Neuronal Cell Death

Activated Microglia Desialylate and Phagocytose Cells via Neuraminidase, Galectin-3, and Mer Tyrosine Kinase

(2017) Koji Nomura et al.   JOURNAL OF IMMUNOLOGY

Endo-lysosomal and autophagic dysfunction: a driving factor in Alzheimer's disease?

(2017) Lauren S. Whyte et al.   JOURNAL OF NEUROCHEMISTRY

Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities

(2017) Fiona M. Menzies et al.   NEURON

Hallmarks of Alzheimer’s Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse Brain

(2017) Ira Espuny-Camacho et al.   NEURON

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

(2017) Jianjin Shi et al.   TRENDS IN BIOCHEMICAL SCIENCES

Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death

(2017) Corey Rogers et al.   Nature Communications

Ablation of ferroptosis regulator glutathione peroxidase 4 in forebrain neurons promotes cognitive impairment and neurodegeneration

(2017) William Sealy Hambright et al.   Redox Biology

Galectin-3 released in response to traumatic brain injury acts as an alarmin orchestrating brain immune response and promoting neurodegeneration

(2017) Ping Kei Yip et al.   Scientific Reports

Granulovacuolar degeneration: a neurodegenerative change that accompanies tau pathology

(2016) Christoph Köhler   ACTA NEUROPATHOLOGICA

Can ‘calpain-cathepsin hypothesis’ explain Alzheimer neuronal death?

(2016) Tetsumori Yamashima   AGEING RESEARCH REVIEWS

Disorders of lysosomal acidification—The emerging role of v-ATPase in aging and neurodegenerative disease

(2016) Daniel J. Colacurcio et al.   AGEING RESEARCH REVIEWS

Impaired protein degradation in FTLD and related disorders

(2016) Julia K. Götzl et al.   AGEING RESEARCH REVIEWS

Molecular genetics of early-onset Alzheimer's disease revisited

(2016) Rita Cacace et al.   Alzheimers & Dementia

Real-time monitoring of oxidative injury of vascular endothelial cells and protective effect of quercetin using quartz crystal microbalance

(2016) Jiaming Zhu et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Amyloid Plaque in the Human Brain Can Decompose from Aβ(1-40/1-42) by Spontaneous Nonenzymatic Processes

(2016) Brian Lyons et al.   ANALYTICAL CHEMISTRY

Dihydroceramide accumulation mediates cytotoxic autophagy of cancer cells via autolysosome destabilization

(2016) Sonia Hernández-Tiedra et al.   Autophagy

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

The mitochondrial permeability transition pore in AD 2016: An update

(2016) Lucia Biasutto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Both the apoptotic suicide pathway and phagocytosis are required for a programmed cell death in Caenorhabditis elegans

(2016) Holly L. Johnsen et al.   BMC BIOLOGY

Eliminating microglia in Alzheimer’s mice prevents neuronal loss without modulating amyloid-β pathology

(2016) Elizabeth E. Spangenberg et al.   BRAIN

Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer’s disease

(2016) Rik Ossenkoppele et al.   BRAIN

Early and protective microglial activation in Alzheimer’s disease: a prospective study using18F-DPA-714 PET imaging

(2016) Lorraine Hamelin et al.   BRAIN

The UPR and synaptic dysfunction in neurodegeneration

(2016) Oliver J. Freeman et al.   BRAIN RESEARCH

Mechanisms of tau and Aβ-induced excitotoxicity

(2016) Susanne P. Pallo et al.   BRAIN RESEARCH

ER stress and Parkinson's disease: Pathological inputs that converge into the secretory pathway

(2016) Gabriela Mercado et al.   BRAIN RESEARCH

BOK Is a Non-canonical BCL-2 Family Effector of Apoptosis Regulated by ER-Associated Degradation

(2016) Fabien Llambi et al.   CELL

Axon Degeneration Gated by Retrograde Activation of Somatic Pro-apoptotic Signaling

(2016) David J. Simon et al.   CELL

Global ischemia induces lysosomal-mediated degradation of mTOR and activation of autophagy in hippocampal neurons destined to die

(2016) Jee-Yeon Hwang et al.   CELL DEATH AND DIFFERENTIATION

RIPK3 deficiency or catalytically inactive RIPK1 provides greater benefit than MLKL deficiency in mouse models of inflammation and tissue injury

(2016) K Newton et al.   CELL DEATH AND DIFFERENTIATION

MLKL forms cation channels

(2016) Bingqing Xia et al.   CELL RESEARCH

Pyroptosis is driven by non-selective gasdermin-D pore and its morphology is different from MLKL channel-mediated necroptosis

(2016) Xin Chen et al.   CELL RESEARCH

Mechanisms and consequences of entosis

(2016) Shefali Krishna et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Cyclosporine A, a Potential Therapy of Ischemic Reperfusion Injury. A Common History for Heart and Brain

(2016) Norbert Nighoghossian et al.   CEREBROVASCULAR DISEASES

PERK-opathies: An Endoplasmic Reticulum Stress Mechanism Underlying Neurodegeneration

(2016) Michelle C. Bell et al.   Current Alzheimer Research

Common and Divergent Mechanisms in Developmental Neuronal Remodeling and Dying Back Neurodegeneration

(2016) Avraham Yaron et al.   CURRENT BIOLOGY

Critical role of the Mac1/NOX2 pathway in mediating reactive microgliosis-generated chronic neuroinflammation and progressive neurodegeneration

(2016) Shih-Heng Chen et al.   CURRENT OPINION IN PHARMACOLOGY

Bax assembly into rings and arcs in apoptotic mitochondria is linked to membrane pores

(2016) R. Salvador-Gallego et al.   EMBO JOURNAL

Bax assembles into large ring-like structures remodeling the mitochondrial outer membrane in apoptosis

(2016) L. Grosse et al.   EMBO JOURNAL

Autophagosome–lysosome fusion in neurons requires INPP5E, a protein associated with Joubert syndrome

(2016) Junya Hasegawa et al.   EMBO JOURNAL

Inactivation of prosurvival Bcl-2 proteins activates Bax/Bak through the outer mitochondrial membrane

(2016) Katelyn L. O'Neill et al.   GENES & DEVELOPMENT

Microglial phagocytosis and activation underlying photoreceptor degeneration is regulated by CX3CL1-CX3CR1 signaling in a mouse model of retinitis pigmentosa

(2016) Matthew K. Zabel et al.   GLIA

RIPK1 and RIPK3 Kinases Promote Cell-Death-Independent Inflammation by Toll-like Receptor 4

(2016) Malek Najjar et al.   IMMUNITY

Injury site-specific targeting of complement inhibitors for treating stroke

(2016) Ali Alawieh et al.   IMMUNOLOGICAL REVIEWS

Amyloid β induces microglia to phagocytose neurons via activation of protein kinase Cs and NADPH oxidase

(2016) Urte Neniskyte et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Neonatal anoxia leads to time dependent progression of mitochondrial linked apoptosis in rat cortex and associated long term sensorimotor deficits

(2016) Puneet K. Samaiya et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Dual Kinase Inhibition Affords Extended in vitro Neuroprotection in Amyloid-β Toxicity

(2016) Sarah Gourmaud et al.   JOURNAL OF ALZHEIMERS DISEASE

Loss of OMA1 delays neurodegeneration by preventing stress-induced OPA1 processing in mitochondria

(2016) Anne Korwitz et al.   JOURNAL OF CELL BIOLOGY

Tau physiology and pathomechanisms in frontotemporal lobar degeneration

(2016) Liviu-Gabriel Bodea et al.   JOURNAL OF NEUROCHEMISTRY

Histamine induces microglia activation and dopaminergic neuronal toxicity via H1 receptor activation

(2016) Sandra M. Rocha et al.   Journal of Neuroinflammation

Large Soluble Oligomers of Amyloid β-Protein from Alzheimer Brain Are Far Less Neuroactive Than the Smaller Oligomers to Which They Dissociate

(2016) Ting Yang et al.   JOURNAL OF NEUROSCIENCE

Bok Is Not Pro-Apoptotic But Suppresses Poly ADP-Ribose Polymerase-Dependent Cell Death Pathways and Protects against Excitotoxic and Seizure-Induced Neuronal Injury

(2016) B. D'Orsi et al.   JOURNAL OF NEUROSCIENCE

Transition rates between amyloid and neurodegeneration biomarker states and to dementia: a population-based, longitudinal cohort study

(2016) Clifford R Jack et al.   LANCET NEUROLOGY

A Small Molecule That Protects the Integrity of the Electron Transfer Chain Blocks the Mitochondrial Apoptotic Pathway

(2016) Xian Jiang et al.   MOLECULAR CELL

An Autophagic Flux Probe that Releases an Internal Control

(2016) Takeshi Kaizuka et al.   MOLECULAR CELL

Effect of glutamate on lysosomal membrane permeabilization in primary cultured cortical neurons

(2016) MIN YAN et al.   Molecular Medicine Reports

Oligomeropathies and pathogenesis of Alzheimer and Parkinson's diseases

(2016) Gianluigi Forloni et al.   MOVEMENT DISORDERS

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

(2016) Xing Liu et al.   NATURE

RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation

(2016) Juan Lin et al.   NATURE

TAM receptors regulate multiple features of microglial physiology

(2016) Lawrence Fourgeaud et al.   NATURE

Picture imperfect: Going beyond imaging amyloid in Alzheimer's disease

(2016) Ellie Kincaid   NATURE MEDICINE

Regulated necrosis: disease relevance and therapeutic opportunities

(2016) Marcus Conrad et al.   NATURE REVIEWS DRUG DISCOVERY

A critical appraisal of the pathogenic protein spread hypothesis of neurodegeneration

(2016) Dominic M. Walsh et al.   NATURE REVIEWS NEUROSCIENCE

TREM2 variants: new keys to decipher Alzheimer disease pathogenesis

(2016) Marco Colonna et al.   NATURE REVIEWS NEUROSCIENCE

11 C-PBR28 binding to translocator protein increases with progression of Alzheimer's disease

(2016) William C. Kreisl et al.   NEUROBIOLOGY OF AGING

Ferroptosis, a newly characterized form of cell death in Parkinson's disease that is regulated by PKC

(2016) Bruce Do Van et al.   NEUROBIOLOGY OF DISEASE

Glia and alpha-synuclein in neurodegeneration: A complex interaction

(2016) Dominik Brück et al.   NEUROBIOLOGY OF DISEASE

Axonal Degeneration Is Regulated by a Transcriptional Program that Coordinates Expression of Pro- and Anti-degenerative Factors

(2016) Maya Maor-Nof et al.   NEURON

PET Imaging of Tau Deposition in the Aging Human Brain

(2016) Michael Schöll et al.   NEURON

Deletion of autophagy-related gene 7 in dopaminergic neurons prevents their loss induced by MPTP

(2016) Xue-Yuan Niu et al.   NEUROSCIENCE

Physiological and Pathophysiological Implications of Synaptic Tau

(2016) Philip Regan et al.   NEUROSCIENTIST

Clinical Trials of Immunomodulation in Ischemic Stroke

(2016) Roland Veltkamp et al.   Neurotherapeutics

NADPH Oxidase: A Potential Target for Treatment of Stroke

(2016) Li Zhang et al.   Oxidative Medicine and Cellular Longevity

Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis

(2016) Wan Seok Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Xkr8 phospholipid scrambling complex in apoptotic phosphatidylserine exposure

(2016) Jun Suzuki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of the Cell Cycle Re-Initiation in DNA Damage Response of Post-Mitotic Cells and Its Implication in the Pathogenesis of Neurodegenerative Diseases

(2016) Paulina Tokarz et al.   REJUVENATION RESEARCH

RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS

(2016) Yasushi Ito et al.   SCIENCE

Complement and microglia mediate early synapse loss in Alzheimer mouse models

(2016) S. Hong et al.   SCIENCE

Ferroptosis: Death by Lipid Peroxidation

(2016) Wan Seok Yang et al.   TRENDS IN CELL BIOLOGY

Digesting the Expanding Mechanisms of Autophagy

(2016) Nicholas T. Ktistakis et al.   TRENDS IN CELL BIOLOGY

BID Mediates Oxygen-Glucose Deprivation-Induced Neuronal Injury in Organotypic Hippocampal Slice Cultures and Modulates Tissue Inflammation in a Transient Focal Cerebral Ischemia Model without Changing Lesion Volume

(2016) Nellie Anne Martin et al.   Frontiers in Cellular Neuroscience

Identification of an activation site in Bak and mitochondrial Bax triggered by antibodies

(2016) Sweta Iyer et al.   Nature Communications

Therapeutic hypothermia attenuates tissue damage and cytokine expression after traumatic brain injury by inhibiting necroptosis in the rat

(2016) Tao Liu et al.   Scientific Reports

NMNAT1 inhibits axon degeneration via blockade of SARM1-mediated NAD+ depletion

(2016) Yo Sasaki et al.   eLife

Evaluation of Tau Imaging in Staging Alzheimer Disease and Revealing Interactions Between β-Amyloid and Tauopathy

(2016) Liang Wang et al.   JAMA Neurology

Genomics of Alzheimer Disease

(2016) Roger N. Rosenberg et al.   JAMA Neurology

Association of Elevated Amyloid Levels With Cognition and Biomarkers in Cognitively Normal People From the Community

(2016) Ronald C. Petersen et al.   JAMA Neurology

Autophagic and lysosomal defects in human tauopathies: analysis of post-mortem brain from patients with familial Alzheimer disease, corticobasal degeneration and progressive supranuclear palsy

(2016) Antonio Piras et al.   Acta Neuropathologica Communications

Molecular Mechanisms of Amyloid Oligomers Toxicity

(2016) Rakez Kayed et al.   JOURNAL OF ALZHEIMERS DISEASE

Receptor Interacting Protein 3-Mediated Necroptosis Promotes Lipopolysaccharide-Induced Inflammation and Acute Respiratory Distress Syndrome in Mice

(2016) Linlin Wang et al.   PLoS One

Lysosomal membrane permeabilization in cell death: new evidence and implications for health and disease

(2015) Ana Serrano-Puebla et al.   Annals of the New York Academy of Sciences

NADPH Oxidase-2: Linking Glucose, Acidosis, and Excitotoxicity in Stroke

(2015) Angela M. Brennan-Minnella et al.   ANTIOXIDANTS & REDOX SIGNALING

Genetic perspective on the role of the autophagy-lysosome pathway in Parkinson disease

(2015) Ziv Gan-Or et al.   Autophagy

Sensitive detection of lysosomal membrane permeabilization by lysosomal galectin puncta assay

(2015) Sonja Aits et al.   Autophagy

The 5-Lipoxygenase Inhibitor Zileuton Confers Neuroprotection against Glutamate Oxidative Damage by Inhibiting Ferroptosis

(2015) Yang Liu et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Upregulation of the receptor-interacting protein 3 expression and involvement in neural tissue damage after spinal cord injury in mice

(2015) Haruo Kanno et al.   BMC NEUROSCIENCE

Neuronal response in Alzheimer’s and Parkinson’s disease: the effect of toxic proteins on intracellular pathways

(2015) Shohreh Majd et al.   BMC NEUROSCIENCE

GWAS of longitudinal amyloid accumulation on18F-florbetapir PET in Alzheimer’s disease implicates microglial activation geneIL1RAP

(2015) Vijay K Ramanan et al.   BRAIN

The preclinical phase of the pathological process underlying sporadic Alzheimer’s disease

(2015) Heiko Braak et al.   BRAIN

Inhibition of receptor-interacting protein 3 upregulation and nuclear translocation involved in Necrostatin-1 protection against hippocampal neuronal programmed necrosis induced by ischemia/reperfusion injury

(2015) Bo Yin et al.   BRAIN RESEARCH

How microglia kill neurons

(2015) Guy C. Brown et al.   BRAIN RESEARCH

Role of synaptic and nonsynaptic glutamate receptors in ischaemia induced neurotoxicity

(2015) A. Brassai et al.   BRAIN RESEARCH BULLETIN

Neuronal cell cycle: the neuron itself and its circumstances

(2015) José M Frade et al.   CELL CYCLE

Loss of cysteinyl-tRNA synthetase (CARS) induces the transsulfuration pathway and inhibits ferroptosis induced by cystine deprivation

(2015) M Hayano et al.   CELL DEATH AND DIFFERENTIATION

Gasdermin D: the long-awaited executioner of pyroptosis

(2015) Si Ming Man et al.   CELL RESEARCH

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

(2015) Wan-ting He et al.   CELL RESEARCH

Taming Glutamate Excitotoxicity: Strategic Pathway Modulation for Neuroprotection

(2015) Ming Jia et al.   CNS DRUGS

Entosis and Related Forms of Cell Death within Cells.

(2015) Y. Wang et al.   CURRENT MOLECULAR MEDICINE

Autophagy and checkpoints for intracellular pathogen defense

(2015) Geraldine L.C. Paulus et al.   CURRENT OPINION IN GASTROENTEROLOGY

Programmed Cell Death in Neurodevelopment

(2015) Yoshifumi Yamaguchi et al.   DEVELOPMENTAL CELL

The role of the nitric oxide pathway in brain injury and its treatment — From bench to bedside

(2015) P.S. Garry et al.   EXPERIMENTAL NEUROLOGY

BH3-only proteins: a 20-year stock-take

(2015) Marcel Doerflinger et al.   FEBS Journal

Contribution of autophagy to antiviral immunity

(2015) Emma Rey-Jurado et al.   FEBS LETTERS

Neuronal death after perinatal cerebral hypoxia-ischemia: Focus on autophagy—mediated cell death

(2015) C. Descloux et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Mitochondrial Optic Atrophy (OPA) 1 Processing Is Altered in Response to Neonatal Hypoxic-Ischemic Brain Injury

(2015) Ana Baburamani et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ablation of the Ferroptosis Inhibitor Glutathione Peroxidase 4 in Neurons Results in Rapid Motor Neuron Degeneration and Paralysis

(2015) Liuji Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SARM1, Not MyD88, Mediates TLR7/TLR9-Induced Apoptosis in Neurons

(2015) Piyali Mukherjee et al.   JOURNAL OF IMMUNOLOGY

The mitochondrial permeability transition: A current perspective on its identity and role in ischaemia/reperfusion injury

(2015) Andrew P. Halestrap et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

NLRP1 inflammasome is activated in patients with medial temporal lobe epilepsy and contributes to neuronal pyroptosis in amygdala kindling-induced rat model

(2015) Chen-Chen Tan et al.   Journal of Neuroinflammation

Complement C3-Deficient Mice Fail to Display Age-Related Hippocampal Decline

(2015) Q. Shi et al.   JOURNAL OF NEUROSCIENCE

The Progranulin Cleavage Products, Granulins, Exacerbate TDP-43 Toxicity and Increase TDP-43 Levels

(2015) D. A. Salazar et al.   JOURNAL OF NEUROSCIENCE

Bax Regulates Neuronal Ca2+ Homeostasis

(2015) B. D'Orsi et al.   JOURNAL OF NEUROSCIENCE

Visual and functional demonstration of growing Bax-induced pores in mitochondrial outer membranes

(2015) Laura A Gillies et al.   MOLECULAR BIOLOGY OF THE CELL

Inhibition of Pro-Apoptotic BAX by a Noncanonical Interaction Mechanism

(2015) Lauren A. Barclay et al.   MOLECULAR CELL

SPG7 Is an Essential and Conserved Component of the Mitochondrial Permeability Transition Pore

(2015) Santhanam Shanmughapriya et al.   MOLECULAR CELL

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

(2015) Michael Lazarou et al.   NATURE

Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits

(2015) Sang-Won Min et al.   NATURE MEDICINE

Oxidative and nitrative stress in neurodegeneration

(2015) Catherine A. Cobb et al.   NEUROBIOLOGY OF DISEASE

Cyclosporine in acute ischemic stroke

(2015) N. Nighoghossian et al.   NEUROLOGY

The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease

(2015) Alicia M. Pickrell et al.   NEURON

Hypersialylation is a common feature of neurofibrillary tangles and granulovacuolar degenerations in Alzheimer's disease and tauopathy brains

(2015) Shun Nagamine et al.   NEUROPATHOLOGY

Invited review: Animal models of tauopathies and their implications for research/translation into the clinic

(2015) Simon Dujardin et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Invited review: Prion-like transmission and spreading of tau pathology

(2015) Florence Clavaguera et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Enduring Elevations of Hippocampal Amyloid Precursor Protein and Iron Are Features of β-Amyloid Toxicity and Are Mediated by Tau

(2015) Xuling Li et al.   Neurotherapeutics

Cell death by autophagy: emerging molecular mechanisms and implications for cancer therapy

(2015) S Fulda et al.   ONCOGENE

The Ambiguous Relationship of Oxidative Stress, Tau Hyperphosphorylation, and Autophagy Dysfunction in Alzheimer’s Disease

(2015) Zhenzhen Liu et al.   Oxidative Medicine and Cellular Longevity

Neuroprotection for ischaemic stroke: Current status and challenges

(2015) Antonio Moretti et al.   PHARMACOLOGY & THERAPEUTICS

Apoptotic markers and DNA damage are related to late phase of stroke: Involvement of dyslipidemia and inflammation

(2015) Eduardo Tanuri Pascotini et al.   PHYSIOLOGY & BEHAVIOR

SARM1 activation triggers axon degeneration locally via NAD+ destruction

(2015) J. Gerdts et al.   SCIENCE

Connecting the dots between tau dysfunction and neurodegeneration

(2015) Bess Frost et al.   TRENDS IN CELL BIOLOGY

Beclin orthologs: integrative hubs of cell signaling, membrane trafficking, and physiology

(2015) Beth Levine et al.   TRENDS IN CELL BIOLOGY

Interleukin-1 and acute brain injury

(2015) Katie N. Murray et al.   Frontiers in Cellular Neuroscience

DRAM1 regulates apoptosis through increasing protein levels and lysosomal localization of BAX

(2015) J-J Guan et al.   Cell Death & Disease

Role of necroptosis in the pathogenesis of solid organ injury

(2015) H Zhao et al.   Cell Death & Disease

Re-examining tau-immunoreactive pathology in the population: granulovacuolar degeneration and neurofibrillary tangles

(2015) Sally Hunter et al.   Alzheimers Research & Therapy

Absence of SARM1 Rescues Development and Survival of NMNAT2-Deficient Axons

(2015) Jonathan Gilley et al.   Cell Reports

Presenilin 1 Maintains Lysosomal Ca2+ Homeostasis via TRPML1 by Regulating vATPase-Mediated Lysosome Acidification

(2015) Ju-Hyun Lee et al.   Cell Reports

Wallerian Degeneration Is Executed by an NMN-SARM1-Dependent Late Ca 2+ Influx but Only Modestly Influenced by Mitochondria

(2015) Andrea Loreto et al.   Cell Reports

MiR-21 in Extracellular Vesicles Leads to Neurotoxicity via TLR7 Signaling in SIV Neurological Disease

(2015) Sowmya V. Yelamanchili et al.   PLoS Pathogens

Tissue acidosis induces neuronal necroptosis via ASIC1a channel independent of its ionic conduction

(2015) Yi-Zhi Wang et al.   eLife

Understanding Conflicting Neuropathological Findings in Patients Clinically Diagnosed as Having Alzheimer Dementia

(2015) Stephen Salloway et al.   JAMA Neurology

Characterizing Apolipoprotein E ε4 Carriers and Noncarriers With the Clinical Diagnosis of Mild to Moderate Alzheimer Dementia and Minimal β-Amyloid Peptide Plaques

(2015) Sarah E. Monsell et al.   JAMA Neurology

β-Amyloid: the key peptide in the pathogenesis of Alzheimer’s disease

(2015) Xiaojuan Sun et al.   Frontiers in Pharmacology

Intracellular amyloid β oligomers impair organelle transport and induce dendritic spine loss in primary neurons

(2015) Tomohiro Umeda et al.   Acta Neuropathologica Communications

The Role of Excitotoxic Programmed Necrosis in Acute Brain Injury

(2015) Denson G. Fujikawa   Computational and Structural Biotechnology Journal

Lysosome and calcium dysregulation in Alzheimer's disease: partners in crime

(2015) MaryKate McBrayer et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The Effects of Soluble A.β Oligomers on Neurodegeneration in Alzheimer's Disease

(2015) Jonathan Brouillette   CURRENT PHARMACEUTICAL DESIGN

Autophagy revisited: A conversation with Christian de Duve

(2014) Daniel J. Klionsky   Autophagy

Involvement of autophagy in hypoxic-excitotoxic neuronal death

(2014) Vanessa Ginet et al.   Autophagy

BAX channel activity mediates lysosomal disruption linked to Parkinson disease

(2014) Jordi Bové et al.   Autophagy

Alzheimer neurodegeneration, autophagy, and Abeta secretion: The ins and outs (comment on DOI 10.1002/bies.201400002)

(2014) Ralph A. Nixon   BIOESSAYS

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Lysosomal membrane permeabilization and autophagy blockade contribute to photoreceptor cell death in a mouse model of retinitis pigmentosa

(2014) N Rodríguez-Muela et al.   CELL DEATH AND DIFFERENTIATION

A rise in NAD precursor nicotinamide mononucleotide (NMN) after injury promotes axon degeneration

(2014) M Di Stefano et al.   CELL DEATH AND DIFFERENTIATION

Calpain inhibition mediates autophagy-dependent protection against polyglutamine toxicity

(2014) F M Menzies et al.   CELL DEATH AND DIFFERENTIATION

Autosis and autophagic cell death: the dark side of autophagy

(2014) Y Liu et al.   CELL DEATH AND DIFFERENTIATION

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015

(2014) L Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Inflammation in Ischemic Stroke: Mechanisms, Consequences and Possible Drug Targets

(2014) Muzamil Ahmad et al.   CNS & Neurological Disorders-Drug Targets

Mechanisms and Potential Therapeutic Applications of Microglial Activation after Brain Injury

(2014) Jong-Youl Kim et al.   CNS Neuroscience & Therapeutics

Differential retrotranslocation of mitochondrial Bax and Bak

(2014) F. Todt et al.   EMBO JOURNAL

Tumour necrosis factor alpha-induced neuronal loss is mediated by microglial phagocytosis

(2014) Urte Neniskyte et al.   FEBS LETTERS

Inhibition of UDP/P2Y6purinergic signaling prevents phagocytosis of viable neurons by activated microgliain vitroandin vivo

(2014) Jonas J. Neher et al.   GLIA

Permeability transition pore-dependent and PARP-mediated depletion of neuronal pyridine nucleotides during anoxia and glucose deprivation

(2014) Sibel Kahraman et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Prions: Generation and SpreadVersusNeurotoxicity

(2014) Mark Halliday et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pyroptotic Neuronal Cell Death Mediated by the AIM2 Inflammasome

(2014) Stephanie E Adamczak et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Extrasynaptic glutamate release through cystine/glutamate antiporter contributes to ischemic damage

(2014) Federico N. Soria et al.   JOURNAL OF CLINICAL INVESTIGATION

Calcineurin and glial signaling: neuroinflammation and beyond

(2014) Jennifer L Furman et al.   Journal of Neuroinflammation

A Death Receptor 6-Amyloid Precursor Protein Pathway Regulates Synapse Density in the Mature CNS But Does Not Contribute to Alzheimer's Disease-Related Pathophysiology in Murine Models

(2014) D. Y. Kallop et al.   JOURNAL OF NEUROSCIENCE

Poly(ADP-Ribose) Polymerase-1 Causes Mitochondrial Damage and Neuron Death Mediated by Bnip3

(2014) P. Lu et al.   JOURNAL OF NEUROSCIENCE

Specific Calpain Inhibition by Calpastatin Prevents Tauopathy and Neurodegeneration and Restores Normal Lifespan in Tau P301L Mice

(2014) M. V. Rao et al.   JOURNAL OF NEUROSCIENCE

Neurodegeneration by Activation of the Microglial Complement-Phagosome Pathway

(2014) L.-G. Bodea et al.   JOURNAL OF NEUROSCIENCE

Mitochondrial Dysfunction Induces Sarm1-Dependent Cell Death in Sensory Neurons

(2014) D. W. Summers et al.   JOURNAL OF NEUROSCIENCE

Local Pruning of Dendrites and Spines by Caspase-3-Dependent and Proteasome-Limited Mechanisms

(2014) A. Erturk et al.   JOURNAL OF NEUROSCIENCE

Genetic Analysis Reveals that Amyloid Precursor Protein and Death Receptor 6 Function in the Same Pathway to Control Axonal Pruning Independent of  -Secretase

(2014) O. Olsen et al.   JOURNAL OF NEUROSCIENCE

Small Aβ1-42oligomer-induced membrane depolarization of neuronal and microglial cells: Role of N-methyl-D-aspartate receptors

(2014) Ramune Morkuniene et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Imaging Cell Death

(2014) A. A. Neves et al.   JOURNAL OF NUCLEAR MEDICINE

Necroptosis, a novel type of programmed cell death, contributes to early neural cells damage after spinal cord injury in adult mice

(2014) Ming Liu et al.   JOURNAL OF SPINAL CORD MEDICINE

Ferrostatins Inhibit Oxidative Lipid Damage and Cell Death in Diverse Disease Models

(2014) Rachid Skouta et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Hsp27 binding to the 3′UTR of bim mRNA prevents neuronal death during oxidative stress–induced injury: a novel cytoprotective mechanism

(2014) David Dávila et al.   MOLECULAR BIOLOGY OF THE CELL

The HOPS complex mediates autophagosome–lysosome fusion through interaction with syntaxin 17

(2014) Peidu Jiang et al.   MOLECULAR BIOLOGY OF THE CELL

RIP3 Induces Apoptosis Independent of Pronecrotic Kinase Activity

(2014) Pratyusha Mandal et al.   MOLECULAR CELL

Structural Model of Active Bax at the Membrane

(2014) Stephanie Bleicken et al.   MOLECULAR CELL

Mechanism of Oxidative Stress and Synapse Dysfunction in the Pathogenesis of Alzheimer’s Disease: Understanding the Therapeutics Strategies

(2014) Pradip K. Kamat et al.   MOLECULAR NEUROBIOLOGY

Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease

(2014) Zhentao Zhang et al.   NATURE MEDICINE

Regulated necrosis: the expanding network of non-apoptotic cell death pathways

(2014) Tom Vanden Berghe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Microglial phagocytosis of live neurons

(2014) Guy C. Brown et al.   NATURE REVIEWS NEUROSCIENCE

Wallerian degeneration: an emerging axon death pathway linking injury and disease

(2014) Laura Conforti et al.   NATURE REVIEWS NEUROSCIENCE

Ischemic insults induce necroptotic cell death in hippocampal neurons through the up-regulation of endogenous RIP3

(2014) M. Vieira et al.   NEUROBIOLOGY OF DISEASE

Necroptosis Drives Motor Neuron Death in Models of Both Sporadic and Familial ALS

(2014) Diane B. Re et al.   NEURON

Microglial NADPH oxidase activation mediates rod cell death in the retinal degeneration in rd mice

(2014) H. Zeng et al.   NEUROSCIENCE

Necroptosis inhibitor necrostatin-1 promotes cell protection and physiological function in traumatic spinal cord injury

(2014) Y. Wang et al.   NEUROSCIENCE

Pathologic role of glial nitric oxide in adult and pediatric neuroinflammatory diseases

(2014) Mehdi Ghasemi et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Necroptosis

(2014) Andreas Linkermann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Apoptotic pore formation is associated with in-plane insertion of Bak or Bax central helices into the mitochondrial outer membrane

(2014) Dana Westphal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of mitochondrial protease OMA1 by Bax and Bak promotes cytochrome c release during apoptosis

(2014) X. Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death

(2014) Joanne M. Hildebrand et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caspase-mediated cleavage of phospholipid flippase for apoptotic phosphatidylserine exposure

(2014) K. Segawa et al.   SCIENCE

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(2014) Lorenzo Galluzzi et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Pathophysiology and Biomarkers in Acute Ischemic Stroke – A Review

(2014) Y Guo et al.   TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH

Depletion of RIPK3 or MLKL blocks TNF-driven necroptosis and switches towards a delayed RIPK1 kinase-dependent apoptosis

(2014) Q Remijsen et al.   Cell Death & Disease

Inhibition of apoptotic Bax translocation to the mitochondria is a central function of parkin

(2014) R A Charan et al.   Cell Death & Disease

Amyloid-β induces NLRP1-dependent neuronal pyroptosis in models of Alzheimer’s disease

(2014) M-S Tan et al.   Cell Death & Disease

Cystatin C protects neuronal cells against mutant copper-zinc superoxide dismutase-mediated toxicity

(2014) S Watanabe et al.   Cell Death & Disease

Inhibition of the AIF/CypA complex protects against intrinsic death pathways induced by oxidative stress

(2014) N Doti et al.   Cell Death & Disease

Akt and mTOR mediate programmed necrosis in neurons

(2014) Q Liu et al.   Cell Death & Disease

Activation of autophagy and paraptosis in retinal ganglion cells after retinal ischemia and reperfusion injury in rats

(2014) TING WEI et al.   Experimental and Therapeutic Medicine

Blm-s , a BH3-Only Protein Enriched in Postmitotic Immature Neurons, Is Transcriptionally Upregulated by p53 during DNA Damage

(2014) Wei-Wen Liu et al.   Cell Reports

MLKL Compromises Plasma Membrane Integrity by Binding to Phosphatidylinositol Phosphates

(2014) Yves Dondelinger et al.   Cell Reports

Necroptosis Mediates TNF-Induced Toxicity of Hippocampal Neurons

(2014) Shan Liu et al.   Biomed Research International

Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis

(2014) Scott J Dixon et al.   eLife

Amyloid-β and Tau

(2014) George S. Bloom   JAMA Neurology

Peripheral administration of tau aggregates triggers intracerebral tauopathy in transgenic mice

(2013) Florence Clavaguera et al.   ACTA NEUROPATHOLOGICA

Control of Life-or-Death Decisions by RIP1 Kinase

(2013) Dana E Christofferson et al.   Annual Review of Physiology

Crosstalk between apoptosis, necrosis and autophagy

(2013) Vassiliki Nikoletopoulou et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Calpain 1 induce lysosomal permeabilization by cleavage of lysosomal associated membrane protein 2

(2013) Gloria E. Villalpando Rodriguez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Retrograde transneuronal degeneration in the retina and lateral geniculate nucleus of the V1-lesioned marmoset monkey

(2013) A. Hendrickson et al.   Brain Structure & Function

Parthanatos: mitochondrial-linked mechanisms and therapeutic opportunities

(2013) Amos A Fatokun et al.   BRITISH JOURNAL OF PHARMACOLOGY

Bax Crystal Structures Reveal How BH3 Domains Activate Bax and Nucleate Its Oligomerization to Induce Apoptosis

(2013) Peter E. Czabotar et al.   CELL

Historical landmarks of autophagy research

(2013) Yoshinori Ohsumi   CELL RESEARCH

Chaperone-mediated autophagy: roles in disease and aging

(2013) Ana Maria Cuervo et al.   CELL RESEARCH

Local Apoptosis Modulates Early Mammalian Brain Development through the Elimination of Morphogen-Producing Cells

(2013) Keiko Nonomura et al.   DEVELOPMENTAL CELL

Amyloid-β oligomers induce synaptic damage via Tau-dependent microtubule severing by TTLL6 and spastin

(2013) Hans Zempel et al.   EMBO JOURNAL

Endonuclease G mediates α-synuclein cytotoxicity during Parkinson's disease

(2013) Sabrina Büttner et al.   EMBO JOURNAL

Caspase-6 as a novel early target in the treatment of Alzheimer's disease

(2013) Andrea C. LeBlanc   EUROPEAN JOURNAL OF NEUROSCIENCE

Mislocalization of neuronal mitochondria reveals regulation of Wallerian degeneration and NMNAT/WLDS-mediated axon protection independent of axonal mitochondria

(2013) Brandon M. Kitay et al.   HUMAN MOLECULAR GENETICS

Activation of the Innate Signaling Molecule MAVS by Bunyavirus Infection Upregulates the Adaptor Protein SARM1, Leading to Neuronal Death

(2013) Piyali Mukherjee et al.   IMMUNITY

The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism

(2013) James M. Murphy et al.   IMMUNITY

Direct Interaction of Bax and Bak Proteins with Bcl-2 Homology Domain 3 (BH3)-only Proteins in Living Cells Revealed by Fluorescence Complementation

(2013) Laura Vela et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Calcium-dependent Phospholipid Scramblase Activity of TMEM16 Protein Family Members

(2013) Jun Suzuki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caspase Inhibitors Protect Neurons by Enabling Selective Necroptosis of Inflamed Microglia

(2013) Michael Fricker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alternative fates of newly formed PrPSc upon prion conversion on the plasma membrane

(2013) R. Goold et al.   JOURNAL OF CELL SCIENCE

Lysosomal cell death at a glance

(2013) S. Aits et al.   JOURNAL OF CELL SCIENCE

Amyloid-  signals through tau to drive ectopic neuronal cell cycle re-entry in Alzheimer's disease

(2013) M. E. Seward et al.   JOURNAL OF CELL SCIENCE

Involvement of presenilin holoprotein upregulation in calcium dyshomeostasis of Alzheimer's disease

(2013) Kamran Honarnejad et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Selective Neuronal Loss in Ischemic Stroke and Cerebrovascular Disease

(2013) Jean-Claude Baron et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Anti-Necroptosis Chemical Necrostatin-1 Can Also Suppress Apoptotic and Autophagic Pathway to Exert Neuroprotective Effect in Mice Intracerebral Hemorrhage Model

(2013) Pan Chang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

IL-1β and TNF-α induce neurotoxicity through glutamate production: a potential role for neuronal glutaminase

(2013) Ling Ye et al.   JOURNAL OF NEUROCHEMISTRY

Proteolytic Cleavage of Polymeric Tau Protein by Caspase-3: Implications for Alzheimer Disease

(2013) Jose J. Jarero-Basulto et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Sarm1-Mediated Axon Degeneration Requires Both SAM and TIR Interactions

(2013) J. Gerdts et al.   JOURNAL OF NEUROSCIENCE

Rescue of Peripheral and CNS Axon Defects in Mice Lacking NMNAT2

(2013) J. Gilley et al.   JOURNAL OF NEUROSCIENCE

Microglia Regulate the Number of Neural Precursor Cells in the Developing Cerebral Cortex

(2013) C. L. Cunningham et al.   JOURNAL OF NEUROSCIENCE

Distinct Roles for  -Calpain and m-Calpain in Synaptic NMDAR-Mediated Neuroprotection and Extrasynaptic NMDAR-Mediated Neurodegeneration

(2013) Y. Wang et al.   JOURNAL OF NEUROSCIENCE

PARP-1 Inhibition Attenuates Neuronal Loss, Microglia Activation and Neurological Deficits after Traumatic Brain Injury

(2013) Bogdan A. Stoica et al.   JOURNAL OF NEUROTRAUMA

Tau pathology and neurodegeneration

(2013) Maria Grazia Spillantini et al.   LANCET NEUROLOGY

Regulation of Axon Degeneration after Injury and in Development by the Endogenous Calpain Inhibitor Calpastatin

(2013) Jing Yang et al.   NEURON

Postnatal neuronal apoptosis in the cerebral cortex: Physiological and pathophysiological mechanisms

(2013) M. Nikolić et al.   NEUROSCIENCE

Transneuronal Retrograde Degeneration of the Retinal Ganglion Cells in Patients with Cerebral Infarction

(2013) Hae-Young Lopilly Park et al.   OPHTHALMOLOGY

NADPH Oxidase and the Degeneration of Dopaminergic Neurons in Parkinsonian Mice

(2013) Marina S. Hernandes et al.   Oxidative Medicine and Cellular Longevity

Microglial Cells Are Involved in the Susceptibility of NADPH Oxidase Knockout Mice to 6-Hydroxy-Dopamine-Induced Neurodegeneration

(2013) Marina S. Hernandes et al.   PLoS One

Molecular Markers for Granulovacuolar Degeneration Are Present in Rimmed Vacuoles

(2013) Masahiro Nakamori et al.   PLoS One

Neurofibrillary tangle-bearing neurons are functionally integrated in cortical circuits in vivo

(2013) K. V. Kuchibhotla et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dimers of mitochondrial ATP synthase form the permeability transition pore

(2013) V. Giorgio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phagocytosis executes delayed neuronal death after focal brain ischemia

(2013) J. J. Neher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intracellular pH reduction prevents excitotoxic and ischemic neuronal death by inhibiting NADPH oxidase

(2013) T. I. Lam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Brain homogenates from human tauopathies induce tau inclusions in mouse brain

(2013) Florence Clavaguera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autosis is a Na+,K+-ATPase-regulated form of cell death triggered by autophagy-inducing peptides, starvation, and hypoxia-ischemia

(2013) Y. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Excitotoxicity and stroke: Identifying novel targets for neuroprotection

(2013) Ted Weita Lai et al.   PROGRESS IN NEUROBIOLOGY

Programmed Cell Death in Neuronal Development

(2013) M. P. J. Dekkers et al.   SCIENCE

The unfolded protein response in Alzheimer’s disease

(2013) Víctor Hugo Cornejo et al.   Seminars in Immunopathology

At the end of the autophagic road: an emerging understanding of lysosomal functions in autophagy

(2013) Han-Ming Shen et al.   TRENDS IN BIOCHEMICAL SCIENCES

Phosphoinositide 3-kinase couples NMDA receptors to superoxide release in excitotoxic neuronal death

(2013) A M Brennan-Minnella et al.   Cell Death & Disease

Multiple mechanisms repress N-Bak mRNA translation in the healthy and apoptotic neurons

(2013) M Jakobson et al.   Cell Death & Disease

(ADP-ribose) polymerase 1 and AMP-activated protein kinase mediate progressive dopaminergic neuronal degeneration in a mouse model of Parkinson’s disease

(2013) T W Kim et al.   Cell Death & Disease

Caspase blockade induces RIP3-mediated programmed necrosis in Toll-like receptor-activated microglia

(2013) S J Kim et al.   Cell Death & Disease

Mature neurons: equipped for survival

(2013) A J Kole et al.   Cell Death & Disease

A DR6/p75NTR complex is responsible for β-amyloid-induced cortical neuron death

(2013) Y Hu et al.   Cell Death & Disease

Aβ Secretion and Plaque Formation Depend on Autophagy

(2013) Per Nilsson et al.   Cell Reports

Biochemistry and Cell Biology of Tau Protein in Neurofibrillary Degeneration

(2013) E.-M. Mandelkow et al.   Cold Spring Harbor Perspectives in Medicine

Autophagic cell death exists

(2012) Peter G.H. Clarke et al.   Autophagy

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(2012) Shensi Shen et al.   Autophagy

Beclin 1 knockdown inhibits autophagic activation and prevents the secondary neurodegenerative damage in the ipsilateral thalamus following focal cerebral infarction

(2012) Shihui Xing et al.   Autophagy

Inhibition of complex I regulates the mitochondrial permeability transition through a phosphate-sensitive inhibitory site masked by cyclophilin D

(2012) Bo Li et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Novel model for the mechanisms of glutamate-dependent excitotoxicity: Role of neuronal gap junctions

(2012) Andrei B. Belousov   BRAIN RESEARCH

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

p53 Opens the Mitochondrial Permeability Transition Pore to Trigger Necrosis

(2012) Angelina V. Vaseva et al.   CELL

Optic atrophy 1 mediates mitochondria remodeling and dopaminergic neurodegeneration linked to complex I deficiency

(2012) D Ramonet et al.   CELL DEATH AND DIFFERENTIATION

T-cell death following immune activation is mediated by mitochondria-localized SARM

(2012) P Panneerselvam et al.   CELL DEATH AND DIFFERENTIATION

BH3-only proteins are tail-anchored in the outer mitochondrial membrane and can initiate the activation of Bax

(2012) F Wilfling et al.   CELL DEATH AND DIFFERENTIATION

Necrostatin-1 blocks both RIPK1 and IDO: consequences for the study of cell death in experimental disease models

(2012) P Vandenabeele et al.   CELL DEATH AND DIFFERENTIATION

Oncosis: An important non-apoptotic mode of cell death

(2012) Priya Weerasinghe et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Gpx4 ablation in adult mice results in a lethal phenotype accompanied by neuronal loss in brain

(2012) Si-Eun Yoo et al.   FREE RADICAL BIOLOGY AND MEDICINE

Elevated NADPH oxidase activity contributes to oxidative stress and cell death in Huntington's disease

(2012) A. Valencia et al.   HUMAN MOLECULAR GENETICS

Targeted Gene Inactivation of Calpain-1 Suppresses Cortical Degeneration Due to Traumatic Brain Injury and Neuronal Apoptosis Induced by Oxidative Stress

(2012) Kaori H. Yamada et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphatidic acid mediates the targeting of tBid to induce lysosomal membrane permeabilization and apoptosis

(2012) Kai Zhao et al.   JOURNAL OF LIPID RESEARCH

Primary phagocytosis of viable neurons by microglia activated with LPS or Aβ is dependent on calreticulin/LRP phagocytic signalling

(2012) Michael Fricker et al.   Journal of Neuroinflammation

Calpains Are Downstream Effectors of bax-Dependent Excitotoxic Apoptosis

(2012) B. D'Orsi et al.   JOURNAL OF NEUROSCIENCE

Extracellular Alpha-Synuclein Oligomers Modulate Synaptic Transmission and Impair LTP Via NMDA-Receptor Activation

(2012) M. J. Diogenes et al.   JOURNAL OF NEUROSCIENCE

MFG-E8 Mediates Primary Phagocytosis of Viable Neurons during Neuroinflammation

(2012) M. Fricker et al.   JOURNAL OF NEUROSCIENCE

Sialic Acid on the Neuronal Glycocalyx Prevents Complement C1 Binding and Complement Receptor-3-Mediated Removal by Microglia

(2012) B. Linnartz et al.   JOURNAL OF NEUROSCIENCE

A Caspase Cascade Regulating Developmental Axon Degeneration

(2012) D. J. Simon et al.   JOURNAL OF NEUROSCIENCE

Activation of Neuronal NMDA Receptors Induces Superoxide-Mediated Oxidative Stress in Neighboring Neurons and Astrocytes

(2012) R. C. Reyes et al.   JOURNAL OF NEUROSCIENCE

DNase activation by hypoxia–acidosis parallels but is independent of programmed cell death

(2012) John W. Thompson et al.   LIFE SCIENCES

Poly(ADP-ribose) Polymerase-1 in Amyloid Beta Toxicity and Alzheimer's Disease

(2012) Joanna B. Strosznajder et al.   MOLECULAR NEUROBIOLOGY

Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway

(2012) Keiichi Inoue et al.   Molecular Neurodegeneration

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

(2012) Thorlakur Jonsson et al.   NATURE

Intrinsically determined cell death of developing cortical interneurons

(2012) Derek G. Southwell et al.   NATURE

Apoptotic and non-apoptotic roles of caspases in neuronal physiology and pathophysiology

(2012) Bradley T. Hyman et al.   NATURE REVIEWS NEUROSCIENCE

Combined inhibition of cell death induced by apoptosis inducing factor and caspases provides additive neuroprotection in experimental traumatic brain injury

(2012) Chun-Shu Piao et al.   NEUROBIOLOGY OF DISEASE

AIF, reactive oxygen species, and neurodegeneration: A “complex” problem

(2012) Brian M. Polster   NEUROCHEMISTRY INTERNATIONAL

Cyclin D1 Induction Preceding Neuronal Death via the Excitotoxic NMDA Pathway Involves Selective Stimulation of Extrasynaptic NMDA Receptors and JNK Pathway

(2012) L. Efthimiadi et al.   Neurodegenerative Diseases

Necrostatin-1 attenuates mitochondrial dysfunction in neurons and astrocytes following neonatal hypoxia–ischemia

(2012) R. Chavez-Valdez et al.   NEUROSCIENCE

A BAX/BAK and Cyclophilin D-Independent Intrinsic Apoptosis Pathway

(2012) Sebastián Zamorano et al.   PLoS One

The JNK- and AKT/GSK3β- Signaling Pathways Converge to Regulate Puma Induction and Neuronal Apoptosis Induced by Trophic Factor Deprivation

(2012) Kristin K. Ambacher et al.   PLoS One

dSarm/Sarm1 Is Required for Activation of an Injury-Induced Axon Death Pathway

(2012) J. M. Osterloh et al.   SCIENCE

The DNA Replication Stress Hypothesis of Alzheimer’s Disease

(2012) Yuri B. Yurov et al.   TheScientificWorldJOURNAL

Membrane Trafficking Pathways in Alzheimer's Disease

(2012) Lawrence Rajendran et al.   TRAFFIC

The restricted binding repertoire of Bcl-B leaves Bim as the universal BH3-only prosurvival Bcl-2 protein antagonist

(2012) G J P Rautureau et al.   Cell Death & Disease

Caspase-1: is IL-1 just the tip of the ICEberg?

(2012) A Denes et al.   Cell Death & Disease

Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models

(2012) N Takahashi et al.   Cell Death & Disease

ROCK/Cdc42-mediated microglial motility and gliapse formation lead to phagocytosis of degenerating dopaminergic neurons in vivo

(2012) Carlos Barcia et al.   Scientific Reports

LC3-Associated Phagocytosis (LAP): Connections with Host Autophagy

(2012) Shu-chin Lai et al.   Cells

Stages of granulovacuolar degeneration: their relation to Alzheimer’s disease and chronic stress response

(2011) Dietmar Rudolf Thal et al.   ACTA NEUROPATHOLOGICA

Dual modification of Alzheimer’s disease PHF-tau protein by lysine methylation and ubiquitylation: a mass spectrometry approach

(2011) Stefani N. Thomas et al.   ACTA NEUROPATHOLOGICA

NADPH Oxidase 1-Mediated Oxidative Stress Leads to Dopamine Neuron Death in Parkinson's Disease

(2011) Dong-Hee Choi et al.   ANTIOXIDANTS & REDOX SIGNALING

Perfusion computer tomography: imaging and clinical validation in acute ischaemic stroke

(2011) Andrew Bivard et al.   BRAIN

Mouse models of Alzheimer's disease

(2011) Alicia M. Hall et al.   BRAIN RESEARCH BULLETIN

Autophagy promotes survival of retinal ganglion cells after optic nerve axotomy in mice

(2011) N Rodríguez-Muela et al.   CELL DEATH AND DIFFERENTIATION

Can the analysis of BH3-only protein knockout mice clarify the issue of ‘direct versus indirect’ activation of Bax and Bak?

(2011) A Villunger et al.   CELL DEATH AND DIFFERENTIATION

Bax dimerizes via a symmetric BH3:groove interface during apoptosis

(2011) G Dewson et al.   CELL DEATH AND DIFFERENTIATION

Tau Oligomers as Potential Targets for Immunotherapy for Alzheimers Disease and Tauopathies

(2011) C. A. Lasagna-Reeves et al.   Current Alzheimer Research

FTD and ALS: A Tale of Two Diseases

(2011) R. Ferrari et al.   Current Alzheimer Research

An angiogenic inhibitor, cyclic RGDfV, attenuates MPTP-induced dopamine neuron toxicity

(2011) Aditiben Patel et al.   EXPERIMENTAL NEUROLOGY

AIF-mediated caspase-independent necroptosis: A new chance for targeted therapeutics

(2011) Laure Delavallée et al.   IUBMB LIFE

24(S)-Hydroxycholesterol Induces Neuronal Cell Death through Necroptosis, a Form of Programmed Necrosis

(2011) Kazunori Yamanaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuronal Death Induced by Nanomolar Amyloid β Is Mediated by Primary Phagocytosis of Neurons by Microglia

(2011) Urte Neniskyte et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The toxicity of tau in Alzheimer disease: turnover, targets and potential therapeutics

(2011) Susanne M. Pritchard et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

In vivo Contributions of BH3-Only Proteins to Neuronal Death Following Seizures, Ischemia, and Traumatic Brain Injury

(2011) Tobias Engel et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Inhibition of Microglial Phagocytosis Is Sufficient To Prevent Inflammatory Neuronal Death

(2011) J. J. Neher et al.   JOURNAL OF IMMUNOLOGY

Akt Suppresses Retrograde Degeneration of Dopaminergic Axons by Inhibition of Macroautophagy

(2011) H.-C. Cheng et al.   JOURNAL OF NEUROSCIENCE

The Mitochondrial Permeability Transition Pore Regulates Nitric Oxide-Mediated Apoptosis of Neurons Induced by Target Deprivation

(2011) L. J. Martin et al.   JOURNAL OF NEUROSCIENCE

Glutaminase Dysregulation in HIV-1-Infected Human Microglia Mediates Neurotoxicity: Relevant to HIV-1-Associated Neurocognitive Disorders

(2011) Y. Huang et al.   JOURNAL OF NEUROSCIENCE

Soluble A  Oligomers Inhibit Long-Term Potentiation through a Mechanism Involving Excessive Activation of Extrasynaptic NR2B-Containing NMDA Receptors

(2011) S. Li et al.   JOURNAL OF NEUROSCIENCE

Alzheimer's disease

(2011) Clive Ballard et al.   LANCET

There is no evidence that mitochondria are the main source of reactive oxygen species in mammalian cells

(2011) Guy C. Brown et al.   MITOCHONDRION

RIP3 mediates the embryonic lethality of caspase-8-deficient mice

(2011) William J. Kaiser et al.   NATURE

Catalytic activity of the caspase-8–FLIPL complex inhibits RIPK3-dependent necrosis

(2011) Andrew Oberst et al.   NATURE

Functional complementation between FADD and RIP1 in embryos and lymphocytes

(2011) Haibing Zhang et al.   NATURE

Caspase signalling controls microglia activation and neurotoxicity

(2011) Miguel A. Burguillos et al.   NATURE

Heterogeneity of CNS myeloid cells and their roles in neurodegeneration

(2011) Marco Prinz et al.   NATURE NEUROSCIENCE

Mitotic catastrophe: a mechanism for avoiding genomic instability

(2011) Ilio Vitale et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Canonical and non-canonical autophagy: variations on a common theme of self-eating?

(2011) Patrice Codogno et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Calpastatin modulates APP processing in the brains of β-amyloid depositing but not wild-type mice

(2011) Jose Morales-Corraliza et al.   NEUROBIOLOGY OF AGING

Prevention of Motor Neuron Degeneration by Novel Iron Chelators in SOD1G93A Transgenic Mice of Amyotrophic Lateral Sclerosis

(2011) Qian Wang et al.   Neurodegenerative Diseases

Role of apoptosis inducing factor (AIF) for hippocampal neuronal cell death following global cerebral ischemia in mice

(2011) Simone E. Thal et al.   NEUROSCIENCE LETTERS

Neuronal Autophagy as a Mediator of Life and Death

(2011) Julien Puyal et al.   NEUROSCIENTIST

Role of Cell Cycle Re-Entry in Neurons: A Common Apoptotic Mechanism of Neuronal Cell Death

(2011) Jaume Folch et al.   NEUROTOXICITY RESEARCH

Neuronal Deletion of Caspase 8 Protects against Brain Injury in Mouse Models of Controlled Cortical Impact and Kainic Acid-Induced Excitotoxicity

(2011) Maryla Krajewska et al.   PLoS One

Poly(ADP-Ribose) (PAR) Binding to Apoptosis-Inducing Factor Is Critical for PAR Polymerase-1-Dependent Cell Death (Parthanatos)

(2011) Y. Wang et al.   Science Signaling

Molecular Pathophysiology of Cerebral Hemorrhage

(2011) Jaroslaw Aronowski et al.   STROKE

The acetylation of tau inhibits its function and promotes pathological tau aggregation

(2011) Todd J. Cohen et al.   Nature Communications

The roles of amyloid precursor protein (APP) in neurogenesis

(2011) Zhi-dong Zhou et al.   Cell Adhesion & Migration

Altered longevity-assurance activity of p53:p44 in the mouse causes memory loss, neurodegeneration and premature death

(2010) Mariana Pehar et al.   AGING CELL

Evidence for the Involvement of Apoptosis-Inducing Factor–Mediated Caspase-Independent Neuronal Death in Alzheimer Disease

(2010) Wenfeng Yu et al.   AMERICAN JOURNAL OF PATHOLOGY

Lysosomal membrane permeabilization in Parkinson disease

(2010) Miquel Vila et al.   Autophagy

Calpain-mediated Hsp70.1 cleavage in hippocampal CA1 neuronal death

(2010) Shunya Sahara et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Acute NMDA toxicity in cultured rat cerebellar granule neurons is accompanied by autophagy induction and late onset autophagic cell death phenotype

(2010) Shankar Sadasivan et al.   BMC NEUROSCIENCE

The role of PARP activation in glutamate-induced necroptosis in HT-22 cells

(2010) Xingshun Xu et al.   BRAIN RESEARCH

Motor neuron trophic factors: Therapeutic use in ALS?

(2010) Thomas W. Gould et al.   BRAIN RESEARCH REVIEWS

Mechanisms Underlying Inflammation in Neurodegeneration

(2010) Christopher K. Glass et al.   CELL

Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations

(2010) Ju-Hyun Lee et al.   CELL

Cyclin-C-dependent cell-cycle entry is required for activation of non-homologous end joining DNA repair in postmitotic neurons

(2010) A Tomashevski et al.   CELL DEATH AND DIFFERENTIATION

Kainate-Mediated Excitotoxicity Induces Neuronal Death in the Rat Spinal Cord In Vitro via a PARP-1 Dependent Cell Death Pathway (Parthanatos)

(2010) Anujaianthi Kuzhandaivel et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Apoptosis-Inducing Factor and Cyclophilin A Cotranslocate to the Motor Neuronal Nuclei in Amyotrophic Lateral Sclerosis Model Mice

(2010) Hirotaka Tanaka et al.   CNS Neuroscience & Therapeutics

Calcium Signaling and Amyloid Toxicity in Alzheimer Disease

(2010) Angelo Demuro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AMP kinase–mediated activation of the BH3-only protein Bim couples energy depletion to stress-induced apoptosis

(2010) Caoimhín G. Concannon et al.   JOURNAL OF CELL BIOLOGY

Regulation of the Apaf-1-caspase-9 apoptosome

(2010) S. B. Bratton et al.   JOURNAL OF CELL SCIENCE

Nadph Oxidase Mediates Striatal Neuronal Injury after Transient Global Cerebral Ischemia

(2010) Hideyuki Yoshioka et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Increased Nuclear Apoptosis-Inducing Factor after Transient Focal Ischemia: A 12/15-Lipoxygenase-dependent Organelle Damage Pathway

(2010) Stefanie Pallast et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Implication of TAp73 in the p53-independent pathway of Puma induction and Puma-dependent apoptosis in primary cortical neurons

(2010) Michael Fricker et al.   JOURNAL OF NEUROCHEMISTRY

Contributions of poly(ADP-ribose) polymerase-1 and -2 to nuclear translocation of apoptosis-inducing factor and injury from focal cerebral ischemia

(2010) Xiaoling Li et al.   JOURNAL OF NEUROCHEMISTRY

Gp91phox (NOX2) in classically activated microglia exacerbates traumatic brain injury

(2010) Kenji Dohi et al.   Journal of Neuroinflammation

Alleviation of Neurotoxicity by Microglial Human Siglec-11

(2010) Y. Wang et al.   JOURNAL OF NEUROSCIENCE

Suppression of the Intrinsic Apoptosis Pathway by Synaptic Activity

(2010) F. Leveille et al.   JOURNAL OF NEUROSCIENCE

NAD+ Depletion Is Necessary and Sufficient forPoly(ADP-Ribose) Polymerase-1-Mediated Neuronal Death

(2010) C. C. Alano et al.   JOURNAL OF NEUROSCIENCE

Pathogenic Lysosomal Depletion in Parkinson's Disease

(2010) B. Dehay et al.   JOURNAL OF NEUROSCIENCE

Small-Molecule Biomarkers for Clinical PET Imaging of Apoptosis

(2010) A. Reshef et al.   JOURNAL OF NUCLEAR MEDICINE

Effects of cyclosporine A and its immunosuppressive or non-immunosuppressive derivatives [D-Ser]8-CsA and Cs9 on mitochondria from different brain regions

(2010) Zemfira Z. Gizatullina et al.   MITOCHONDRION

BH3-Triggered Structural Reorganization Drives the Activation of Proapoptotic BAX

(2010) Evripidis Gavathiotis et al.   MOLECULAR CELL

Calcium-dependent phospholipid scrambling by TMEM16F

(2010) Jun Suzuki et al.   NATURE

Treatment of cerebral ischemia by disrupting ischemia-induced interaction of nNOS with PSD-95

(2010) Li Zhou et al.   NATURE MEDICINE

Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer's disease

(2010) Martin Fuhrmann et al.   NATURE NEUROSCIENCE

Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease

(2010) Marcello D'Amelio et al.   NATURE NEUROSCIENCE

Apoptosis-inducing factor mediates dopaminergic cell death in response to LPS-induced inflammatory stimulusEvidence in Parkinson's disease patients

(2010) M.A. Burguillos et al.   NEUROBIOLOGY OF DISEASE

Post-treatment of Bax-inhibiting peptide reduces neuronal death and behavioral deficits following global cerebral ischemia

(2010) Bojun Han et al.   NEUROCHEMISTRY INTERNATIONAL

Granulovacuolar degeneration (GVD) bodies of Alzheimer's disease (AD) resemble late-stage autophagic organelles

(2010) K. E. Funk et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Loss of tau elicits axonal degeneration in a mouse model of Alzheimer's disease

(2010) H.N. Dawson et al.   NEUROSCIENCE

Persistent oxygen-glucose deprivation induces astrocytic death through two different pathways and calpain-mediated proteolysis of cytoskeletal proteins during astrocytic oncosis

(2010) Xu Cao et al.   NEUROSCIENCE LETTERS

Nitric oxide and neuronal death

(2010) Guy C. Brown   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease

(2010) M. M. Lipinski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential roles of phospholipases A2 in neuronal death and neurogenesis: Implications for Alzheimer disease

(2010) Evelin L. Schaeffer et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Preclinical and clinical research on inflammation after intracerebral hemorrhage

(2010) Jian Wang   PROGRESS IN NEUROBIOLOGY

BID, BIM, and PUMA Are Essential for Activation of the BAX- and BAK-Dependent Cell Death Program

(2010) D. Ren et al.   SCIENCE

Phosphorylation of Puma modulates its apoptotic function by regulating protein stability

(2010) M Fricker et al.   Cell Death & Disease

Post-Stroke Inhibition of Induced NADPH Oxidase Type 4 Prevents Oxidative Stress and Neurodegeneration

(2010) Christoph Kleinschnitz et al.   PLOS BIOLOGY

Endogenous Nmnat2 Is an Essential Survival Factor for Maintenance of Healthy Axons

(2010) Jonathan Gilley et al.   PLOS BIOLOGY

Persistent cleavage and nuclear translocation of apoptosis-inducing factor in motor neurons in the spinal cord of sporadic amyotrophic lateral sclerosis patients

(2009) Noriyuki Shibata et al.   ACTA NEUROPATHOLOGICA

Mitochondrial permeability transition pore in Alzheimer's disease: Cyclophilin D and amyloid beta

(2009) Heng Du et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Caspase substrates and neurodegenerative diseases

(2009) Natasa Bulat et al.   BRAIN RESEARCH BULLETIN

Necroptosis, necrosis and secondary necrosis converge on similar cellular disintegration features

(2009) T Vanden Berghe et al.   CELL DEATH AND DIFFERENTIATION

From the Gla domain to a novel small-molecule detector of apoptosis

(2009) Avi Cohen et al.   CELL RESEARCH

Beta amyloid peptide: from different aggregation forms to the activation of different biochemical pathways

(2009) Marta Di Carlo   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Molecular imaging of neurodegeneration by a novel cross-disease biomarker

(2009) Anat Shirvan et al.   EXPERIMENTAL NEUROLOGY

Calcium dysregulation induces apoptosis-inducing factor release: Cross-talk between PARP-1- and calpain- signaling pathways

(2009) Peter S. Vosler et al.   EXPERIMENTAL NEUROLOGY

Role of cyclophilin D-dependent mitochondrial permeability transition in glutamate-induced calcium deregulation and excitotoxic neuronal death

(2009) Viacheslav Li et al.   EXPERIMENTAL NEUROLOGY

AIP-1 ameliorates β-amyloid peptide toxicity in a Caenorhabditis elegans Alzheimer's disease model

(2009) Wail M. Hassan et al.   HUMAN MOLECULAR GENETICS

Reversible Cyclosporin A-sensitive Mitochondrial Depolarization Occurs within Minutes of Stroke Onset in Mouse Somatosensory Cortexin Vivo

(2009) Ran R. Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

WldSrequires Nmnat1 enzymatic activity and N16–VCP interactions to suppress Wallerian degeneration

(2009) Michelle A. Avery et al.   JOURNAL OF CELL BIOLOGY

WldSprotein requires Nmnat activity and a short N-terminal sequence to protect axons in mice

(2009) Laura Conforti et al.   JOURNAL OF CELL BIOLOGY

In vitroglutaminase regulation and mechanisms of glutamate generation in HIV-1-infected macrophage

(2009) Nathan Erdmann et al.   JOURNAL OF NEUROCHEMISTRY

Relationship between microglial activation and dopaminergic neuronal loss in the substantia nigra: a time course study in a 6-hydroxydopamine model of Parkinson’s disease

(2009) Lilia Marinova-Mutafchieva et al.   JOURNAL OF NEUROCHEMISTRY

Neuronal and glial tau pathology in early frontotemporal lobar degeneration-tau, Pick's disease subtype

(2009) Maya Mimuro et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Stepwise Activation of BAX and BAK by tBID, BIM, and PUMA Initiates Mitochondrial Apoptosis

(2009) Hyungjin Kim et al.   MOLECULAR CELL

APP binds DR6 to trigger axon pruning and neuron death via distinct caspases

(2009) Anatoly Nikolaev et al.   NATURE

The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C–Cdh1

(2009) Angel Herrero-Mendez et al.   NATURE CELL BIOLOGY

NADPH oxidase is the primary source of superoxide induced by NMDA receptor activation

(2009) Angela M Brennan et al.   NATURE NEUROSCIENCE

Mitochondrial membrane permeabilization in neuronal injury

(2009) Lorenzo Galluzzi et al.   NATURE REVIEWS NEUROSCIENCE

Genetic iron chelation protects against proteasome inhibition-induced dopamine neuron degeneration

(2009) Wen Zhu et al.   NEUROBIOLOGY OF DISEASE

Heterogeneity of microglia and TNF signaling as determinants for neuronal death or survival

(2009) Andrew D. Kraft et al.   NEUROTOXICOLOGY

The role of lysosomal rupture in neuronal death

(2009) Tetsumori Yamashima et al.   PROGRESS IN NEUROBIOLOGY

A Recessive Mutation in the APP Gene with Dominant-Negative Effect on Amyloidogenesis

(2009) G. Di Fede et al.   SCIENCE

Apoptotic Mechanisms After Cerebral Ischemia

(2009) Brad R.S. Broughton et al.   STROKE

Causal Role of Apoptosis-Inducing Factor for Neuronal Cell Death Following Traumatic Brain Injury

(2008) Jennifer E. Slemmer et al.   AMERICAN JOURNAL OF PATHOLOGY

Inhibition of Autophagy Prevents Hippocampal Pyramidal Neuron Death after Hypoxic-Ischemic Injury

(2008) Masato Koike et al.   AMERICAN JOURNAL OF PATHOLOGY

Regulation of apoptosis by the redox state of cytochrome c

(2008) Guy C. Brown et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Selective neuronal loss in rescued penumbra relates to initial hypoperfusion

(2008) J. V. Guadagno et al.   BRAIN

Staging of Neurofibrillary Pathology in Alzheimer's Disease: A Study of the BrainNet Europe Consortium

(2008) Irina Alafuzoff et al.   BRAIN PATHOLOGY

Caspases indirectly regulate cleavage of the mitochondrial fusion GTPase OPA1 in neurons undergoing apoptosis

(2008) F. Alexandra Loucks et al.   BRAIN RESEARCH

Membrane Binding by tBid Initiates an Ordered Series of Events Culminating in Membrane Permeabilization by Bax

(2008) Jonathan F. Lovell et al.   CELL

The autophagic machinery is necessary for removal of cell corpses from the developing retinal neuroepithelium

(2008) M A Mellén et al.   CELL DEATH AND DIFFERENTIATION

Bid-induced release of AIF from mitochondria causes immediate neuronal cell death

(2008) S Landshamer et al.   CELL DEATH AND DIFFERENTIATION

Death through a tragedy: mitotic catastrophe

(2008) H Vakifahmetoglu et al.   CELL DEATH AND DIFFERENTIATION

Autophagosome-Independent Essential Function for the Autophagy Protein Atg5 in Cellular Immunity to Intracellular Pathogens

(2008) Zijiang Zhao et al.   Cell Host & Microbe

Glutathione Peroxidase 4 Senses and Translates Oxidative Stress into 12/15-Lipoxygenase Dependent- and AIF-Mediated Cell Death

(2008) Alexander Seiler et al.   Cell Metabolism

Synthetic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer Cells

(2008) Wan Seok Yang et al.   CHEMISTRY & BIOLOGY

Signaling by death receptors in the nervous system

(2008) Georg Haase et al.   CURRENT OPINION IN NEUROBIOLOGY

TheWldSgene delays axonal but not somatic degeneration in a rat glaucoma model

(2008) Bogdan Beirowski et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Impaired ERAD and ER stress are early and specific events in polyglutamine toxicity

(2008) M. L. Duennwald et al.   GENES & DEVELOPMENT

Inhibition of Apoptosome Activation Protects Injured Motor Neurons from Cell Death

(2008) Anish Kumar Kanungo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Necrostatin-1 Reduces Histopathology and Improves Functional Outcome after Controlled Cortical Impact in Mice

(2008) Zerong You et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

A role for p53 in the regulation of lysosomal permeability by Δ9-tetrahydrocannabinol in rat cortical neurones: implications for neurodegeneration

(2008) Aoife Gowran et al.   JOURNAL OF NEUROCHEMISTRY

Lysosomal release of cathepsins causes ischemic damage in the rat hippocampal slice and depends on NMDA-mediated calcium influx, arachidonic acid metabolism, and free radical production

(2008) James A. Windelborn et al.   JOURNAL OF NEUROCHEMISTRY

TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease

(2008) Melissa K McCoy et al.   Journal of Neuroinflammation

Developing Postmitotic Mammalian Neurons In Vivo Lacking Apaf-1 Undergo Programmed Cell Death by a Caspase-Independent, Nonapoptotic Pathway Involving Autophagy

(2008) R. W. Oppenheim et al.   JOURNAL OF NEUROSCIENCE

Marked Calpastatin (CAST) Depletion in Alzheimer's Disease Accelerates Cytoskeleton Disruption and Neurodegeneration: Neuroprotection by CAST Overexpression

(2008) M. V. Rao et al.   JOURNAL OF NEUROSCIENCE

Disruption of Bax Protein Prevents Neuronal Cell Death but Produces Cognitive Impairment in Mice following Traumatic Brain Injury

(2008) Roya Tehranian et al.   JOURNAL OF NEUROTRAUMA

Molecular Imaging of Neurovascular Cell Death in Experimental Cerebral Stroke by PET

(2008) A. Reshef et al.   JOURNAL OF NUCLEAR MEDICINE

BAX activation is initiated at a novel interaction site

(2008) Evripidis Gavathiotis et al.   NATURE

NAD synthase NMNAT acts as a chaperone to protect against neurodegeneration

(2008) R. Grace Zhai et al.   NATURE

Glucose metabolism inhibits apoptosis in neurons and cancer cells by redox inactivation of cytochrome c

(2008) Allyson E. Vaughn et al.   NATURE CELL BIOLOGY

Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease

(2008) Heng Du et al.   NATURE MEDICINE

A role for p53 in the β-amyloid-mediated regulation of the lysosomal system

(2008) Marie P. Fogarty et al.   NEUROBIOLOGY OF AGING

Necroptosis contributes to the NMDA-induced excitotoxicity in rat’s cultured cortical neurons

(2008) Yanli Li et al.   NEUROSCIENCE LETTERS

Improvement in behavioural symptoms in patients with moderate to severe Alzheimer's disease by memantine: a pooled data analysis

(2007) S. Gauthier et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

The BCL-2 protein family: opposing activities that mediate cell death

(2007) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Characteristics of the Calcium-Triggered Mitochondrial Permeability Transition in Nonsynaptic Brain Mitochondria

(2003) Tibor Kristián et al.   JOURNAL OF NEUROCHEMISTRY