The immunostimulatory RNA RN7SL1 enables CAR-T cells to enhance autonomous and endogenous immune function

Peripheral T cell expansion predicts tumour infiltration and clinical response

(2020) Thomas D. Wu et al.   NATURE

Defining the emergence of myeloid-derived suppressor cells in breast cancer using single-cell transcriptomics

(2020) Hamad Alshetaiwi et al.   Science Immunology

Pooled Knockin Targeting for Genome Engineering of Cellular Immunotherapies

(2020) Theodore L. Roth et al.   CELL

Developmental Relationships of Four Exhausted CD8+ T Cell Subsets Reveals Underlying Transcriptional and Epigenetic Landscape Control Mechanisms

(2020) Jean-Christophe Beltra et al.   IMMUNITY

A conserved dendritic-cell regulatory program limits antitumour immunity

(2020) Barbara Maier et al.   NATURE

Tuning the Antigen Density Requirement for CAR T-cell Activity

(2020) Robbie G. Majzner et al.   Cancer Discovery

cGAS-STING–mediated DNA sensing maintains CD8+ T cell stemness and promotes antitumor T cell therapy

(2020) Wenwen Li et al.   Science Translational Medicine

STING-mediated intestinal barrier dysfunction contributes to lethal sepsis

(2019) Qiongyuan Hu et al.   EBioMedicine

CAR T cell trogocytosis and cooperative killing regulate tumour antigen escape

(2019) Mohamad Hamieh et al.   NATURE

Neoantigen screening identifies broad TP53 mutant immunogenicity in patients with epithelial cancers

(2019) Parisa Malekzadeh et al.   JOURNAL OF CLINICAL INVESTIGATION

Double-Stranded RNA Sensors and Modulators in Innate Immunity

(2019) Sun Hur   Annual Review of Immunology

Single-Cell Transcriptomics of Human and Mouse Lung Cancers Reveals Conserved Myeloid Populations across Individuals and Species

(2019) Rapolas Zilionis et al.   IMMUNITY

RB constrains lineage fidelity and multiple stages of tumour progression and metastasis

(2019) David M. Walter et al.   NATURE

Systemic clinical tumor regressions and potentiation of PD1 blockade with in situ vaccination

(2019) Linda Hammerich et al.   NATURE MEDICINE

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

Opposing Functions of Interferon Coordinate Adaptive and Innate Immune Responses to Cancer Immune Checkpoint Blockade

(2019) Joseph L. Benci et al.   CELL

Sustained Type I interferon signaling as a mechanism of resistance to PD-1 blockade

(2019) Nicolas Jacquelot et al.   CELL RESEARCH

Type I IFN protects cancer cells from CD8+ T cell–mediated cytotoxicity after radiation

(2019) Jianzhou Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Clinical lessons learned from the first leg of the CAR T cell journey

(2019) Robbie G. Majzner et al.   NATURE MEDICINE

RIG-I-like receptors direct inflammatory macrophage polarization against West Nile virus infection

(2019) Amy E. L. Stone et al.   Nature Communications

Proliferating Transitory T Cells with an Effector-like Transcriptional Signature Emerge from PD-1+ Stem-like CD8+ T Cells during Chronic Infection

(2019) William H. Hudson et al.   IMMUNITY

Inhibiting extracellular vesicles formation and release: a review of EV inhibitors

(2019) Mariadelva Catalano et al.   Journal of Extracellular Vesicles

Dominant-Negative TGF-β Receptor Enhances PSMA-Targeted Human CAR T Cell Proliferation And Augments Prostate Cancer Eradication

(2018) Christopher C. Kloss et al.   MOLECULAR THERAPY

Chromosomal instability drives metastasis through a cytosolic DNA response

(2018) Samuel F. Bakhoum et al.   NATURE

SAVER: gene expression recovery for single-cell RNA sequencing

(2018) Mo Huang et al.   NATURE METHODS

Intra-tumoral delivery of CXCL11 via a vaccinia virus, but not by modified T cells, enhances the efficacy of adoptive T cell therapy and vaccines

(2018) Edmund K. Moon et al.   OncoImmunology

Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial

(2018) Derin B. Keskin et al.   NATURE

Design of amidobenzimidazole STING receptor agonists with systemic activity

(2018) Joshi M. Ramanjulu et al.   NATURE

Magnitude of Therapeutic STING Activation Determines CD8+ T Cell-Mediated Anti-tumor Immunity

(2018) Kelsey E. Sivick et al.   Cell Reports

Shared cancer neoantigens: Making private matters public

(2017) Christopher A. Klebanoff et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Reversed graph embedding resolves complex single-cell trajectories

(2017) Xiaojie Qiu et al.   NATURE METHODS

Acquisition of a CD19-negative myeloid phenotype allows immune escape of MLL-rearranged B-ALL from CD19 CAR-T-cell therapy

(2016) R. Gardner et al.   BLOOD

A Chimeric Switch-Receptor Targeting PD1 Augments the Efficacy of Second-Generation CAR T Cells in Advanced Solid Tumors

(2016) Xiaojun Liu et al.   CANCER RESEARCH

Tumor Interferon Signaling Regulates a Multigenic Resistance Program to Immune Checkpoint Blockade

(2016) Joseph L. Benci et al.   CELL

Engineering T Cells with Customized Therapeutic Response Programs Using Synthetic Notch Receptors

(2016) Kole T. Roybal et al.   CELL

Engineered CAR T Cells Targeting the Cancer-Associated Tn-Glycoform of the Membrane Mucin MUC1 Control Adenocarcinoma

(2016) Avery D. Posey et al.   IMMUNITY

Carcinoma–astrocyte gap junctions promote brain metastasis by cGAMP transfer

(2016) Qing Chen et al.   NATURE

Temporally Programmed CD8α + DC Activation Enhances Combination Cancer Immunotherapy

(2016) Alice Tzeng et al.   Cell Reports

RIG-I Signaling Is Critical for Efficient Polyfunctional T Cell Responses during Influenza Virus Infection

(2016) Matheswaran Kandasamy et al.   PLoS Pathogens

Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer

(2015) Christina Twyman-Saint Victor et al.   NATURE

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Neoantigens in cancer immunotherapy

(2015) T. N. Schumacher et al.   SCIENCE

Convergence of Acquired Mutations and Alternative Splicing of CD19 Enables Resistance to CART-19 Immunotherapy

(2015) E. Sotillo et al.   Cancer Discovery

Exosome Transfer from Stromal to Breast Cancer Cells Regulates Therapy Resistance Pathways

(2014) Mirjam C. Boelens et al.   CELL

The Sec translocon mediated protein transport in prokaryotes and eukaryotes

(2014) Kärt Denks et al.   MOLECULAR MEMBRANE BIOLOGY

Polarized release of T-cell-receptor-enriched microvesicles at the immunological synapse

(2014) Kaushik Choudhuri et al.   NATURE

GSVA: gene set variation analysis for microarray and RNA-Seq data

(2013) Sonja Hänzelmann et al.   BMC BIOINFORMATICS

Endogenous T Cell Responses to Antigens Expressed in Lung Adenocarcinomas Delay Malignant Tumor Progression

(2011) Michel DuPage et al.   CANCER CELL

Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells

(2011) María Mittelbrunn et al.   Nature Communications

RNAstructure: software for RNA secondary structure prediction and analysis

(2010) Jessica S Reuter et al.   BMC BIOINFORMATICS

Sequential treatment of drug-resistant tumors with targeted minicells containing siRNA or a cytotoxic drug

(2009) Jennifer A MacDiarmid et al.   NATURE BIOTECHNOLOGY