Pyroptotic Neuronal Cell Death Mediated by the AIM2 Inflammasome

The food dye FD&C Blue No. 1 is a selective inhibitor of the ATP release channel Panx1

(2013) Junjie Wang et al.   JOURNAL OF GENERAL PHYSIOLOGY

AIM2/ASC triggers caspase-8-dependent apoptosis in Francisella-infected caspase-1-deficient macrophages

(2012) R Pierini et al.   CELL DEATH AND DIFFERENTIATION

Circulating nucleic acids in plasma and serum: an intriguing phenomenon

(2012) Dolores C García-Olmo et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Structures of the HIN Domain:DNA Complexes Reveal Ligand Binding and Activation Mechanisms of the AIM2 Inflammasome and IFI16 Receptor

(2012) Tengchuan Jin et al.   IMMUNITY

First Report of Successful Treatment of Multidrug-Resistant Cytomegalovirus Disease with the Novel Anti-CMV Compound AIC246

(2011) D. R. Kaul et al.   AMERICAN JOURNAL OF TRANSPLANTATION

IFI16 Acts as a Nuclear Pathogen Sensor to Induce the Inflammasome in Response to Kaposi Sarcoma-Associated Herpesvirus Infection

(2011) Nagaraj Kerur et al.   Cell Host & Microbe

Caspase-1-induced pyroptotic cell death

(2011) Edward A. Miao et al.   IMMUNOLOGICAL REVIEWS

Coordinated Host Responses during Pyroptosis: Caspase-1-Dependent Lysosome Exocytosis and Inflammatory Cytokine Maturation

(2011) T. Bergsbaken et al.   JOURNAL OF IMMUNOLOGY

Cell-Free DNA as a Marker for Prediction of Brain Damage in Traumatic Brain Injury in Rats

(2011) Sharon Ohayon et al.   JOURNAL OF NEUROTRAUMA

AIM2 Joins the Gang of Microbial Sensors

(2010) Luigi Franchi et al.   Cell Host & Microbe

Involvement of the AIM2, NLRC4, and NLRP3 Inflammasomes in Caspase-1 Activation by Listeria monocytogenes

(2010) Jianghong Wu et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Sustained Inflammation Due to Nuclear Factor-Kappa B Activation in Irradiated Human Arteries

(2010) Martin Halle et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Pannexin 1 channels mediate ‘find-me’ signal release and membrane permeability during apoptosis

(2010) Faraaz B. Chekeni et al.   NATURE

The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses

(2010) Vijay A K Rathinam et al.   NATURE IMMUNOLOGY

The AIM2 inflammasome is critical for innate immunity to Francisella tularensis

(2010) Teresa Fernandes-Alnemri et al.   NATURE IMMUNOLOGY

The Pannexin 1 Channel Activates the Inflammasome in Neurons and Astrocytes

(2009) William R. Silverman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Therapeutic Neutralization of the NLRP1 Inflammasome Reduces the Innate Immune Response and Improves Histopathology after Traumatic Brain Injury

(2009) Juan Pablo de Rivero Vaccari et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

(2009) Teresa Fernandes-Alnemri et al.   NATURE

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

(2009) Veit Hornung et al.   NATURE

HIN-200 Proteins Regulate Caspase Activation in Response to Foreign Cytoplasmic DNA

(2009) T. L. Roberts et al.   SCIENCE

AIMing 2 Detect Foreign DNA

(2009) A. M. Krieg   Science Signaling

Efficacy and tolerability of urate-lowering drugs in gout: a randomised controlled trial of benzbromarone versus probenecid after failure of allopurinol

(2008) M K Reinders et al.   ANNALS OF THE RHEUMATIC DISEASES

A Molecular Platform in Neurons Regulates Inflammation after Spinal Cord Injury

(2008) J. P. de Rivero Vaccari et al.   JOURNAL OF NEUROSCIENCE

Targeted Peptidecentric Proteomics Reveals Caspase-7 as a Substrate of the Caspase-1 Inflammasomes

(2008) Mohamed Lamkanfi et al.   MOLECULAR & CELLULAR PROTEOMICS