标题
CAR T cell therapy for patients with solid tumours: key lessons to learn and unlearn
作者
关键词
-
出版物
Nature Reviews Clinical Oncology
Volume -, Issue -, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2023-10-31
DOI
10.1038/s41571-023-00832-4
参考文献
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Chimeric antigen receptor T‐cell therapy in multiple myeloma: A comprehensive review of current data and implications for clinical practice
- (2023) Rujul H. Parikh et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Exploration of Tumor Biopsy Gene Signatures to Understand the Role of the Tumor Microenvironment in Outcomes to Lisocabtagene Maraleucel
- (2023) N. Eric Olson et al. MOLECULAR CANCER THERAPEUTICS
- Modulation of the gut microbiota engages antigen cross-presentation to enhance antitumor effects of CAR T cell immunotherapy
- (2023) Mireia Uribe-Herranz et al. MOLECULAR THERAPY
- CAR T-cell behavior and function revealed by real-time imaging
- (2023) David Espie et al. Seminars in Immunopathology
- CAR T-Cell Persistence Correlates with Improved Outcome in Patients with B-Cell Lymphoma
- (2023) Valerie Wittibschlager et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- CLDN6 CAR-T cell therapy of relapsed/refractory solid tumors ± a CLDN6-encoding mRNA vaccine: Dose escalation data from the BNT211-01 phase 1 trial using an automated product.
- (2023) Andreas Mackensen et al. JOURNAL OF CLINICAL ONCOLOGY
- FAP-targeted CAR-T suppresses MDSCs recruitment to improve the antitumor efficacy of claudin18.2-targeted CAR-T against pancreatic cancer
- (2023) Yifan Liu et al. Journal of Translational Medicine
- CAR immune cells: design principles, resistance and the next generation
- (2023) Louai Labanieh et al. NATURE
- Base-Edited CAR7 T Cells for Relapsed T-Cell Acute Lymphoblastic Leukemia
- (2023) Robert Chiesa et al. NEW ENGLAND JOURNAL OF MEDICINE
- GD2-CART01 for Relapsed or Refractory High-Risk Neuroblastoma
- (2023) Francesca Del Bufalo et al. NEW ENGLAND JOURNAL OF MEDICINE
- Combined disruption of T cell inflammatory regulators Regnase-1 and Roquin-1 enhances antitumor activity of engineered human T cells
- (2023) David Mai et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Strategies for precise gene edits in mammalian cells
- (2023) Katye M. Fichter et al. Molecular Therapy-Nucleic Acids
- Intratumoral pan-ErbB targeted CAR-T for head and neck squamous cell carcinoma: interim analysis of the T4 immunotherapy study
- (2023) Sophie Papa et al. Journal for ImmunoTherapy of Cancer
- CAR-Based Immunotherapy of Solid Tumours—A Survey of the Emerging Targets
- (2023) John Maher et al. Cancers
- c-Kit signaling potentiates CAR T cell efficacy in solid tumors by CD28- and IL-2-independent co-stimulation
- (2023) Yuquan Xiong et al. Nature Cancer
- Tissue-resident memory CAR T cells with stem-like characteristics display enhanced efficacy against solid and liquid tumors
- (2023) In-Young Jung et al. Cell Reports Medicine
- Vaccine-boosted CAR T crosstalk with host immunity to reject tumors with antigen heterogeneity
- (2023) Leyuan Ma et al. CELL
- Mesothelin-targeting T cell receptor fusion construct cell therapy in refractory solid tumors: phase 1/2 trial interim results
- (2023) Raffit Hassan et al. NATURE MEDICINE
- GD2-CAR T cell therapy for H3K27M-mutated diffuse midline gliomas
- (2022) Robbie G. Majzner et al. NATURE
- CAR T cells produced in vivo to treat cardiac injury
- (2022) Joel G. Rurik et al. SCIENCE
- Controlling Cell Trafficking: Addressing Failures in CAR T and NK Cell Therapy of Solid Tumours
- (2022) Lydia G. White et al. Cancers
- Knowns and Unknowns about CAR-T Cell Dysfunction
- (2022) Aleksei Titov et al. Cancers
- Advances in Allogeneic Cancer Cell Therapy and Future Perspectives on “Off-the-Shelf” T Cell Therapy Using iPSC Technology and Gene Editing
- (2022) Yoshiki Furukawa et al. Cells
- CAR T cell killing requires the IFNγR pathway in solid but not liquid tumours
- (2022) Rebecca C. Larson et al. NATURE
- Claudin18.2-specific CAR T cells in gastrointestinal cancers: phase 1 trial interim results
- (2022) Changsong Qi et al. NATURE MEDICINE
- PSMA-targeting TGFβ-insensitive armored CAR T cells in metastatic castration-resistant prostate cancer: a phase 1 trial
- (2022) Vivek Narayan et al. NATURE MEDICINE
- CAR-T Cell Performance: How to Improve Their Persistence?
- (2022) Gina López-Cantillo et al. Frontiers in Immunology
- Bioorthogonal Equipping CAR-T Cells with Hyaluronidase and Checkpoint Blocking Antibody for Enhanced Solid Tumor Immunotherapy
- (2022) Yangyang Zhao et al. ACS Central Science
- Improving CAR-T immunotherapy: Overcoming the challenges of T cell exhaustion
- (2022) Diana Gumber et al. EBioMedicine
- Monitoring Therapeutic Response to Anti-Fibroblast Activation Protein (FAP) CAR T Cells using [18F]AlF-FAPI-74
- (2022) Iris K. Lee et al. CLINICAL CANCER RESEARCH
- Multiplexed LNP-mRNA vaccination against pathogenic coronavirus species
- (2022) Lei Peng et al. Cell Reports
- The Past, Present, and Future of Non-Viral CAR T Cells
- (2022) Alex Moretti et al. Frontiers in Immunology
- Revolution of CAR Engineering For Next-Generation Immunotherapy In Solid Tumors
- (2022) Tao Yu et al. Frontiers in Immunology
- Generation of T-cell-receptor-negative CD8αβ-positive CAR T cells from T-cell-derived induced pluripotent stem cells
- (2022) Sjoukje J. C. van der Stegen et al. Nature Biomedical Engineering
- LBA38 BNT211-01: A phase I trial to evaluate safety and efficacy of CLDN6 CAR T cells and CLDN6-encoding mRNA vaccine-mediated in vivo expansion in patients with CLDN6-positive advanced solid tumours
- (2022) A. Mackensen et al. ANNALS OF ONCOLOGY
- Multifunctional mRNA-Based CAR T Cells Display Promising Antitumor Activity Against Glioblastoma
- (2022) Hanna Meister et al. CLINICAL CANCER RESEARCH
- Tumor immune contexture is a determinant of anti-CD19 CAR T cell efficacy in large B cell lymphoma
- (2022) Nathalie Scholler et al. NATURE MEDICINE
- Clinical implications of T cell exhaustion for cancer immunotherapy
- (2022) Andrew Chow et al. Nature Reviews Clinical Oncology
- Migratory Engineering of T Cells for Cancer Therapy
- (2022) Stefanos Michaelides et al. Vaccines
- Expression of inducible factors reprograms CAR-T cells for enhanced function and safety
- (2022) Anže Smole et al. CANCER CELL
- Tumor-Infiltrating Lymphocyte Therapy in Melanoma: Facts to the Future
- (2022) Allison Betof Warner et al. CLINICAL CANCER RESEARCH
- Comprehensive clinical evaluation of CAR-T cell immunotherapy for solid tumors: a path moving forward or a dead end?
- (2022) Konstantinos Drougkas et al. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
- Tumor-Infiltrating Lymphocyte Therapy or Ipilimumab in Advanced Melanoma
- (2022) Maartje W. Rohaan et al. NEW ENGLAND JOURNAL OF MEDICINE
- Applying a clinical lens to animal models of CAR-T cell therapies
- (2022) Brynn B. Duncan et al. Molecular Therapy-Methods & Clinical Development
- Insight into next-generation CAR therapeutics: designing CAR T cells to improve clinical outcomes
- (2021) Emiliano Roselli et al. JOURNAL OF CLINICAL INVESTIGATION
- A clinically applicable and scalable method to regenerate T-cells from iPSCs for off-the-shelf T-cell immunotherapy
- (2021) Shoichi Iriguchi et al. Nature Communications
- A critical role for fas-mediated off-target tumor killing in T cell immunotherapy
- (2021) Ranjan Upadhyay et al. Cancer Discovery
- TCR-engineered T cells targeting E7 for patients with metastatic HPV-associated epithelial cancers
- (2021) Nisha B. Nagarsheth et al. NATURE MEDICINE
- CD28 Co-Stimulus Achieves Superior CAR T Cell Effector Function against Solid Tumors Than 4-1BB Co-Stimulus
- (2021) Ana Textor et al. Cancers
- In Situ Programming of CAR T Cells
- (2021) Neha N. Parayath et al. Annual Review of Biomedical Engineering
- Transient rest restores functionality in exhausted CAR-T cells through epigenetic remodeling
- (2021) Evan W. Weber et al. SCIENCE
- Imaging of T-cell Responses in the Context of Cancer Immunotherapy
- (2021) Zebin Xiao et al. Cancer Immunology Research
- Recruitment and Expansion of Tregs Cells in the Tumor Environment—How to Target Them?
- (2021) Justine Cinier et al. Cancers
- CD19 target evasion as a mechanism of relapse in large B-cell lymphoma treated with axicabtagene ciloleucel
- (2021) Vicki Plaks et al. BLOOD
- Combination therapy with CAR T cells and oncolytic viruses: a new era in cancer immunotherapy
- (2021) Ramazan Rezaei et al. CANCER GENE THERAPY
- The immunostimulatory RNA RN7SL1 enables CAR-T cells to enhance autonomous and endogenous immune function
- (2021) Lexus R. Johnson et al. CELL
- Tumor-infiltrating lymphocyte treatment for anti-PD-1-resistant metastatic lung cancer: a phase 1 trial
- (2021) Benjamin C. Creelan et al. NATURE MEDICINE
- Clinical and therapeutic relevance of cancer-associated fibroblasts
- (2021) Yang Chen et al. Nature Reviews Clinical Oncology
- A phase I trial of regional mesothelin-targeted CAR T-cell therapy in patients with malignant pleural disease, in combination with the anti-PD-1 agent pembrolizumab
- (2021) Prasad S Adusumilli et al. Cancer Discovery
- Development of a Clinically Relevant Reporter for Chimeric Antigen Receptor T-cell Expansion, Trafficking, and Toxicity
- (2021) Reona Sakemura et al. Cancer Immunology Research
- Human Hyaluronidase PH20 Potentiates the Antitumor Activities of Mesothelin-Specific CAR-T Cells Against Gastric Cancer
- (2021) Ruocong Zhao et al. Frontiers in Immunology
- Imaging CAR T-cell kinetics in solid tumors: Translational implications
- (2021) Matthew S. Skovgard et al. Molecular Therapy-Oncolytics
- Lipid nanoparticles for mRNA delivery
- (2021) Xucheng Hou et al. Nature Reviews Materials
- Cytolytic Activity of CAR T Cells and Maintenance of Their CD4+ Subset Is Critical for Optimal Antitumor Activity in Preclinical Solid Tumor Models
- (2021) Marianna Csaplár et al. Cancers
- Prospects for Development of Induced Pluripotent Stem Cell-Derived CAR-Targeted Immunotherapies
- (2021) Roberta Mazza et al. ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS
- An NK-like CAR T cell transition in CAR T cell dysfunction
- (2021) Charly R. Good et al. CELL
- Non-invasive cell-tracking methods for adoptive T cell therapies
- (2021) Jelter Van Hoeck et al. DRUG DISCOVERY TODAY
- Combining a CAR and a chimeric costimulatory receptor enhances T cell sensitivity to low antigen density and promotes persistence
- (2021) Afroditi Katsarou et al. Science Translational Medicine
- Deleting DNMT3A in CAR T cells prevents exhaustion and enhances antitumor activity
- (2021) Brooke Prinzing et al. Science Translational Medicine
- CAR T-cell Entry into Tumor Islets Is a Two-Step Process Dependent on IFNγ and ICAM-1
- (2021) Chahrazade Kantari-Mimoun et al. Cancer Immunology Research
- Advances in Adoptive Cell Therapy Using Induced Pluripotent Stem Cell-Derived T Cells
- (2021) Ratchapong Netsrithong et al. Frontiers in Immunology
- Immune Modulatory Properties of Collagen in Cancer
- (2021) Anne Mette Askehøj Rømer et al. Frontiers in Immunology
- Epitope spreading driven by the joint action of CART cells and pharmacological STING stimulation counteracts tumor escape via antigen-loss variants
- (2021) Enrique Conde et al. Journal for ImmunoTherapy of Cancer
- CRISPR-engineered T cells in patients with refractory cancer
- (2020) Edward A. Stadtmauer et al. SCIENCE
- An RNA vaccine drives expansion and efficacy of claudin-CAR-T cells against solid tumors
- (2020) Katharina Reinhard et al. SCIENCE
- Tumor Antigen Heterogeneity: The “Elephant in the Room” of Adoptive T-cell Therapy for Solid Tumors
- (2020) Steven M. Albelda Cancer Immunology Research
- Quantitative Control of Gene-Engineered T-Cell Activity through the Covalent Attachment of Targeting Ligands to a Universal Immune Receptor
- (2020) Nicholas G. Minutolo et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Adoptive cellular therapy with T cells expressing the dendritic cell growth factor Flt3L drives epitope spreading and antitumor immunity
- (2020) Junyun Lai et al. NATURE IMMUNOLOGY
- Prolonged Persistence of Chimeric Antigen Receptor (CAR) T Cell in Adoptive Cancer Immunotherapy: Challenges and Ways Forward
- (2020) Leila Jafarzadeh et al. Frontiers in Immunology
- Preclinical evaluation of CD8+ anti-BCMA mRNA CAR T cells for treatment of multiple myeloma
- (2020) Liang Lin et al. LEUKEMIA
- Ligand-Induced Degradation of a CAR Permits Reversible Remote Control of CAR T Cell Activity In Vitro and In Vivo
- (2020) Sarah A. Richman et al. MOLECULAR THERAPY
- Engineering Immune Cells for in vivo Secretion of Tumor-Specific T Cell-Redirecting Bispecific Antibodies
- (2020) Belén Blanco et al. Frontiers in Immunology
- Humanized Mice Are Precious Tools for Preclinical Evaluation of CAR T and CAR NK Cell Therapies
- (2020) Rana Mhaidly et al. Cancers
- Activation of CAR and non-CAR T cells within the tumor microenvironment following CAR T cell therapy
- (2020) Pei-Hsuan Chen et al. JCI Insight
- CD19-Specific CAR-T Cells that Express a PD-1/CD28 Chimeric Switch-Receptor is Effective in Patients with PD-L1 Positive B-Cell Lymphoma
- (2020) Hui Liu et al. CLINICAL CANCER RESEARCH
- In Vitro-Transcribed mRNA Chimeric Antigen Receptor T Cell (IVT mRNA CAR T) Therapy in Hematologic and Solid Tumor Management: A Preclinical Update
- (2020) Thangavelu Soundara Rajan et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Lisocabtagene maraleucel for patients with relapsed or refractory large B-cell lymphomas (TRANSCEND NHL 001): a multicentre seamless design study
- (2020) Jeremy S Abramson et al. LANCET
- CAR T Cell Therapy for Solid Tumors: Bright Future or Dark Reality?
- (2020) Jessica Wagner et al. MOLECULAR THERAPY
- Characteristics of anti-CD19 CAR T cell infusion products associated with efficacy and toxicity in patients with large B cell lymphomas
- (2020) Qing Deng et al. NATURE MEDICINE
- Fibroblast heterogeneity in tumor micro-environment: Role in immunosuppression and new therapies
- (2020) Rana Mhaidly et al. SEMINARS IN IMMUNOLOGY
- Analysis and Augmentation of the Immunologic Bystander Effects of CAR T Cell Therapy in a Syngeneic Mouse Cancer Model
- (2020) Astero Klampatsa et al. Molecular Therapy-Oncolytics
- Tumor burden, inflammation, and product attributes determine outcomes of axicabtagene ciloleucel in large B-cell lymphoma
- (2020) Frederick L. Locke et al. Blood Advances
- Immunogenic Chemotherapy Enhances Recruitment of CAR-T Cells to Lung Tumors and Improves Antitumor Efficacy when Combined with Checkpoint Blockade
- (2020) Shivani Srivastava et al. CANCER CELL
- Stem-like CD8 T cells mediate response of adoptive cell immunotherapy against human cancer
- (2020) Sri Krishna et al. SCIENCE
- CD103+ cDC1 and endogenous CD8+ T cells are necessary for improved CD40L-overexpressing CAR T cell antitumor function
- (2020) Nicholas F. Kuhn et al. Nature Communications
- Fucosylation enhances the efficacy of adoptively transferred antigen-specific cytotoxic T lymphocytes
- (2019) Gheath Alatrash et al. CLINICAL CANCER RESEARCH
- The First Step in Adoptive Cell Immunotherapeutics: Assuring Cell Delivery via Glycoengineering
- (2019) Robert Sackstein Frontiers in Immunology
- The Emergence of Universal Immune Receptor T Cell Therapy for Cancer
- (2019) Nicholas G. Minutolo et al. Frontiers in Oncology
- NR4A transcription factors limit CAR T cell function in solid tumours
- (2019) Joyce Chen et al. NATURE
- The Emerging Role of In Vitro-Transcribed mRNA in Adoptive T Cell Immunotherapy
- (2019) Jessica B. Foster et al. MOLECULAR THERAPY
- T cells genetically engineered to overcome death signaling enhance adoptive cancer immunotherapy
- (2019) Tori N. Yamamoto et al. JOURNAL OF CLINICAL INVESTIGATION
- CD40 Ligand-Modified Chimeric Antigen Receptor T Cells Enhance Antitumor Function by Eliciting an Endogenous Antitumor Response
- (2019) Nicholas F. Kuhn et al. CANCER CELL
- Chimeric antigen receptor T cell persistence and memory cell formation
- (2019) Alexander D McLellan et al. IMMUNOLOGY AND CELL BIOLOGY
- Combined Adjuvant of Poly I:C Improves Antitumor Effects of CAR-T Cells
- (2019) Shengmeng Di et al. Frontiers in Oncology
- Phase I study of lentiviral-transduced chimeric antigen receptor modified T cells recognizing mesothelin in advanced solid cancers
- (2019) Andrew R. Haas et al. MOLECULAR THERAPY
- CAR-T cells secreting BiTEs circumvent antigen escape without detectable toxicity
- (2019) Bryan D. Choi et al. NATURE BIOTECHNOLOGY
- Synthetic TRuC receptors engaging the complete T cell receptor for potent anti-tumor response
- (2019) Patrick A. Baeuerle et al. Nature Communications
- L-Selectin Enhanced T Cells Improve the Efficacy of Cancer Immunotherapy
- (2019) H. Angharad Watson et al. Frontiers in Immunology
- Imaging CAR T cell therapy with PSMA-targeted positron emission tomography
- (2019) Il Minn et al. Science Advances
- Clinical lessons learned from the first leg of the CAR T cell journey
- (2019) Robbie G. Majzner et al. NATURE MEDICINE
- Beyond the Cell Surface: Targeting Intracellular Negative Regulators to Enhance T cell Anti-Tumor Activity
- (2019) Sitaram et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Glycoengineering of chimeric antigen receptor (CAR) T-cells to enforce E-selectin binding
- (2019) Nandini Mondal et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Imaging CAR T Cell Trafficking with eDHFR as a PET Reporter Gene
- (2019) Mark A. Sellmyer et al. MOLECULAR THERAPY
- Pathogen-Boosted Adoptive Cell Transfer Therapy Induces Endogenous Antitumor Immunity through Antigen Spreading
- (2019) Gang Xin et al. Cancer Immunology Research
- Myeloid cell and cytokine interactions with chimeric antigen receptor-T-cell therapy
- (2019) Rosalie M. Sterner et al. CURRENT OPINION IN HEMATOLOGY
- c-Jun overexpression in CAR T cells induces exhaustion resistance
- (2019) Rachel C. Lynn et al. NATURE
- Engineering strategies to overcome the current roadblocks in CAR T cell therapy
- (2019) Sarwish Rafiq et al. Nature Reviews Clinical Oncology
- High Frequency Production of T Cell-Derived iPSC Clones Capable of Generating Potent Cytotoxic T Cells
- (2019) Seiji Nagano et al. Molecular Therapy-Methods & Clinical Development
- N-acetyl cysteine protects anti-melanoma cytotoxic T cells from exhaustion induced by rapid expansion via the downmodulation of Foxo1 in an Akt-dependent manner
- (2018) Matthew J. Scheffel et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Universal Chimeric Antigen Receptors for Multiplexed and Logical Control of T Cell Responses
- (2018) Jang Hwan Cho et al. CELL
- Driving CARs on the uneven road of antigen heterogeneity in solid tumors
- (2018) Nan Chen et al. CURRENT OPINION IN IMMUNOLOGY
- Development of Anti-Human Mesothelin-Targeted Chimeric Antigen Receptor Messenger RNA–Transfected Peripheral Blood Lymphocytes for Ovarian Cancer Therapy
- (2018) Chien-Fu Hung et al. HUMAN GENE THERAPY
- PI3K orchestration of the in vivo persistence of chimeric antigen receptor-modified T cells
- (2018) Wenting Zheng et al. LEUKEMIA
- CD28-ζ CAR T cells resist TGF-β repression through IL-2 signaling which can be mimicked by IL-7 and an engineered IL-7/IL-2Rβ autocrine loop
- (2018) Viktória Golumba-Nagy et al. MOLECULAR THERAPY
- Dominant-Negative TGF-β Receptor Enhances PSMA-Targeted Human CAR T Cell Proliferation And Augments Prostate Cancer Eradication
- (2018) Christopher C. Kloss et al. MOLECULAR THERAPY
- IL-7 and CCL19 expression in CAR-T cells improves immune cell infiltration and CAR-T cell survival in the tumor
- (2018) Keishi Adachi et al. NATURE BIOTECHNOLOGY
- Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia
- (2018) Joseph A. Fraietta et al. NATURE MEDICINE
- Chimeric Antigen Receptor Therapy
- (2018) Carl H. June et al. NEW ENGLAND JOURNAL OF MEDICINE
- Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes
- (2018) Jonathan T. Sockolosky et al. SCIENCE
- Intra-tumoral delivery of CXCL11 via a vaccinia virus, but not by modified T cells, enhances the efficacy of adoptive T cell therapy and vaccines
- (2018) Edmund K. Moon et al. OncoImmunology
- CART cells are prone to Fas- and DR5-mediated cell death
- (2018) Benjamin O. Tschumi et al. Journal for ImmunoTherapy of Cancer
- Genetic mechanisms of target antigen loss in CAR19 therapy of acute lymphoblastic leukemia
- (2018) Elena J. Orlando et al. NATURE MEDICINE
- The chimeric TAC receptor co-opts the T cell receptor yielding robust anti-tumor activity without toxicity
- (2018) Christopher W. Helsen et al. Nature Communications
- CAR T Cells in Solid Tumors: Blueprints for Building Effective Therapies
- (2018) Hannah M. Knochelmann et al. Frontiers in Immunology
- Enhancing T Cell Receptor Stability in Rejuvenated iPSC-Derived T Cells Improves Their Use in Cancer Immunotherapy
- (2018) Atsutaka Minagawa et al. Cell Stem Cell
- Switchable control over in vivo CAR T expansion, B cell depletion, and induction of memory
- (2018) Sophie Viaud et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Inflammatory CXC Chemokines, GROαhigh, IP-10low, and MIGlow, in Tumor Microenvironment Can Be Used as New Indicators for Non-small Cell Lung Cancer Progression
- (2017) Ya Cao et al. IMMUNOLOGICAL INVESTIGATIONS
- T-lymphocyte homing: an underappreciated yet critical hurdle for successful cancer immunotherapy
- (2017) Robert Sackstein et al. LABORATORY INVESTIGATION
- Vaccination to improve the persistence of CD19CAR gene-modified T cells in relapsed pediatric acute lymphoblastic leukemia
- (2017) C Rossig et al. LEUKEMIA
- Runx3 programs CD8+ T cell residency in non-lymphoid tissues and tumours
- (2017) J. Justin Milner et al. NATURE
- Therapeutic T cell engineering
- (2017) Michel Sadelain et al. NATURE
- Pathogen boosted adoptive cell transfer immunotherapy to treat solid tumors
- (2017) Gang Xin et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma
- (2017) Donald M. O’Rourke et al. Science Translational Medicine
- Reporter gene imaging of targeted T cell immunotherapy in recurrent glioma
- (2017) Khun Visith Keu et al. Science Translational Medicine
- CAR T Cells Releasing IL-18 Convert to T-Bet high FoxO1 low Effectors that Exhibit Augmented Activity against Advanced Solid Tumors
- (2017) Markus Chmielewski et al. Cell Reports
- Oncolytic Adenoviruses Armed with Tumor Necrosis Factor Alpha and Interleukin-2 Enable Successful Adoptive Cell Therapy
- (2017) Riikka Havunen et al. Molecular Therapy-Oncolytics
- Homing to solid cancers: a vascular checkpoint in adoptive cell therapy using CAR T-cells
- (2016) Ann Ager et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Multiplex Genome Editing to Generate Universal CAR T Cells Resistant to PD1 Inhibition
- (2016) Jiangtao Ren et al. CLINICAL CANCER RESEARCH
- Dual-specific Chimeric Antigen Receptor T Cells and an Indirect Vaccine Eradicate a Variety of Large Solid Tumors in an Immunocompetent, Self-antigen Setting
- (2016) Clare Y. Slaney et al. CLINICAL CANCER RESEARCH
- Distinct Signaling of Coreceptors Regulates Specific Metabolism Pathways and Impacts Memory Development in CAR T Cells
- (2016) Omkar U. Kawalekar et al. IMMUNITY
- GD2-specific CAR T Cells Undergo Potent Activation and Deletion Following Antigen Encounter but can be Protected From Activation-induced Cell Death by PD-1 Blockade
- (2016) Tessa Gargett et al. MOLECULAR THERAPY
- Adenoviral Delivery of Tumor Necrosis Factor-α and Interleukin-2 Enables Successful Adoptive Cell Therapy of Immunosuppressive Melanoma
- (2016) Mikko Siurala et al. MOLECULAR THERAPY
- Regression of Glioblastoma after Chimeric Antigen Receptor T-Cell Therapy
- (2016) Christine E. Brown et al. NEW ENGLAND JOURNAL OF MEDICINE
- Reprogramming the tumor microenvironment to enhance adoptive cellular therapy
- (2016) Paul A. Beavis et al. SEMINARS IN IMMUNOLOGY
- Multiparameter comparative analysis reveals differential impacts of various cytokines on CART cell phenotype and function ex vivo and in vivo
- (2016) Xiao-Jun Xu et al. Oncotarget
- Augmentation of CAR T-cell Trafficking and Antitumor Efficacy by Blocking Protein Kinase A Localization
- (2016) K. Newick et al. Cancer Immunology Research
- TLR5 Ligand-Secreting T Cells Reshape the Tumor Microenvironment and Enhance Antitumor Activity
- (2015) D. Geng et al. CANCER RESEARCH
- Tumor-Promoting Desmoplasia Is Disrupted by Depleting FAP-Expressing Stromal Cells
- (2015) A. Lo et al. CANCER RESEARCH
- Neutralization of Tumor Acidity Improves Antitumor Responses to Immunotherapy
- (2015) Shari Pilon-Thomas et al. CANCER RESEARCH
- Coexpressed Catalase Protects Chimeric Antigen Receptor–Redirected T Cells as well as Bystander Cells from Oxidative Stress–Induced Loss of Antitumor Activity
- (2015) Maarten A. Ligtenberg et al. JOURNAL OF IMMUNOLOGY
- Comparative Analysis of T Cell Imaging with Human Nuclear Reporter Genes
- (2015) M. A. Moroz et al. JOURNAL OF NUCLEAR MEDICINE
- CD33-specific chimeric antigen receptor T cells exhibit potent preclinical activity against human acute myeloid leukemia
- (2015) S S Kenderian et al. LEUKEMIA
- Heparanase promotes tumor infiltration and antitumor activity of CAR-redirected T lymphocytes
- (2015) Ignazio Caruana et al. NATURE MEDICINE
- Adoptive cell transfer as personalized immunotherapy for human cancer
- (2015) S. A. Rosenberg et al. SCIENCE
- Rigorous optimization and validation of potent RNA CAR T cell therapy for the treatment of common epithelial cancers expressing folate receptor
- (2015) Keith Schutsky et al. Oncotarget
- Generation of Potent T-cell Immunotherapy for Cancer Using DAP12-Based, Multichain, Chimeric Immunoreceptors
- (2015) E. Wang et al. Cancer Immunology Research
- A high density of tertiary lymphoid structure B cells in lung tumors is associated with increased CD4+T cell receptor repertoire clonality
- (2015) Wei Zhu et al. OncoImmunology
- Armed Oncolytic Virus Enhances Immune Functions of Chimeric Antigen Receptor-Modified T Cells in Solid Tumors
- (2014) N. Nishio et al. CANCER RESEARCH
- Multifactorial T-cell Hypofunction That Is Reversible Can Limit the Efficacy of Chimeric Antigen Receptor-Transduced Human T cells in Solid Tumors
- (2014) E. K. Moon et al. CLINICAL CANCER RESEARCH
- Chimeric Antigen Receptor T Cells for Sustained Remissions in Leukemia
- (2014) Shannon L. Maude et al. NEW ENGLAND JOURNAL OF MEDICINE
- Regional delivery of mesothelin-targeted CAR T cell therapy generates potent and long-lasting CD4-dependent tumor immunity
- (2014) P. S. Adusumilli et al. Science Translational Medicine
- Regimen-Specific Effects of RNA-Modified Chimeric Antigen Receptor T Cells in Mice with Advanced Leukemia
- (2013) David M. Barrett et al. HUMAN GENE THERAPY
- Immune targeting of fibroblast activation protein triggers recognition of multipotent bone marrow stromal cells and cachexia
- (2013) Eric Tran et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Mesothelin-Specific Chimeric Antigen Receptor mRNA-Engineered T Cells Induce Antitumor Activity in Solid Malignancies
- (2013) G. L. Beatty et al. Cancer Immunology Research
- Targeting Fibroblast Activation Protein in Tumor Stroma with Chimeric Antigen Receptor T Cells Can Inhibit Tumor Growth and Augment Host Immunity without Severe Toxicity
- (2013) L.-C. S. Wang et al. Cancer Immunology Research
- T Cells Expressing Chimeric Antigen Receptors Can Cause Anaphylaxis in Humans
- (2013) M. V. Maus et al. Cancer Immunology Research
- Tumor-targeted T cells modified to secrete IL-12 eradicate systemic tumors without need for prior conditioning
- (2012) H. J. Pegram et al. BLOOD
- A Potent Vaccination Strategy That Circumvents Lymphodepletion for Effective Antitumor Adoptive T-cell Therapy
- (2012) H.-I. Cho et al. CANCER RESEARCH
- Bone marrow and the control of immunity
- (2011) Ende Zhao et al. Cellular & Molecular Immunology
- Expression of a Functional CCR2 Receptor Enhances Tumor Localization and Tumor Eradication by Retargeted Human T cells Expressing a Mesothelin-Specific Chimeric Antibody Receptor
- (2011) E. K. Moon et al. CLINICAL CANCER RESEARCH
- Trafficking of CAR-Engineered Human T Cells Following Regional or Systemic Adoptive Transfer in SCID Beige Mice
- (2011) Ana Caterina Parente-Pereira et al. JOURNAL OF CLINICAL IMMUNOLOGY
- Functional Consequences of Human Lymphocyte Cryopreservation
- (2011) Jeff M. Faint et al. JOURNAL OF IMMUNOTHERAPY
- Improving Adoptive T Cell Therapy by Targeting and Controlling IL-12 Expression to the Tumor Environment
- (2011) Ling Zhang et al. MOLECULAR THERAPY
- A human memory T cell subset with stem cell–like properties
- (2011) Luca Gattinoni et al. NATURE MEDICINE
- Multiple Injections of Electroporated Autologous T Cells Expressing a Chimeric Antigen Receptor Mediate Regression of Human Disseminated Tumor
- (2010) Y. Zhao et al. CANCER RESEARCH
- Transiently redirected T cells for adoptive transfer
- (2010) Hilde Almåsbak et al. CYTOTHERAPY
- Case Report of a Serious Adverse Event Following the Administration of T Cells Transduced With a Chimeric Antigen Receptor Recognizing ERBB2
- (2010) Richard A Morgan et al. MOLECULAR THERAPY
- Chimeric Antigen Receptors Combining 4-1BB and CD28 Signaling Domains Augment PI3kinase/AKT/Bcl-XL Activation and CD8+ T Cell–mediated Tumor Eradication
- (2009) Xiao-Song Zhong et al. MOLECULAR THERAPY
- Control of large, established tumor xenografts with genetically retargeted human T cells containing CD28 and CD137 domains
- (2009) C. Carpenito et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Virus-specific T cells engineered to coexpress tumor-specific receptors: persistence and antitumor activity in individuals with neuroblastoma
- (2008) Martin A Pule et al. NATURE MEDICINE
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