY
(2022)
Article
Neurosciences
Bonnie B. Y. Cheng, Brooke J. Ryan, David A. Copland, Sarah J. Wallace
Summary: This study provides valuable insights into the experiences of individuals with aphasia receiving prognoses post-stroke, revealing issues of mistrust in the patient-clinician relationship and complex emotions related to hope and adjustment.
NEUROPSYCHOLOGICAL REHABILITATION
(2023)
Article
Audiology & Speech-Language Pathology
Kirstine Shrubsole, David Copland, Annie Hill, Asaduzzaman Khan, Melissa Lawrie, Denise A. O'Connor, Moya Pattie, Amy Rodriguez, Elizabeth C. Ward, Linda Worrall, Marie-Pier Mcsween
Summary: This study aimed to identify potential barriers and facilitators to implementing Aphasia LIFT into existing healthcare services from the perspectives of clinical stakeholders and experienced LIFT clinicians, and develop a theory-informed implementation intervention for Aphasia LIFT, tailored to the intended implementation context.
Article
Audiology & Speech-Language Pathology
Elaine Kearney, Sonia L. E. Brownsett, David A. Copland, Katharine J. Drummond, Rosalind L. Jeffree, Sarah Olson, Emma Murton, Benjamin Ong, Gail A. Robinson, Valeriya Tolkacheva, Katie L. McMahon, Greig de Zubicaray
Summary: This study found that post-treatment communication-related quality of life was associated with residual tumor, edema, and peri-resection treatment effects as well as white matter disconnection. However, mood-related quality of life and the primary resection lesion maps were not significantly associated with HRQoL.
Article
Rehabilitation
Bethany Best, Jessica Campbell, Tracy Roxbury, Peter Worthy, David A. Copland
Summary: This exploratory research examined the usability and feasibility of a purpose-built music listening mobile application for people living with post-stroke aphasia in the community. The study found that the application was perceived as being usable and feasible, with high system usability rating and moderate effectiveness, efficiency, and satisfaction. This study provides a foundation for further examination of the usability of music listening technology in people with post-stroke aphasia and potential applications in acute care facilities and other clinical populations.
DISABILITY AND REHABILITATION
(2023)
Article
Audiology & Speech-Language Pathology
Sarah J. Wallace, Linda Worrall, Tanya A. Rose, Reem S. W. Alyahya, Edna Babbitt, Suzanne Beeke, Carola de Beer, Arpita Bose, Audrey Bowen, Marian C. Brady, Caterina Breitenstein, Stefanie Bruehl, Lucy Bryant, Bonnie B. Y. Cheng, Leora R. Cherney, Paul Conroy, David A. Copland, Clare Croteau, Madeline Cruice, Lucy Dipper, Katerina Hilari, Tami Howe, Helen Kelly, Swathi Kiran, Ann-Charlotte Laska, Jane Marshall, Laura L. Murray, Janet Patterson, Gill Pearl, Jana Quinting, Elizabeth Rochon, Miranda L. Rose, Ilona Rubi-Fessen, Karen Sage, Nina Simmons-Mackie, Evy Visch-Brink, Anna Volkmer, Janet Webster, Anne Whitworth, Guylaine Le Dorze
Summary: The aim of this study was to establish consensus on a communication OMI for inclusion in the ROMA COS, and it was found that TST is the preferred choice. Implementation of the ROMA COS would improve the quality, relevance, transparency, replicability, and efficiency of aphasia treatment research.
INTERNATIONAL JOURNAL OF LANGUAGE & COMMUNICATION DISORDERS
(2023)
Article
Psychology, Experimental
Emma A. E. Schimke, Anthony J. Angwin, Sjaan R. Gomersall, David A. Copland
Summary: This study examined the impact of overnight sleep on associative novel word learning and found that overnight sleep can enhance the consolidation of novel words. Whether semantic information was provided or not, new words benefited from the overnight sleep period.
Article
Neurosciences
Aleksi J. Sihvonen, Veronika Vadinova, Kimberley L. Garden, Marcus Meinzer, Tracy Roxbury, Kate O'Brien, David Copland, Katie L. McMahon, Sonia L. E. Brownsett
Summary: Poststroke aphasia, caused by left-lateralized language network damage, is often accompanied by uncertainty in the contribution of the right hemisphere's homologues to aphasia recovery. In this study, the role of the right hemisphere's structural connectome in aphasia recovery was investigated. The results showed that certain pathways in the right hemisphere white matter made a maladaptive contribution to language recovery, while others supported the recovery of language comprehension abilities.
HUMAN BRAIN MAPPING
(2023)
Review
Clinical Neurology
Bridget Burton, Megan Isaacs, Emily Brogan, Kirstine Shrubsole, Monique F. Kilkenny, Emma Power, Erin Godecke, Dominique A. Cadilhac, David Copland, Sarah J. Wallace
Summary: The aim of this study was to identify and evaluate high-quality stroke guidelines that can inform aphasia management. We identified 9 high-quality guidelines and extracted 82 recommendations for aphasia management. Most recommendations were aphasia-related, but there were gaps in aphasia-specific recommendations in the areas of accessing community supports, return to work and leisure, driving, and interprofessional practice.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Article
Neurosciences
Jade Dignam, Amy D. Rodriguez, Kate O'Brien, Penni Burfein, David A. Copland
Summary: This study explored the relationship between early within-therapy probe naming performance and treatment outcomes in individuals with aphasia. Results showed that early within-therapy probe naming performance was the strongest predictor of therapy gains for anomia, both immediately after therapy and at 1-month follow-up. These findings have important clinical implications and suggest that early probe naming performance can be used to identify potential response to treatment for aphasia.
NEUROPSYCHOLOGICAL REHABILITATION
(2023)
Article
Cell Biology
Chenyang Zhang, Ben Raveney, Fumio Takahashi, Tzu-wen Yeh, Hirohiko Hohjoh, Takashi Yamamura, Shinji Oki
Summary: In addition to disease-associated microglia (DAM), microglia with MHC-II and/or IFN-I signatures may form additional pathogenic subsets that are relevant to neurodegeneration. However, the significance of such MHC-II and IFN-I signatures remains elusive. We demonstrate here that these microglial subsets play intrinsic roles in orchestrating neurotoxic properties of neurotoxic Eomes(+) Th cells under the neurodegeneration-associated phase of experimental autoimmune encephalomyelitis (EAE) that corresponds to progressive multiple sclerosis (MS).
Meeting Abstract
Clinical Neurology
Miranda L. Rose, Joosup Kim, David Copland, Lyndsey Nickels, Leanne Togher, Erin Godecke, Tapan Rai, Marcus Meinzer, Dominique Cadilhac, Melanie Hurley, Cassie Wilcox, Gillian Steel, John E. Pierce, Marcella Carragher
INTERNATIONAL JOURNAL OF STROKE
(2022)
Article
Psychology, Developmental
Melina J. West, Anthony J. Angwin, David A. Copland, Wendy L. Arnott, Nicole L. Nelson
Summary: The study found that the influence of emotion on attention during word learning in 7-9 year-old children varies depending on their level of autism-like traits, but it does not affect word learning outcomes.
JOURNAL OF CHILD LANGUAGE
(2022)