Sirtuins in gamete biology and reproductive physiology: emerging roles and therapeutic potential in female and male infertility

The Current State of NAD+ -Dependent Histone Deacetylases (Sirtuins) as Novel Therapeutic Targets

(2017) Matthias Schiedel et al.   MEDICINAL RESEARCH REVIEWS

The Natural Carotenoid Crocetin and the Synthetic Tellurium Compound AS101 Protect the Ovary against Cyclophosphamide by Modulating SIRT1 and Mitochondrial Markers

(2017) Giovanna Di Emidio et al.   Oxidative Medicine and Cellular Longevity

mTORC1/2 inhibition preserves ovarian function and fertility during genotoxic chemotherapy

(2017) Kara N. Goldman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vitro maturation affects chromosome segregation, spindle morphology and acetylation of lysine 16 on histone H4 in horse oocytes

(2017) Federica Franciosi et al.   REPRODUCTION FERTILITY AND DEVELOPMENT

Polydatin improves the developmental competence of bovine embryos in vitro via induction of sirtuin 1 (Sirt1)

(2017) Imran Khan et al.   REPRODUCTION FERTILITY AND DEVELOPMENT

KRAS Activation and over-expression of SIRT1/BCL6 Contributes to the Pathogenesis of Endometriosis and Progesterone Resistance

(2017) Jung-Yoon Yoo et al.   Scientific Reports

Overexpression of SIRT1 is Associated With Poor Outcomes in Patients With Ovarian Carcinoma

(2017) David H. Mvunta et al.   APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY

Role of Antioxidants in Assisted Reproductive Techniques

(2017) Ashok Agarwal et al.   World Journal of Mens Health

The role of sirtuins in aging and age-related diseases

(2016) Mateusz Wątroba et al.   Advances in Medical Sciences

SIRT1, 2, 3 protect mouse oocytes from postovulatory aging

(2016) Teng Zhang et al.   Aging-US

Resveratrol inhibits inflammatory signaling implicated in ionizing radiation-induced premature ovarian failure through antagonistic crosstalk between silencing information regulator 1 (SIRT1) and poly(ADP-ribose) polymerase 1 (PARP-1)

(2016) Riham Soliman Said et al.   BIOCHEMICAL PHARMACOLOGY

Spatial Characterization of Bioenergetics and Metabolism of Primordial to Preovulatory Follicles in Whole Ex Vivo Murine Ovary

(2016) R. Cinco et al.   BIOLOGY OF REPRODUCTION

VISFATIN (NAMPT) Improves in Vitro IGF1-Induced Steroidogenesis and IGF1 Receptor Signaling Through SIRT1 in Bovine Granulosa Cells1

(2016) Maxime Reverchon et al.   BIOLOGY OF REPRODUCTION

Sirtuins: Novel Players in Male Reproductive Health

(2016) Luís Rato et al.   CURRENT MEDICINAL CHEMISTRY

Sirt1 regulates acrosome biogenesis by modulating autophagic flux during spermiogenesis in mice

(2016) Chao Liu et al.   DEVELOPMENT

Prevention of chemotherapy-induced ovarian damage

(2016) Hadassa Roness et al.   FERTILITY AND STERILITY

The role of mitochondrial sirtuins in health and disease

(2016) Brenna Osborne et al.   FREE RADICAL BIOLOGY AND MEDICINE

Are sirtuins markers of ovarian aging?

(2016) Jinjin Zhang et al.   GENE

Role ofSirt3in mitochondrial biogenesis and developmental competence of humanin vitromatured oocytes

(2016) Hong-Cui Zhao et al.   HUMAN REPRODUCTION

The management of anovulatory infertility in women with polycystic ovary syndrome: an analysis of the evidence to support the development of global WHO guidance

(2016) Adam H. Balen et al.   HUMAN REPRODUCTION UPDATE

SIRT1 exerts protective effects against paraquat-induced injury in mouse type II alveolar epithelial cells by deacetylating NRF2 in vitro

(2016) YING-WEI DING et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Effects of Resveratrol on Polycystic Ovary Syndrome: A Double-blind, Randomized, Placebo-controlled Trial

(2016) Beata Banaszewska et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Sirt1 decreased adipose inflammation by interacting with Akt2 and inhibiting mTOR/S6K1 pathway in mice

(2016) Zhenjiang Liu et al.   JOURNAL OF LIPID RESEARCH

1,4-Dihydropyridines Active on the SIRT1/AMPK Pathway Ameliorate Skin Repair and Mitochondrial Function and Exhibit Inhibition of Proliferation in Cancer Cells

(2016) Sergio Valente et al.   JOURNAL OF MEDICINAL CHEMISTRY

The role of sirtuins in cellular homeostasis

(2016) Wioleta Kupis et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Potential Modulation of Sirtuins by Oxidative Stress

(2016) Leonardo Santos et al.   Oxidative Medicine and Cellular Longevity

SIRTUIN 1 ACTIVATOR SRT1720 PROTECTS AGAINST ORGAN INJURY INDUCED BY INTESTINAL ISCHEMIA-REPERFUSION

(2016) Laura W. Hansen et al.   SHOCK

Cysteine cathepsins control hepatic NF-κB-dependent inflammation via sirtuin-1 regulation

(2016) Álvaro de Mingo et al.   Cell Death & Disease

Resveratrol compares with melatonin in improving in vitro porcine oocyte maturation under heat stress

(2016) Yu Li et al.   Journal of Animal Science and Biotechnology

Sirtuins Link Inflammation and Metabolism

(2016) Vidula T. Vachharajani et al.   Journal of Immunology Research

Ovarian actions of resveratrol

(2015) Israel Ortega et al.   Annals of the New York Academy of Sciences

Sirt3 prevents maternal obesity-associated oxidative stress and meiotic defects in mouse oocytes

(2015) Liang Zhang et al.   CELL CYCLE

Mitochondrial sirtuins: Emerging roles in metabolic regulations, energy homeostasis and diseases

(2015) Priyanka Parihar et al.   EXPERIMENTAL GERONTOLOGY

Cellular and molecular regulation of the activation of mammalian primordial follicles: somatic cells initiate follicle activation in adulthood

(2015) Hua Zhang et al.   HUMAN REPRODUCTION UPDATE

Rictor/mTORC2 Pathway in Oocytes Regulates Folliculogenesis, and Its Inactivation Causes Premature Ovarian Failure

(2015) Zhenguo Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sirtuin Inhibition Induces Apoptosis-like Changes in Platelets and Thrombocytopenia

(2015) Sharda Kumari et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Silent information regulator 1 modulator resveratrol increases brain lactate production and inhibits mitochondrial metabolism, whereas SRT1720 increases oxidative metabolism

(2015) Benjamin D. Rowlands et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Metabolic Regulation by Lysine Malonylation, Succinylation, and Glutarylation

(2015) Matthew D. Hirschey et al.   MOLECULAR & CELLULAR PROTEOMICS

SIRT3 Blocks Aging-Associated Tissue Fibrosis in Mice by Deacetylating and Activating Glycogen Synthase Kinase 3β

(2015) Nagalingam R. Sundaresan et al.   MOLECULAR AND CELLULAR BIOLOGY

Sirt1-Deficient Mice Have Hypogonadotropic Hypogonadism due to Defective GnRH Neuronal Migration

(2015) Gabriele Di Sante et al.   MOLECULAR ENDOCRINOLOGY

Chromatin remodelling and histonemRNA accumulation in bovine germinal vesicle oocytes

(2015) R. Labrecque et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

Sirtuin Functions in Female Fertility: Possible Role in Oxidative Stress and Aging

(2015) Carla Tatone et al.   Oxidative Medicine and Cellular Longevity

Nicotinamide Impairs Entry into and Exit from Meiosis I in Mouse Oocytes

(2015) Angelique Riepsamen et al.   PLoS One

Sirtuin Inhibition Adversely Affects Porcine Oocyte Meiosis

(2015) Liang Zhang et al.   PLoS One

Effects of Resveratrol on Ovarian Morphology, Plasma Anti-Mullerian Hormone, IGF-1 Levels, and Oxidative Stress Parameters in a Rat Model of Polycystic Ovary Syndrome

(2015) Mete Ergenoglu et al.   Reproductive Sciences

Resveratrol improves the quality of pig oocytes derived from early antral follicles through sirtuin 1 activation

(2015) N. Itami et al.   THERIOGENOLOGY

Assessing sirtuin expression in endometrial carcinoma and non-neoplastic endometrium

(2015) Carla Bartosch et al.   Oncotarget

Sirt6 depletion causes spindle defects and chromosome misalignment during meiosis of mouse oocyte

(2015) Longsen Han et al.   Scientific Reports

SIRT1 Is a Regulator in High Glucose-Induced Inflammatory Response in RAW264.7 Cells

(2015) Yanhui Jia et al.   PLoS One

Roles of SIRT1 in granulosa cell apoptosis during the process of follicular atresia in porcine ovary

(2014) Fang Zhao et al.   ANIMAL REPRODUCTION SCIENCE

Nucleosome signalling; An evolving concept

(2014) Bryan M. Turner   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Sirtuin 4 Is a Lipoamidase Regulating Pyruvate Dehydrogenase Complex Activity

(2014) Rommel A. Mathias et al.   CELL

Interrelationships between sirtuin 1 and transcription factors p53 and NF-κB (p50/p65) in the control of ovarian cell apoptosis and proliferation

(2014) Alexander V. Sirotkin et al.   CELL AND TISSUE RESEARCH

A SIRT7-Dependent Acetylation Switch of GABPβ1 Controls Mitochondrial Function

(2014) Dongryeol Ryu et al.   Cell Metabolism

SIRT7 Controls Hepatic Lipid Metabolism by Regulating the Ubiquitin-Proteasome Pathway

(2014) Tatsuya Yoshizawa et al.   Cell Metabolism

SirT1 is required in the male germ cell for differentiation and fecundity in mice

(2014) E. L. Bell et al.   DEVELOPMENT

SIRT3 Positively Regulates the Expression of Folliculogenesis- and Luteinization-Related Genes and Progesterone Secretion by Manipulating Oxidative Stress in Human Luteinized Granulosa Cells

(2014) Houju Fu et al.   ENDOCRINOLOGY

Mitochondrial SIRT3 and its target glutamate dehydrogenase are altered in follicular cells of women with reduced ovarian reserve or advanced maternal age

(2014) L. Pacella-Ince et al.   HUMAN REPRODUCTION

SIRT1 signalling protects mouse oocytes against oxidative stress and is deregulated during aging

(2014) Giovanna Di Emidio et al.   HUMAN REPRODUCTION

The Warburg Effect Revisited-Lesson from the Sertoli Cell

(2014) Pedro F. Oliveira et al.   MEDICINAL RESEARCH REVIEWS

Minireview: Metabolism of Female Reproduction: Regulatory Mechanisms and Clinical Implications

(2014) Emre Seli et al.   MOLECULAR ENDOCRINOLOGY

Relationship between mitochondrial DNA Copy Number and SIRT1 Expression in Porcine Oocytes

(2014) Daichi Sato et al.   PLoS One

Caloric Restriction Promotes the Reserve of Follicle Pool in Adult Female Rats by Inhibiting the Activation of Mammalian Target of Rapamycin Signaling

(2014) Li Li et al.   Reproductive Sciences

Chromatin and beyond: the multitasking roles for SIRT6

(2014) Sita Kugel et al.   TRENDS IN BIOCHEMICAL SCIENCES

SIRT1 and other sirtuins in metabolism

(2014) Hung-Chun Chang et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Writers and Readers of Histone Acetylation: Structure, Mechanism, and Inhibition

(2014) R. Marmorstein et al.   Cold Spring Harbor Perspectives in Biology

Erasers of Histone Acetylation: The Histone Deacetylase Enzymes

(2014) E. Seto et al.   Cold Spring Harbor Perspectives in Biology

SIRT1 activator (SRT1720) improves the follicle reserve and prolongs the ovarian lifespan of diet-induced obesity in female mice via activating SIRT1 and suppressing mTOR signaling

(2014) Xiao-Ling Zhou et al.   Journal of Ovarian Research

The SIRT1 Activator SRT1720 Extends Lifespan and Improves Health of Mice Fed a Standard Diet

(2014) Sarah J. Mitchell et al.   Cell Reports

Molecular Links between Caloric Restriction and Sir2/SIRT1 Activation

(2014) Yu Wang   Diabetes & Metabolism Journal

The involvement of SIRT1 and transcription factor NF-κB (p50/p65) in regulation of porcine ovarian cell function

(2013) Silvia Pavlová et al.   ANIMAL REPRODUCTION SCIENCE

Sirt2 suppresses glioma cell growth through targeting NF-κB–miR-21 axis

(2013) Ya’nan Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

SIRT5 desuccinylates and activates SOD1 to eliminate ROS

(2013) Zhi-Feng Lin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Pre-diabetes alters testicular PGC1-α/SIRT3 axis modulating mitochondrial bioenergetics and oxidative stress

(2013) Luís Rato et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

SIRT4 Has Tumor-Suppressive Activity and Regulates the Cellular Metabolic Response to DNA Damage by Inhibiting Mitochondrial Glutamine Metabolism

(2013) Seung Min Jeong et al.   CANCER CELL

Sirt2 functions in spindle organization and chromosome alignment in mouse oocyte meiosis

(2013) Liang Zhang et al.   FASEB JOURNAL

Beneficial effect of resveratrol on bovine oocyte maturation and subsequent embryonic development after in vitro fertilization

(2013) Feng Wang et al.   FERTILITY AND STERILITY

SIRT3 deacetylates FOXO3 to protect mitochondria against oxidative damage

(2013) Anne H.H. Tseng et al.   FREE RADICAL BIOLOGY AND MEDICINE

Rapamycin preserves the follicle pool reserve and prolongs the ovarian lifespan of female rats via modulating mTOR activation and sirtuin expression

(2013) Xing-mei Zhang et al.   GENE

SIRT3: As Simple As It Seems?

(2013) David B. Lombard et al.   GERONTOLOGY

Resveratrol protects against age-associated infertility in mice

(2013) Mengyuan Liu et al.   HUMAN REPRODUCTION

Oocyte ageing and its cellular basis

(2013) Ursula Eichenlaub-Ritter   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Resveratrol suppresses inflammatory responses in endometrial stromal cells derived from endometriosis: A possible role of the sirtuin 1 pathway

(2013) Ayumi Taguchi et al.   JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH

Resveratrol Improves the Mitochondrial Function and Fertilization Outcome of Bovine Oocytes

(2013) Shun TAKEO et al.   JOURNAL OF REPRODUCTION AND DEVELOPMENT

Spontaneous Electrical Activity of Cultured Interstitial Cells of Cajal from Mouse Urinary Bladder

(2013) Sun-Ouck Kim et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Obesity accelerates ovarian follicle development and follicle loss in rats

(2013) Na Wang et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Sirtuin 7 Plays a Role in Ribosome Biogenesis and Protein Synthesis

(2013) Yuan-Chin Tsai et al.   MOLECULAR & CELLULAR PROTEOMICS

Visfatin is expressed in human granulosa cells: regulation by metformin through AMPK/SIRT1 pathways and its role in steroidogenesis

(2013) M. Reverchon et al.   MOLECULAR HUMAN REPRODUCTION

Age-associated changes in gene expression and developmental competence of bovine oocytes, and a possible countermeasure against age-associated events

(2013) S. Takeo et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

Regulation of nucleosome dynamics by histone modifications

(2013) Gabriel E Zentner et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Pharmacological Inhibition of mTORC1 Prevents Over-Activation of the Primordial Follicle Pool in Response to Elevated PI3K Signaling

(2013) Deepak Adhikari et al.   PLoS One

Regulation of FOXOs and p53 by SIRT1 Modulators under Oxidative Stress

(2013) Yusuke S. Hori et al.   PLoS One

Oxidative stress and ageing of the post-ovulatory oocyte

(2013) Tessa Lord et al.   REPRODUCTION

Mitochondrial SIRT5 is present in follicular cells and is altered by reduced ovarian reserve and advanced maternal age

(2013) Leanne Pacella-Ince et al.   REPRODUCTION FERTILITY AND DEVELOPMENT

The ways and means that fine tune Sirt1 activity

(2013) Javier R. Revollo et al.   TRENDS IN BIOCHEMICAL SCIENCES

An acetylome peptide microarray reveals specificities and deacetylation substrates for all human sirtuin isoforms

(2013) David Rauh et al.   Nature Communications

Metabolic Characterization of a Sirt5 deficient mouse model

(2013) Jiujiu Yu et al.   Scientific Reports

Histone Deacetylase 2 (HDAC2) Regulates Chromosome Segregation and Kinetochore Function via H4K16 Deacetylation during Oocyte Maturation in Mouse

(2013) Pengpeng Ma et al.   PLoS Genetics

High-energy diets may induce a pre-diabetic state altering testicular glycolytic metabolic profile and male reproductive parameters

(2013) L. Rato et al.   Andrology

SIRT1 and energy metabolism

(2012) X. Li   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Regulation of the Intrinsic Apoptosis Pathway by Reactive Oxygen Species

(2012) Chu-Chiao Wu et al.   ANTIOXIDANTS & REDOX SIGNALING

Regulation of SIRT1 determines initial step of endometrial receptivity by controlling E-cadherin expression

(2012) Akira Shirane et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

SIRT5 deacetylates and activates urate oxidase in liver mitochondria of mice

(2012) Yasuhiko Nakamura et al.   FEBS LETTERS

From Sirtuin Biology to Human Diseases: An Update

(2012) Carlos Sebastián et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT3 Functions in the Nucleus in the Control of Stress-Related Gene Expression

(2012) T. Iwahara et al.   MOLECULAR AND CELLULAR BIOLOGY

SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation

(2012) Matthew F. Barber et al.   NATURE

The sirtuin SIRT6 regulates lifespan in male mice

(2012) Yariv Kanfi et al.   NATURE

Sirtuins as regulators of metabolism and healthspan

(2012) Riekelt H. Houtkooper et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

SIRT1 induces EMT by cooperating with EMT transcription factors and enhances prostate cancer cell migration and metastasis

(2012) V Byles et al.   ONCOGENE

Exendin-4 Improves Steatohepatitis by Increasing Sirt1 Expression in High-Fat Diet-Induced Obese C57BL/6J Mice

(2012) Jinmi Lee et al.   PLoS One

Resveratrol promotes expression of SIRT1 and StAR in rat ovarian granulosa cells: an implicative role of SIRT1 in the ovary

(2012) Yoshihiro Morita et al.   Reproductive Biology and Endocrinology

Sirtuin 1 activator SRT1720 suppresses inflammation in an ovalbumin-induced mouse model of asthma

(2012) TOMOMI ICHIKAWA et al.   RESPIROLOGY

Expression patterns of sirtuin genes in porcine preimplantation embryos and effects of sirtuin inhibitors on in vitro embryonic development after parthenogenetic activation and in vitro fertilization

(2012) Seong-Sung Kwak et al.   THERIOGENOLOGY

Metabolic regulation by SIRT3: implications for tumorigenesis

(2012) Lydia W.S. Finley et al.   TRENDS IN MOLECULAR MEDICINE

Mitochondrial Metabolism, Sirtuins, and Aging

(2012) M. N. Sack et al.   Cold Spring Harbor Perspectives in Biology

Deacetylation of H4-K16Ac and heterochromatin assembly in senescence

(2012) Kévin Contrepois et al.   Epigenetics & Chromatin

Epigenetic histone acetylation and deacetylation mechanisms in experimental models of neurodegenerative disorders

(2012) Zacharoula Konsoula et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

SIRT2 as a Therapeutic Target for Age-Related Disorders

(2012) Rita Machado de Oliveira et al.   Frontiers in Pharmacology

MicroRNA Regulation of SIRT1

(2012) Munekazu Yamakuchi   Frontiers in Physiology

Gap Junction-Mediated Communications Regulate Chromatin Remodeling During Bovine Oocyte Growth and Differentiation Through cAMP-Dependent Mechanism(s)1

(2011) Alberto M. Luciano et al.   BIOLOGY OF REPRODUCTION

Regulation of chromatin by histone modifications

(2011) Andrew J Bannister et al.   CELL RESEARCH

Structure, mechanism, and inhibition of histone deacetylases and related metalloenzymes

(2011) Patrick M Lombardi et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

SirT1 catalytic activity is required for male fertility and metabolic homeostasis in mice

(2011) Erin L. Seifert et al.   FASEB JOURNAL

Effect of vaginal probiotic lactobacilli on in vitro–induced sperm lipid peroxidation and its impact on sperm motility and viability

(2011) Arcangelo Barbonetti et al.   FERTILITY AND STERILITY

Calorie restriction increases primordial follicle reserve in mature female chemotherapy-treated rats

(2011) Yanfang Xiang et al.   GENE

Genome-wide analysis of translation reveals a critical role for deleted in azoospermia-like (Dazl) at the oocyte-to-zygote transition

(2011) J. Chen et al.   GENES & DEVELOPMENT

A Role for Histone H4K16 Hypoacetylation inSaccharomyces cerevisiaeKinetochore Function

(2011) John S. Choy et al.   GENETICS

Transcription factor FOXL2 protects granulosa cells from stress and delays cell cycle: role of its regulation by the SIRT1 deacetylase

(2011) Bérénice A. Benayoun et al.   HUMAN MOLECULAR GENETICS

Inhibition of cortactin and SIRT1 expression attenuates migration and invasion of prostate cancer DU145 cells

(2011) Keita Nakane et al.   INTERNATIONAL JOURNAL OF UROLOGY

A SIRT1-LSD1 Corepressor Complex Regulates Notch Target Gene Expression and Development

(2011) Peter Mulligan et al.   MOLECULAR CELL

Acetylation Regulates Gluconeogenesis by Promoting PEPCK1 Degradation via Recruiting the UBR5 Ubiquitin Ligase

(2011) Wenqing Jiang et al.   MOLECULAR CELL

Changes in histone H4 acetylation during in vivo versus in vitro maturation of equine oocytes

(2011) Federica Franciosi et al.   MOLECULAR HUMAN REPRODUCTION

Prevention of maternal aging-associated oocyte aneuploidy and meiotic spindle defects in mice by dietary and genetic strategies

(2011) K. Selesniemi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SIRT6 in mouse spermatogenesis is modulated by diet-induced obesity

(2011) Nicole O. Palmer et al.   REPRODUCTION FERTILITY AND DEVELOPMENT

SIRT6 Promotes DNA Repair Under Stress by Activating PARP1

(2011) Z. Mao et al.   SCIENCE

Sirt5 Is a NAD-Dependent Protein Lysine Demalonylase and Desuccinylase

(2011) J. Du et al.   SCIENCE

SIRT3 Is a Mitochondria-Localized Tumor Suppressor Required for Maintenance of Mitochondrial Integrity and Metabolism during Stress

(2010) Hyun-Seok Kim et al.   CANCER CELL

SIRT3 Deacetylates Mitochondrial 3-Hydroxy-3-Methylglutaryl CoA Synthase 2 and Regulates Ketone Body Production

(2010) Tadahiro Shimazu et al.   Cell Metabolism

Induction ofSirt1by Mechanical Stretch of Skeletal Muscle through the Early Response Factor EGR1 Triggers an Antioxidative Response

(2010) Patricia S. Pardo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT2 regulates NF- B-dependent gene expression through deacetylation of p65 Lys310

(2010) K. M. Rothgiesser et al.   JOURNAL OF CELL SCIENCE

Sirt3 protects in vitro–fertilized mouse preimplantation embryos against oxidative stress–induced p53-mediated developmental arrest

(2010) Yumiko Kawamura et al.   JOURNAL OF CLINICAL INVESTIGATION

Metformin suppresses hepatic gluconeogenesis through induction of SIRT1 and GCN5

(2010) Paul W Caton et al.   JOURNAL OF ENDOCRINOLOGY

Sirt3-Mediated Deacetylation of Evolutionarily Conserved Lysine 122 Regulates MnSOD Activity in Response to Stress

(2010) Randa Tao et al.   MOLECULAR CELL

Sirtuin 3, a New Target of PGC-1α, Plays an Important Role in the Suppression of ROS and Mitochondrial Biogenesis

(2010) Xingxing Kong et al.   PLoS One

Aging changes the chromatin configuration and histone methylation of mouse oocytes at germinal vesicle stage

(2010) I. Manosalva et al.   THERIOGENOLOGY

Treatment with SRT1720, a SIRT1 activator, ameliorates fatty liver with reduced expression of lipogenic enzymes in MSG mice

(2009) Yu Yamazaki et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

SUMOylation and cell signalling

(2009) Artemisia M. Andreou et al.   Biotechnology Journal

Sumoylation precedes accumulation of phosphorylated H2AX on sex chromosomes during their meiotic inactivation

(2009) Margarita Vigodner   CHROMOSOME RESEARCH

Molecular Mechanisms Underlying the Activation of Mammalian Primordial Follicles

(2009) Deepak Adhikari et al.   ENDOCRINE REVIEWS

Involvement of SIRT7 in resumption of rDNA transcription at the exit from mitosis

(2009) A. Grob et al.   JOURNAL OF CELL SCIENCE

MicroRNA 132 Regulates Nutritional Stress-Induced Chemokine Production through Repression of SirT1

(2009) Jay C. Strum et al.   MOLECULAR ENDOCRINOLOGY

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

(2009) Carles Cantó et al.   NATURE

Hypothalamic Sirt1 Regulates Food Intake in a Rodent Model System

(2009) Işin Çakir et al.   PLoS One

Identification and characterization of proteins interacting with SIRT1 and SIRT3: implications in the anti-aging and metabolic effects of sirtuins

(2009) Ivy K. M. Law et al.   PROTEOMICS

Sirt1 protects against oxidative stress-induced renal tubular cell apoptosis by the bidirectional regulation of catalase expression

(2008) Kazuhiro Hasegawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Sirt2 interacts with 14-3-3 β/γ and down-regulates the activity of p53

(2008) Yun-Hye Jin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Concurrent regulation of AMP-activated protein kinase and SIRT1 in mammalian cells

(2008) Gabriela Suchankova et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Histone Deacetylase SIRT1 Controls Male Fertility in Mice Through Regulation of Hypothalamic-Pituitary Gonadotropin Signaling1

(2008) Ullas Kolthur-Seetharam et al.   BIOLOGY OF REPRODUCTION

Discovery, In Vivo Activity, and Mechanism of Action of a Small-Molecule p53 Activator

(2008) Sonia Lain et al.   CANCER CELL

SirT1 Gain of Function Increases Energy Efficiency and Prevents Diabetes in Mice

(2008) Alexander S. Banks et al.   Cell Metabolism

In human pachytene spermatocytes, SUMO protein is restricted to the constitutive heterochromatin

(2008) Catherine Metzler-Guillemain et al.   CHROMOSOME RESEARCH

Histone deacetylase 1 (HDAC1) regulates histone acetylation, development, and gene expression in preimplantation mouse embryos

(2008) Pengpeng Ma et al.   DEVELOPMENTAL BIOLOGY

Oocyte senescence: A firm link to age-related female subfertility

(2008) Carla Tatone   GYNECOLOGICAL ENDOCRINOLOGY

Positive and negative feedback regulates the transcription factor FOXL2 in response to cell stress: evidence for a regulatory imbalance induced by disease-causing mutations

(2008) Bérénice A. Benayoun et al.   HUMAN MOLECULAR GENETICS

Small ubiquitin-related modifier (SUMO)-1, SUMO-2/3 and SUMOylation are involved with centromeric heterochromatin of chromosomes 9 and 1 and proteins of the synaptonemal complex during meiosis in men

(2008) Petrice W. Brown et al.   HUMAN REPRODUCTION

Cellular and molecular aspects of ovarian follicle ageing

(2008) Carla Tatone et al.   HUMAN REPRODUCTION UPDATE

Oxidative stress and male infertility—a clinical perspective

(2008) Kelton Tremellen   HUMAN REPRODUCTION UPDATE

Substrates and Regulation Mechanisms for the Human Mitochondrial Sirtuins Sirt3 and Sirt5

(2008) Christine Schlicker et al.   JOURNAL OF MOLECULAR BIOLOGY

SIRT3 Is a Stress-Responsive Deacetylase in Cardiomyocytes That Protects Cells from Stress-Mediated Cell Death by Deacetylation of Ku70

(2008) N. R. Sundaresan et al.   MOLECULAR AND CELLULAR BIOLOGY

SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin

(2008) Eriko Michishita et al.   NATURE

Deacetylation of cortactin by SIRT1 promotes cell migration

(2008) Y Zhang et al.   ONCOGENE

SirT1 Regulates Energy Metabolism and Response to Caloric Restriction in Mice

(2008) Gino Boily et al.   PLoS One

Sirt1 Deficiency Attenuates Spermatogenesis and Germ Cell Function

(2008) Matthew Coussens et al.   PLoS One

Caloric Restriction and Aging: Studies in Mice and Monkeys

(2008) Rozalyn M. Anderson et al.   TOXICOLOGIC PATHOLOGY

Oocyte morphology and transcriptional silencing in relation to chromatin remodeling during the final phases of bovine oocyte growth

(2007) Valentina Lodde et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT