标题
TREM2 variants: new keys to decipher Alzheimer disease pathogenesis
作者
关键词
-
出版物
NATURE REVIEWS NEUROSCIENCE
Volume 17, Issue 4, Pages 201-207
出版商
Springer Nature
发表日期
2016-02-25
DOI
10.1038/nrn.2016.7
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- TREM2 regulates microglial cell activation in response to demyelination in vivo
- (2015) Claudia Cantoni et al. ACTA NEUROPATHOLOGICA
- The role of TREM2 R47H as a risk factor for Alzheimer's disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and Parkinson's disease
- (2015) Christina M. Lill et al. Alzheimers & Dementia
- ATREM1variant alters the accumulation of Alzheimer-related amyloid pathology
- (2015) Joseph M. Replogle et al. ANNALS OF NEUROLOGY
- TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model
- (2015) Yaming Wang et al. CELL
- TREM2 enables amyloid β clearance by microglia
- (2015) Serge Rivest CELL RESEARCH
- Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2)
- (2015) Yuka Atagi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Triggering Receptor Expressed on Myeloid Cells 2 Binds Apolipoprotein E
- (2015) Charles C. Bailey et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- TREM2 sustains microglial expansion during aging and response to demyelination
- (2015) Pietro Luigi Poliani et al. JOURNAL OF CLINICAL INVESTIGATION
- TREM-2 promotes macrophage survival and lung disease after respiratory viral infection
- (2015) Kangyun Wu et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Replacement of brain-resident myeloid cells does not alter cerebral amyloid-β deposition in mouse models of Alzheimer’s disease
- (2015) Nicholas H. Varvel et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Impact of peripheral myeloid cells on amyloid-β pathology in Alzheimer’s disease–like mice
- (2015) Stefan Prokop et al. JOURNAL OF EXPERIMENTAL MEDICINE
- TREM2 deficiency eliminates TREM2+inflammatory macrophages and ameliorates pathology in Alzheimer’s disease mouse models
- (2015) Taylor R. Jay et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) Deficiency Attenuates Phagocytic Activities of Microglia and Exacerbates Ischemic Damage in Experimental Stroke
- (2015) M. Kawabori et al. JOURNAL OF NEUROSCIENCE
- Innate immunity in Alzheimer's disease
- (2015) Michael T Heneka et al. NATURE IMMUNOLOGY
- CD33 modulates TREM2: convergence of Alzheimer loci
- (2015) Gail Chan et al. NATURE NEUROSCIENCE
- RNA-sequencing reveals transcriptional up-regulation of Trem2 in response to bexarotene treatment
- (2015) Iliya Lefterov et al. NEUROBIOLOGY OF DISEASE
- TREM2 and Risk of Alzheimer’s Disease — Friend or Foe?
- (2015) Rudolph E. Tanzi NEW ENGLAND JOURNAL OF MEDICINE
- Myeloid Cells in Alzheimer's Disease: Culprits, Victims or Innocent Bystanders?
- (2015) Melanie Meyer-Luehmann et al. TRENDS IN NEUROSCIENCES
- Microglia in Health and Disease
- (2015) Richard M. Ransohoff et al. Cold Spring Harbor Perspectives in Biology
- Targeting miR-155 restores abnormal microglia and attenuates disease in SOD1 mice
- (2014) Oleg Butovsky et al. ANNALS OF NEUROLOGY
- The active enhancer network operated by liganded RXR supports angiogenic activity in macrophages
- (2014) B. Daniel et al. GENES & DEVELOPMENT
- TREM2 VARIANTS INCREASE RISK OF TYPICAL EARLY-ONSET ALZHEIMER'S DISEASE BUT NOT OF PRION OR FRONTOTEMPORAL DEMENTIA
- (2014) C. Slattery et al. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
- An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex
- (2014) Y. Zhang et al. JOURNAL OF NEUROSCIENCE
- Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2
- (2014) Jason D Ulrich et al. Molecular Neurodegeneration
- Homozygous TREM2 mutation in a family with atypical frontotemporal dementia
- (2014) Isabelle Le Ber et al. NEUROBIOLOGY OF AGING
- Investigation of the role of rare TREM2 variants in frontotemporal dementia subtypes
- (2014) Mathias Thelen et al. NEUROBIOLOGY OF AGING
- Upregulation of TREM2 Ameliorates Neuropathology and Rescues Spatial Cognitive Impairment in a Transgenic Mouse Model of Alzheimer’s Disease
- (2014) Teng Jiang et al. NEUROPSYCHOPHARMACOLOGY
- TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis
- (2014) G. Kleinberger et al. Science Translational Medicine
- TREM2Variant p.R47H as a Risk Factor for Sporadic Amyotrophic Lateral Sclerosis
- (2014) Janet Cady et al. JAMA Neurology
- Homeostatic and injury-induced microglia behavior in the aging brain
- (2013) Jasmin K. Hefendehl et al. AGING CELL
- Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease
- (2013) Bin Zhang et al. CELL
- Sequential Proteolytic Processing of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) Protein by Ectodomain Shedding and γ-Secretase-dependent Intramembranous Cleavage
- (2013) Patrick Wunderlich et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson’s disease
- (2013) Sruti Rayaprolu et al. Molecular Neurodegeneration
- CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology
- (2013) Elizabeth M Bradshaw et al. NATURE NEUROSCIENCE
- Identification of a unique TGF-β–dependent molecular and functional signature in microglia
- (2013) Oleg Butovsky et al. NATURE NEUROSCIENCE
- The microglial sensome revealed by direct RNA sequencing
- (2013) Suzanne E Hickman et al. NATURE NEUROSCIENCE
- TREM2 mutations are rare in a French cohort of patients with frontotemporal dementia
- (2013) Serena Lattante et al. NEUROBIOLOGY OF AGING
- Insights into TREM2 biology by network analysis of human brain gene expression data
- (2013) Paola Forabosco et al. NEUROBIOLOGY OF AGING
- A novel compound heterozygous mutation in TREM2 found in a Turkish frontotemporal dementia-like family
- (2013) Rita Guerreiro et al. NEUROBIOLOGY OF AGING
- TREM2 is associated with the risk of Alzheimer's disease in Spanish population
- (2013) Bruno A. Benitez et al. NEUROBIOLOGY OF AGING
- No association of the LRRK2 genetic variants with Alzheimer's disease in Han Chinese individuals
- (2013) Rui Bi et al. NEUROBIOLOGY OF AGING
- Heterozygous TREM2 mutations in frontotemporal dementia
- (2013) Barbara Borroni et al. NEUROBIOLOGY OF AGING
- Investigating the role of rare heterozygous TREM2 variants in Alzheimer's disease and frontotemporal dementia
- (2013) Elise Cuyvers et al. NEUROBIOLOGY OF AGING
- Missense variant in TREML2 protects against Alzheimer's disease
- (2013) Bruno A. Benitez et al. NEUROBIOLOGY OF AGING
- Alzheimer’s Disease Risk Gene CD33 Inhibits Microglial Uptake of Amyloid Beta
- (2013) Ana Griciuc et al. NEURON
- TREM2 and Neurodegenerative Disease
- (2013) NEW ENGLAND JOURNAL OF MEDICINE
- Attenuated Inflammatory Response in Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) Knock-Out Mice following Stroke
- (2013) Matthias W. Sieber et al. PLoS One
- The Genetics of Alzheimer Disease
- (2013) R. E. Tanzi Cold Spring Harbor Perspectives in Medicine
- Using Exome Sequencing to Reveal Mutations in TREM2 Presenting as a Frontotemporal Dementia–like Syndrome Without Bone Involvement
- (2013) Rita João Guerreiro et al. JAMA Neurology
- Development and homeostasis of “resident” myeloid cells: The case of the microglia
- (2012) Elisa Gomez Perdiguero et al. GLIA
- Regulation of microglia development and homeostasis
- (2012) Melanie Greter et al. GLIA
- TREM2 and -Catenin Regulate Bone Homeostasis by Controlling the Rate of Osteoclastogenesis
- (2012) K. Otero et al. JOURNAL OF IMMUNOLOGY
- Variant of TREM2 Associated with the Risk of Alzheimer's Disease
- (2012) Thorlakur Jonsson et al. NEW ENGLAND JOURNAL OF MEDICINE
- TREM2 Variants in Alzheimer's Disease
- (2012) Rita Guerreiro et al. NEW ENGLAND JOURNAL OF MEDICINE
- Microglial repopulation model reveals a robust homeostatic process for replacing CNS myeloid cells
- (2012) N. H. Varvel et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Specific lipid recognition is a general feature of CD300 and TREM molecules
- (2011) John P. Cannon et al. IMMUNOGENETICS
- Distinct and Non-Redundant Roles of Microglia and Myeloid Subsets in Mouse Models of Alzheimer's Disease
- (2011) A. Mildner et al. JOURNAL OF NEUROSCIENCE
- Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease
- (2011) Adam C Naj et al. NATURE GENETICS
- Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease
- (2011) Paul Hollingworth et al. NATURE GENETICS
- Alzheimer's Disease: The Challenge of the Second Century
- (2011) D. M. Holtzman et al. Science Translational Medicine
- Dual Induction of TREM2 and Tolerance-Related Transcript, Tmem176b, in Amyloid Transgenic Mice: Implications for Vaccine-Based Therapies for Alzheimer's Disease
- (2010) Benoit Melchior et al. ASN Neuro
- TREM2- and DAP12-Dependent Activation of PI3K Requires DAP10 and Is Inhibited by SHIP1
- (2010) Q. Peng et al. Science Signaling
- Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer’s disease
- (2009) Wolfgang J. Streit et al. ACTA NEUROPATHOLOGICA
- TREM and TREM-like receptors in inflammation and disease
- (2009) Jill W Ford et al. CURRENT OPINION IN IMMUNOLOGY
- TREM-2 (triggering receptor expressed on myeloid cells 2) is a phagocytic receptor for bacteria
- (2009) Elsa-Noah N'Diaye et al. JOURNAL OF CELL BIOLOGY
- Inhibition of RANK Expression and Osteoclastogenesis by TLRs and IFN- in Human Osteoclast Precursors
- (2009) J.-D. Ji et al. JOURNAL OF IMMUNOLOGY
- A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia
- (2009) Christine L. Hsieh et al. JOURNAL OF NEUROCHEMISTRY
- The surface-exposed chaperone, Hsp60, is an agonist of the microglial TREM2 receptor
- (2009) Luisa Stefano et al. JOURNAL OF NEUROCHEMISTRY
- Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease
- (2009) Jean-Charles Lambert et al. NATURE GENETICS
- Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease
- (2009) Denise Harold et al. NATURE GENETICS
- Macrophage colony-stimulating factor induces the proliferation and survival of macrophages via a pathway involving DAP12 and β-catenin
- (2009) Karel Otero et al. NATURE IMMUNOLOGY
- Genome-wide Association Analysis Reveals Putative Alzheimer's Disease Susceptibility Loci in Addition to APOE
- (2008) Lars Bertram et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Identification of soluble TREM-2 in the cerebrospinal fluid and its association with multiple sclerosis and CNS inflammation
- (2008) Laura Piccio et al. BRAIN
- Efficient colonic mucosal wound repair requires Trem2 signaling
- (2008) H. Seno et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started