PSMA-targeting TGFβ-insensitive armored CAR T cells in metastatic castration-resistant prostate cancer: a phase 1 trial
出版年份 2022 全文链接
标题
PSMA-targeting TGFβ-insensitive armored CAR T cells in metastatic castration-resistant prostate cancer: a phase 1 trial
作者
关键词
-
出版物
NATURE MEDICINE
Volume 28, Issue 4, Pages 724-734
出版商
Springer Science and Business Media LLC
发表日期
2022-03-22
DOI
10.1038/s41591-022-01726-1
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- NPM-ALK induces reprogramming of mature TCR-stimulated T cells resulting in de-differentiation and malignant transformation
- (2021) Jan M. Pawlicki et al. CANCER RESEARCH
- Immune Checkpoint Inhibitors in Prostate Cancer
- (2021) Shobi Venkatachalam et al. Cancers
- Locoregional infusion of HER2-specific CAR T cells in children and young adults with recurrent or refractory CNS tumors: an interim analysis
- (2021) Nicholas A. Vitanza et al. NATURE MEDICINE
- A phase I trial of regional mesothelin-targeted CAR T-cell therapy in patients with malignant pleural disease, in combination with the anti-PD-1 agent pembrolizumab
- (2021) Prasad S Adusumilli et al. Cancer Discovery
- Multiplex digital spatial profiling of proteins and RNA in fixed tissue
- (2020) Christopher R. Merritt et al. NATURE BIOTECHNOLOGY
- Elevated serum interleukin-8 is associated with enhanced intratumor neutrophils and reduced clinical benefit of immune-checkpoint inhibitors
- (2020) Kurt A. Schalper et al. NATURE MEDICINE
- High systemic and tumor-associated IL-8 correlates with reduced clinical benefit of PD-L1 blockade
- (2020) Kobe C. Yuen et al. NATURE MEDICINE
- Locoregionally administered B7-H3-targeted CAR T cells for treatment of atypical teratoid/rhabdoid tumors
- (2020) Johanna Theruvath et al. NATURE MEDICINE
- Nonprostatic diseases on PSMA PET imaging: a spectrum of benign and malignant findings
- (2020) Felipe de Galiza Barbosa et al. CANCER IMAGING
- Inhibition of TGF-β-receptor signaling augments the antitumor function of ROR1-specific CAR T-cells against triple-negative breast cancer
- (2020) Tanja Stüber et al. Journal for ImmunoTherapy of Cancer
- GLCCI1 is a novel protector against glucocorticoid-induced apoptosis in T cells
- (2019) Zentaro Kiuchi et al. FASEB JOURNAL
- The response to lymphodepletion impacts PFS in aggressive non-Hodgkin lymphoma patients treated with CD19 CAR-T cells
- (2019) Alexandre V. Hirayama et al. BLOOD
- Long-term in vivo microscopy of CAR T cell dynamics during eradication of CNS lymphoma in mice
- (2019) Matthias Mulazzani et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- CD19-targeting CAR T cell immunotherapy outcomes correlate with genomic modification by vector integration
- (2019) Christopher L. Nobles et al. JOURNAL OF CLINICAL INVESTIGATION
- Tumor-Specific T-Cells Engineered to Overcome Tumor Immune Evasion Induce Clinical Responses in Patients With Relapsed Hodgkin Lymphoma
- (2018) Catherine M. Bollard et al. JOURNAL OF CLINICAL ONCOLOGY
- Optimization of IL13Rα2-Targeted Chimeric Antigen Receptor T Cells for Improved Anti-tumor Efficacy against Glioblastoma
- (2018) Christine E. Brown et al. MOLECULAR THERAPY
- Dominant-Negative TGF-β Receptor Enhances PSMA-Targeted Human CAR T Cell Proliferation And Augments Prostate Cancer Eradication
- (2018) Christopher C. Kloss et al. MOLECULAR THERAPY
- Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia
- (2018) Joseph A. Fraietta et al. NATURE MEDICINE
- Long-Term Follow-up of CD19 CAR Therapy in Acute Lymphoblastic Leukemia
- (2018) Jae H. Park et al. NEW ENGLAND JOURNAL OF MEDICINE
- Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia
- (2018) Shannon L. Maude et al. NEW ENGLAND JOURNAL OF MEDICINE
- Improved Expansion and In Vivo Function of Patient T Cells by a Serum-free Medium
- (2018) Andrew R. Medvec et al. Molecular Therapy-Methods & Clinical Development
- Disruption of TET2 promotes the therapeutic efficacy of CD19-targeted T cells
- (2018) Joseph A. Fraietta et al. NATURE
- Comparing the expression profiles of steroid hormone receptors and stromal cell markers in prostate cancer at different Gleason scores
- (2018) Thomas Gevaert et al. Scientific Reports
- Effective combinatorial immunotherapy for castration-resistant prostate cancer
- (2017) Xin Lu et al. NATURE
- Chimeric Antigen Receptor T Cells in Refractory B-Cell Lymphomas
- (2017) Stephen J. Schuster et al. NEW ENGLAND JOURNAL OF MEDICINE
- Axicabtagene Ciloleucel CAR T-Cell Therapy in Refractory Large B-Cell Lymphoma
- (2017) Sattva S. Neelapu et al. NEW ENGLAND JOURNAL OF MEDICINE
- Clinical significance of endothelial cell marker CD34 and mast cell marker CD117 in prostate adenocarcinoma
- (2017) Mozhdeh Foroozan et al. PATHOLOGY RESEARCH AND PRACTICE
- A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma
- (2017) Donald M. O’Rourke et al. Science Translational Medicine
- Complex heatmaps reveal patterns and correlations in multidimensional genomic data
- (2016) Zuguang Gu et al. BIOINFORMATICS
- Ibrutinib enhances chimeric antigen receptor T-cell engraftment and efficacy in leukemia
- (2016) Joseph A. Fraietta et al. BLOOD
- Regression of Glioblastoma after Chimeric Antigen Receptor T-Cell Therapy
- (2016) Christine E. Brown et al. NEW ENGLAND JOURNAL OF MEDICINE
- Immunotherapy of non-Hodgkin’s lymphoma with a defined ratio of CD8 + and CD4 + CD19-specific chimeric antigen receptor–modified T cells
- (2016) Cameron J. Turtle et al. Science Translational Medicine
- Identification of Predictive Biomarkers for Cytokine Release Syndrome after Chimeric Antigen Receptor T-cell Therapy for Acute Lymphoblastic Leukemia
- (2016) D. T. Teachey et al. Cancer Discovery
- Expression and regulatory effects on cancer cell behavior of NELL1 and NELL2 in human renal cell carcinoma
- (2015) Ritsuko Nakamura et al. CANCER SCIENCE
- TLR9-Targeted STAT3 Silencing Abrogates Immunosuppressive Activity of Myeloid-Derived Suppressor Cells from Prostate Cancer Patients
- (2015) D. M. S. Hossain et al. CLINICAL CANCER RESEARCH
- Fitting Linear Mixed-Effects Models Usinglme4
- (2015) Douglas Bates et al. Journal of Statistical Software
- Comparing DNA integration site clusters with scan statistics
- (2014) Charles C. Berry et al. BIOINFORMATICS
- Development of the National Cancer Institute's Patient-Reported Outcomes Version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE)
- (2014) E. Basch et al. JNCI-Journal of the National Cancer Institute
- Chimeric Antigen Receptor T Cells for Sustained Remissions in Leukemia
- (2014) Shannon L. Maude et al. NEW ENGLAND JOURNAL OF MEDICINE
- Easy quantitative assessment of genome editing by sequence trace decomposition
- (2014) Eva K. Brinkman et al. NUCLEIC ACIDS RESEARCH
- Regional delivery of mesothelin-targeted CAR T cell therapy generates potent and long-lasting CD4-dependent tumor immunity
- (2014) P. S. Adusumilli et al. Science Translational Medicine
- Immunotherapy for Prostate Cancer: Lessons from Responses to Tumor-Associated Antigens
- (2014) Harm Westdorp et al. Frontiers in Immunology
- Blockade of TGF- Signaling Greatly Enhances the Efficacy of TCR Gene Therapy of Cancer
- (2013) G. M. Bendle et al. JOURNAL OF IMMUNOLOGY
- Truncated Form of TGF- RII, But Not Its Absence, Induces Memory CD8+ T Cell Expansion and Lymphoproliferative Disorder in Mice
- (2013) H. Ishigame et al. JOURNAL OF IMMUNOLOGY
- Estimating abundances of retroviral insertion sites from DNA fragment length data
- (2012) Charles C. Berry et al. BIOINFORMATICS
- Inhibition of TGF-β signaling in genetically engineered tumor antigen-reactive T cells significantly enhances tumor treatment efficacy
- (2012) L Zhang et al. GENE THERAPY
- Decade-Long Safety and Function of Retroviral-Modified Chimeric Antigen Receptor T Cells
- (2012) J. Scholler et al. Science Translational Medicine
- Chimeric Antigen Receptor–Modified T Cells in Chronic Lymphoid Leukemia
- (2011) David L. Porter et al. NEW ENGLAND JOURNAL OF MEDICINE
- A method to sequence and quantify DNA integration for monitoring outcome in gene therapy
- (2011) Troy Brady et al. NUCLEIC ACIDS RESEARCH
- T Cells with Chimeric Antigen Receptors Have Potent Antitumor Effects and Can Establish Memory in Patients with Advanced Leukemia
- (2011) M. Kalos et al. Science Translational Medicine
- Preclinical Evaluation of a Recombinant Anti-Prostate Specific Membrane Antigen Single-Chain Immunotoxin Against Prostate Cancer
- (2010) Philipp Wolf et al. JOURNAL OF IMMUNOTHERAPY
- Immunosuppressive CD14+HLA-DRlow/−monocytes in prostate cancer
- (2009) Stanimir Vuk-Pavlović et al. PROSTATE
- Empirical Evaluation of a New Method for Calculating Signal-to-Noise Ratio for Microarray Data Analysis
- (2008) Z. He et al. APPLIED AND ENVIRONMENTAL MICROBIOLOGY
- New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1)
- (2008) E.A. Eisenhauer et al. EUROPEAN JOURNAL OF CANCER
- Design and End Points of Clinical Trials for Patients With Progressive Prostate Cancer and Castrate Levels of Testosterone: Recommendations of the Prostate Cancer Clinical Trials Working Group
- (2008) Howard I. Scher et al. JOURNAL OF CLINICAL ONCOLOGY
- Antitumor Activity of EBV-specific T Lymphocytes Transduced With a Dominant Negative TGF-?? Receptor
- (2008) Aaron E. Foster et al. JOURNAL OF IMMUNOTHERAPY
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now