Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models

Rip1 (Receptor-interacting protein kinase 1) mediates necroptosis and contributes to renal ischemia/reperfusion injury

(2012) Andreas Linkermann et al.   KIDNEY INTERNATIONAL

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(2012) Andreas Linkermann et al.   MOLECULAR MEDICINE

A novel role for RIP1 kinase in mediating TNFα production

(2012) D E Christofferson et al.   Cell Death & Disease

Avogadro: an advanced semantic chemical editor, visualization, and analysis platform

(2012) Marcus D Hanwell et al.   Journal of Cheminformatics

NEMO and RIP1 Control Cell Fate in Response to Extensive DNA Damage via TNF-α Feedforward Signaling

(2011) Sharon Biton et al.   CELL

NO donor induces Nec-1-inhibitable, but RIP1-independent, necrotic cell death in pancreatic β-cells

(2011) Yoshiaki Tamura et al.   FEBS LETTERS

RIP Kinase-Dependent Necrosis Drives Lethal Systemic Inflammatory Response Syndrome

(2011) Linde Duprez et al.   IMMUNITY

cIAPs Block Ripoptosome Formation, a RIP1/Caspase-8 Containing Intracellular Cell Death Complex Differentially Regulated by cFLIP Isoforms

(2011) Maria Feoktistova et al.   MOLECULAR CELL

The Ripoptosome, a Signaling Platform that Assembles in Response to Genotoxic Stress and Loss of IAPs

(2011) Tencho Tenev et al.   MOLECULAR CELL

The Ripoptosome: Death Decision in the Cytosol

(2011) Mathieu J.M. Bertrand et al.   MOLECULAR CELL

RIP1-Dependent and Independent Effects of Necrostatin-1 in Necrosis and T Cell Activation

(2011) YoungSik Cho et al.   PLoS One

The Dual Functions of Receptor Interacting Protein 1 in Fas-Induced Hepatocyte Death During Sepsis

(2011) Sam I. McNeal et al.   SHOCK

Indoleamine 2,3-Dioxygenase

(2010) Hatem Soliman et al.   CANCER JOURNAL

cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species production

(2010) N Vanlangenakker et al.   CELL DEATH AND DIFFERENTIATION

Necrostatin Decreases Oxidative Damage, Inflammation, and Injury after Neonatal HI

(2010) Frances J Northington et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Enhanced Indoleamine 2,3‐Dioxygenase Activity in Patients with Severe Sepsis and Septic Shock

(2010) Pierre Tattevin et al.   JOURNAL OF INFECTIOUS DISEASES

Kynurenine is an endothelium-derived relaxing factor produced during inflammation

(2010) Yutang Wang et al.   NATURE MEDICINE

Molecular mechanisms of necroptosis: an ordered cellular explosion

(2010) Peter Vandenabeele et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Receptor interacting protein kinases mediate retinal detachment-induced photoreceptor necrosis and compensate for inhibition of apoptosis

(2010) G. Trichonas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation

(2009) YoungSik Cho et al.   CELL

RIP Kinases at the Crossroads of Cell Death and Survival

(2009) Wim Declercq et al.   CELL

Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α

(2009) Sudan He et al.   CELL

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Blockade of Indoleamine 2,3-Dioxygenase Protects Mice against Lipopolysaccharide-Induced Endotoxin Shock

(2009) I. D. Jung et al.   JOURNAL OF IMMUNOLOGY

RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis

(2009) D.-W. Zhang et al.   SCIENCE

Exploring the mechanism of tryptophan 2,3-dioxygenase

(2008) Sarah J. Thackray et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Necrostatin-1 Reduces Histopathology and Improves Functional Outcome after Controlled Cortical Impact in Mice

(2008) Zerong You et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Structure Based Development of Phenylimidazole-Derived Inhibitors of Indoleamine 2,3-Dioxygenase

(2008) Sanjeev Kumar et al.   JOURNAL OF MEDICINAL CHEMISTRY

Indoleamine 2,3-dioxygenase in infection: the paradox of an evasive strategy that benefits the host

(2008) T ZELANTE et al.   MICROBES AND INFECTION

Identification of RIP1 kinase as a specific cellular target of necrostatins

(2008) Alexei Degterev et al.   Nature Chemical Biology