Melatonin and its derivatives counteract the ultraviolet B radiation-induced damage in human and porcine skin ex vivo

Melatonin: A Cutaneous Perspective on its Production, Metabolism, and Functions

(2018) Andrzej T. Slominski et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Metabolism of melatonin in the skin: Why is it important?

(2017) Andrzej T. Slominski et al.   EXPERIMENTAL DERMATOLOGY

Nrf2 in keratinocytes modulates UVB-induced DNA damage and apoptosis in melanocytes through MAPK signaling

(2017) Saowanee Jeayeng et al.   FREE RADICAL BIOLOGY AND MEDICINE

Melatonin and its metabolites protect human melanocytes against UVB-induced damage: Involvement of NRF2-mediated pathways

(2017) Zorica Janjetovic et al.   Scientific Reports

Dose dependent sun protective effect of topical melatonin: A randomized, placebo-controlled, double-blind study

(2016) Cecilie Scheuer et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Effect of topical application of melatonin cream 12.5% on cognitive parameters: A randomized, placebo-controlled, double-blind crossover study in healthy volunteers

(2016) Cecilie Scheuer et al.   JOURNAL OF DERMATOLOGICAL TREATMENT

Melatonin enhances mitochondrial ATP synthesis, reduces reactive oxygen species formation, and mediates translocation of the nuclear erythroid 2-related factor 2 resulting in activation of phase-2 antioxidant enzymes (γ-GCS, HO-1, NQO1) in ultraviolet rad

(2016) Konrad Kleszczyński et al.   JOURNAL OF PINEAL RESEARCH

Melatonin and the pathologies of weakened or dysregulated circadian oscillators

(2016) Rüdiger Hardeland   JOURNAL OF PINEAL RESEARCH

Melatonin as an antioxidant: under promises but over delivers

(2016) Russel J. Reiter et al.   JOURNAL OF PINEAL RESEARCH

Inflammaging, Metabolic Syndrome and Melatonin: A Call for Treatment Studies

(2016) Daniel P. Cardinali et al.   NEUROENDOCRINOLOGY

N1-Acetyl-5-Methoxykynuramine (AMK) Is Produced in the Human Epidermis and Shows Antiproliferative Effects

(2015) Tae-Kang Kim et al.   ENDOCRINOLOGY

UVB Activates Hypothalamic–Pituitary–Adrenal Axis in C57BL/6 Mice

(2015) Cezary Skobowiat et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Novel non-calcemic secosteroids that are produced by human epidermal keratinocytes protect against solar radiation

(2015) Andrzej T. Slominski et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Melatonin and its metabolites accumulate in the human epidermis in vivo and inhibit proliferation and tyrosinase activity in epidermal melanocytes in vitro

(2015) Tae-Kang Kim et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The immunology of the porcine skin and its value as a model for human skin

(2015) Artur Summerfield et al.   MOLECULAR IMMUNOLOGY

Melatonin as a Potent and Inducible Endogenous Antioxidant: Synthesis and Metabolism

(2015) Dun-Xian Tan et al.   MOLECULES

Extrapineal melatonin: sources, regulation, and potential functions

(2014) Darío Acuña-Castroviejo et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

RORα and ROR γ are expressed in human skin and serve as receptors for endogenously produced noncalcemic 20-hydroxy- and 20,23-dihydroxyvitamin D

(2014) Andrzej T. Slominski et al.   FASEB JOURNAL

Local Melatoninergic System as the Protector of Skin Integrity

(2014) Andrzej Slominski et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Melatonin and its metabolites ameliorate ultraviolet B-induced damage in human epidermal keratinocytes

(2014) Zorica Janjetovic et al.   JOURNAL OF PINEAL RESEARCH

Critical role for p53-serine 15 phosphorylation in stimulating transactivation at p53-responsive promoters

(2014) Jayne Loughery et al.   NUCLEIC ACIDS RESEARCH

Oxidatively Generated Damage to Cellular DNA by UVB and UVA Radiation,

(2014) Jean Cadet et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Ultraviolet radiation regulates cortisol activity in a waveband-dependent manner in human skinex vivo

(2013) C. Skobowiat et al.   BRITISH JOURNAL OF DERMATOLOGY

Attenuation of ultraviolet A-induced alterations in NIH3T3 dermal fibroblasts by melatonin

(2013) R. Rezzani et al.   BRITISH JOURNAL OF DERMATOLOGY

Blockage of melatonin receptors impairs p53-mediated prevention of DNA damage accumulation

(2013) Raffaela Santoro et al.   CARCINOGENESIS

Metabolism of melatonin and biological activity of intermediates of melatoninergic pathway in human skin cells

(2013) Tae-Kang Kim et al.   FASEB JOURNAL

Melatonin prevents ultraviolet radiation-induced alterations in plasma membrane potential and intracellular pH in human keratinocytes

(2012) Konrad Kleszczyński et al.   JOURNAL OF PINEAL RESEARCH

Melatonin enhances antioxidative enzyme gene expression (CAT, GPx, SOD), prevents their UVR-induced depletion, and protects against the formation of DNA damage (8-hydroxy-2'-deoxyguanosine) in ex vivo human skin

(2012) Tobias W. Fischer et al.   JOURNAL OF PINEAL RESEARCH

Cutaneous hypothalamic-pituitary-adrenal axis homolog: regulation by ultraviolet radiation

(2011) Cezary Skobowiat et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Melatonin triggers p53Ser phosphorylation and prevents DNA damage accumulation

(2011) R Santoro et al.   ONCOGENE

γH2AX, an Accurate Marker That Analyzes UV Genotoxic Effects on Human Keratinocytes and on Human Skin

(2010) Laurent Barnes et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Nrf2:INrf2 (Keap1) signaling in oxidative stress

(2009) James W. Kaspar et al.   FREE RADICAL BIOLOGY AND MEDICINE

Porcine Skin as a Model System for Studies of Adverse Effects of Narrow-Band UVB Pulses on Human Skin

(2009) Anna Brożyna et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Melatonin as a major skin protectant: from free radical scavenging to DNA damage repair

(2008) Tobias W. Fischer et al.   EXPERIMENTAL DERMATOLOGY

Melatonin maintains mitochondrial membrane potential and attenuates activation of initiator (casp-9) and effector caspases (casp-3/casp-7) and PARP in UVR-exposed HaCaT keratinocytes

(2008) T. W. Fischer et al.   JOURNAL OF PINEAL RESEARCH

The melatonin metaboliteN1-acetyl-5-methoxykynuramine is a potent singlet oxygen scavenger

(2008) Meike Schaefer et al.   JOURNAL OF PINEAL RESEARCH

Melatonin in the skin: synthesis, metabolism and functions

(2008) Andrzej Slominski et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM