Antitarget, Anti-SARS-CoV-2 Leads, Drugs, and the Drug Discovery–Genetics Alliance Perspective
出版年份 2023 全文链接
标题
Antitarget, Anti-SARS-CoV-2 Leads, Drugs, and the Drug Discovery–Genetics Alliance Perspective
作者
关键词
-
出版物
Journal of Medicinal Chemistry
Volume 66, Issue 6, Pages 3664-3702
出版商
American Chemical Society (ACS)
发表日期
2023-03-02
DOI
10.1021/acs.jmedchem.2c01229
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Remdesivir, Molnupiravir and Nirmatrelvir remain active against SARS-CoV-2 Omicron and other variants of concern
- (2022) Laura Vangeel et al. ANTIVIRAL RESEARCH
- SARS-CoV-2 Omicron variant is highly sensitive to molnupiravir, nirmatrelvir, and the combination
- (2022) Pengfei Li et al. CELL RESEARCH
- Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts tropism and fusogenicity
- (2022) Bo Meng et al. NATURE
- Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies
- (2022) Yunlong Cao et al. NATURE
- Potential Resistance of SARS-CoV-2 Main Protease (Mpro) against Protease Inhibitors: Lessons Learned from HIV-1 Protease
- (2022) János András Mótyán et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Structural basis for the in vitro efficacy of nirmatrelvir against SARS-CoV-2 variants
- (2022) Samantha E. Greasley et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Discovery of S-217622, a Noncovalent Oral SARS-CoV-2 3CL Protease Inhibitor Clinical Candidate for Treating COVID-19
- (2022) Yuto Unoh et al. JOURNAL OF MEDICINAL CHEMISTRY
- S-217622, a 3CL Protease Inhibitor and Clinical Candidate for SARS-CoV-2
- (2022) Joel D. A. Tyndall JOURNAL OF MEDICINAL CHEMISTRY
- Characterization and antiviral susceptibility of SARS-CoV-2 Omicron/BA.2
- (2022) Ryuta Uraki et al. NATURE
- Mutations in the SARS-CoV-2 RNA dependent RNA polymerase confer resistance to remdesivir by distinct mechanisms
- (2022) Laura J. Stevens et al. Science Translational Medicine
- Synthetic lethality-based prediction of anti-SARS-CoV-2 targets
- (2022) Lipika R. Pal et al. iScience
- Structure and activity of human TMPRSS2 protease implicated in SARS-CoV-2 activation
- (2022) Bryan J. Fraser et al. Nature Chemical Biology
- Comprehensive fitness landscape of SARS-CoV-2 Mpro reveals insights into viral resistance mechanisms
- (2022) Julia M Flynn et al. eLife
- Molecular Mechanism of the Non-Covalent Orally Targeted SARS-CoV-2 Mpro Inhibitor S-217622 and Computational Assessment of Its Effectiveness against Mainstream Variants
- (2022) Danyang Xiong et al. Journal of Physical Chemistry Letters
- Nanomolar inhibition of SARS-CoV-2 infection by an unmodified peptide targeting the prehairpin intermediate of the spike protein
- (2022) Kailu Yang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- S-217622, a SARS-CoV-2 main protease inhibitor, decreases viral load and ameliorates COVID-19 severity in hamsters
- (2022) Michihito Sasaki et al. Science Translational Medicine
- Profile of chimeric RNAs and TMPRSS2-ERG e2e4 isoform in neuroendocrine prostate cancer
- (2022) Qiong Wang et al. Cell and Bioscience
- Discovery of New Fusion Inhibitor Peptides against SARS-CoV-2 by Targeting the Spike S2 Subunit
- (2021) Mahmoud Kandeel et al. Biomolecules & Therapeutics
- RNA-dependent RNA polymerase (RdRp) inhibitors: the current landscape and repurposing for the COVID-19 pandemic
- (2021) Lei Tian et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- ACE-2-Derived Biomimetic Peptides for the Inhibition of Spike Protein of SARS-CoV-2
- (2021) Saroj Kumar Panda et al. JOURNAL OF PROTEOME RESEARCH
- Coronavirus replication–transcription complex: Vital and selective NMPylation of a conserved site in nsp9 by the NiRAN-RdRp subunit
- (2021) Heiko Slanina et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mechanism of SARS-CoV-2 polymerase stalling by remdesivir
- (2021) Goran Kokic et al. Nature Communications
- Identification of SARS-CoV-2 spike mutations that attenuate monoclonal and serum antibody neutralization
- (2021) Zhuoming Liu et al. Cell Host & Microbe
- Efficacy of ribavirin and interferon-α therapy for hospitalized patients with COVID-19: A multicenter, retrospective cohort study
- (2021) Hui Li et al. INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
- A comparative analysis of SARS-CoV-2 antivirals characterizes 3CLpro inhibitor PF-00835231 as a potential new treatment for COVID-19
- (2021) Maren de Vries et al. JOURNAL OF VIROLOGY
- Intranasal fusion inhibitory lipopeptide prevents direct-contact SARS-CoV-2 transmission in ferrets
- (2021) Rory D. de Vries et al. SCIENCE
- SARS-CoV-2 Mpro inhibitors with antiviral activity in a transgenic mouse model
- (2021) Jingxin Qiao et al. SCIENCE
- A small molecule compound with an indole moiety inhibits the main protease of SARS-CoV-2 and blocks virus replication
- (2021) Shin-ichiro Hattori et al. Nature Communications
- Identification of mutation resistance coldspots for targeting the SARS‐CoV2 main protease
- (2021) Navaneethakrishnan Krishnamoorthy et al. IUBMB LIFE
- Design, Synthesis, and Biological Evaluation of Peptidomimetic Aldehydes as Broad-Spectrum Inhibitors against Enterovirus and SARS-CoV-2
- (2021) Wenhao Dai et al. JOURNAL OF MEDICINAL CHEMISTRY
- Remdesivir is a delayed translocation inhibitor of SARS-CoV-2 replication
- (2021) Jack P.K. Bravo et al. MOLECULAR CELL
- D936Y and Other Mutations in the Fusion Core of the SARS-CoV-2 Spike Protein Heptad Repeat 1: Frequency, Geographical Distribution, and Structural Effect
- (2021) Romina Oliva et al. MOLECULES
- X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease
- (2021) Sebastian Günther et al. SCIENCE
- Gene variants of coagulation related proteins that interact with SARS-CoV-2
- (2021) David Holcomb et al. PLoS Computational Biology
- SARS-CoV-2 Mpro: A Potential Target for Peptidomimetics and Small-Molecule Inhibitors
- (2021) Andrea Citarella et al. Biomolecules
- Case Report: Paucisymptomatic College-Age Population as a Reservoir for Potentially Neutralization-Resistant Severe Acute Respiratory Syndrome Coronavirus 2 Variants
- (2021) Benjamin W. Neuman et al. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
- Transient and stabilized complexes of Nsp7, Nsp8, and Nsp12 in SARS-CoV-2 replication
- (2021) Mateusz Wilamowski et al. BIOPHYSICAL JOURNAL
- Optimal dose and safety of molnupiravir in patients with early SARS-CoV-2: a Phase I, open-label, dose-escalating, randomized controlled study
- (2021) Saye H Khoo et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Correction: Template-dependent inhibition of coronavirus RNA-dependent RNA polymerase by remdesivir reveals a second mechanism of action
- (2021) Egor P. Tchesnokov et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- 3CL Protease Inhibitors with an Electrophilic Arylketone Moiety as Anti-SARS-CoV-2 Agents
- (2021) Sho Konno et al. JOURNAL OF MEDICINAL CHEMISTRY
- Peptidomimetic α-Acyloxymethylketone Warheads with Six-Membered Lactam P1 Glutamine Mimic: SARS-CoV-2 3CL Protease Inhibition, Coronavirus Antiviral Activity, and in Vitro Biological Stability
- (2021) Bing Bai et al. JOURNAL OF MEDICINAL CHEMISTRY
- Structural Basis of Covalent Inhibitory Mechanism of TMPRSS2-Related Serine Proteases by Camostat
- (2021) Gaohui Sun et al. JOURNAL OF VIROLOGY
- SARS-CoV-2 variants, spike mutations and immune escape
- (2021) William T. Harvey et al. NATURE REVIEWS MICROBIOLOGY
- SAS: A Platform of Spike Antigenicity for SARS-CoV-2
- (2021) Lu Zhang et al. Frontiers in Cell and Developmental Biology
- Mutations on RBD of SARS-CoV-2 Omicron variant result in stronger binding to human ACE2 receptor
- (2021) Cecylia S. Lupala et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Emerging mutation patterns in SARS-CoV-2 variants
- (2021) David A. Ostrov et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Structural and functional insights into the spike protein mutations of emerging SARS-CoV-2 variants
- (2021) Deepali Gupta et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- 25-Hydroxycholesterol-Conjugated EK1 Peptide with Potent and Broad-Spectrum Inhibitory Activity against SARS-CoV-2, Its Variants of Concern, and Other Human Coronaviruses
- (2021) Qiaoshuai Lan et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Efficient incorporation and template-dependent polymerase inhibition are major determinants for the broad-spectrum antiviral activity of remdesivir
- (2021) Calvin J. Gordon et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Enhanced fusogenicity and pathogenicity of SARS-CoV-2 Delta P681R mutation
- (2021) Akatsuki Saito et al. NATURE
- A tale of two antiviral targets — and the COVID-19 drugs that bind them
- (2021) Megan Cully NATURE REVIEWS DRUG DISCOVERY
- Mechanisms of SARS-CoV-2 entry into cells
- (2021) Cody B. Jackson et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Early Remdesivir to Prevent Progression to Severe Covid-19 in Outpatients
- (2021) Robert L. Gottlieb et al. NEW ENGLAND JOURNAL OF MEDICINE
- An oral SARS-CoV-2 M pro inhibitor clinical candidate for the treatment of COVID-19
- (2021) Dafydd R. Owen et al. SCIENCE
- SARS-CoV-2-antibody response in health care workers after vaccination or natural infection in a longitudinal observational study
- (2021) Jonas Herzberg et al. VACCINE
- Developing a direct acting, orally available antiviral agent in a pandemic: the evolution of molnupiravir as a potential treatment for COVID-19
- (2021) George R Painter et al. Current Opinion in Virology
- Crystal structure of SARS-CoV-2 main protease in complex with protease inhibitor PF-07321332
- (2021) Yao Zhao et al. Protein & Cell
- Inhibition of SARS-CoV-2 polymerase by nucleotide analogs from a single-molecule perspective
- (2021) Mona Seifert et al. eLife
- Structure and Mutations of SARS-CoV-2 Spike Protein: A Focused Overview
- (2021) Rukmankesh Mehra et al. ACS Infectious Diseases
- Crystal structures of human coronavirus NL63 main protease at different pH values
- (2021) Hongxia Gao et al. Acta Crystallographica Section F-Structural Biology Communications
- Targeting SARS-CoV-2 Variants with Nucleic Acid Therapeutic Nanoparticle Conjugates
- (2021) Hanah F. Huber et al. Pharmaceuticals
- A phase I dose-escalation study of enzalutamide in combination with the AKT inhibitor AZD5363 (capivasertib) in patients with metastatic castration resistant prostate cancer.
- (2020) M.P. Kolinsky et al. ANNALS OF ONCOLOGY
- Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro
- (2020) Manli Wang et al. CELL RESEARCH
- Learning from the Past: Possible Urgent Prevention and Treatment Options for Severe Acute Respiratory Infections Caused by 2019‐nCoV
- (2020) Jared S. Morse et al. CHEMBIOCHEM
- Computers and viral diseases. Preliminary bioinformatics studies on the design of a synthetic vaccine and a preventative peptidomimetic antagonist against the SARS-CoV-2 (2019-nCoV, COVID-19) coronavirus
- (2020) B. Robson COMPUTERS IN BIOLOGY AND MEDICINE
- Recent discovery and development of inhibitors targeting coronaviruses
- (2020) Thanigaimalai Pillaiyar et al. DRUG DISCOVERY TODAY
- The antiviral compound remdesivir potently inhibits RNA-dependent RNA polymerase from Middle East respiratory syndrome coronavirus
- (2020) Calvin J Gordon et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- α-Ketoamides as Broad-Spectrum Inhibitors of Coronavirus and Enterovirus Replication: Structure-Based Design, Synthesis, and Activity Assessment
- (2020) Linlin Zhang et al. JOURNAL OF MEDICINAL CHEMISTRY
- Anti-HCV, nucleotide inhibitors, repurposing against COVID-19
- (2020) Abdo A. Elfiky LIFE SCIENCES
- A pneumonia outbreak associated with a new coronavirus of probable bat origin
- (2020) Peng Zhou et al. NATURE
- Nafamostat Mesylate Blocks Activation of SARS-CoV-2: New Treatment Option for COVID-19
- (2020) Markus Hoffmann et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein
- (2020) Alexandra C. Walls et al. CELL
- SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
- (2020) Markus Hoffmann et al. CELL
- Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion
- (2020) Shuai Xia et al. CELL RESEARCH
- Digestive system is a potential route of COVID-19: an analysis of single-cell coexpression pattern of key proteins in viral entry process
- (2020) Hao Zhang et al. GUT
- Structural and Evolutionary Analysis Indicate That the SARS-CoV-2 Mpro Is a Challenging Target for Small-Molecule Inhibitor Design
- (2020) Maria Bzówka et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Peptide-like and small-molecule inhibitors against Covid-19
- (2020) Suyash Pant et al. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
- Drug repurposing for coronavirus (COVID-19): in silico screening of known drugs against coronavirus 3CL hydrolase and protease enzymes
- (2020) Ammar D. Elmezayen et al. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
- Identification of new anti-nCoV drug chemical compounds from Indian spices exploiting SARS-CoV-2 main protease as target
- (2020) Umesh et al. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
- Fast Identification of Possible Drug Treatment of Coronavirus Disease-19 (COVID-19) through Computational Drug Repurposing Study
- (2020) Junmei Wang Journal of Chemical Information and Modeling
- The potential chemical structure of anti‐SARS‐CoV‐2 RNA‐dependent RNA polymerase
- (2020) Jrhau Lung et al. JOURNAL OF MEDICAL VIROLOGY
- ACE2 receptor polymorphism: Susceptibility to SARS-CoV-2, hypertension, multi-organ failure, and COVID-19 disease outcome
- (2020) Christian A. Devaux et al. JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
- Potential therapeutic agents against COVID-19
- (2020) Chih-Chia Lu et al. Journal of the Chinese Medical Association
- Computational Inference of Selection Underlying the Evolution of the Novel Coronavirus, Severe Acute Respiratory Syndrome Coronavirus 2
- (2020) Rachele Cagliani et al. JOURNAL OF VIROLOGY
- Putative Inhibitors of SARS-CoV-2 Main Protease from A Library of Marine Natural Products: A Virtual Screening and Molecular Modeling Study
- (2020) Davide Gentile et al. Marine Drugs
- Rapid Identification of Potential Inhibitors of SARS‐CoV‐2 Main Protease by Deep Docking of 1.3 Billion Compounds
- (2020) Anh-Tien Ton et al. Molecular Informatics
- Structure of replicating SARS-CoV-2 polymerase
- (2020) Hauke S. Hillen et al. NATURE
- A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
- (2020) David E. Gordon et al. NATURE
- Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors
- (2020) Zhenming Jin et al. NATURE
- Structural basis for the inhibition of SARS-CoV-2 main protease by antineoplastic drug carmofur
- (2020) Zhenming Jin et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Remdesivir for the Treatment of Covid-19 — Preliminary Report
- (2020) John H. Beigel et al. NEW ENGLAND JOURNAL OF MEDICINE
- A Trial of Lopinavir–Ritonavir in Adults Hospitalized with Severe Covid-19
- (2020) Bin Cao et al. NEW ENGLAND JOURNAL OF MEDICINE
- Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease
- (2020) Wenhao Dai et al. SCIENCE
- Structure of the RNA-dependent RNA polymerase from COVID-19 virus
- (2020) Yan Gao et al. SCIENCE
- Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors
- (2020) Linlin Zhang et al. SCIENCE
- Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir
- (2020) Wanchao Yin et al. SCIENCE
- An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice
- (2020) Timothy P. Sheahan et al. Science Translational Medicine
- Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV
- (2020) Xiuyuan Ou et al. Nature Communications
- Potential anti‐SARS‐CoV‐2 drug candidates identified through virtual screening of the ChEMBL database for compounds that target the main coronavirus protease
- (2020) Motonori Tsuji FEBS Open Bio
- Coronavirus membrane fusion mechanism offers a potential target for antiviral development
- (2020) Tiffany Tang et al. ANTIVIRAL RESEARCH
- Identification of potential binders of the main protease 3CLpro of the COVID-19 via structure-based ligand design and molecular modeling
- (2020) Marina Macchiagodena et al. CHEMICAL PHYSICS LETTERS
- The Development of Coronavirus 3C-Like Protease (3CLpro) Inhibitors from 2010 to 2020
- (2020) Yuzhi Liu et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Identifying potential treatments of COVID-19 from Traditional Chinese Medicine (TCM) by using a data-driven approach
- (2020) Xia Ren et al. JOURNAL OF ETHNOPHARMACOLOGY
- Virtual screening and repurposing of FDA approved drugs against COVID-19 main protease
- (2020) Mahmoud Kandeel et al. LIFE SCIENCES
- Controlling the SARS-CoV-2 spike glycoprotein conformation
- (2020) Rory Henderson et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Remdesivir Inhibits SARS-CoV-2 in Human Lung Cells and Chimeric SARS-CoV Expressing the SARS-CoV-2 RNA Polymerase in Mice
- (2020) Andrea J. Pruijssers et al. Cell Reports
- The MERS-CoV Receptor DPP4 as a Candidate Binding Target of the SARS-CoV-2 Spike
- (2020) Yu Li et al. iScience
- Cholesterol 25‐Hydroxylase inhibits SARS ‐CoV‐2 and other coronaviruses by depleting membrane cholesterol
- (2020) Shaobo Wang et al. EMBO JOURNAL
- Emergence of genomic diversity and recurrent mutations in SARS-CoV-2
- (2020) Lucy van Dorp et al. INFECTION GENETICS AND EVOLUTION
- Effect of Remdesivir vs Standard Care on Clinical Status at 11 Days in Patients With Moderate COVID-19
- (2020) Christoph D. Spinner et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Targeted therapy strategies against SARS-CoV-2 cell entry mechanisms: A systematic review of in vitro and in vivo studies
- (2020) Simin Seyedpour et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Discovery of Ketone-Based Covalent Inhibitors of Coronavirus 3CL Proteases for the Potential Therapeutic Treatment of COVID-19
- (2020) Robert L. Hoffman et al. JOURNAL OF MEDICINAL CHEMISTRY
- A SARS-CoV-2 vaccine candidate would likely match all currently circulating variants
- (2020) Bethany Dearlove et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease
- (2020) Alice Douangamath et al. Nature Communications
- A Quick Route to Multiple Highly Potent SARS‐CoV‐2 Main Protease Inhibitors**
- (2020) Kai S. Yang et al. ChemMedChem
- An Updated Review on SARS-CoV-2 Main Proteinase (MPro): Protein Structure and Small-Molecule Inhibitors
- (2020) Dima A. Sabbah et al. CURRENT TOPICS IN MEDICINAL CHEMISTRY
- Treatment for COVID-19: An overview
- (2020) Cristina Stasi et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Fragment-to-Lead Medicinal Chemistry Publications in 2019
- (2020) Wolfgang Jahnke et al. JOURNAL OF MEDICINAL CHEMISTRY
- ACE2 and TMPRSS2 polymorphisms in various diseases with special reference to its impact on COVID-19 disease
- (2020) HariOm Singh et al. MICROBIAL PATHOGENESIS
- N‐Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS‐CoV‐2 Main Protease
- (2020) Tomas Koudelka et al. PROTEOMICS
- Global SNP analysis of 11,183 SARS‐CoV‐2 strains reveals high genetic diversity
- (2020) Fangfeng Yuan et al. Transboundary and Emerging Diseases
- Synonymous mutations and the molecular evolution of SARS-CoV-2 origins
- (2020) Hongru Wang et al. Virus Evolution
- Potent MERS-CoV Fusion Inhibitory Peptides Identified from HR2 Domain in Spike Protein of Bat Coronavirus HKU4
- (2019) Shuai Xia et al. Viruses-Basel
- Mechanism of Inhibition of Ebola Virus RNA-Dependent RNA Polymerase by Remdesivir
- (2019) Egor Tchesnokov et al. Viruses-Basel
- A pan-coronavirus fusion inhibitor targeting the HR1 domain of human coronavirus spike
- (2019) Shuai Xia et al. Science Advances
- Advances in respiratory virus therapeutics – A meeting report from the 6th isirv Antiviral Group conference
- (2019) John H. Beigel et al. ANTIVIRAL RESEARCH
- Structure of the SARS-CoV nsp12 polymerase bound to nsp7 and nsp8 co-factors
- (2019) Robert N. Kirchdoerfer et al. Nature Communications
- Small-Molecule Antiviral β-D-N4-Hydroxycytidine Inhibits a Proofreading-Intact Coronavirus with a High Genetic Barrier to Resistance
- (2019) Maria L. Agostini et al. JOURNAL OF VIROLOGY
- NOS1 inhibits the interferon response of cancer cells by S-nitrosylation of HDAC2
- (2019) Pengfei Xu et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Identification of a peptide derived from the heptad repeat 2 region of the porcine epidemic diarrhea virus (PEDV) spike glycoprotein that is capable of suppressing PEDV entry and inducing neutralizing antibodies
- (2018) Pengwei Zhao et al. ANTIVIRAL RESEARCH
- Identification of Novel Linear Epitopes Located in the Infectious Bronchitis Virus Spike S2 Region
- (2018) Kiyohiko Andoh et al. AVIAN DISEASES
- Nextstrain: real-time tracking of pathogen evolution
- (2018) James Hadfield et al. BIOINFORMATICS
- Could human coronavirus OC43 have co-evolved with early humans?
- (2018) Paulo Eduardo Brandão GENETICS AND MOLECULAR BIOLOGY
- Beclabuvir in combination with asunaprevir and daclatasvir for hepatitis C virus genotype 1 infection: A systematic review and meta-analysis
- (2018) Ali Mahmoud Ahmed et al. JOURNAL OF MEDICAL VIROLOGY
- Discovery of Hydrocarbon-Stapled Short α-Helical Peptides as Promising Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Fusion Inhibitors
- (2018) Chao Wang et al. JOURNAL OF MEDICINAL CHEMISTRY
- Middle East respiratory syndrome coronavirus spike protein is not activated directly by cellular furin during viral entry into target cells
- (2018) Shutoku Matsuyama et al. JOURNAL OF VIROLOGY
- Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease
- (2018) Maria L. Agostini et al. mBio
- NAADP-dependent Ca2+ signaling regulates Middle East respiratory syndrome-coronavirus pseudovirus translocation through the endolysosomal system
- (2018) Gihan S. Gunaratne et al. CELL CALCIUM
- Adaptive Evolution of MERS-CoV to Species Variation in DPP4
- (2018) Michael Letko et al. Cell Reports
- Phase 2b Study of Pimodivir (JNJ-63623872) as Monotherapy or in Combination With Oseltamivir for Treatment of Acute Uncomplicated Seasonal Influenza A: TOPAZ Trial
- (2018) Robert W Finberg et al. JOURNAL OF INFECTIOUS DISEASES
- In Silico Design of New Inhibitors Against Hemagglutinin of Influenza
- (2018) Aurélie Perrier et al. JOURNAL OF PHYSICAL CHEMISTRY B
- Development of Small-Molecule MERS-CoV Inhibitors
- (2018) Ruiying Liang et al. Viruses-Basel
- Virus and host interactions critical for filoviral RNA synthesis as therapeutic targets
- (2018) Christopher F. Basler et al. ANTIVIRAL RESEARCH
- Quantitative structure-activity relationship and molecular docking revealed a potency of anti-hepatitis C virus drugs against human corona viruses
- (2017) Abdo A. Elfiky et al. JOURNAL OF MEDICAL VIROLOGY
- A Lipopeptide HIV-1/2 Fusion Inhibitor with Highly Potent In Vitro , Ex Vivo , and In Vivo Antiviral Activity
- (2017) Huihui Chong et al. JOURNAL OF VIROLOGY
- Proteases and protease inhibitors in infectious diseases
- (2017) Ayodeji A. Agbowuro et al. MEDICINAL RESEARCH REVIEWS
- Host-directed therapies for bacterial and viral infections
- (2017) Stefan H. E. Kaufmann et al. NATURE REVIEWS DRUG DISCOVERY
- Synthetic lethality and cancer
- (2017) Nigel J. O'Neil et al. NATURE REVIEWS GENETICS
- Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses
- (2017) Timothy P. Sheahan et al. Science Translational Medicine
- A New Strategy to Reduce Influenza Escape: Detecting Therapeutic Targets Constituted of Invariance Groups
- (2017) Julie Lao et al. Viruses-Basel
- Effects of a Fixed-Dose Co-Formulation of Daclatasvir, Asunaprevir, and Beclabuvir on the Pharmacokinetics of a Cocktail of Cytochrome P450 and Drug Transporter Substrates in Healthy Subjects
- (2017) Tushar Garimella et al. Drugs in research & development
- The phosphatidylinositol-3-phosphate 5-kinase inhibitor apilimod blocks filoviral entry and infection
- (2017) Elizabeth A. Nelson et al. PLoS Neglected Tropical Diseases
- Identification of Nafamostat as a Potent Inhibitor of Middle East Respiratory Syndrome Coronavirus S Protein-Mediated Membrane Fusion Using the Split-Protein-Based Cell-Cell Fusion Assay
- (2016) Mizuki Yamamoto et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Single-dose treatment with a humanized neutralizing antibody affords full protection of a human transgenic mouse model from lethal Middle East respiratory syndrome (MERS)-coronavirus infection
- (2016) Hongjie Qiu et al. ANTIVIRAL RESEARCH
- In vitro characterization of TMPRSS2 inhibition in IPEC-J2 cells
- (2016) Erzsebet Pászti-Gere et al. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
- An Overview of Severe Acute Respiratory Syndrome–Coronavirus (SARS-CoV) 3CL Protease Inhibitors: Peptidomimetics and Small Molecule Chemotherapy
- (2016) Thanigaimalai Pillaiyar et al. JOURNAL OF MEDICINAL CHEMISTRY
- Coronaviruses — drug discovery and therapeutic options
- (2016) Alimuddin Zumla et al. NATURE REVIEWS DRUG DISCOVERY
- Structure of Main Protease from Human Coronavirus NL63: Insights for Wide Spectrum Anti-Coronavirus Drug Design
- (2016) Fenghua Wang et al. Scientific Reports
- Recent progress in the discovery of inhibitors targeting coronavirus proteases
- (2016) Haofeng Wang et al. VIROLOGICA SINICA
- COVALENT DRUGS FORM LONG-LIVED TIES
- (2016) LILA GUTERMAN CHEMICAL & ENGINEERING NEWS
- Protease inhibitors targeting coronavirus and filovirus entry
- (2015) Yanchen Zhou et al. ANTIVIRAL RESEARCH
- Synthetic lethals in HIV: ways to avoid drug resistance
- (2015) Michel Petitjean et al. Biology Direct
- Intranasally administered peptidic viral fusion inhibitor protected hDPP4 transgenic mice from MERS-CoV infection
- (2015) Shibo Jiang et al. LANCET
- Discovery of an essential nucleotidylating activity associated with a newly delineated conserved domain in the RNA polymerase-containing protein of all nidoviruses
- (2015) Kathleen C. Lehmann et al. NUCLEIC ACIDS RESEARCH
- Recent Advances on Plasmin Inhibitors for the Treatment of Fibrinolysis-Related Disorders
- (2014) Rami A. Al-Horani et al. MEDICINAL RESEARCH REVIEWS
- Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430
- (2014) Travis K. Warren et al. NATURE
- Insights into RNA synthesis, capping, and proofreading mechanisms of SARS-coronavirus
- (2014) Marion Sevajol et al. VIRUS RESEARCH
- Structure-based discovery of Middle East respiratory syndrome coronavirus fusion inhibitor
- (2014) Lu Lu et al. Nature Communications
- Thinking Outside the Triangle: Replication Fidelity of the Largest RNA Viruses
- (2014) Everett Clinton Smith et al. Annual Review of Virology
- Favipiravir (T-705), a novel viral RNA polymerase inhibitor
- (2013) Yousuke Furuta et al. ANTIVIRAL RESEARCH
- Identification of the first synthetic inhibitors of the type II transmembrane serine protease TMPRSS2 suitable for inhibition of influenza virus activation
- (2013) Daniela Meyer et al. BIOCHEMICAL JOURNAL
- Discovery of N-(benzo[1,2,3]triazol-1-yl)-N-(benzyl)acetamido)phenyl) carboxamides as severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro inhibitors: Identification of ML300 and noncovalent nanomolar inhibitors with an induced-fit binding
- (2013) Mark Turlington et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Development of potent dipeptide-type SARS-CoV 3CL protease inhibitors with novel P3 scaffolds: Design, synthesis, biological evaluation, and docking studies
- (2013) Pillaiyar Thanigaimalai et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Virus entry at a glance
- (2013) Y. Yamauchi et al. JOURNAL OF CELL SCIENCE
- Middle East Respiratory Syndrome Coronavirus Infection Mediated by the Transmembrane Serine Protease TMPRSS2
- (2013) Kazuya Shirato et al. JOURNAL OF VIROLOGY
- BeAtMuSiC: prediction of changes in protein–protein binding affinity on mutations
- (2013) Yves Dehouck et al. NUCLEIC ACIDS RESEARCH
- The newly emerged SARS-Like coronavirus HCoV-EMC also has an “Achilles’ heel”: current effective inhibitor targeting a 3C-like protease
- (2013) Zhilin Ren et al. Protein & Cell
- Functional dissociation between PIKfyve-synthesized PtdIns5P and PtdIns(3,5)P2 by means of the PIKfyve inhibitor YM201636
- (2012) Diego Sbrissa et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Discovery, Synthesis, And Structure-Based Optimization of a Series of N-(tert-Butyl)-2-(N-arylamido)-2-(pyridin-3-yl) Acetamides (ML188) as Potent Noncovalent Small Molecule Inhibitors of the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) 3CL Protease
- (2012) Jon Jacobs et al. JOURNAL OF MEDICINAL CHEMISTRY
- Human Monoclonal Antibodies against Highly Conserved HR1 and HR2 Domains of the SARS-CoV Spike Protein Are More Broadly Neutralizing
- (2012) Hatem A. Elshabrawy et al. PLoS One
- Virus Pathogen Database and Analysis Resource (ViPR): A Comprehensive Bioinformatics Database and Analysis Resource for the Coronavirus Research Community
- (2012) Brett Pickett et al. Viruses-Basel
- Down-regulation of granulocyte-macrophage colony-stimulating factor by 3C-like proteinase in transfected A549 human lung carcinoma cells
- (2011) Hsien-Hua Liao et al. BMC IMMUNOLOGY
- Distinct and redundant functions of histone deacetylases HDAC1 and HDAC2 in proliferation and tumorigenesis
- (2011) Jennifer Jurkin et al. CELL CYCLE
- Evidence that TMPRSS2 Activates the Severe Acute Respiratory Syndrome Coronavirus Spike Protein for Membrane Fusion and Reduces Viral Control by the Humoral Immune Response
- (2011) I. Glowacka et al. JOURNAL OF VIROLOGY
- Co-lethality studied as an asset against viral drug escape: the HIV protease case
- (2010) Sophie Brouillet et al. Biology Direct
- Novel Peptidyl Aryl Vinyl Sulfones as Highly Potent and Selective Inhibitors of Cathepsins L and B
- (2010) Laura Mendieta et al. ChemMedChem
- Discovery of a β-d-2′-Deoxy-2′-α-fluoro-2′-β-C-methyluridine Nucleotide Prodrug (PSI-7977) for the Treatment of Hepatitis C Virus
- (2010) Michael J. Sofia et al. JOURNAL OF MEDICINAL CHEMISTRY
- Crystal Structure of HIV-1 gp41 Including Both Fusion Peptide and Membrane Proximal External Regions
- (2010) Victor Buzon et al. PLoS Pathogens
- Antimicrobial Strategies
- (2009) Jerome Deval DRUGS
- Structural Basis of Inhibition Specificities of 3C and 3C-like Proteases by Zinc-coordinating and Peptidomimetic Compounds
- (2009) Cheng-Chung Lee et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Camostat Attenuates Airway Epithelial Sodium Channel Function in Vivo through the Inhibition of a Channel-Activating Protease
- (2009) K. Coote et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Role of HDAC2 in the Pathophysiology of COPD
- (2008) Peter J. Barnes Annual Review of Physiology
- Design, synthesis and antiviral efficacy of a series of potent chloropyridyl ester-derived SARS-CoV 3CLpro inhibitors
- (2008) Arun K. Ghosh et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- eIF4GI links nutrient sensing by mTOR to cell proliferation and inhibition of autophagy
- (2008) Francisco Ramírez-Valle et al. JOURNAL OF CELL BIOLOGY
- Design of a Novel HIV-1 Fusion Inhibitor That Displays a Minimal Interface for Binding Affinity
- (2008) Shinya Oishi et al. JOURNAL OF MEDICINAL CHEMISTRY
- Molecular docking identifies the binding of 3-chloropyridine moieties specifically to the S1 pocket of SARS-CoV Mpro
- (2007) Chunying Niu et al. BIOORGANIC & MEDICINAL CHEMISTRY
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