Involvement of sphingosine 1-phosphate in palmitate-induced insulin resistance of hepatocytes via the S1P2 receptor subtype

Oleate prevents saturated-fatty-acid-induced ER stress, inflammation and insulin resistance in skeletal muscle cells through an AMPK-dependent mechanism

(2013) L. Salvadó et al.   DIABETOLOGIA

Acid sphingomyelinase–ceramide system mediates effects of antidepressant drugs

(2013) Erich Gulbins et al.   NATURE MEDICINE

Plasma Sphingosine-1-Phosphate Is Elevated in Obesity

(2013) Greg M. Kowalski et al.   PLoS One

Fatty acid transporters involved in the palmitate and oleate induced insulin resistance in primary rat hepatocytes

(2012) A. Chabowski et al.   Acta Physiologica

Mechanisms for Insulin Resistance: Common Threads and Missing Links

(2012) Varman T. Samuel et al.   CELL

Hepatic mTORC2 Activates Glycolysis and Lipogenesis through Akt, Glucokinase, and SREBP1c

(2012) Asami Hagiwara et al.   Cell Metabolism

Diacylglycerol Activation of Protein Kinase Cε and Hepatic Insulin Resistance

(2012) François R. Jornayvaz et al.   Cell Metabolism

Sphingosine 1-Phosphate Modulates Antigen Capture by Murine Langerhans Cells via the S1P2 Receptor Subtype

(2012) Lukasz Japtok et al.   PLoS One

Activation of Pak1/Akt/eNOS signaling following sphingosine-1-phosphate release as part of a mechanism protecting cardiomyocytes against ischemic cell injury

(2011) Emmanuel Eroume A. Egom et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

FTY720 Normalizes Hyperglycemia by Stimulating β-Cellin VivoRegeneration indb/dbMice through Regulation of Cyclin D3 and p57KIP2

(2011) Zhengshan Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The sphingosine 1-phosphate receptor S1P2 maintains the homeostasis of germinal center B cells and promotes niche confinement

(2011) Jesse A Green et al.   NATURE IMMUNOLOGY

Blockade of sphingosine 1-phosphate receptor 2 signaling attenuates streptozotocin-induced apoptosis of pancreatic β-cells

(2010) Toshiyuki Imasawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhibition of De Novo Ceramide Synthesis Reverses Diet-Induced Insulin Resistance and Enhances Whole-Body Oxygen Consumption

(2010) J. R. Ussher et al.   DIABETES

Circulating sphingolipid biomarkers in models of type 1 diabetes

(2010) Todd E. Fox et al.   JOURNAL OF LIPID RESEARCH

Lipid-induced insulin resistance: unravelling the mechanism

(2010) Varman T Samuel et al.   LANCET

Aerobic Training in Rats Increases Skeletal Muscle Sphingomyelinase and Serine Palmitoyltransferase Activity, While Decreasing Ceramidase Activity

(2010) Agnieszka Błachnio-Zabielska et al.   LIPIDS

Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis

(2010) Volker Brinkmann et al.   NATURE REVIEWS DRUG DISCOVERY

Sphingosine 1-phosphate increases glucose uptake through trans-activation of insulin receptor

(2009) Elena Rapizzi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Aggravation by prostaglandin E2 of interleukin-6-dependent insulin resistance in hepatocytes

(2009) Janin Henkel et al.   HEPATOLOGY

Palmitate induces insulin resistance without significant intracellular triglyceride accumulation in HepG2 cells

(2009) Jin-young Lee et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Sphingosine 1-Phosphate Restrains Insulin-Mediated Keratinocyte Proliferation via Inhibition of Akt through the S1P2 Receptor Subtype

(2008) Melanie Schüppel et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY