Harwinder Sidhu

United States Research

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Commented on Circulating Tumor Cells and Circulating Tumor DNA
Interesting! now we need a point of care device to test for CTC's early on!

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Commented on The need for a global COVID-19 maternal immunisation research plan
UC San Francisco and UCLA have a joint study that is asking pregnant women who got COVID vaccination to participate in their study. Hopefully, we will have some exciting data soon.

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Commented on Pecan nuts: A review of reported bioactivities and health effects
It seems pecans are similar to almonds and walnuts in exerting cardiovascular health benefits.

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Commented on Sleepy neurons?
This is one of the most interesting articles I have read recently. It says the single cortical neurons take a nap when the brain is forced to stay awake leading to reduced performance and more errors. So sleep your way to the top?

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Commented on A new cause of silent myocardial infarction: Bonsai
Bonsai-a synthetic derivative of cannabis leads to cardiac issues and lung toxicity. However natural cannabinoids are known to be beneficial for the heart. I wonder what the constituents are in bonsai and how it is manufactured.

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Commented on Breast Enlargement With Prednisone Treatment
This is one case only and kind of accidental finding that prednisone lead to breast enlargement in a 17 year old boy. I do wonder if other factors had a role?

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Commented on Docetaxel for hormone-refractory prostate cancer
This very brief article mentions a conflict of interest but Docetaxel in combination with other treatments has been proven to be useful for metastatic prostate cancer.

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Commented on Susceptibility of ferrets, cats, dogs, and other domesticated animals to SARS–coronavirus 2
Interesting article! According to this paper pigs chickens and ducks are not susceptible to covid. However a recent Canada-US study done by University of Iowa found pigs to be susceptible to covid19.

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Commented on Ready‐to‐use Thermally Stable Mastermix Pills for Molecular Biology Applications
Though this method will increase shelf life, the pills will require mixing in solvent prior to use. The article says this method is cost-effective so i guess researchers wouldn't mind the extra effort!

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Commented on Enhancement of PCR Detection Limit by Single-Tube Restriction Endonuclease-PCR (RE-PCR)
Simple use of restriction enzyme to linearize supercoiled template leading to increased detection. Supercoiled DNA can also be efficiently quantified by using the right PCR master mix by qPCR method.

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Commented on RNAzol® RT: a new single-step method for isolation of RNA
RNA separation from biological samples in less than 1 hour!

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Commented on Transgenic mouse models for ADHD
Transgenic mouse model for ADHD! Though it does not account for the environmental factors associated with ADHD.

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Commented on Transgenic mice models in autoimmunity – discussion
Many presets to consider! Transgenic mice are tricky to work with due to several reasons including but not limited to the stability of the transgenic line.

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Commented on Orthotopic mouse models expressing fluorescent proteins for cancer drug discovery
Orthotopic mouse models are better for drug discovery provided the surgery is done well and the mice survive the implant.

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Commented on Clostridium difficile Toxins and Severe C. difficile Infection
Presence of toxins (TcdA and TcdB) increase the severity of C. difficile. This article discusses the impact of dual treatment; combining monoclonal antibodies with antibiotic treatment to reduce the severity of the disease. Could be extremely useful for patients with recurring CDI.