A clinically applicable and scalable method to regenerate T-cells from iPSCs for off-the-shelf T-cell immunotherapy

Organoid-Induced Differentiation of Conventional T Cells from Human Pluripotent Stem Cells

(2019) Amélie Montel-Hagen et al.   Cell Stem Cell

Hypoimmunogenic derivatives of induced pluripotent stem cells evade immune rejection in fully immunocompetent allogeneic recipients

(2019) Tobias Deuse et al.   NATURE BIOTECHNOLOGY

Targeted Disruption of HLA Genes via CRISPR-Cas9 Generates iPSCs with Enhanced Immune Compatibility

(2019) Huaigeng Xu et al.   Cell Stem Cell

Generation of TCR-Expressing Innate Lymphoid-like Helper Cells that Induce Cytotoxic T Cell-Mediated Anti-leukemic Cell Response

(2018) Norihiro Ueda et al.   Stem Cell Reports

Enhancing T Cell Receptor Stability in Rejuvenated iPSC-Derived T Cells Improves Their Use in Cancer Immunotherapy

(2018) Atsutaka Minagawa et al.   Cell Stem Cell

HLA-E-expressing pluripotent stem cells escape allogeneic responses and lysis by NK cells

(2017) Germán G Gornalusse et al.   NATURE BIOTECHNOLOGY

Regeneration of CD8αβ T Cells from T-cell–Derived iPSC Imparts Potent Tumor Antigen-Specific Cytotoxicity

(2016) Takuya Maeda et al.   CANCER RESEARCH

Differentiation of human embryonic stem cells to HOXA+ hemogenic vasculature that resembles the aorta-gonad-mesonephros

(2016) Elizabeth S Ng et al.   NATURE BIOTECHNOLOGY

A view of human haematopoietic development from the Petri dish

(2016) Andrea Ditadi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Tethered IL-15 augments antitumor activity and promotes a stem-cell memory subset in tumor-specific T cells

(2016) Lenka V. Hurton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T Cell Genesis: In Vitro Veritas Est ?

(2016) Patrick M. Brauer et al.   TRENDS IN IMMUNOLOGY

Cellular Adjuvant Properties, Direct Cytotoxicity of Re-differentiated Vα24 Invariant NKT-like Cells from Human Induced Pluripotent Stem Cells

(2016) Shuichi Kitayama et al.   Stem Cell Reports

New Cell Sources for T Cell Engineering and Adoptive Immunotherapy

(2015) Maria Themeli et al.   Cell Stem Cell

Chimeric antigen receptor-modified T cells derived from defined CD8+ and CD4+ subsets confer superior antitumor reactivity in vivo

(2015) D Sommermeyer et al.   LEUKEMIA

Technical Advance: Ascorbic acid induces development of double-positive T cells from human hematopoietic stem cells in the absence of stromal cells

(2014) Mirelle J. A. J. Huijskens et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Phase I Clinical Trial of Fibronectin CH296-Stimulated T Cell Therapy in Patients with Advanced Cancer

(2014) Takeshi Ishikawa et al.   PLoS One

A novel efficient feeder-free culture system for the derivation of human induced pluripotent stem cells

(2014) Masato Nakagawa et al.   Scientific Reports

Tenascin C Promotes Hematoendothelial Development and T Lymphoid Commitment from Human Pluripotent Stem Cells in Chemically Defined Conditions

(2014) Gene Uenishi et al.   Stem Cell Reports

Regeneration of Human Tumor Antigen-Specific T Cells from iPSCs Derived from Mature CD8 + T Cells

(2013) Raul Vizcardo et al.   Cell Stem Cell

Generation of Rejuvenated Antigen-Specific T Cells by Reprogramming to Pluripotency and Redifferentiation

(2013) Toshinobu Nishimura et al.   Cell Stem Cell

Expansion of Functional Human Mucosal-Associated Invariant T Cells via Reprogramming to Pluripotency and Redifferentiation

(2013) Hiroshi Wakao et al.   Cell Stem Cell

Generation of tumor-targeted human T lymphocytes from induced pluripotent stem cells for cancer therapy

(2013) Maria Themeli et al.   NATURE BIOTECHNOLOGY

Defining the path to hematopoietic stem cells

(2013) Christopher M Sturgeon et al.   NATURE BIOTECHNOLOGY

Synergistic, Context-Dependent, and Hierarchical Functions of Epithelial Components in Thymic Microenvironments

(2012) Lesly Calderón et al.   CELL

Generating an iPSC Bank for HLA-Matched Tissue Transplantation Based on Known Donor and Recipient HLA Types

(2012) Craig J. Taylor et al.   Cell Stem Cell

Human T-Lymphoid Progenitors Generated in a Feeder-Cell-Free Delta-Like-4 Culture System Promote T-Cell Reconstitution in NOD/SCID/γc−/− Mice

(2012) Christian Reimann et al.   STEM CELLS

Novel adoptive T-cell immunotherapy using a WT1-specific TCR vector encoding silencers for endogenous TCRs shows marked antileukemia reactivity and safety

(2011) T. Ochi et al.   BLOOD

A more efficient method to generate integration-free human iPS cells

(2011) Keisuke Okita et al.   NATURE METHODS

Characterization in vitro and engraftment potential in vivo of human progenitor T cells generated from hematopoietic stem cells

(2009) G. Awong et al.   BLOOD

Thymic development beyond β-selection requires phosphatidylinositol 3-kinase activation by CXCR4

(2009) Michelle L. Janas et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Generation of T Cells from Human Embryonic Stem Cell-Derived Hematopoietic Zones

(2009) F. Timmermans et al.   JOURNAL OF IMMUNOLOGY

CXCR4 acts as a costimulator during thymic β-selection

(2009) Paul C Trampont et al.   NATURE IMMUNOLOGY

In vivo persistence of genetically modified T cells generated ex vivo using the fibronectin CH296 stimulation method

(2008) S S Yu et al.   CANCER GENE THERAPY

HLA-haplotype banking and iPS cells

(2008) Norio Nakatsuji et al.   NATURE BIOTECHNOLOGY