Mechanism of Oxidative Stress and Synapse Dysfunction in the Pathogenesis of Alzheimer’s Disease: Understanding the Therapeutics Strategies
出版年份 2014 全文链接
标题
Mechanism of Oxidative Stress and Synapse Dysfunction in the Pathogenesis of Alzheimer’s Disease: Understanding the Therapeutics Strategies
作者
关键词
NMDA receptor, Oxidative stress, Kinases, Tau protein, Synaptic function, Alzheimer’s disease
出版物
MOLECULAR NEUROBIOLOGY
Volume 53, Issue 1, Pages 648-661
出版商
Springer Nature
发表日期
2014-12-16
DOI
10.1007/s12035-014-9053-6
参考文献
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Synthesis of New Lipoic Acid Conjugates and Evaluation of Their Free Radical Scavenging and Neuroprotective Activities
- (2014) Maria Laura Bolognesi et al. Chemical Biology & Drug Design
- Mechanism of synapse redox stress in Okadaic acid (ICV) induced memory impairment: Role of NMDA receptor
- (2014) Pradip K. Kamat et al. NEUROCHEMISTRY INTERNATIONAL
- Latrepirdine (Dimebon®), a potential Alzheimer therapeutic, regulates autophagy and neuropathology in an Alzheimer mouse model
- (2013) John W. Steele et al. Autophagy
- Design, synthesis and biological evaluation of imine resveratrol derivatives as multi-targeted agents against Alzheimer's disease
- (2013) Su-Yi Li et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Neuroprotective effect of curcumin on okadaic acid induced memory impairment in mice
- (2013) N. Rajasekar et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Reversal of Metabolic Deficits by Lipoic Acid in a Triple Transgenic Mouse Model of Alzheimer's Disease: A 13C NMR Study
- (2013) Harsh Sancheti et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Design, Synthesis, and Evaluation of Multitarget-Directed Resveratrol Derivatives for the Treatment of Alzheimer’s Disease
- (2013) Chuanjun Lu et al. JOURNAL OF MEDICINAL CHEMISTRY
- Mitochondrial Alterations near Amyloid Plaques in an Alzheimer's Disease Mouse Model
- (2013) Hong Xie et al. JOURNAL OF NEUROSCIENCE
- A randomized controlled Alzheimer’s disease prevention trial’s evolution into an exposure trial: The preadvise trial
- (2013) R. J. Kryscio et al. Journal of Nutrition Health & Aging
- (−)-Epigallocatechin-3-gallate alleviates spatial memory impairment in APP/PS1 mice by restoring IRS-1 signaling defects in the hippocampus
- (2013) Ning Jia et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- NMDA receptors in nervous system diseases
- (2013) Qiang Zhou et al. NEUROPHARMACOLOGY
- Okadaic acid-induced Tau phosphorylation in rat brain: Role of NMDA receptor
- (2013) P.K. Kamat et al. NEUROSCIENCE
- Glial activation and post-synaptic neurotoxicity: The key events in Streptozotocin (ICV) induced memory impairment in rats
- (2013) Shivika Rai et al. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
- Neuropathological Alterations in Alzheimer Disease
- (2013) A. Serrano-Pozo et al. Cold Spring Harbor Perspectives in Medicine
- Latrepirdine: molecular mechanisms underlying potential therapeutic roles in Alzheimer’s and other neurodegenerative diseases
- (2013) P R Bharadwaj et al. Translational Psychiatry
- Oxidative modification of lipoic acid by HNE in Alzheimer disease brain
- (2013) Sarita S. Hardas et al. Redox Biology
- Involvement of hippocampal CAMKII/CREB signaling in the spatial memory retention induced by creatine
- (2012) Mauren Assis Souza et al. AMINO ACIDS
- Mitochondrial Redox Signaling: Interaction of Mitochondrial Reactive Oxygen Species with Other Sources of Oxidative Stress
- (2012) Eberhard Schulz et al. ANTIOXIDANTS & REDOX SIGNALING
- Antioxidants for Alzheimer Disease
- (2012) Douglas R. Galasko et al. ARCHIVES OF NEUROLOGY
- Effect of the Proline-Rich Polypeptide Complex/Colostrinin™ on the Enzymatic Antioxidant System
- (2012) Agnieszka Zabłocka et al. ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS
- Correlation between Cognitive Functions and Nitric Oxide Levels in Patients with Dementia
- (2012) Richa Sachdeva et al. CLINICAL EEG AND NEUROSCIENCE
- Role of APP and Aβ in Synaptic Physiology
- (2012) Zilai Wang et al. Current Alzheimer Research
- Creb is modulated in the mouse superior colliculus in developmental and experimentally-induced models of plasticity
- (2012) Gabriela Vierci et al. INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
- Interaction of Endogenous Tau Protein with Synaptic Proteins Is Regulated byN-Methyl-d-aspartate Receptor-dependent Tau Phosphorylation
- (2012) Siddhartha Mondragón-Rodríguez et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A study on neuroinflammation and NMDA receptor function in STZ (ICV) induced memory impaired rats
- (2012) Shivika Rai et al. JOURNAL OF NEUROIMMUNOLOGY
- Opposing Roles of Synaptic and Extrasynaptic NMDA Receptor Signaling in Cocultured Striatal and Cortical Neurons
- (2012) A. M. Kaufman et al. JOURNAL OF NEUROSCIENCE
- Long-term use of standardised ginkgo biloba extract for the prevention of Alzheimer's disease (GuidAge): a randomised placebo-controlled trial
- (2012) Bruno Vellas et al. LANCET NEUROLOGY
- The BCM theory of synapse modification at 30: interaction of theory with experiment
- (2012) Leon N Cooper et al. NATURE REVIEWS NEUROSCIENCE
- Effect of One-Year Vitamin C- and E-Supplementation on Cerebrospinal Fluid Oxidation Parameters and Clinical Course in Alzheimer’s Disease
- (2012) Sönke Arlt et al. NEUROCHEMICAL RESEARCH
- Protein Tyrosine Phosphatase PTP1B Is Involved in Hippocampal Synapse Formation and Learning
- (2012) Federico Fuentes et al. PLoS One
- Improvement of brain energy metabolism and cholinergic functions contributes to the beneficial effects of silibinin against streptozotocin induced memory impairment
- (2011) Santoshkumar Tota et al. BEHAVIOURAL BRAIN RESEARCH
- Overexpression of cationic amino acid transporter-1 increases nitric oxide production in hypoxic human pulmonary microvascular endothelial cells
- (2011) Hongmei Cui et al. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
- Neurobiological aspects of Alzheimer's disease
- (2011) Kanwaljit Chopra et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- Behavioral deficit, oxidative stress, and mitochondrial dysfunction precede tau pathology in P301S transgenic mice
- (2011) Magali Dumont et al. FASEB JOURNAL
- Amyloid- /Fyn-Induced Synaptic, Network, and Cognitive Impairments Depend on Tau Levels in Multiple Mouse Models of Alzheimer's Disease
- (2011) E. D. Roberson et al. JOURNAL OF NEUROSCIENCE
- Regulation of Long-Term Plasticity Induction by the Channel and C-Terminal Domains of GluN2 Subunits
- (2011) Frank Fetterolf et al. MOLECULAR NEUROBIOLOGY
- Aβ1–42 inhibition of LTP is mediated by a signaling pathway involving caspase-3, Akt1 and GSK-3β
- (2011) Jihoon Jo et al. NATURE NEUROSCIENCE
- Mitochondrial dysfunction: A crucial event in okadaic acid (ICV) induced memory impairment and apoptotic cell death in rat brain
- (2011) Pradeep K. Kamat et al. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
- Protective effect of quercetin against intracerebral streptozotocin induced reduction in cerebral blood flow and impairment of memory in mice
- (2010) Santoshkumar Tota et al. BEHAVIOURAL BRAIN RESEARCH
- CREB is a regulatory target for the protein kinase Akt/PKB in the differentiation of pancreatic ductal cells into islet β-cells mediated by hepatocyte growth factor
- (2010) Xin-Yu Li et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Gonadal Steroids do not Affect Apolipoprotein E Expression in Aging Mouse Cerebral Cortex
- (2010) Sarika Singh et al. CELLULAR AND MOLECULAR NEUROBIOLOGY
- Caffeine protects against oxidative stress and Alzheimer's disease-like pathology in rabbit hippocampus induced by cholesterol-enriched diet
- (2010) Jaya R.P. Prasanthi et al. FREE RADICAL BIOLOGY AND MEDICINE
- A vitamin/nutriceutical formulation improves memory and cognitive performance in community-dwelling adults without dementia
- (2010) A. Chan et al. Journal of Nutrition Health & Aging
- Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease
- (2010) Marcello D'Amelio et al. NATURE NEUROSCIENCE
- Amyloid-β and tau — a toxic pas de deux in Alzheimer's disease
- (2010) Lars M. Ittner et al. NATURE REVIEWS NEUROSCIENCE
- Tau Mislocalization to Dendritic Spines Mediates Synaptic Dysfunction Independently of Neurodegeneration
- (2010) Brian R. Hoover et al. NEURON
- Dimebon disappointment
- (2010) Roy W Jones Alzheimers Research & Therapy
- Synaptic degeneration in Alzheimer’s disease
- (2009) Thomas Arendt ACTA NEUROPATHOLOGICA
- Regulation of NMDA receptor Ca2+signalling and synaptic plasticity
- (2009) C. Geoffrey Lau et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Dynamics of mitochondrial structure during apoptosis and the enigma of Opa1
- (2009) Ryuji Yamaguchi et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
- Mitochondria: A therapeutic target in neurodegeneration
- (2009) Paula I. Moreira et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Okadaic acid (ICV) induced memory impairment in rats: A suitable experimental model to test anti-dementia activity
- (2009) Pradeep K. Kamat et al. BRAIN RESEARCH
- Silibinin prevents amyloid β peptide-induced memory impairment and oxidative stress in mice
- (2009) P Lu et al. BRITISH JOURNAL OF PHARMACOLOGY
- Vitamin E Use Is Associated with Improved Survival in an Alzheimer’s Disease Cohort
- (2009) Valory N. Pavlik et al. DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
- GSK3: A possible link between beta amyloid peptide and tau protein
- (2009) Félix Hernández et al. EXPERIMENTAL NEUROLOGY
- Ginkgo biloba for Preventing Cognitive Decline in Older AdultsA Randomized Trial
- (2009) Beth E. Snitz JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Evaluation of guggulipid and nimesulide on production of inflammatory mediators and GFAP expression in LPS stimulated rat astrocytoma, cell line (C6)
- (2009) Rituraj Niranjan et al. JOURNAL OF ETHNOPHARMACOLOGY
- Down-regulation of Bcl-2 enhances autophagy activation and cell death induced by mitochondrial dysfunction in rat striatum
- (2009) Xing-Ding Zhang et al. JOURNAL OF NEUROSCIENCE RESEARCH
- Early biophysics of the NMDA receptor channel
- (2009) Philippe Ascher et al. JOURNAL OF PHYSIOLOGY-LONDON
- Excitatory amino acid involvement in dendritic spine formation, maintenance and remodelling
- (2009) R. Anne McKinney JOURNAL OF PHYSIOLOGY-LONDON
- GSK-3 is a master regulator of neural progenitor homeostasis
- (2009) Woo-Yang Kim et al. NATURE NEUROSCIENCE
- Melatonin alleviates memory deficits and neuronal degeneration induced by intracerebroventricular administration of streptozotocin in rats
- (2009) Gunjan Saxena et al. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
- Selective induction of calcineurin activity and signaling by oligomeric amyloid beta
- (2008) Lindsay C. Reese et al. AGING CELL
- Efficacy of a Vitamin/Nutriceutical Formulation for Moderate-stage to Later-stage Alzheimer's disease: A Placebo-controlled Pilot Study
- (2008) Ruth Remington et al. American Journal of Alzheimers Disease and Other Dementias
- Caspase-3 Is Enriched in Postsynaptic Densities and Increased in Alzheimer's Disease
- (2008) Natalia Louneva et al. AMERICAN JOURNAL OF PATHOLOGY
- GuidAge Study: A 5-Year Double Blind, Randomised Trial of EGb 761 for the Prevention of Alzheimers Disease in Elderly Subjects with Memory Complaints. I. Rationale, Design and Baseline Data
- (2008) Sandrine Andrieu et al. Current Alzheimer Research
- Neuronal viability is controlled by a functional relation between synaptic and extrasynaptic NMDA receptors
- (2008) F. Léveillé et al. FASEB JOURNAL
- Expression and modification of ARC (apoptosis repressor with a CARD domain) is distinctly regulated by oxidative stress in cancer cells
- (2008) Yi-Qiang Zhang et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- GSK-3β down-regulates the transcription factor Nrf2 after oxidant damage: relevance to exposure of neuronal cells to oxidative stress
- (2008) Ana I. Rojo et al. JOURNAL OF NEUROCHEMISTRY
- Aβ Plaques Lead to Aberrant Regulation of Calcium Homeostasis In Vivo Resulting in Structural and Functional Disruption of Neuronal Networks
- (2008) Kishore V. Kuchibhotla et al. NEURON
- Clusters of Hyperactive Neurons Near Amyloid Plaques in a Mouse Model of Alzheimer's Disease
- (2008) M. A. Busche et al. SCIENCE
- Phosphorylation by p38 MAPK as an Alternative Pathway for GSK3 Inactivation
- (2008) T. M. Thornton et al. SCIENCE
- Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease
- (2008) Ilya Bezprozvanny et al. TRENDS IN NEUROSCIENCES
- Activation of glycogen synthase kinase-3 inhibits protein phosphatase-2A and the underlying mechanisms
- (2007) Gong-Ping Liu et al. NEUROBIOLOGY OF AGING
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