The preclinical phase of the pathological process underlying sporadic Alzheimer’s disease

Alzheimer's Disease-Specific Tau Phosphorylation is Induced by Herpes Simplex Virus Type 1

(2017) Matthew A. Wozniak et al.   JOURNAL OF ALZHEIMERS DISEASE

Anesthesia Induces Phosphorylation of Tau

(2017) Xiaoqin Run et al.   JOURNAL OF ALZHEIMERS DISEASE

Tau pathology spread in PS19 tau transgenic mice following locus coeruleus (LC) injections of synthetic tau fibrils is determined by the LC’s afferent and efferent connections

(2015) Michiyo Iba et al.   ACTA NEUROPATHOLOGICA

PART is part of Alzheimer disease

(2015) Charles Duyckaerts et al.   ACTA NEUROPATHOLOGICA

Rapidly progressive Alzheimer’s disease features distinct structures of amyloid-β

(2015) Mark L. Cohen et al.   BRAIN

Tau Trimers Are the Minimal Propagation Unit Spontaneously Internalized to Seed Intracellular Aggregation

(2015) Hilda Mirbaha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synaptic Contacts Enhance Cell-to-Cell Tau Pathology Propagation

(2015) Sara Calafate et al.   Cell Reports

Herpes simplex type 2 virus deleted in glycoprotein D protects against vaginal, skin and neural disease

(2015) Christopher Petro et al.   eLife

Contributions of Increasing Obesity and Diabetes to Slowing Decline in Subclinical Coronary Artery Disease

(2015) C. Y. Smith et al.   Journal of the American Heart Association

Early neurone loss in Alzheimer’s disease: cortical or subcortical?

(2015) Thomas Arendt et al.   Acta Neuropathologica Communications

Are cases with tau pathology occurring in the absence of Aβ deposits part of the AD-related pathological process?

(2014) Heiko Braak et al.   ACTA NEUROPATHOLOGICA

Is there a risk of prion-like disease transmission by Alzheimer- or Parkinson-associated protein particles?

(2014) Michael Beekes et al.   ACTA NEUROPATHOLOGICA

A novel in vivo model of tau propagation with rapid and progressive neurofibrillary tangle pathology: the pattern of spread is determined by connectivity, not proximity

(2014) Zeshan Ahmed et al.   ACTA NEUROPATHOLOGICA

Primary age-related tauopathy (PART): a common pathology associated with human aging

(2014) John F. Crary et al.   ACTA NEUROPATHOLOGICA

Endothelial dysfunction and coronary artery disease

(2014) Yasushi Matsuzawa et al.   CORONARY ARTERY DISEASE

Prion-like Mechanisms in the Pathogenesis of Tauopathies and Synucleinopathies

(2014) Michel Goedert et al.   Current Neurology and Neuroscience Reports

Conformation Determines the Seeding Potencies of Native and Recombinant Tau Aggregates

(2014) Benjamin Falcon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Brain hypometabolism triggers PHF-like phosphorylation of tau, a major hallmark of Alzheimer’s disease pathology

(2014) Thomas Arendt et al.   JOURNAL OF NEURAL TRANSMISSION

Cognitive Reserve and Alzheimer’s Disease

(2014) Wei Xu et al.   MOLECULAR NEUROBIOLOGY

Grid cells and cortical representation

(2014) Edvard I. Moser et al.   NATURE REVIEWS NEUROSCIENCE

Distinct Tau Prion Strains Propagate in Cells and Mice and Define Different Tauopathies

(2014) David W. Sanders et al.   NEURON

Proteopathic tau seeding predicts tauopathy in vivo

(2014) B. B. Holmes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Herpes simplex virus type 1 and Alzheimer’s disease: increasing evidence for a major role of the virus

(2014) Ruth F. Itzhaki   Frontiers in Aging Neuroscience

The identification of mitochondrial DNA variants in glioblastoma multiforme

(2014) Ka Yu Yeung et al.   Acta Neuropathologica Communications

Amyloid-β may be released from non-junctional varicosities of axons generated from abnormal tau-containing brainstem nuclei in sporadic Alzheimer’s disease: a hypothesis

(2013) Heiko Braak et al.   ACTA NEUROPATHOLOGICA

“Prion-Like” Templated Misfolding in Tauopathies

(2013) Florence Clavaguera et al.   BRAIN PATHOLOGY

Structural networks in Alzheimer's disease

(2013) Andrew T. Reid et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Neurofibrillary tangle-like tau pathology induced by synthetic tau fibrils in primary neurons over-expressing mutant tau

(2013) Jing L. Guo et al.   FEBS LETTERS

Tau pathology and neurodegeneration

(2013) Maria Grazia Spillantini et al.   LANCET NEUROLOGY

Aβ-independent processes—rethinking preclinical AD

(2013) Gaël Chételat   Nature Reviews Neurology

Grid Cells and Neural Coding in High-End Cortices

(2013) Edvard I. Moser et al.   NEURON

Intercellular transfer of tau aggregates and spreading of tau pathology: Implications for therapeutic strategies

(2013) Florence Clavaguera et al.   NEUROPHARMACOLOGY

Ascending monoaminergic systems alterations in Alzheimer's disease. Translating basic science into clinical care

(2013) Ludwig Trillo et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Brain homogenates from human tauopathies induce tau inclusions in mouse brain

(2013) Florence Clavaguera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neurodegenerative lesions: Seeding and spreading

(2013) C. Duyckaerts   REVUE NEUROLOGIQUE

Efficiency, capacity, compensation, maintenance, plasticity: emerging concepts in cognitive reserve

(2013) Daniel Barulli et al.   TRENDS IN COGNITIVE SCIENCES

Propagation of tau pathology in Alzheimer’s disease: identification of novel therapeutic targets

(2013) Amy M Pooler et al.   Alzheimers Research & Therapy

Targeting norepinephrine in mild cognitive impairment and Alzheimer's disease

(2013) Termpanit Chalermpalanupap et al.   Alzheimers Research & Therapy

Inflammation in Alzheimer Disease--A Brief Review of the Basic Science and Clinical Literature

(2013) T. Wyss-Coray et al.   Cold Spring Harbor Perspectives in Medicine

Biochemistry and Cell Biology of Tau Protein in Neurofibrillary Degeneration

(2013) E.-M. Mandelkow et al.   Cold Spring Harbor Perspectives in Medicine

Epidemiology of Alzheimer Disease

(2013) R. Mayeux et al.   Cold Spring Harbor Perspectives in Medicine

Biochemistry of Amyloid  -Protein and Amyloid Deposits in Alzheimer Disease

(2013) C. L. Masters et al.   Cold Spring Harbor Perspectives in Medicine

Trafficking and Proteolytic Processing of APP

(2013) C. Haass et al.   Cold Spring Harbor Perspectives in Medicine

The epidemiology of Alzheimer’s disease: Laying the foundation for drug design, conduct, and analysis of clinical trials

(2012) Kristine Yaffe et al.   Alzheimers & Dementia

Alzheimer’s disease: Pathogenesis and prevention

(2012) Heiko Braak et al.   Alzheimers & Dementia

Intracerebral propagation of Alzheimer’s disease: Strengthening evidence of a herpes simplex virus etiology

(2012) Melvyn J. Ball et al.   Alzheimers & Dementia

Physical Activity, Brain Plasticity, and Alzheimer's Disease

(2012) Kirk I. Erickson et al.   ARCHIVES OF MEDICAL RESEARCH

The relationship between subcortical tau pathology and Alzheimer's disease

(2012) Johannes Attems et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Extensive p-Tau Pathology and SDS-Stable p-Tau Oligomers in Alzheimer's Cortical Synapses

(2012) Kristen M. Henkins et al.   BRAIN PATHOLOGY

Where, when, and in what form does sporadic Alzheimerʼs disease begin?

(2012) Heiko Braak et al.   CURRENT OPINION IN NEUROLOGY

Small Misfolded Tau Species Are Internalized via Bulk Endocytosis and Anterogradely and Retrogradely Transported in Neurons

(2012) Jessica W. Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature

(2012) Peter T. Nelson et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Norepinephrine: A Neuromodulator That Boosts the Function of Multiple Cell Types to Optimize CNS Performance

(2012) John O’Donnell et al.   NEUROCHEMICAL RESEARCH

Propagation of Tau Pathology in a Model of Early Alzheimer's Disease

(2012) Alix de Calignon et al.   NEURON

Trans-Synaptic Spread of Tau Pathology In Vivo

(2012) Li Liu et al.   PLoS One

Education and Dementia in the Context of the Cognitive Reserve Hypothesis: A Systematic Review with Meta-Analyses and Qualitative Analyses

(2012) Xiangfei Meng et al.   PLoS One

Defining Alzheimer as a common age-related neurodegenerative process not inevitably leading to dementia

(2012) Isidro Ferrer   PROGRESS IN NEUROBIOLOGY

A Unifying Role for Prions in Neurodegenerative Diseases

(2012) S. B. Prusiner   SCIENCE

Soluble forms of tau are toxic in Alzheimer’s disease

(2012) Katherine Kopeikina et al.   Translational Neuroscience

Mechanisms of Protein Seeding in Neurodegenerative Diseases

(2012) Lary C. Walker et al.   JAMA Neurology

Tau pathology in children and young adults: can you still be unconditionally baptist?

(2011) Charles Duyckaerts   ACTA NEUROPATHOLOGICA

Hyperphosphorylated tau in young and middle-aged subjects

(2011) Adila Elobeid et al.   ACTA NEUROPATHOLOGICA

Opportunities and challenges in developing Alzheimer disease therapeutics

(2011) Khalid Iqbal et al.   ACTA NEUROPATHOLOGICA

Alzheimer’s pathogenesis: is there neuron-to-neuron propagation?

(2011) Heiko Braak et al.   ACTA NEUROPATHOLOGICA

National Institute on Aging–Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach

(2011) Thomas J. Montine et al.   ACTA NEUROPATHOLOGICA

The diagnosis of mild cognitive impairment due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Marilyn S. Albert et al.   Alzheimers & Dementia

Pathogenic protein seeding in alzheimer disease and other neurodegenerative disorders

(2011) Mathias Jucker et al.   ANNALS OF NEUROLOGY

Brief update on different roles of tau in neurodegeneration

(2011) Arne Ittner et al.   IUBMB LIFE

Seeding of Normal Tau by Pathological Tau Conformers Drives Pathogenesis of Alzheimer-like Tangles

(2011) Jing L. Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stages of the Pathologic Process in Alzheimer Disease: Age Categories From 1 to 100 Years

(2011) Heiko Braak et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Anterograde Transport of Herpes Simplex Virus Capsids in Neurons by both Separate and Married Mechanisms

(2011) T. W. Wisner et al.   JOURNAL OF VIROLOGY

Expanding morphological dimensions in neuropathology, from sequence biology to pathological sequences and clinical consequences

(2011) Toshiki Uchihara   NEUROPATHOLOGY

Protein aggregate spreading in neurodegenerative diseases: Problems and perspectives

(2011) Seung-Jae Lee et al.   NEUROSCIENCE RESEARCH

Imaging Learning: The Search for a Memory Trace

(2011) R. Douglas Fields   NEUROSCIENTIST

Biomarkers and evolution in Alzheimer disease

(2011) Stanley I. Rapoport et al.   PROGRESS IN NEUROBIOLOGY

Translational Neurodegeneration, a platform to share knowledge and experience in translational study of neurodegenerative diseases

(2011) Shengdi Chen et al.   Translational Neurodegeneration

Soluble hyper-phosphorylated tau causes microtubule breakdown and functionally compromises normal tau in vivo

(2010) Catherine M. Cowan et al.   ACTA NEUROPATHOLOGICA

The pathological process underlying Alzheimer’s disease in individuals under thirty

(2010) Heiko Braak et al.   ACTA NEUROPATHOLOGICA

Alzheimer's disease and infection: Do infectious agents contribute to progression of Alzheimer's disease?

(2010) Ruth F. Itzhaki et al.   Alzheimers & Dementia

The cholinergic system in aging and neuronal degeneration

(2010) Reinhard Schliebs et al.   BEHAVIOURAL BRAIN RESEARCH

Functional, Global and Cognitive Decline Correlates to Accumulation of Alzheimers Pathology in MCI and AD

(2010) M.N. Sabbagh et al.   Current Alzheimer Research

MYELINATION AS AN EXPRESSION OF THE FUNCTIONAL MATURITY OF THE BRAIN

(2010) M. S. Knaap et al.   DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY

Keep it in the subfamily: the conserved alphaherpesvirus US3 protein kinase

(2010) M. J. Deruelle et al.   JOURNAL OF GENERAL VIROLOGY

The biochemical aftermath of anti-amyloid immunotherapy

(2010) Chera L Maarouf et al.   Molecular Neurodegeneration

Prion-like transmission of protein aggregates in neurodegenerative diseases

(2010) Patrik Brundin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Centenary of Brodmann's map — conception and fate

(2010) Karl Zilles et al.   NATURE REVIEWS NEUROSCIENCE

Transition of Tau Protein from Disordered to Misordered in Alzheimer’s Disease

(2010) Branislav Kovacech et al.   Neurodegenerative Diseases

‘Prion-Like’ Propagation of Mouse and Human Tau Aggregates in an Inducible Mouse Model of Tauopathy

(2010) Astrid Sydow et al.   Neurodegenerative Diseases

Review: Sporadic cerebral amyloid angiopathy

(2010) J. Attems et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Tau protein and tau aggregation inhibitors

(2010) Bruno Bulic et al.   NEUROPHARMACOLOGY

The propagation of prion-like protein inclusions in neurodegenerative diseases

(2010) Michel Goedert et al.   TRENDS IN NEUROSCIENCES

Antiviral agents in Alzheimer’s disease: hope for the future?

(2010) Matthew A. Wozniak et al.   Therapeutic Advances in Neurological Disorders

Assessment of β-amyloid deposits in human brain: a study of the BrainNet Europe Consortium

(2009) Irina Alafuzoff et al.   ACTA NEUROPATHOLOGICA

Classification and basic pathology of Alzheimer disease

(2009) Charles Duyckaerts et al.   ACTA NEUROPATHOLOGICA

Mechanisms of tau-induced neurodegeneration

(2009) Khalid Iqbal et al.   ACTA NEUROPATHOLOGICA

Olfactory epithelium amyloid-β and paired helical filament-tau pathology in Alzheimer disease

(2009) Steven E. Arnold et al.   ANNALS OF NEUROLOGY

Propagation of Tau Misfolding from the Outside to the Inside of a Cell

(2009) Bess Frost et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Developmental regulation of tau phosphorylation, tau kinases, and tau phosphatases

(2009) Yang Yu et al.   JOURNAL OF NEUROCHEMISTRY

Systematic Review of Measures of Clinical Significance Employed in Randomized Controlled Trials of Drugs for Dementia

(2009) Frank J. Molnar et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Transmission and spreading of tauopathy in transgenic mouse brain

(2009) Florence Clavaguera et al.   NATURE CELL BIOLOGY

The locus coeruleus and noradrenergic modulation of cognition

(2009) Susan J. Sara   NATURE REVIEWS NEUROSCIENCE

Prion-like mechanisms in neurodegenerative diseases

(2009) Bess Frost et al.   NATURE REVIEWS NEUROSCIENCE

The locus ceruleus norepinephrine system: Functional organization and potential clinical significance

(2009) E. E. Benarroch   NEUROLOGY

Is activity regulation of late myelination a plastic mechanism in the human nervous system?

(2009) Fredrik Ullén   Neuron Glia Biology

The dorsal raphe nucleus shows phospho-tau neurofibrillary changes before the transentorhinal region in Alzheimer's disease. A precocious onset?

(2009) L. T. Grinberg et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Does Alzheimer's disease begin in the brainstem?

(2009) G. Simic et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Cognitive reserve☆

(2009) Yaakov Stern   NEUROPSYCHOLOGIA

Training-induced structural changes in the adult human brain

(2008) B. Draganski et al.   BEHAVIOURAL BRAIN RESEARCH

Mechanism of Tau-Induced Neurodegeneration in Alzheimer Disease and Related Tauopathies

(2008) Alejandra del Alonso et al.   Current Alzheimer Research

Functional Consequences of Locus Coeruleus Degeneration in Alzheimers Disease

(2008) David Weinshenker   Current Alzheimer Research

Reassessing the amyloid cascade hypothesis of Alzheimer's disease

(2008) Sanjay W. Pimplikar   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Herpes simplex virus type 1 DNA is located within Alzheimer's disease amyloid plaques

(2008) MA Wozniak et al.   JOURNAL OF PATHOLOGY

Seeding Neuritic Plaques from the Distance: A Possible Role for Brainstem Neurons in the Development of Alzheimer’s Disease Pathology

(2008) Zoia Muresan et al.   Neurodegenerative Diseases