Liver-specific loss of lipin-1-mediated phosphatidic acid phosphatase activity does not mitigate intrahepatic TG accumulation in mice

Lipin 2 Binds Phosphatidic Acid by the Electrostatic Hydrogen Bond Switch Mechanism Independent of Phosphorylation

(2014) James M. Eaton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Diet-induced mouse model of fatty liver disease and nonalcoholic steatohepatitis reflecting clinical disease progression and methods of assessment

(2013) Jason R. Clapper et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Lipin1 regulates PPARγ transcriptional activity

(2013) Hee Eun Kim et al.   BIOCHEMICAL JOURNAL

Hepatic-specific lipin-1 deficiency exacerbates experimental alcohol-induced steatohepatitis in mice

(2013) Ming Hu et al.   HEPATOLOGY

Differential regulation of the expressions of the PGC-1α splice variants, lipins, and PPARα in heart compared to liver

(2013) Bernard P. C. Kok et al.   JOURNAL OF LIPID RESEARCH

Lipin-1 and lipin-3 together determine adiposity in vivo

(2013) Lauren S. Csaki et al.   Molecular Metabolism

Complex Interplay between the Lipin 1 and the Hepatocyte Nuclear Factor 4 α (HNF4α) Pathways to Regulate Liver Lipid Metabolism

(2012) Zhouji Chen et al.   PLoS One

Mouse lipin-1 and lipin-2 cooperate to maintain glycerolipid homeostasis in liver and aging cerebellum

(2012) J. R. Dwyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mice with an adipocyte-specific lipin 1 separation-of-function allele reveal unexpected roles for phosphatidic acid in metabolic regulation

(2012) M. S. Mitra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glycerolipid signals alter mTOR complex 2 (mTORC2) to diminish insulin signaling

(2012) C. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway

(2011) Timothy R. Peterson et al.   CELL

Endoplasmic Reticulum Stress Promotes LIPIN2-Dependent Hepatic Insulin Resistance

(2011) D. Ryu et al.   DIABETES

Regulation of hepatic lipin-1 by ethanol: Role of AMP-activated protein kinase/sterol regulatory element-binding protein 1 signaling in mice

(2011) Ming Hu et al.   HEPATOLOGY

Phosphatidic Acid Activates Mammalian Target of Rapamycin Complex 1 (mTORC1) Kinase by Displacing FK506 Binding Protein 38 (FKBP38) and Exerting an Allosteric Effect

(2011) Mee-Sup Yoon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multi-dimensional mass spectrometry-based shotgun lipidomics and novel strategies for lipidomic analyses

(2011) Xianlin Han et al.   MASS SPECTROMETRY REVIEWS

Liver regeneration is impaired in lipodystrophic fatty liver dystrophy mice

(2010) Vered Gazit et al.   HEPATOLOGY

Peroxisome Proliferator-activated Receptor-γ Coactivator-1α (PGC-1α) Stimulates VLDL Assembly through Activation of Cell Death-inducing DFFA-like Effector B (CideB)

(2010) Zhouji Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipin 1 Represses NFATc4 Transcriptional Activity in Adipocytes To Inhibit Secretion of Inflammatory Factors

(2010) H. B. Kim et al.   MOLECULAR AND CELLULAR BIOLOGY

TORC2 Regulates Hepatic Insulin Signaling via a Mammalian Phosphatidic Acid Phosphatase, LIPIN1

(2009) Dongryeol Ryu et al.   Cell Metabolism

A Conserved Serine Residue Is Required for the Phosphatidate Phosphatase Activity but Not the Transcriptional Coactivator Functions of Lipin-1 and Lipin-2

(2009) Jimmy Donkor et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sterol-mediated Regulation of Human Lipin 1 Gene Expression in Hepatoblastoma Cells

(2009) Kenji Ishimoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipin 2 Is a Liver-enriched Phosphatidate Phosphohydrolase Enzyme That Is Dynamically Regulated by Fasting and Obesity in Mice

(2009) Matthew C. Gropler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamic and differential regulation of proteins that coat lipid droplets infatty liver dystrophicmice

(2009) Angela M. Hall et al.   JOURNAL OF LIPID RESEARCH

Alterations in Hepatic Metabolism in fld Mice Reveal a Role for Lipin 1 in Regulating VLDL-Triacylglyceride Secretion

(2008) Zhouji Chen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Phosphatidic acid mediates demyelination in Lpin1 mutant mice

(2008) K. Nadra et al.   GENES & DEVELOPMENT

Temporal and Spatial Regulation of the Phosphatidate Phosphatases Lipin 1 and 2

(2008) Neil Grimsey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipin1 Is a Key Factor for the Maturation and Maintenance of Adipocytes in the Regulatory Network with CCAAT/Enhancer-binding Protein α and Peroxisome Proliferator-activated Receptor γ2

(2008) Yoo-Kyung Koh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glucocorticoids and cyclic AMP selectively increase hepatic lipin-1 expression, and insulin acts antagonistically

(2008) Boripont Manmontri et al.   JOURNAL OF LIPID RESEARCH