标题
CAR-T Cell Performance: How to Improve Their Persistence?
作者
关键词
-
出版物
Frontiers in Immunology
Volume 13, Issue -, Pages -
出版商
Frontiers Media SA
发表日期
2022-04-29
DOI
10.3389/fimmu.2022.878209
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- T-SIGn tumor reengineering therapy and CAR T cells synergize in combination therapy to clear human lung tumor xenografts and lung metastases in NSG mice
- (2022) Olmo Sonzogni et al. OncoImmunology
- CD4 T cell-intrinsic STING signaling controls the differentiation and effector functions of TH1 and TH9 cells
- (2022) Isis Benoit-Lizon et al. Journal for ImmunoTherapy of Cancer
- Rapid manufacturing of non-activated potent CAR T cells
- (2022) Saba Ghassemi et al. Nature Biomedical Engineering
- The interplay between membrane topology and mechanical forces in regulating T cell receptor activity
- (2022) Mohammad Ameen Al-Aghbar et al. Communications Biology
- Axicabtagene ciloleucel and brexucabtagene autoleucel in relapsed and refractory diffuse large B-cell and mantle cell lymphomas
- (2021) Patrick M Reagan et al. Future Oncology
- Evaluation of Production Protocols for the Generation of NY-ESO-1-Specific T Cells
- (2021) Wenjie Gong et al. Cells
- Development of CAR-T Cell Persistence in Adoptive Immunotherapy of Solid Tumors
- (2021) Jiaqiao Fan et al. Frontiers in Oncology
- FDA approves fourth CAR-T cell therapy
- (2021) Asher Mullard NATURE REVIEWS DRUG DISCOVERY
- Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma
- (2021) Nikhil C. Munshi et al. NEW ENGLAND JOURNAL OF MEDICINE
- Exhausted CD8+T Cells in the Tumor Immune Microenvironment: New Pathways to Therapy
- (2021) Weiqin Jiang et al. Frontiers in Immunology
- Engineering Metabolism of Chimeric Antigen Receptor (CAR) Cells for Developing Efficient Immunotherapies
- (2021) Joslyn L. Mangal et al. Cancers
- An oncolytic virus expressing IL-15/IL-15Rα combined with off-the-shelf EGFR-CAR NK cells targets glioblastoma
- (2021) Rui Ma et al. CANCER RESEARCH
- CAR-T cell persistence in the treatment of leukemia and lymphoma
- (2021) Arjun Gupta et al. LEUKEMIA & LYMPHOMA
- The immunostimulatory RNA RN7SL1 enables CAR-T cells to enhance autonomous and endogenous immune function
- (2021) Lexus R. Johnson et al. CELL
- Metabolic reprogramming of terminally exhausted CD8+ T cells by IL-10 enhances anti-tumor immunity
- (2021) Yugang Guo et al. NATURE IMMUNOLOGY
- Tisagenlecleucel for treatment of children and young adults with relapsed/refractory B‐cell acute lymphoblastic leukemia
- (2021) Stephanie J. Si Lim et al. PEDIATRIC BLOOD & CANCER
- Engineered Cytokine Signaling to Improve CAR T Cell Effector Function
- (2021) Matthew Bell et al. Frontiers in Immunology
- Cytolytic Activity of CAR T Cells and Maintenance of Their CD4+ Subset Is Critical for Optimal Antitumor Activity in Preclinical Solid Tumor Models
- (2021) Marianna Csaplár et al. Cancers
- Alternative to FBS in animal cell culture - An overview and future perspective
- (2021) Karthikeyan Subbiahanadar Chelladurai et al. Heliyon
- Adoptive cell therapy with tumor-specific Th9 cells induces viral mimicry to eliminate antigen-loss-variant tumor cells
- (2021) Gang Xue et al. CANCER CELL
- Adoptive transfer of tumor-specific Th9 cells eradicates heterogeneous antigen-expressing tumor cells
- (2021) Kevin Sek et al. CANCER CELL
- Engineering living therapeutics with synthetic biology
- (2021) Andres Cubillos-Ruiz et al. NATURE REVIEWS DRUG DISCOVERY
- Special delivery! CAR-T cells transport RN7SL1 to the tumor microenvironment
- (2021) W. Sam Nutt et al. TRENDS IN MOLECULAR MEDICINE
- Relationship between Th17 immune response and cancer
- (2021) Hanna Santos Marques et al. World Journal of Clinical Oncology
- Enforced PGC-1α expression promotes CD8 T cell fitness, memory formation and antitumor immunity
- (2020) Nina Dumauthioz et al. Cellular & Molecular Immunology
- An RNA vaccine drives expansion and efficacy of claudin-CAR-T cells against solid tumors
- (2020) Katharina Reinhard et al. SCIENCE
- Revisiting the role of CD4+ T cells in cancer immunotherapy—new insights into old paradigms
- (2020) Rong En Tay et al. CANCER GENE THERAPY
- Replacing CAR-T cell resistance with persistence by changing a single residue
- (2020) Emily M. Hsieh et al. JOURNAL OF CLINICAL INVESTIGATION
- Single residue in CD28-costimulated CAR-T cells limits long-term persistence and antitumor durability
- (2020) Sonia Guedan et al. JOURNAL OF CLINICAL INVESTIGATION
- Engineering Cytoplasmic Signaling of CD28ζ CARs for Improved Therapeutic Functions
- (2020) Xianhui Meng et al. Frontiers in Immunology
- A Novel Siglec-4 Derived Spacer Improves the Functionality of CAR T Cells Against Membrane-Proximal Epitopes
- (2020) Daniel Schäfer et al. Frontiers in Immunology
- Lisocabtagene maraleucel for patients with relapsed or refractory large B-cell lymphomas (TRANSCEND NHL 001): a multicentre seamless design study
- (2020) Jeremy S Abramson et al. LANCET
- Enhancing Chimeric Antigen Receptor T Cell Anti-tumor Function through Advanced Media Design
- (2020) Saba Ghassemi et al. Molecular Therapy-Methods & Clinical Development
- Engineering Next-Generation CAR-T Cells for Better Toxicity Management
- (2020) Alain E. Andrea et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Gene Modified CAR-T Cellular Therapy for Hematologic Malignancies
- (2020) Wen-Ying Lin et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- STING agonist promotes CAR T cell trafficking and persistence in breast cancer
- (2020) Nuo Xu et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Human platelet lysates for human cell propagation
- (2020) Lassina Barro et al. PLATELETS
- A metabolic switch to memory CAR T cells: Implications for cancer treatment
- (2020) Hosein Rostamian et al. CANCER LETTERS
- IL-15-mediated reduction of mTORC1 activity preserves the stem cell memory phenotype of CAR-T cells and confers superior antitumor activity
- (2019) Darya Alizadeh et al. Cancer Immunology Research
- The role of T helper 17 and regulatory T cells in tumor microenvironment
- (2019) Soheil Najafi et al. IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
- Factors associated with durable EFS in adult B-cell ALL patients achieving MRD-negative CR after CD19 CAR-T cells
- (2019) Kevin A. Hay et al. BLOOD
- Chimeric antigen receptor T cell persistence and memory cell formation
- (2019) Alexander D McLellan et al. IMMUNOLOGY AND CELL BIOLOGY
- The Role of Checkpoint Inhibitors and Cytokines in Adoptive Cell-Based Cancer Immunotherapy with Genetically Modified T Cells
- (2019) P. M. Gershovich et al. BIOCHEMISTRY-MOSCOW
- Gaps in the knowledge of human platelet lysate as a cell culture supplement for cell therapy: A joint publication from the AABB and the International Society of Cell Therapy
- (2019) KAREN Bieback et al. CYTOTHERAPY
- Enhanced CAR T cell expansion and prolonged persistence in pediatric patients with ALL treated with a low-affinity CD19 CAR
- (2019) Sara Ghorashian et al. NATURE MEDICINE
- Age related human T cell subset evolution and senescence
- (2019) Mingde Li et al. Immunity & Ageing
- Human Platelet Lysate Media Supplement Supports Lentiviral Transduction and Expansion of Human T Lymphocytes While Maintaining Memory Phenotype
- (2019) Emanuele Canestrari et al. Journal of Immunology Research
- Targeting the interleukin-17 immune axis for cancer immunotherapy
- (2019) Gerardo A. Vitiello et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Expanding CAR T cells in human platelet lysate renders T cells with in vivo longevity
- (2019) Alejandro Torres Chavez et al. Journal for ImmunoTherapy of Cancer
- CD8 T Cell Exhaustion in Chronic Infection and Cancer: Opportunities for Interventions
- (2018) Masao Hashimoto et al. Annual Review of Medicine
- Th9 Cells Represent a Unique Subset of CD4 + T Cells Endowed with the Ability to Eradicate Advanced Tumors
- (2018) Yong Lu et al. CANCER CELL
- Induction of a central memory and stem cell memory phenotype in functionally active CD4+ and CD8+ CAR T cells produced in an automated good manufacturing practice system for the treatment of CD19+ acute lymphoblastic leukemia
- (2018) Franziska Blaeschke et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- A new approach to CAR T-cell gene engineering and cultivation using piggyBac transposon in the presence of IL-4, IL-7 and IL-21
- (2018) Pavlína Ptáčková et al. CYTOTHERAPY
- Influence of retronectin-mediated T cell activation on expansion and phenotype of CD19-specific chimeric antigen receptor T cells
- (2018) Sophia Stock et al. HUMAN GENE THERAPY
- Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia
- (2018) Joseph A. Fraietta et al. NATURE MEDICINE
- Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia
- (2018) Shannon L. Maude et al. NEW ENGLAND JOURNAL OF MEDICINE
- IL-21 modulates memory and exhaustion phenotype of T-cells in a fatty acid oxidation-dependent manner
- (2018) Romy Loschinski et al. Oncotarget
- Reducing Ex Vivo Culture Improves the Anti-leukemic Activity of Chimeric Antigen Receptor (CAR)-T Cells
- (2018) Saba Ghassemi et al. Cancer Immunology Research
- Improved Expansion and In Vivo Function of Patient T Cells by a Serum-free Medium
- (2018) Andrew R. Medvec et al. Molecular Therapy-Methods & Clinical Development
- Phosphoproteomic analysis of chimeric antigen receptor signaling reveals kinetic and quantitative differences that affect cell function
- (2018) Alexander I. Salter et al. Science Signaling
- Teaching an old dog new tricks: next-generation CAR T cells
- (2018) Nicholas Tokarew et al. BRITISH JOURNAL OF CANCER
- FDA Approval Summary: Tisagenlecleucel for Treatment of Patients with Relapsed or Refractory B-cell Precursor Acute Lymphoblastic Leukemia
- (2018) Maura C. O’Leary et al. CLINICAL CANCER RESEARCH
- FDA Approval Summary: Axicabtagene Ciloleucel for Relapsed or Refractory Large B-cell Lymphoma
- (2018) Najat Bouchkouj et al. CLINICAL CANCER RESEARCH
- A role for Th1-like Th17 cells in the pathogenesis of inflammatory and autoimmune disorders
- (2018) Ali N. Kamali et al. MOLECULAR IMMUNOLOGY
- Design of amidobenzimidazole STING receptor agonists with systemic activity
- (2018) Joshi M. Ramanjulu et al. NATURE
- Calibration of CAR activation potential directs alternative T cell fates and therapeutic potency
- (2018) Judith Feucht et al. NATURE MEDICINE
- Defining Memory CD8 T Cell
- (2018) Matthew D. Martin et al. Frontiers in Immunology
- CAR-T Cells and Oncolytic Viruses: Joining Forces to Overcome the Solid Tumor Challenge
- (2018) Sonia Guedan et al. Frontiers in Immunology
- Understanding memory CD8 + T cells
- (2017) Tasleem Samji et al. IMMUNOLOGY LETTERS
- Vaccination to improve the persistence of CD19CAR gene-modified T cells in relapsed pediatric acute lymphoblastic leukemia
- (2017) C Rossig et al. LEUKEMIA
- Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection
- (2017) Justin Eyquem et al. NATURE
- Axicabtagene Ciloleucel CAR T-Cell Therapy in Refractory Large B-Cell Lymphoma
- (2017) Sattva S. Neelapu et al. NEW ENGLAND JOURNAL OF MEDICINE
- TCR engagement negatively affects CD8 but not CD4 CAR T cell expansion and leukemic clearance
- (2017) Yinmeng Yang et al. Science Translational Medicine
- The Th17 Lineage: From Barrier Surfaces Homeostasis to Autoimmunity, Cancer, and HIV-1 Pathogenesis
- (2017) Vanessa Wacleche et al. Viruses-Basel
- An oxygen sensitive self-decision making engineered CAR T-cell
- (2017) Alexandre Juillerat et al. Scientific Reports
- Human Tissue-Resident Memory T Cells Are Defined by Core Transcriptional and Functional Signatures in Lymphoid and Mucosal Sites
- (2017) Brahma V. Kumar et al. Cell Reports
- The Affinity of Elongated Membrane-Tethered Ligands Determines Potency of T Cell Receptor Triggering
- (2017) Bing-Mae Chen et al. Frontiers in Immunology
- Phase 1 studies of central memory-derived CD19 CAR T-cell therapy following autologous HSCT in patients with B-cell NHL
- (2016) X. Wang et al. BLOOD
- Exploiting IL-17-producing CD4+ and CD8+ T cells to improve cancer immunotherapy in the clinic
- (2016) Kinga Majchrzak et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity
- (2016) Roger Geiger et al. CELL
- Distinct Signaling of Coreceptors Regulates Specific Metabolism Pathways and Impacts Memory Development in CAR T Cells
- (2016) Omkar U. Kawalekar et al. IMMUNITY
- Bioenergetic Insufficiencies Due to Metabolic Alterations Regulated by the Inhibitory Receptor PD-1 Are an Early Driver of CD8 + T Cell Exhaustion
- (2016) Bertram Bengsch et al. IMMUNITY
- CD19 CAR–T cells of defined CD4+:CD8+ composition in adult B cell ALL patients
- (2016) Cameron J. Turtle et al. JOURNAL OF CLINICAL INVESTIGATION
- 203. Shortened T Cell Culture with IL-7 and IL-15 Provides the Most Potent Chimeric Antigen Receptor (CAR)-Modified T Cells for Adoptive Immunotherapy
- (2016) Saba Ghassemi et al. MOLECULAR THERAPY
- Human memory T cells with a naive phenotype accumulate with aging and respond to persistent viruses
- (2016) Vesna Pulko et al. NATURE IMMUNOLOGY
- Role of memory T cell subsets for adoptive immunotherapy
- (2016) Dirk H. Busch et al. SEMINARS IN IMMUNOLOGY
- Modulation of mTOR Signalling Triggers the Formation of Stem Cell-like Memory T Cells
- (2016) Godehard Scholz et al. EBioMedicine
- Different Subsets of T Cells, Memory, Effector Functions, and CAR-T Immunotherapy
- (2016) Vita Golubovskaya et al. Cancers
- Early T Cell Activation: Integrating Biochemical, Structural, and Biophysical Cues
- (2015) Bernard Malissen et al. Annual Review of Immunology
- Different cytokine and stimulation conditions influence the expansion and immune phenotype of third-generation chimeric antigen receptor T cells specific for tumor antigen GD2
- (2015) Tessa Gargett et al. CYTOTHERAPY
- TRUCKs: the fourth generation of CARs
- (2015) Markus Chmielewski et al. EXPERT OPINION ON BIOLOGICAL THERAPY
- Mechanisms and Αpplications of Ιnterleukins in Cancer Immunotherapy
- (2015) Doxakis Anestakis et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Treg(s) in Cancer: Friends or Foe?
- (2015) Dominik Wolf et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Chimeric antigen receptor-modified T cells derived from defined CD8+ and CD4+ subsets confer superior antitumor reactivity in vivo
- (2015) D Sommermeyer et al. LEUKEMIA
- Chimeric Antigen Receptors With Mutated IgG4 Fc Spacer Avoid Fc Receptor Binding and Improve T Cell Persistence and Antitumor Efficacy
- (2015) Mahesh Jonnalagadda et al. MOLECULAR THERAPY
- STING activation of tumor endothelial cells initiates spontaneous and therapeutic antitumor immunity
- (2015) Olivier Demaria et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Chimeric antigen receptor T cells persist and induce sustained remissions in relapsed refractory chronic lymphocytic leukemia
- (2015) David L. Porter et al. Science Translational Medicine
- PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation
- (2015) Nikolaos Patsoukis et al. Nature Communications
- Individual Motile CD4 + T Cells Can Participate in Efficient Multikilling through Conjugation to Multiple Tumor Cells
- (2015) Ivan Liadi et al. Cancer Immunology Research
- ICOS-based chimeric antigen receptors program bipolar TH17/TH1 cells
- (2014) S. Guedan et al. BLOOD
- Closely related T-memory stem cells correlate with in vivo expansion of CAR.CD19-T cells and are preserved by IL-7 and IL-15
- (2014) Y. Xu et al. BLOOD
- Adoptive Therapy With Chimeric Antigen Receptor–Modified T Cells of Defined Subset Composition
- (2014) Stanley R. Riddell et al. CANCER JOURNAL
- Armed Oncolytic Virus Enhances Immune Functions of Chimeric Antigen Receptor-Modified T Cells in Solid Tumors
- (2014) N. Nishio et al. CANCER RESEARCH
- Stimulation through very late antigen-4 and -5 improves the multifunctionality and memory formation of CD8+T cells
- (2014) Hayato Hosoi et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Antigen Sensitivity of CD22-Specific Chimeric TCR Is Modulated by Target Epitope Distance from the Cell Membrane
- (2014) S. E. James et al. JOURNAL OF IMMUNOLOGY
- Differential Role of Th1 and Th2 Cytokines in Autotoxicity Driven by CD19-Specific Second-Generation Chimeric Antigen Receptor T Cells in a Mouse Model
- (2014) E. J. Cheadle et al. JOURNAL OF IMMUNOLOGY
- Chimeric Antigen Receptor T Cells for Sustained Remissions in Leukemia
- (2014) Shannon L. Maude et al. NEW ENGLAND JOURNAL OF MEDICINE
- An Efficient Large-Scale Retroviral Transduction Method Involving Preloading the Vector into a RetroNectin-Coated Bag with Low-Temperature Shaking
- (2014) Katsuyuki Dodo et al. PLoS One
- T Cell Receptor-Engineered T Cells to Treat Solid Tumors: T Cell Processing Toward Optimal T Cell Fitness
- (2014) Cor H.J. Lamers et al. Human Gene Therapy Methods
- Definition and application of good manufacturing process-compliant production of CEA-specific chimeric antigen receptor expressing T-cells for phase I/II clinical trial
- (2013) Ryan D. Guest et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- The Multifaceted Role of Th17 Lymphocytes and Their Associated Cytokines in Cancer
- (2013) Darya Alizadeh et al. Clinical & Developmental Immunology
- Receptor Affinity and Extracellular Domain Modifications Affect Tumor Recognition by ROR1-Specific Chimeric Antigen Receptor T Cells
- (2013) M. Hudecek et al. CLINICAL CANCER RESEARCH
- Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function
- (2013) Madhusudhanan Sukumar et al. JOURNAL OF CLINICAL INVESTIGATION
- Wnt signaling inhibits CTL memory programming
- (2013) Zhengguo Xiao et al. MOLECULAR IMMUNOLOGY
- IL-7 and IL-15 instruct the generation of human memory stem T cells from naive precursors
- (2012) N. Cieri et al. BLOOD
- Modulating the differentiation status of ex vivo-cultured anti-tumor T cells using cytokine cocktails
- (2012) Shicheng Yang et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Properties of end-stage human T cells defined by CD45RA re-expression
- (2012) Sian M Henson et al. CURRENT OPINION IN IMMUNOLOGY
- Human T cells expressing affinity-matured TCR display accelerated responses but fail to recognize low density of MHC-peptide antigen
- (2011) S. Thomas et al. BLOOD
- Antitumor activity and long-term fate of chimeric antigen receptor-positive T cells in patients with neuroblastoma
- (2011) C. U. Louis et al. BLOOD
- Th17 Cells Are Long Lived and Retain a Stem Cell-like Molecular Signature
- (2011) Pawel Muranski et al. IMMUNITY
- A human memory T cell subset with stem cell–like properties
- (2011) Luca Gattinoni et al. NATURE MEDICINE
- Chimeric Antigen Receptor–Modified T Cells in Chronic Lymphoid Leukemia
- (2011) David L. Porter et al. NEW ENGLAND JOURNAL OF MEDICINE
- Evidence for a TCR Affinity Threshold Delimiting Maximal CD8 T Cell Function
- (2010) D. A. Schmid et al. JOURNAL OF IMMUNOLOGY
- Retronectin enhances lentivirus-mediated gene delivery into hematopoietic progenitor cells
- (2009) Hyun-Joo Lee et al. BIOLOGICALS
- T Helper 17 Cells Promote Cytotoxic T Cell Activation in Tumor Immunity
- (2009) Natalia Martin-Orozco et al. IMMUNITY
- Chimeric Receptors Containing CD137 Signal Transduction Domains Mediate Enhanced Survival of T Cells and Increased Antileukemic Efficacy In Vivo
- (2009) Michael C. Milone et al. MOLECULAR THERAPY
- Adoptively transferred effector cells derived from naive rather than central memory CD8+ T cells mediate superior antitumor immunity
- (2009) C. S. Hinrichs et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- In vivo persistence of genetically modified T cells generated ex vivo using the fibronectin CH296 stimulation method
- (2008) S S Yu et al. CANCER GENE THERAPY
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