Imaging of T-cell Responses in the Context of Cancer Immunotherapy

Immunotherapy, which promotes the induction of cytotoxic T lymphocytes and enhances their infiltration into and function within tumors, is a rapidly expanding and evolving approach to treating cancer. However, many of the critical denominators for inducing effective anticancer immune responses remain unknown. Efforts are underway to develop comprehensive ex vivo assessments of the immune landscape of patients prior to and during response to immunotherapy. An important complementary approach to these efforts involves the development of noninvasive imaging approaches to detect immune targets, assess delivery of immune-based therapeutics, and evaluate responses to immunotherapy. Herein, we review the merits and limitations of various noninvasive imaging modalities (MRI, PET, and single-photon emission tomography) and discuss candidate targets for cellular and molecular imaging for visualization of T-cell responses at various stages along the cancer-immunity cycle in the context of immunotherapy. We also discuss the potential use of these imaging strategies in monitoring treatment responses and predicting prognosis for patients treated with immunotherapy.

Automated summary

Immunotherapy is a rapidly expanding approach to treating cancer by enhancing cytotoxic T lymphocytes' function within tumors, but there are still unknown factors in inducing effective anticancer immune responses. Efforts are being made to develop comprehensive ex vivo assessments and noninvasive imaging approaches to detect immune targets and evaluate responses to immunotherapy. These imaging strategies could also be used to monitor treatment responses and predict prognosis for patients treated with immunotherapy.