Insulin-Sensitizing Effects of Omega-3 Fatty Acids: Lost in Translation?

Predictors of Whole-Body Insulin Sensitivity Across Ages and Adiposity in Adult Humans

(2016) Antigoni Z. Lalia et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Docosahexaenoic acid attenuates adipose tissue angiogenesis and insulin resistance in high fat diet-fed middle-aged mice via a sirt1-dependent mechanism

(2016) Xiaoqin Luo et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Eicosapentaenoic acid but not docosahexaenoic acid restores skeletal muscle mitochondrial oxidative capacity in old mice

(2015) Matthew L. Johnson et al.   AGING CELL

Effect of n-3 PUFA supplementation at different EPA:DHA ratios on the spontaneously hypertensive obese rat model of the metabolic syndrome

(2015) Eunice Molinar-Toribio et al.   BRITISH JOURNAL OF NUTRITION

Mechanism by which caloric restriction improves insulin sensitivity in sedentary obese adults

(2015) Matthew L. Johnson et al.   DIABETES

Defects in Mitochondrial Efficiency and H2O2Emissions in Obese Women Are Restored to a Lean Phenotype With Aerobic Exercise Training

(2015) Adam R. Konopka et al.   DIABETES

Effects of Dietary n-3 Fatty Acids on Hepatic and Peripheral Insulin Sensitivity in Insulin-Resistant Humans

(2015) Antigoni Z. Lalia et al.   DIABETES CARE

Fish oil supplementation does not lower C-reactive protein or interleukin-6 levels in healthy adults

(2015) M. F. Muldoon et al.   JOURNAL OF INTERNAL MEDICINE

Dietary Docosahexaenoic Acid and Eicosapentaenoic Acid Influence Liver Triacylglycerol and Insulin Resistance in Rats Fed a High-Fructose Diet

(2015) Gabriela Salim de Castro et al.   Marine Drugs

Nonalcoholic fatty liver disease: Roles of the gut and the liver and metabolic modulation by some dietary factors and especially long-chain n-3 PUFA

(2015) Jacques Delarue et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Ratio of Dietary n-6/n-3 Polyunsaturated Fatty Acids Independently Related to Muscle Mass Decline in Hemodialysis Patients

(2015) Te-Chih Wong et al.   PLoS One

Effects of supplementation with omega-3 on insulin sensitivity and non-esterified free fatty acid (NEFA) in type 2 diabetic patients

(2014) Payam Farahbakhsh Farsi et al.   Arquivos Brasileiros de Endocrinologia e Metabologia

Fish oil omega-3 fatty acids partially prevent lipid-induced insulin resistance in human skeletal muscle without limiting acylcarnitine accumulation

(2014) Francis B. Stephens et al.   CLINICAL SCIENCE

Omega-3 fatty acid therapy dose-dependently and significantly decreased triglycerides and improved flow-mediated dilation, however, did not significantly improve insulin sensitivity in patients with hypertriglyceridemia

(2014) Pyung Chun Oh et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Differential Effects of High-Fish Oil and High-Lard Diets on Cells and Cytokines Involved in the Inflammatory Process in Rat Insulin-Sensitive Tissues

(2014) Lillà Lionetti et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Serum phospholipid omega-3 polyunsaturated fatty acids and insulin resistance in type 2 diabetes mellitus and non-alcoholic fatty liver disease

(2014) Da-jun Lou et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Omega-3 supplementation alters mitochondrial membrane composition and respiration kinetics in human skeletal muscle

(2014) E. A. F. Herbst et al.   JOURNAL OF PHYSIOLOGY-LONDON

Effect of Probiotic (VSL#3) and Omega-3 on Lipid Profile, Insulin Sensitivity, Inflammatory Markers, and Gut Colonization in Overweight Adults: A Randomized, Controlled Trial

(2014) Hemalatha Rajkumar et al.   MEDIATORS OF INFLAMMATION

Protectin DX alleviates insulin resistance by activating a myokine-liver glucoregulatory axis

(2014) Phillip J White et al.   NATURE MEDICINE

Influence of fish oil on skeletal muscle mitochondrial energetics and lipid metabolites during high-fat diet

(2013) Ian R. Lanza et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

n-6:n-3 PUFA ratio is involved in regulating lipid metabolism and inflammation in pigs

(2013) Yehui Duan et al.   BRITISH JOURNAL OF NUTRITION

n-3 PUFA status in school children is associated with beneficial lipid profile, reduced physical activity and increased blood pressure in boys

(2013) Camilla T. Damsgaard et al.   BRITISH JOURNAL OF NUTRITION

Resolvins, Specialized Proresolving Lipid Mediators, and Their Potential Roles in Metabolic Diseases

(2013) Matthew Spite et al.   Cell Metabolism

Association of dietary omega-3 fatty acids with prevalence of metabolic syndrome: The National Heart, Lung, and Blood Institute Family Heart Study

(2013) Y.H. Lana Lai et al.   CLINICAL NUTRITION

Resolution phase lipid mediators of inflammation: agonists of resolution

(2013) Charles N. Serhan et al.   CURRENT OPINION IN PHARMACOLOGY

Omega-3 Fatty Acids Reduce Adipose Tissue Macrophages in Human Subjects With Insulin Resistance

(2013) M. Spencer et al.   DIABETES

Fish Oil Supplementation Ameliorates Fructose-Induced Hypertriglyceridemia and Insulin Resistance in Adult Male Rhesus Macaques

(2013) Andrew A. Bremer et al.   JOURNAL OF NUTRITION

n−3 polyunsaturated fatty acids modulate metabolism of insulin-sensitive tissues: implication for the prevention of type 2 diabetes

(2013) Alexandre Pinel et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Eicosapentaenoic acid-enriched phospholipid ameliorates insulin resistance and lipid metabolism in diet-induced-obese mice

(2013) Xiaofang Liu et al.   Lipids in Health and Disease

Primary Prevention of Cardiovascular Disease with a Mediterranean Diet

(2013) Ramón Estruch et al.   NEW ENGLAND JOURNAL OF MEDICINE

A randomized trial of fish oil omega-3 fatty acids on arterial health, inflammation, and metabolic syndrome in a young healthy population

(2013) Martin Root et al.   Nutrition Journal

A high ratio of dietary n-3/n-6 polyunsaturated fatty acids improves obesity-linked inflammation and insulin resistance through suppressing activation of TLR4 in SD rats

(2013) Han-Qiang Liu et al.   NUTRITION RESEARCH

Omega-3 polyunsaturated fatty acids reduce insulin resistance and triglycerides in obese children and adolescents

(2013) Carlos Juárez-López et al.   PEDIATRIC DIABETES

Docosahexaenoic and Eicosapentaenoic Acids Segregate Differently between Raft and Nonraft Domains

(2012) Justin A. Williams et al.   BIOPHYSICAL JOURNAL

The effect of EPA and DHA on metabolic syndrome patients: a systematic review of randomised controlled trials

(2012) Eduardo Lopez-Huertas   BRITISH JOURNAL OF NUTRITION

Omega-3 fatty acids and incident type 2 diabetes: a systematic review and meta-analysis

(2012) Jason H. Y. Wu et al.   BRITISH JOURNAL OF NUTRITION

Mechanisms for Insulin Resistance: Common Threads and Missing Links

(2012) Varman T. Samuel et al.   CELL

Fish Consumption and Incidence of Diabetes: Meta-analysis of data from 438,000 individuals in 12 independent prospective cohorts with an average 11-year follow-up

(2012) P. Xun et al.   DIABETES CARE

Fish Consumption, Dietary Long-Chain n-3 Fatty Acids, and Risk of Type 2 Diabetes: Systematic review and meta-analysis of prospective studies

(2012) A. Wallin et al.   DIABETES CARE

Effects of n-3 PUFAs on postprandial variation of metalloproteinases, and inflammatory and insulin resistance parameters in dyslipidemic patients: Evaluation with euglycemic clamp and oral fat load

(2012) Giuseppe Derosa et al.   Journal of Clinical Lipidology

Effects of ALA, EPA and DHA in high-carbohydrate, high-fat diet-induced metabolic syndrome in rats

(2012) Hemant Poudyal et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

ω-3 Polyunsaturated Fatty Acid Supplementation Does Not Influence Body Composition, Insulin Resistance, and Lipemia in Women With Type 2 Diabetes and Obesity

(2012) Izabella Candido Carvalho Crochemore et al.   NUTRITION IN CLINICAL PRACTICE

Marine N-3 Polyunsaturated Fatty Acids Are Inversely Associated with Risk of Type 2 Diabetes in Asians: A Systematic Review and Meta-Analysis

(2012) Ju-Sheng Zheng et al.   PLoS One

(n-3) Fatty Acids Alleviate Adipose Tissue Inflammation and Insulin Resistance: Mechanistic Insights

(2012) Nishan S. Kalupahana et al.   Advances in Nutrition

Supplementation of n3 Long-chain Polyunsaturated Fatty Acid Synergistically Decreases Insulin Resistance with Weight Loss of Obese Prepubertal and Pubertal Children

(2011) Mardia López-Alarcón et al.   ARCHIVES OF MEDICAL RESEARCH

Fish intake, erythrocyte n-3 fatty acid status and metabolic health in Danish adolescent girls and boys

(2011) Lotte Lauritzen et al.   BRITISH JOURNAL OF NUTRITION

Omega-3 polyunsaturated fatty acid and insulin sensitivity: A meta-analysis of randomized controlled trials

(2011) Akintunde O. Akinkuolie et al.   CLINICAL NUTRITION

Omega-3 index, obesity and insulin resistance in children

(2011) T. Burrows et al.   International Journal of Pediatric Obesity

Docosahexaenoic Acid Content in Plasma Phospholipids and Desaturase Indices in Obese Children

(2011) Emiko Saito et al.   Journal of Atherosclerosis and Thrombosis

Docosahexaenoic Acid Supplementation Improved Lipocentric but Not Glucocentric Markers of Insulin Sensitivity in Hypertriglyceridemic Men

(2011) Darshan S. Kelley et al.   Metabolic Syndrome and Related Disorders

n–3 Fatty Acids in Cardiovascular Disease

(2011) Raffaele De Caterina   NEW ENGLAND JOURNAL OF MEDICINE

Dose-response effects of omega-3 fatty acids on triglycerides, inflammation, and endothelial function in healthy persons with moderate hypertriglyceridemia

(2010) Ann C Skulas-Ray et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

A decreased n-6/n-3 ratio in the fat-1 mouse is associated with improved glucose tolerance

(2010) Brennan K. Smith et al.   Applied Physiology Nutrition and Metabolism

Endogenously Decreasing Tissue n-6/n-3 Fatty Acid Ratio Reduces Atherosclerotic Lesions in Apolipoprotein E –Deficient Mice by Inhibiting Systemic and Vascular Inflammation

(2010) Jian-Bo Wan et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

GPR120 Is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing Effects

(2010) Da Young Oh et al.   CELL

The nutritional and clinical significance of lipid rafts

(2010) Parveen Yaqoob et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

AMP-activated Protein Kinase  2 Subunit Is Required for the Preservation of Hepatic Insulin Sensitivity by n-3 Polyunsaturated Fatty Acids

(2010) T. Jelenik et al.   DIABETES

Transgenic Restoration of Long-Chain n-3 Fatty Acids in Insulin Target Tissues Improves Resolution Capacity and Alleviates Obesity-Linked Inflammation and Insulin Resistance in High-Fat-Fed Mice

(2010) P. J. White et al.   DIABETES

Body and Liver Fat Mass Rather Than Muscle Mitochondrial Function Determine Glucose Metabolism in Women With a History of Gestational Diabetes Mellitus

(2010) T. Prikoszovich et al.   DIABETES CARE

The Effects of Low Dose n-3 Fatty Acids on Serum Lipid Profiles and Insulin Resistance of the Elderly: a Randomized Controlled Clinical Trial

(2010) Hossein Fakhrzadeh et al.   INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH

Association of Marine Omega-3 Fatty Acid Levels With Telomeric Aging in Patients With Coronary Heart Disease

(2010) Ramin Farzaneh-Far   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Eicosapentaenoic Acid Prevents and Reverses Insulin Resistance in High-Fat Diet-Induced Obese Mice via Modulation of Adipose Tissue Inflammation

(2010) Nishan S. Kalupahana et al.   JOURNAL OF NUTRITION

Effects of Fish Oil Supplementation on Markers of the Metabolic Syndrome

(2010) Maiken Højgaard Pedersen et al.   JOURNAL OF PEDIATRICS

Intake of Fish and n-3 Fatty Acids and Future Risk of Metabolic Syndrome

(2010) Inkyung Baik et al.   JOURNAL OF THE AMERICAN DIETETIC ASSOCIATION

Regulation of adipokine secretion by n-3 fatty acids

(2010) María J. Moreno-Aliaga et al.   PROCEEDINGS OF THE NUTRITION SOCIETY

Lipid Rafts As a Membrane-Organizing Principle

(2010) D. Lingwood et al.   SCIENCE

Decreased activity of desaturase 5 in association with obesity and insulin resistance aggravates declining long-chain n-3 fatty acid status in Cree undergoing dietary transition

(2009) Yuan E. Zhou et al.   BRITISH JOURNAL OF NUTRITION

Omega-3 Dietary Supplements and the Risk of Cardiovascular Events: A Systematic Review

(2009) Paul E. Marik et al.   CLINICAL CARDIOLOGY

Age, Obesity, and Sex Effects on Insulin Sensitivity and Skeletal Muscle Mitochondrial Function

(2009) H. Karakelides et al.   DIABETES

n-3 Fatty acids and rosiglitazone improve insulin sensitivity through additive stimulatory effects on muscle glycogen synthesis in mice fed a high-fat diet

(2009) O. Kuda et al.   DIABETOLOGIA

Functional Modulation of Mitochondria by Eicosapentaenoic Acid Provides Protection against Ceramide Toxicity to C6 Glioma Cells

(2009) Jaan-Yeh Jeng et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans

(2009) Ethan J. Anderson et al.   JOURNAL OF CLINICAL INVESTIGATION

Effects of Olanzapine and Risperidone on Glucose Metabolism and Insulin Sensitivity in Chronic Schizophrenic Patients With Long-Term Antipsychotic Treatment

(2009) Robert C. Smith et al.   JOURNAL OF CLINICAL PSYCHIATRY

Addition of n-3 fatty acids to a 4-hour lipid infusion does not affect insulin sensitivity, insulin secretion, or markers of oxidative stress in subjects with type 2 diabetes mellitus

(2009) Ingrid L. Mostad et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis

(2009) Matthew Spite et al.   NATURE

n-3 Polyunsaturated fatty acids and trans fatty acids in patients with the metabolic syndrome: a case–control study in Korea

(2008) Eunjeong Lee et al.   BRITISH JOURNAL OF NUTRITION

Endurance Exercise as a Countermeasure for Aging

(2008) I. R. Lanza et al.   DIABETES

Beneficial effects of long-chain n-3 fatty acids included in an energy-restricted diet on insulin resistance in overweight and obese European young adults

(2008) A. Ramel et al.   DIABETOLOGIA

Effects of conjugated linoleic acid plus n-3 polyunsaturated fatty acids on insulin secretion and estimated insulin sensitivity in men

(2008) B Ahrén et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

High Omega-3 Fat Intake Improves Insulin Sensitivity and Reduces CRP and IL6, but does not Affect Other Endocrine Axes in Healthy Older Adults

(2008) P. Tsitouras et al.   HORMONE AND METABOLIC RESEARCH

Relationship between n-3 and n-6 plasma fatty acid levels and insulin resistance in coronary patients with and without metabolic syndrome

(2008) A. Nigam et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES