Wallerian degeneration: an emerging axon death pathway linking injury and disease

Transcriptomic indices of fast and slow disease progression in two mouse models of amyotrophic lateral sclerosis

(2013) Giovanni Nardo et al.   BRAIN

Vesicular Glycolysis Provides On-Board Energy for Fast Axonal Transport

(2013) Diana Zala et al.   CELL

Efficient Retrograde Transport of Pseudorabies Virus within Neurons Requires Local Protein Synthesis in Axons

(2013) Orkide O. Koyuncu et al.   Cell Host & Microbe

The challenges of axon survival: Introduction to the special issue on axonal degeneration

(2013) Michael P. Coleman   EXPERIMENTAL NEUROLOGY

NAD+ acts on mitochondrial SirT3 to prevent axonal caspase activation and axonal degeneration

(2013) Sébastien Magnifico et al.   FASEB JOURNAL

Diversification of NAD biological role : the importance of location

(2013) Michele Di Stefano et al.   FEBS Journal

Mislocalization of neuronal mitochondria reveals regulation of Wallerian degeneration and NMNAT/WLDS-mediated axon protection independent of axonal mitochondria

(2013) Brandon M. Kitay et al.   HUMAN MOLECULAR GENETICS

A genome-wide association meta-analysis identifies a novel locus at 17q11.2 associated with sporadic amyotrophic lateral sclerosis

(2013) I. Fogh et al.   HUMAN MOLECULAR GENETICS

Activation of the Innate Signaling Molecule MAVS by Bunyavirus Infection Upregulates the Adaptor Protein SARM1, Leading to Neuronal Death

(2013) Piyali Mukherjee et al.   IMMUNITY

Neuronally-expressed Sarm1 regulates expression of inflammatory and antiviral cytokines in brains

(2013) Chia-Wen Lin et al.   Innate Immunity

Sarm1-Mediated Axon Degeneration Requires Both SAM and TIR Interactions

(2013) J. Gerdts et al.   JOURNAL OF NEUROSCIENCE

Rescue of Peripheral and CNS Axon Defects in Mice Lacking NMNAT2

(2013) J. Gilley et al.   JOURNAL OF NEUROSCIENCE

Sodium and Potassium Currents Influence Wallerian Degeneration of Injured Drosophila Axons

(2013) B. Mishra et al.   JOURNAL OF NEUROSCIENCE

WldS and PGC-1  Regulate Mitochondrial Transport and Oxidation State after Axonal Injury

(2013) K. C. O'Donnell et al.   JOURNAL OF NEUROSCIENCE

Maintaining energy homeostasis is an essential component of WldS-mediated axon protection

(2013) Hua Shen et al.   NEUROBIOLOGY OF DISEASE

Calpains mediate axonal cytoskeleton disintegration during Wallerian degeneration

(2013) Marek Ma et al.   NEUROBIOLOGY OF DISEASE

Regulation of Axon Degeneration after Injury and in Development by the Endogenous Calpain Inhibitor Calpastatin

(2013) Jing Yang et al.   NEURON

Simultaneous Single-Sample Determination of NMNAT Isozyme Activities in Mouse Tissues

(2013) Giuseppe Orsomando et al.   PLoS One

The Evolutionary Portrait of Metazoan NAD Salvage

(2013) João Carneiro et al.   PLoS One

Insight into Molecular and Functional Properties of NMNAT3 Reveals New Hints of NAD Homeostasis within Human Mitochondria

(2013) Roberta Felici et al.   PLoS One

Deletions within its subcellular targeting domain enhance the axon protective capacity of Nmnat2 in vivo

(2013) Stefan Milde et al.   Scientific Reports

The Phr1 Ubiquitin Ligase Promotes Injury-Induced Axon Self-Destruction

(2013) Elisabetta Babetto et al.   Cell Reports

Subcellular Localization Determines the Stability and Axon Protective Capacity of Axon Survival Factor Nmnat2

(2013) Stefan Milde et al.   PLOS BIOLOGY

Retinal ganglion cell survival and axon regeneration in WldS transgenic rats after optic nerve crush and lens injury

(2012) Barbara Lorber et al.   BMC NEUROSCIENCE

T-cell death following immune activation is mediated by mitochondria-localized SARM

(2012) P Panneerselvam et al.   CELL DEATH AND DIFFERENTIATION

Chemical Genetic-Mediated Spatial Regulation of Protein Expression in Neurons Reveals an Axonal Function for WldS

(2012) Michael S. Cohen et al.   CHEMISTRY & BIOLOGY

A Novel Drosophila Model of Nerve Injury Reveals an Essential Role of Nmnat in Maintaining Axonal Integrity

(2012) Yanshan Fang et al.   CURRENT BIOLOGY

WldS Prevents Axon Degeneration through Increased Mitochondrial Flux and Enhanced Mitochondrial Ca2+ Buffering

(2012) Michelle A. Avery et al.   CURRENT BIOLOGY

Molecular characterization of porcine SARM1 and its role in regulating TLRs signaling during highly pathogenic porcine reproductive and respiratory syndrome virus infection in vivo

(2012) Xiang Zhou et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Nicotinamide mononucleotide adenylyltransferase maintains active zone structure by stabilizing Bruchpilot

(2012) Shaoyun Zang et al.   EMBO REPORTS

The mechanism of axonal degeneration after perikaryal excitotoxic injury to the retina

(2012) Natalie D. Bull et al.   EXPERIMENTAL NEUROLOGY

Axonal transport of adeno-associated viral vectors is serotype-dependent

(2012) E A Salegio et al.   GENE THERAPY

Molecular chaperones protect against JNK- and Nmnat-regulated axon degeneration in Drosophila

(2012) A. Rallis et al.   JOURNAL OF CELL SCIENCE

The NAMPT inhibitor FK866 reverts the damage in spinal cord injury

(2012) Emanuela Esposito et al.   Journal of Neuroinflammation

A Model of Toxic Neuropathy in Drosophila Reveals a Role for MORN4 in Promoting Axonal Degeneration

(2012) M. R. C. Bhattacharya et al.   JOURNAL OF NEUROSCIENCE

A Caspase Cascade Regulating Developmental Axon Degeneration

(2012) D. J. Simon et al.   JOURNAL OF NEUROSCIENCE

WldS but not Nmnat1 protects dopaminergic neurites from MPP+ neurotoxicity

(2012) Jo Ann V Antenor-Dorsey et al.   Molecular Neurodegeneration

Emerging functions of the VCP/p97 AAA-ATPase in the ubiquitin system

(2012) Hemmo Meyer et al.   NATURE CELL BIOLOGY

Mutations in NMNAT1 cause Leber congenital amaurosis with early-onset severe macular and optic atrophy

(2012) Isabelle Perrault et al.   NATURE GENETICS

NMNAT1 mutations cause Leber congenital amaurosis

(2012) Marni J Falk et al.   NATURE GENETICS

Exome sequencing identifies NMNAT1 mutations as a cause of Leber congenital amaurosis

(2012) Pei-Wen Chiang et al.   NATURE GENETICS

Mutations in NMNAT1 cause Leber congenital amaurosis and identify a new disease pathway for retinal degeneration

(2012) Robert K Koenekoop et al.   NATURE GENETICS

An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration

(2012) Sabrina M Lehmann et al.   NATURE NEUROSCIENCE

Will the real multiple sclerosis please stand up?

(2012) Peter K. Stys et al.   NATURE REVIEWS NEUROSCIENCE

Intra-axonal calcium changes after axotomy in wild-type and slow Wallerian degeneration axons

(2012) R. Adalbert et al.   NEUROSCIENCE

Animal Models of Peripheral Neuropathies

(2012) Ahmet Höke   Neurotherapeutics

Reduced Axonal Transport and Increased Excitotoxic Retinal Ganglion Cell Degeneration in Mice Transgenic for Human Mutant P301S Tau

(2012) Natalie D. Bull et al.   PLoS One

Nicotinamide Mononucleotide Adenylyltransferase 2 (Nmnat2) Regulates Axon Integrity in the Mouse Embryo

(2012) Amy N. Hicks et al.   PLoS One

SCG10 is a JNK target in the axonal degeneration pathway

(2012) J. E. Shin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

dSarm/Sarm1 Is Required for Activation of an Injury-Induced Axon Death Pathway

(2012) J. M. Osterloh et al.   SCIENCE

Mitochondria as a central sensor for axonal degenerative stimuli

(2012) Felipe A. Court et al.   TRENDS IN NEUROSCIENCES

The Highwire Ubiquitin Ligase Promotes Axonal Degeneration by Tuning Levels of Nmnat Protein

(2012) Xin Xiong et al.   PLOS BIOLOGY

Mutations in a P-Type ATPase Gene Cause Axonal Degeneration

(2012) Xianjun Zhu et al.   PLoS Genetics

Diapause Formation and Downregulation of Insulin-Like Signaling via DAF-16/FOXO Delays Axonal Degeneration and Neuronal Loss

(2012) Andrea Calixto et al.   PLoS Genetics

Antioxidants halt axonal degeneration in a mouse model of X-adrenoleukodystrophy

(2011) Jone López-Erauskin et al.   ANNALS OF NEUROLOGY

Targeting of pro-apoptotic TLR adaptor SARM to mitochondria: definition of the critical region and residues in the signal sequence

(2011) Porkodi Panneerselvam et al.   BIOCHEMICAL JOURNAL

Colony-stimulating factor-1 mediates macrophage-related neural damage in a model for Charcot–Marie–Tooth disease type 1X

(2011) Janos Groh et al.   BRAIN

WldS Enhances Insulin Transcription and Secretion via a SIRT1-Dependent Pathway and Improves Glucose Homeostasis

(2011) J. Wu et al.   DIABETES

Wld S protects against peripheral neuropathy and retinopathy in an experimental model of diabetes in mice

(2011) S. S. Zhu et al.   DIABETOLOGIA

Reducing expression of NAD+ synthesizing enzyme NMNAT1 does not affect the rate of Wallerian degeneration

(2011) Laura Conforti et al.   FEBS Journal

CREB-activity and nmnat2 transcription are down-regulated prior to neurodegeneration, while NMNAT2 over-expression is neuroprotective, in a mouse model of human tauopathy

(2011) M. Cecilia Ljungberg et al.   HUMAN MOLECULAR GENETICS

NMNAT suppresses Tau-induced neurodegeneration by promoting clearance of hyperphosphorylated Tau oligomers in a Drosophila model of tauopathy

(2011) Yousuf O. Ali et al.   HUMAN MOLECULAR GENETICS

Nicotinamide Mononucleotide Adenylyltransferase Is a Stress Response Protein Regulated by the Heat Shock Factor/Hypoxia-inducible Factor 1α Pathway

(2011) Yousuf O. Ali et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Image-based Screening Identifies Novel Roles for IκB Kinase and Glycogen Synthase Kinase 3 in Axonal Degeneration

(2011) Josiah Gerdts et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pathways and Subcellular Compartmentation of NAD Biosynthesis in Human Cells

(2011) Andrey Nikiforov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sarm1, a negative regulator of innate immunity, interacts with syndecan-2 and regulates neuronal morphology

(2011) Chiung-Ya Chen et al.   JOURNAL OF CELL BIOLOGY

Age-Related Alterations in Neurons of the Mouse Retina

(2011) M. A. Samuel et al.   JOURNAL OF NEUROSCIENCE

Axonal Degeneration Is Mediated by the Mitochondrial Permeability Transition Pore

(2011) S. A. Barrientos et al.   JOURNAL OF NEUROSCIENCE

Wallerian degeneration slow mouse neurons are protected against cell death caused by mechanisms involving mitochondrial electron transport dysfunction

(2011) Shinji Tokunaga et al.   JOURNAL OF NEUROSCIENCE RESEARCH

ZNRF1 promotes Wallerian degeneration by degrading AKT to induce GSK3B-dependent CRMP2 phosphorylation

(2011) Shuji Wakatsuki et al.   NATURE CELL BIOLOGY

A reversible form of axon damage in experimental autoimmune encephalomyelitis and multiple sclerosis

(2011) Ivana Nikić et al.   NATURE MEDICINE

Nicotinamide mononucleotide adenylyl transferase 1 protects against acute neurodegeneration in developing CNS by inhibiting excitotoxic-necrotic cell death

(2011) P. B. Verghese et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wallerian degeneration of zebrafish trigeminal axons in the skin is required for regeneration and developmental pruning

(2010) S. M. Martin et al.   DEVELOPMENT

Axonal Degeneration Is Blocked by Nicotinamide Mononucleotide Adenylyltransferase (Nmnat) Protein Transduction into Transected Axons

(2010) Yo Sasaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The WldSmutation delays anterograde, but not retrograde, axonal degeneration of the dopaminergic nigro-striatal pathwayin vivo

(2010) Hsiao-Chun Cheng et al.   JOURNAL OF NEUROCHEMISTRY

Targeting NMNAT1 to Axons and Synapses Transforms Its Neuroprotective Potency In Vivo

(2010) E. Babetto et al.   JOURNAL OF NEUROSCIENCE

Amyloid Precursor Protein Cleavage-Dependent and -Independent Axonal Degeneration Programs Share a Common Nicotinamide Mononucleotide Adenylyltransferase 1-Sensitive Pathway

(2010) B. P. S. Vohra et al.   JOURNAL OF NEUROSCIENCE

Axonal Degeneration Is Regulated by the Apoptotic Machinery or a NAD+-Sensitive Pathway in Insects and Mammals

(2010) Z. Schoenmann et al.   JOURNAL OF NEUROSCIENCE

An assessment of mechanisms underlying peripheral axonal degeneration caused by aminoacyl-tRNA synthetase mutations

(2010) Morgane Stum et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

The Wlds transgene reduces axon loss in a Charcot-Marie-Tooth disease 1A rat model and nicotinamide delays post-traumatic axonal degeneration

(2010) Gerd Meyer zu Horste et al.   NEUROBIOLOGY OF DISEASE

Endogenous Nmnat2 Is an Essential Survival Factor for Maintenance of Healthy Axons

(2010) Jonathan Gilley et al.   PLOS BIOLOGY

Early ultrastructural defects of axons and axon-glia junctions in mice lacking expression ofCnp1

(2009) Julia M. Edgar et al.   GLIA

Enzymes in the NAD+Salvage Pathway Regulate SIRT1 Activity at Target Gene Promoters

(2009) Tong Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

WldSrequires Nmnat1 enzymatic activity and N16–VCP interactions to suppress Wallerian degeneration

(2009) Michelle A. Avery et al.   JOURNAL OF CELL BIOLOGY

WldSprotein requires Nmnat activity and a short N-terminal sequence to protect axons in mice

(2009) Laura Conforti et al.   JOURNAL OF CELL BIOLOGY

Non-Nuclear WldS Determines Its Neuroprotective Efficacy for Axons and Synapses In Vivo

(2009) B. Beirowski et al.   JOURNAL OF NEUROSCIENCE

Nicotinamide Mononucleotide Adenylyltransferase Expression in Mitochondrial Matrix Delays Wallerian Degeneration

(2009) N. Yahata et al.   JOURNAL OF NEUROSCIENCE

Transgenic Mice Expressing the Nmnat1 Protein Manifest Robust Delay in Axonal Degeneration In Vivo

(2009) Y. Sasaki et al.   JOURNAL OF NEUROSCIENCE

Nicotinamide Mononucleotide Adenylyl Transferase-Mediated Axonal Protection Requires Enzymatic Activity But Not Increased Levels of Neuronal Nicotinamide Adenine Dinucleotide

(2009) Y. Sasaki et al.   JOURNAL OF NEUROSCIENCE

The Immune Adaptor Molecule SARM Modulates Tumor Necrosis Factor Alpha Production and Microglia Activation in the Brainstem and Restricts West Nile Virus Pathogenesis

(2009) K. J. Szretter et al.   JOURNAL OF VIROLOGY

APP binds DR6 to trigger axon pruning and neuron death via distinct caspases

(2009) Anatoly Nikolaev et al.   NATURE

A dual leucine kinase–dependent axon self-destruction program promotes Wallerian degeneration

(2009) Bradley R Miller et al.   NATURE NEUROSCIENCE

Nmnat2 delays axon degeneration in superior cervical ganglia dependent on its NAD synthesis activity

(2009) Tingting Yan et al.   NEUROCHEMISTRY INTERNATIONAL

Prion disease development in slow Wallerian degeneration (WldS) mice

(2009) Sandra Gültner et al.   NEUROSCIENCE LETTERS

The Wallerian degeneration slow ( Wlds ) gene does not attenuate disease in a mouse model of spinal muscular atrophy

(2008) Ferrill F. Rose et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

TheWldSgene delays axonal but not somatic degeneration in a rat glaucoma model

(2008) Bogdan Beirowski et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Axonal degeneration as a self-destructive defense mechanism against neurotropic virus infection

(2008) Ikuo Tsunoda   Future Virology

Nmnat Delays Axonal Degeneration Caused by Mitochondrial and Oxidative Stress

(2008) C. Press et al.   JOURNAL OF NEUROSCIENCE

NAD synthase NMNAT acts as a chaperone to protect against neurodegeneration

(2008) R. Grace Zhai et al.   NATURE

The neuroprotective factor Wlds fails to mitigate distal axonal and neuromuscular junction (NMJ) defects in mouse models of spinal muscular atrophy

(2008) Shingo Kariya et al.   NEUROSCIENCE LETTERS