Melatonin and sirtuins: A “not-so unexpected” relationship

The growing landscape of tubulin acetylation: lysine 40 and many more

(2016) K. Sadoul et al.   BIOCHEMICAL JOURNAL

Melatonin Stimulates the SIRT1/Nrf2 Signaling Pathway Counteracting Lipopolysaccharide (LPS)-Induced Oxidative Stress to Rescue Postnatal Rat Brain

(2016) Shahid Ali Shah et al.   CNS Neuroscience & Therapeutics

CLOCK and BMAL1 Regulate Muscle Insulin Sensitivity via SIRT1 in Male Mice

(2016) Jun Liu et al.   ENDOCRINOLOGY

Clock GeneBmal1Modulates Human Cartilage Gene Expression by Crosstalk With Sirt1

(2016) Wei Yang et al.   ENDOCRINOLOGY

SOD2 and Sirt3 Control Osteoclastogenesis by Regulating Mitochondrial ROS

(2016) Haemin Kim et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Potential benefits of melatonin in organ transplantation: a review

(2016) Eduardo Esteban-Zubero et al.   JOURNAL OF ENDOCRINOLOGY

Structural Basis for p53 Lys120-Acetylation-Dependent DNA-Binding Mode

(2016) Radion Vainer et al.   JOURNAL OF MOLECULAR BIOLOGY

Melatonin modulates neonatal brain inflammation through endoplasmic reticulum stress, autophagy, and miR-34a/silent information regulator 1 pathway

(2016) Silvia Carloni et al.   JOURNAL OF PINEAL RESEARCH

Melatonin enhances hyperthermia-induced apoptotic cell death in human leukemia cells

(2016) Carlos Quintana et al.   JOURNAL OF PINEAL RESEARCH

Same molecule but different expression: aging and sepsis trigger NLRP3 inflammasome activation, a target of melatonin

(2016) Huayqui Volt et al.   JOURNAL OF PINEAL RESEARCH

Melatonin as an antioxidant: under promises but over delivers

(2016) Russel J. Reiter et al.   JOURNAL OF PINEAL RESEARCH

Melatonin: the dawning of a treatment for fibrosis?

(2016) Wei Hu et al.   JOURNAL OF PINEAL RESEARCH

Melatonin promotes cardiomyogenesis of embryonic stem cells via inhibition of HIF-1α stabilization

(2016) Jana Kudová et al.   JOURNAL OF PINEAL RESEARCH

Evidence for possible role of melatonin in reducing oxidative stress in multiple sclerosis through its effect on SIRT1 and antioxidant enzymes

(2016) Solaleh Emamgholipour et al.   LIFE SCIENCES

Endoplasmic reticulum stress related molecular mechanisms in nonalcoholic steatohepatitis

(2016) Perinur Bozaykut et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Melatonin Attenuates Early Brain Injury via the Melatonin Receptor/Sirt1/NF-κB Signaling Pathway Following Subarachnoid Hemorrhage in Mice

(2016) Lei Zhao et al.   MOLECULAR NEUROBIOLOGY

Histone deacetylase 6 structure and molecular basis of catalysis and inhibition

(2016) Yang Hai et al.   Nature Chemical Biology

Melatonin administration reverses the alteration of amyloid precursor protein-cleaving secretases expression in aged mouse hippocampus

(2016) Sujira Mukda et al.   NEUROSCIENCE LETTERS

Evidence of melatonin synthesis in the ram reproductive tract

(2016) M. Gonzalez-Arto et al.   Andrology

Resveratrol compares with melatonin in improving in vitro porcine oocyte maturation under heat stress

(2016) Yu Li et al.   Journal of Animal Science and Biotechnology

Hepatic Macrosteatosis Is Partially Converted to Microsteatosis by Melatonin Supplementation in ob/ob Mice Non-Alcoholic Fatty Liver Disease

(2016) Alessandra Stacchiotti et al.   PLoS One

Melatonin prevents acute kidney injury in severely burned rats via the activation of SIRT1

(2016) Xiao-Zhi Bai et al.   Scientific Reports

SIRT3-SOD2-mROS-dependent autophagy in cadmium-induced hepatotoxicity and salvage by melatonin

(2015) Huifeng Pi et al.   Autophagy

Tubulin acetylation: responsible enzymes, biological functions and human diseases

(2015) Lin Li et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Protective Effects of Melatonin and Mitochondria-targeted Antioxidants Against Oxidative Stress: A Review

(2015) M. Ramis et al.   CURRENT MEDICINAL CHEMISTRY

The Metabolic Regulator Histone Deacetylase 9 Contributes to Glucose Homeostasis Abnormality Induced by Hepatitis C Virus Infection

(2015) Jizheng Chen et al.   DIABETES

(Ubi)quitin’ the h2bit: recent insights into the roles of H2B ubiquitylation in DNA replication and transcription

(2015) Duncan E Wright et al.   Epigenetics

Disruption of the NF-κB/NLRP3 connection by melatonin requires retinoid-related orphan receptor-α and blocks the septic response in mice

(2015) José A. García et al.   FASEB JOURNAL

Melatonin protects hepatocytes against bile acid-induced mitochondrial oxidative stress via the AMPK-SIRT3-SOD2 pathway

(2015) Y. Chen et al.   FREE RADICAL RESEARCH

Daily differential expression of melatonin-related genes and clock genes in rat cumulus-oocyte complex: changes after pinealectomy

(2015) L. A. Coelho et al.   JOURNAL OF PINEAL RESEARCH

Reduced silent information regulator 1 signaling exacerbates myocardial ischemia-reperfusion injury in type 2 diabetic rats and the protective effect of melatonin

(2015) Liming Yu et al.   JOURNAL OF PINEAL RESEARCH

Melatonin reverses H2O2-induced premature senescence in mesenchymal stem cells via the SIRT1-dependent pathway

(2015) Long Zhou et al.   JOURNAL OF PINEAL RESEARCH

Melatonin alleviates brain injury in mice subjected to cecal ligation and puncture via attenuating inflammation, apoptosis, and oxidative stress: the role of SIRT1 signaling

(2015) Lei Zhao et al.   JOURNAL OF PINEAL RESEARCH

Melatonin: an ancient molecule that makes oxygen metabolically tolerable

(2015) Lucien C. Manchester et al.   JOURNAL OF PINEAL RESEARCH

Melatonin facilitates adipose-derived mesenchymal stem cells to repair the murine infarcted heartviathe SIRT1 signaling pathway

(2015) Dong Han et al.   JOURNAL OF PINEAL RESEARCH

Functions of melatonin in plants: a review

(2015) Marino B. Arnao et al.   JOURNAL OF PINEAL RESEARCH

Protein acetylation in metabolism — metabolites and cofactors

(2015) Keir J. Menzies et al.   Nature Reviews Endocrinology

Histone exchange, chromatin structure and the regulation of transcription

(2015) Swaminathan Venkatesh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Sirtuin 3 regulates Foxo3a-mediated antioxidant pathway in microglia

(2015) P. Rangarajan et al.   NEUROSCIENCE

HDAC4 as a potential therapeutic target in neurodegenerative diseases: a summary of recent achievements

(2015) Michal Mielcarek et al.   Frontiers in Cellular Neuroscience

Melatonin and oestrogen treatments were able to improve neuroinflammation and apoptotic processes in dentate gyrus of old ovariectomized female rats

(2014) Roman A. Kireev et al.   AGE

The role of melatonin, sirtuin2 and FoXO1 transcription factor in the aging process of colon in male rats

(2014) Kazime Gonca Akbulut et al.   BIOGERONTOLOGY

Extrapineal melatonin: sources, regulation, and potential functions

(2014) Darío Acuña-Castroviejo et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Circadian clock: linking epigenetics to aging

(2014) Ricardo Orozco-Solis et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Melatonin in plants and other phototrophs: advances and gaps concerning the diversity of functions

(2014) R. Hardeland   JOURNAL OF EXPERIMENTAL BOTANY

Melatonin and its metabolites as copper chelating agents and their role in inhibiting oxidative stress: a physicochemical analysis

(2014) Annia Galano et al.   JOURNAL OF PINEAL RESEARCH

Melatonin down-regulates MDM2 gene expression and enhances p53 acetylation in MCF-7 cells

(2014) Sara Proietti et al.   JOURNAL OF PINEAL RESEARCH

Melatonin reduces endoplasmic reticulum stress and preserves sirtuin 1 expression in neuronal cells of newborn rats after hypoxia-ischemia

(2014) Silvia Carloni et al.   JOURNAL OF PINEAL RESEARCH

Melatonin: a well-documented antioxidant with conditional pro-oxidant actions

(2014) Hong-Mei Zhang et al.   JOURNAL OF PINEAL RESEARCH

The growing landscape of lysine acetylation links metabolism and cell signalling

(2014) Chunaram Choudhary et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Melatonin: Exceeding Expectations

(2014) Russel J. Reiter et al.   PHYSIOLOGY

Melatonin Improves Mitochondrial Function by Promoting MT1/SIRT1/PGC-1 Alpha-Dependent Mitochondrial Biogenesis in Cadmium-Induced Hepatotoxicity In Vitro

(2014) Pan Guo et al.   TOXICOLOGICAL SCIENCES

SIRT1 and other sirtuins in metabolism

(2014) Hung-Chun Chang et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

CCAR2 deficiency augments genotoxic stress-induced apoptosis in the presence of melatonin in non-small cell lung cancer cells

(2014) Wootae Kim et al.   TUMOR BIOLOGY

Growth hormone and melatonin prevent age-related alteration in apoptosis processes in the dentate gyrus of male rats

(2013) R. A. Kireev et al.   BIOGERONTOLOGY

SIRT4 Has Tumor-Suppressive Activity and Regulates the Cellular Metabolic Response to DNA Damage by Inhibiting Mitochondrial Glutamine Metabolism

(2013) Seung Min Jeong et al.   CANCER CELL

Protein post-translational modifications and regulation of pluripotency in human stem cells

(2013) Yu-Chieh Wang et al.   CELL RESEARCH

SIRT1 inhibition by melatonin exerts antitumor activity in human osteosarcoma cells

(2013) Yedong Cheng et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Molecular mechanisms of the pro-apoptotic actions of melatonin in cancer: a review

(2013) Mariano Bizzarri et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Calorie restriction and sirtuins revisited

(2013) L. Guarente   GENES & DEVELOPMENT

Selective class IIa histone deacetylase inhibition via a nonchelating zinc-binding group

(2013) Mercedes Lobera et al.   Nature Chemical Biology

Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways

(2013) M. J. Rardin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Melatonin can improve insulin resistance and aging-induced pancreas alterations in senescence-accelerated prone male mice (SAMP8)

(2012) Sara Cuesta et al.   AGE

Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

(2012) Patrick S. Ward et al.   CANCER CELL

Brown Remodeling of White Adipose Tissue by SirT1-Dependent Deacetylation of Pparγ

(2012) Li Qiang et al.   CELL

The Histone Deacetylase SIRT6 Is a Tumor Suppressor that Controls Cancer Metabolism

(2012) Carlos Sebastián et al.   CELL

High-Fat Diet Triggers Inflammation-Induced Cleavage of SIRT1 in Adipose Tissue To Promote Metabolic Dysfunction

(2012) Angeliki Chalkiadaki et al.   Cell Metabolism

Mitochondria and chloroplasts as the original sites of melatonin synthesis: a hypothesis related to melatonin's primary function and evolution in eukaryotes

(2012) Dun-Xian Tan et al.   JOURNAL OF PINEAL RESEARCH

On the free radical scavenging activities of melatonin's metabolites, AFMK and AMK

(2012) Annia Galano et al.   JOURNAL OF PINEAL RESEARCH

Sirtuin 1 and Sirtuin 3: Physiological Modulators of Metabolism

(2012) Ruben Nogueiras et al.   PHYSIOLOGICAL REVIEWS

SIRT1 enhances matrix metalloproteinase-2 expression and tumor cell invasion in prostate cancer cells

(2012) Jenna D. Lovaas et al.   PROSTATE

SIRT3 Opposes Reprogramming of Cancer Cell Metabolism through HIF1α Destabilization

(2011) Lydia W.S. Finley et al.   CANCER CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Regulation of mammalian DNA methyltransferases: a route to new mechanisms

(2011) Hélène Denis et al.   EMBO REPORTS

Resveratrol interacts with estrogen receptor-β to inhibit cell replicative growth and enhance stress resistance by upregulating mitochondrial superoxide dismutase

(2011) Ellen L. Robb et al.   FREE RADICAL BIOLOGY AND MEDICINE

Expression and cellular localizaion of melatonin-synthesizing enzymes in rat and human salivary glands

(2011) Masashi Shimozuma et al.   HISTOCHEMISTRY AND CELL BIOLOGY

The Epigenotype

(2011) C. H. Waddington   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Functional roles of melatonin in plants, and perspectives in nutritional and agricultural science

(2011) D.-X. Tan et al.   JOURNAL OF EXPERIMENTAL BOTANY

Extrapineal melatonin: analysis of its subcellular distribution and daily fluctuations

(2011) Carmen Venegas et al.   JOURNAL OF PINEAL RESEARCH

Neurons from senescence-accelerated SAMP8 mice are protected against frailty by the sirtuin 1 promoting agents melatonin and resveratrol

(2011) Rosa Cristòfol et al.   JOURNAL OF PINEAL RESEARCH

Cancer epigenetics reaches mainstream oncology

(2011) Manuel Rodríguez-Paredes et al.   NATURE MEDICINE

SirT3 suppresses hypoxia inducible factor 1α and tumor growth by inhibiting mitochondrial ROS production

(2011) E L Bell et al.   ONCOGENE

SIRT3 Is a Mitochondria-Localized Tumor Suppressor Required for Maintenance of Mitochondrial Integrity and Metabolism during Stress

(2010) Hyun-Seok Kim et al.   CANCER CELL

Role of p53 in the anti-proliferative effects of Sirt1 inhibition in prostate cancer cells

(2010) Brittney Jung-Hynes et al.   CELL CYCLE

MnSOD drives neuroendocrine differentiation, androgen independence, and cell survival in prostate cancer cells

(2010) Isabel Quiros-Gonzalez et al.   FREE RADICAL BIOLOGY AND MEDICINE

Metformin suppresses hepatic gluconeogenesis through induction of SIRT1 and GCN5

(2010) Paul W Caton et al.   JOURNAL OF ENDOCRINOLOGY

Sirt3-Mediated Deacetylation of Evolutionarily Conserved Lysine 122 Regulates MnSOD Activity in Response to Stress

(2010) Randa Tao et al.   MOLECULAR CELL

Sirtuin 1 Modulates Cellular Responses to Hypoxia by Deacetylating Hypoxia-Inducible Factor 1α

(2010) Ji-Hong Lim et al.   MOLECULAR CELL

Comprehensive methylome map of lineage commitment from haematopoietic progenitors

(2010) Hong Ji et al.   NATURE

SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation

(2010) Matthew D. Hirschey et al.   NATURE

Epigenetic modifications and human disease

(2010) Anna Portela et al.   NATURE BIOTECHNOLOGY

NAMPT overexpression in prostate cancer and its contribution to tumor cell survival and stress response

(2010) B Wang et al.   ONCOGENE

SIRT5 Deacetylates Carbamoyl Phosphate Synthetase 1 and Regulates the Urea Cycle

(2009) Takashi Nakagawa et al.   CELL

SIRT1 controls circadian clock circuitry and promotes cell survival: a connection with age-related neoplasms

(2009) Brittney Jung-Hynes et al.   FASEB JOURNAL

Molecular Mechanisms of Melatonin Anticancer Effects

(2009) Steven M. Hill et al.   INTEGRATIVE CANCER THERAPIES

Upregulation of manganese superoxide dismutase (SOD2) is a common pathway for neuroendocrine differentiation in prostate cancer cells

(2009) Isabel Quirós et al.   INTERNATIONAL JOURNAL OF CANCER

Sirtuins, melatonin and circadian rhythms: building a bridge between aging and cancer

(2009) Brittney Jung-Hynes et al.   JOURNAL OF PINEAL RESEARCH

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

(2009) Carles Cantó et al.   NATURE

Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts

(2009) Akiko Doi et al.   NATURE GENETICS

Developmental programming of CpG island methylation profiles in the human genome

(2009) Ravid Straussman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Circadian Clock Feedback Cycle Through NAMPT-Mediated NAD+ Biosynthesis

(2009) K. M. Ramsey et al.   SCIENCE

Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions

(2009) C. Choudhary et al.   SCIENCE

TiGER: a database for tissue-specific gene expression and regulation

(2008) Xiong Liu et al.   BMC BIOINFORMATICS

Role of melatonin in the epigenetic regulation of breast cancer

(2008) Ahmet Korkmaz et al.   BREAST CANCER RESEARCH AND TREATMENT

SIRT1 Regulates Circadian Clock Gene Expression through PER2 Deacetylation

(2008) Gad Asher et al.   CELL

Melatonin, hormone of darkness and more – occurrence, control mechanisms, actions and bioactive metabolites

(2008) R. Hardeland   CELLULAR AND MOLECULAR LIFE SCIENCES

Glucose Restriction Inhibits Skeletal Myoblast Differentiation by Activating SIRT1 through AMPK-Mediated Regulation of Nampt

(2008) Marcella Fulco et al.   DEVELOPMENTAL CELL

Evaluation of potential pro-survival pathways regulated by melatonin in a murine senescence model

(2008) Javier Gutierrez-Cuesta et al.   JOURNAL OF PINEAL RESEARCH

The histone deacetylase HDAC11 regulates the expression of interleukin 10 and immune tolerance

(2008) Alejandro Villagra et al.   NATURE IMMUNOLOGY

Therapeutic application of histone deacetylase inhibitors for central nervous system disorders

(2008) Aleksey G. Kazantsev et al.   NATURE REVIEWS DRUG DISCOVERY

The many roles of histone deacetylases in development and physiology: implications for disease and therapy

(2008) Michael Haberland et al.   NATURE REVIEWS GENETICS

Acetylation in the globular core of histone H3 on lysine-56 promotes chromatin disassembly during transcriptional activation

(2008) Stephanie K. Williams et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis

(2008) B.-H. Ahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nampt: linking NAD biology, metabolism and cancer

(2008) Antje Garten et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Molecular mechanisms involved in the hormonal prevention of aging in the rat

(2007) Jesús A.F. Tresguerres et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY