Article
Infectious Diseases
Yonghao Xu, Manshu Li, Liang Zhou, Dongdong Liu, Weiqun He, Weibo Liang, Qingwen Sun, Huadong Sun, Yimin Li, Xiaoqing Liu
Summary: This study found that all 19 critically ill COVID-19 patients in ICU survived through 28 days of observation, with some patients being discharged from the hospital. No side effects of ribavirin were observed in these patients, and it may benefit COVID-19 patients through increasing virus clearance.
INFECTION AND DRUG RESISTANCE
(2021)
Review
Biochemistry & Molecular Biology
Lalita Subedi, Stephanie Tchen, Bhakta Prasad Gaire, Bingren Hu, Kurt Hu
Summary: The novel coronavirus, SARS-CoV-2/COVID-19, has become a global pandemic, affecting people of all ages. Nutraceuticals and phytochemicals, such as vitamins C, D, E, zinc, melatonin, and other functional foods, may have potential therapeutic efficacies in fighting the threat of the COVID-19 pandemic.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Virology
Mehdi Hassaniazad, Hossein Farshidi, Abdollah Gharibzadeh, Ali Bazram, Elham Khalili, Afsaneh Noormandi, Mohammad Fathalipour
Summary: This study compared the efficacy and safety of Favipiravir (FVP) and lopinavir/ritonavir (LPV/RTV) for the treatment of COVID-19. The results showed that there was no significant difference between the two groups in terms of viral clearance, ICU admission, in-hospital mortality, and length of stay. Both treatment regimens demonstrated a mild profile of adverse events.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Review
Immunology
Yongliang Yuan, Baihai Jiao, Lili Qu, Duomeng Yang, Ruijuan Liu
Summary: The emergence of SARS-CoV-2 has led to the COVID-19 pandemic, which is the greatest global public health threat of this century. Recent studies have revealed many mysteries of SARS-CoV-2 pathogenesis, greatly enhancing the research on COVID-19 vaccines and therapies. However, significant questions remain regarding its treatment.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Virology
Peng Yin, Juan Meng, Jincheng Chen, Junxiao Gao, Dongqi Wang, Shuyan Liu, Qinglong Guo, Muchun Zhu, Gengwei Zhang, Yingxia Liu, Ye Li, Guoliang Zhang
Summary: The study evaluated the role of antiviral drugs in reducing the severity of illness in patients with moderate COVID-19 pneumonia. The use of arbidol and interferon alpha-1b was associated with lower severity rates, while early use of arbidol within 7 days of symptom onset reduced patients' recovery time.
Article
Virology
Hatem Elalfy, Tarek Besheer, Ahmed El-Mesery, Abdel-Hady El-Gilany, Mahmoud Soliman Abd Elazez, Ahmed Alhawarey, Mohamed Alegezy, Tamer Elhadidy, Asem A. Hewidy, Hossam Zaghloul, Mustafa Ahmed Mohamed Neamatallah, Douaa Raafat, Wafaa M. El-Emshaty, Nermin Y. Abo El Kheir, Mahmoud El-Bendary
Summary: This study compared the rate and time of viral clearance in patients receiving different treatments and found that patients in the combined antiviral group had a higher clearance rate.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Review
Biochemistry & Molecular Biology
Christopher Hopkins, Chidinma Onweni, Victoria Zambito, DeLisa Fairweather, Kathryn McCormick, Hideki Ebihara, Thomas Caulfield, Yu Shrike Zhang, W. David Freeman
Summary: This perspective article emphasizes the importance of combination therapies in battling the severity of complications from SARS-CoV-2 infection, proposing different systems for fast and efficient combinatorial assessment of therapeutic candidates.
JOURNAL OF MOLECULAR BIOLOGY
(2021)
Article
Immunology
Ashkan Bagheri, Seyed Mohammad Iman Moezzi, Pouria Mosaddeghi, Sadra Nadimi Parashkouhi, Seyed Mostafa Fazel Hoseini, Fatemeh Badakhshan, Manica Negahdaripour
Summary: In response to the pandemic urgency of COVID-19, drug repurposing is being explored as a potential solution. Some existing antiviral drugs have shown promise in combating SARS-CoV-2 and warrant further investigation and evaluation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Miguel Angel Martinez
Summary: This article discusses whether drug repurposing is the best strategy for developing effective therapies to treat COVID-19 and other viral human infections.
DRUG DISCOVERY TODAY
(2022)
Article
Immunology
Oliver F. Wirz, Katharina Roltgen, Bryan A. Stevens, Suchitra Pandey, Malaya K. Sahoo, Lorna Tolentino, Michelle Verghese, Khoa Nguyen, Molly Hunter, Theo Thomas Snow, Abhay Raj Singh, Catherine A. Blish, Jennifer R. Cochran, James L. Zehnder, Kari C. Nadeau, Benjamin A. Pinsky, Tho D. Pham, Scott D. Boyd
Summary: The study found that early transfusion of high-titer CCP is beneficial for COVID-19 patients, and high-titer CCP should be collected within 60 days post-recovery from donors who experienced fever. Transfused antibody titers were significantly lower than endogenously produced antibodies, underscoring the importance of providing CCP prior to endogenous seroconversion.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Cenk Babayigit, Nurdan Kokturk, Seval Kul, Pelin Duru Cetinkaya, Sibel Atis Nayci, Serap Argun Baris, Oguz Karcioglu, Pinar Aysert, Ilim Irmak, Aycan Akbas Yuksel, Yonca Sekibag, Oya Baydar Toprak, Emel Azak, Sait Mulamahmutoglu, Caglar Cuhadaroglu, Aslihan Demirel, Bugra Kerget, Burcu Baran Ketencioglu, Hasan Selcuk Ozger, Gulcihan Ozkan, Zeynep Ture, Begum Ergan, Vildan Avkan Oguz, Oguz Kilinc, Merve Ercelik, Tansu Ulukavak Ciftci, Ozlem Alici, Esra Nurlu Temel, Ozlem Ataoglu, Asena Aydin, Dilek Cetiner Bahcetepe, Yusuf Taha Gullu, Fusun Fakili, Figen Deveci, Neslihan Kose, Muge Meltem Tor, Gulsah Gunluoglu, Sedat Altin, Teyfik Turgut, Tibel Tuna, Onder Ozturk, Oner Dikensoy, Pinar Yildiz Gulhan, Ilknur Basyigit, Hasim Boyaci, Ipek Kivilcim Oguzulgen, Sermin Borekci, Bilun Gemicioglu, Firat Bayraktar, Osman Elbek, Ismail Hanta, Hacer Kuzu Okur, Gulseren Sagcan, Oguz Uzun, Metin Akgun, Goksel Altinisik, Berna Dursun, Ebru Cakir Edis, Erkmen Gulhan, Fusun Oner Eyuboglu, Okkes Gultekin, Yavuz Havlucu, Metin Ozkan, Aysin Coskun, Abdullah Sayiner, A. Fuat Kalyoncu, Oya Itil, Hasan Bayram
Summary: This study investigated the association of repurposed antiviral drugs with COVID-19 morbidity. The findings demonstrated that antiviral drugs such as lopinavir, ritonavir, and favipiravir were associated with negative clinical outcomes in COVID-19 patients.
FRONTIERS IN MEDICINE
(2022)
Review
Infectious Diseases
Bryony Simmons, Hannah Wentzel, Sara Mobarak, Gholamali Eslami, Anahita Sadeghi, Ali Ali Asgari, Hamideh Abbaspour Kasgari, Hafez Tirgar Fakheri, Shahin Merat, Andrew Hill
Summary: The combination of sofosbuvir and daclatasvir has shown positive clinical outcomes in COVID-19 patients, including higher clinical recovery rates within 14 days, shorter time to clinical recovery, and lower all-cause mortality. However, the sample size of the analysis was relatively small, some trials were non-randomized, and the designs were not standardized, indicating the need for larger randomized controlled trials to confirm these results.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Review
Chemistry, Medicinal
Susanna Esposito, Giovanni Autore, Alberto Argentiero, Greta Ramundo, Serafina Perrone, Nicola Principi
Summary: With the extension of the COVID-19 pandemic, the epidemiology of COVID-19 in pediatrics has changed significantly. There has been an increase in pediatric COVID-19 cases, including severe cases and long-COVID. Several antivirals are approved for emergency use in pediatric COVID-19 treatment, but there are limitations in their use for younger children. Further research is urgently needed for appropriate management of pediatric COVID-19.
Review
Virology
Francesco Catell, Susanna Giordano, Cecilia Bertiond, Tommaso Lupia, Silvia Corcione, Matilde Scaldaferri, Lorenzo Angelone, Francesco Giuseppe De Rosa
Summary: This narrative review describes the potential antiviral activity of ozone therapy in patients with COVID-19, showing immunological effects and reduction in inflammation. Combined with antiviral drugs, ozone therapy can effectively control lung damage.
Article
Immunology
Susan A. Olender, Katherine K. Perez, Alan S. Go, Bindu Balani, Eboni G. Price-Haywood, Nirav S. Shah, Su Wang, Theresa L. Walunas, Shobha Swaminathan, Jihad Slim, BumSik Chin, Stephane De Wit, Shamim M. Ali, Alex Soriano Viladomiu, Philip Robinson, Robert L. Gottlieb, Tak Yin Owen Tsang, I-Heng Lee, Hao Hu, Richard H. Haubrich, Anand P. Chokkalingam, Lanjia Lin, Lijie Zhong, B. Nebiyou Bekele, Robertino Mera-Giler, Chloe Phulpin, Holly Edgar, Joel Gallant, Helena Diaz-Cuervo, Lindsey E. Smith, Anu O. Osinusi, Diana M. Brainard, Jose Bernardino
Summary: In a comparative analysis, remdesivir was found to be associated with significantly higher recovery rates and a 62% reduced mortality rate compared to standard-of-care treatment by day 14 in patients with severe COVID-19.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Endocrinology & Metabolism
Nan Jiang, Zhenyuan Chen, Li Liu, Xiaoxv Yin, Heping Yang, Xiangping Tan, Jing Wang, Hui Li, Mengge Tian, Zuxun Lu, Nian Xiong, Yanhong Gong
Summary: The study found that metformin may help reduce the incidence of ARDS in patients with COVID-19 and type 2 diabetes, especially in females. However, there was no significant association between metformin use and 30-day all-cause mortality.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2021)
Article
Environmental Sciences
Xiangping Tan, Yanxia Nie, Xiaomin Ma, Zhiming Guo, Yang Liu, Haixia Tian, Mallavarapu Megharaj, Weijun Shen, Wenxiang He
Summary: The study showed that high fertility soils had higher organic carbon, nutrient content, microbial activity, and enzyme kinetics parameters compared to low fertility soils. Soil chemical properties primarily influenced the values of V-max and K-m of enzymes, while the abundance of main microbial groups and fungi/bacteria ratio had a minor effect on them. Soil fertility and microbial communities interactively explained a portion of the variance in Km values.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Immunology
Mengdie Wang, Nan Jiang, Changjun Li, Jing Wang, Heping Yang, Li Liu, Xiangping Tan, Zhenyuan Chen, Yanhong Gong, Xiaoxv Yin, Qiao Zong, Nian Xiong, Guopeng Zhang
Summary: Male patients with COVID-19 are more likely to have poor outcomes compared to females, with higher rates of complications such as lymphopenia and thrombocytopenia. However, there was no significant difference in disease outcomes between postmenopausal and premenopausal females after age-matching. Further studies are needed to explore the underlying causes of these sex-specific differences in disease outcomes.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Economics
Zhenyuan Chen, Xiaoxv Yin, Xiangping Tan, Jing Wang, Nan Jiang, Mengge Tian, Hui Li, Zuxun Lu, Nian Xiong, Yanhong Gong
Summary: The study found that using systemic corticosteroids in nonsevere COVID-19 patients may lead to worse clinical outcomes, and higher doses were associated with an increased risk of disease progression.
Article
Environmental Sciences
Peng Cheng, Rui Shan, Hao-Ran Yuan, Xiangping Tan, Yong Chen, Jinchuan Wu
Summary: This study evaluated the power output performance and aqueous organic waste disposal of seasonal leachate in Microbial Fuel Cell (MFC) using leachate from both sealed and operating landfill. It was found that MFCs inoculated with leachate could generate electricity successfully, but fresh leachate showed better electrical output performance and COD removal efficiency, while the aged leachate had higher Coulombic Efficiency (CE). The study also examined the impact of composition on microbial community and power output performance.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2022)
Article
Microbiology
Yang Liu, Xiangping Tan, Shenglei Fu, Weijun Shen
Summary: This study found that soil bacterial and fungal communities in the organic layer of a temperate forest responded differently to canopy and understory nitrogen (N) addition. Soil pH mainly regulated the response of bacterial diversity and community composition to N addition, while soil moisture and nutrient availability controlled fungal diversity and community composition. Understory N addition had a strong effect on soil bacterial Shannon diversity and community composition, but a weaker effect on soil bacterial richness in the organic soil layer.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Soil Science
Qingshui Yu, Suhui Ma, Xiaofeng Ni, Xiuling Ni, Zhiming Guo, Xiangping Tan, Mengying Zhong, Md Abu Hanif, Jiangling Zhu, Chengjun Ji, Biao Zhu, Jingyun Fang
Summary: Increasing atmospheric nitrogen and phosphorus deposition affect the regulatory processes of soil phosphorus in phosphorus-poor tropical rainforests. Plants and microorganisms acquire most inorganic phosphorus by releasing hydrogen ions and organic acids, while interception by roots and enzymatic mineralization of organic phosphorus are relatively low. Acid phosphatase activity and kinetic parameters increased under low nitrogen addition, while phosphorus addition decreased acid phosphatase activity and arbuscular mycorrhizal diversity in both rainforests.
Article
Plant Sciences
Yanxia Nie, Sharon Yu Ling Lau, Xiangping Tan, Xiankai Lu, Suping Liu, Teemu Tahvanainen, Reika Isoda, Qing Ye, Yasuyuki Hashidoko
Summary: Melting permafrost mounds in subarctic palsa mires are a significant source of N2O emissions, and the N2O emission potential in palsa bogs is driven by bacterial residents of Sphagnum capillifolium, including Pseudomonas sp. and Enterobacteriaceae bacteria, which are highly responsive to pH levels.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Biodiversity Conservation
Senhao Wang, Taiki Mori, Shun Zou, Haifeng Zheng, Petr Hedenec, Yijing Zhu, Weiren Wang, Andi Li, Nan Liu, Shuguang Jian, Zhanfeng Liu, Xiangping Tan, Jiangming Mo, Wei Zhang
Summary: Different vegetation types on tropical coral islands have an impact on soil microbial community composition. The study found that the quantity and composition of soil microorganisms were significantly affected by different vegetation types. Soil water content, organic matter and nitrogen-phosphorus ratio, and pH value may be important driving factors for microbial community composition.
GLOBAL ECOLOGY AND CONSERVATION
(2022)
Article
Agricultural Engineering
Peng Cheng, Yingchuan Zhang, Nianfang Ma, Lining Wang, Liqun Jiang, Zhen Fang, Yitong Wang, Xiangping Tan
Summary: Microbial fuel cell (MFC) has great potential in wastewater treatment and energy generation. This study reveals the electrochemical mechanism of extracellular anaerobic respiration in MFC inoculated with gram-positive Rhodococcus pyridinivorans HR-1. The MFC exhibits rapid recovery of currents on the anode, with redox peaks near -0.38 and -0.18 V. Blocking the biofilm-based pathway with a filter membrane did not prevent electricity generation in the HR-1 inoculated MFC, suggesting the presence of a self-secreted electron shuttle pathway.
BIORESOURCE TECHNOLOGY
(2023)
Article
Environmental Sciences
Jianbo Fang, Xiangping Tan, Ziyin Yang, Weijun Shen, Josep Penuelas
Summary: A two-factor field experiment was conducted in sub-tropical forest plots to investigate the effects of nitrogen addition and precipitation change on terpene emissions. The results showed that nitrogen and precipitation had interactive effects on terpene emissions from forest ecosystems, particularly in the wet season. Including the interaction effects of nitrogen and precipitation in models is recommended for predicting terpene emissions.
ENVIRONMENTAL POLLUTION
(2023)
Article
Soil Science
Jinhong He, Xiangping Tan, Yanxia Nie, Lei Ma, Weiping Zhou, Weijun Shen
Summary: Research found that forest soil microorganisms acclimate to temperature variations by changing the lipid composition of their cell membranes. Saturated fatty acids increase while unsaturated fatty acids decrease with increasing temperature. The long-term warming may result in larger alterations in lipid constitute of soil microbial membranes compared to short-term incubation temperature gradient.
SOIL BIOLOGY & BIOCHEMISTRY
(2023)
Article
Microbiology
Jinhong He, Xiangping Tan, Yanxia Nie, Lei Ma, Juxiu Liu, Xiankai Lu, Jiangming Mo, Julie Leloup, Naoise Nunan, Qing Ye, Weijun Shen
Summary: Atmospheric nitrogen (N) deposition is a global environmental problem that poses a threat to biodiversity and ecosystem functioning. Understanding the responses of abundant and rare soil bacterial taxa to anthropogenic N enrichment is crucial for managing N-polluted forest soils. Our study reveals distinct responses of abundant and rare bacteria to N addition, with higher sensitivity in rare taxa and broader environmental acclimation in abundant taxa.
MICROBIOLOGY SPECTRUM
(2023)
Article
Ecology
Shuo Zhang, Ying-Ping Wang, Xi Fang, Jinlei Chen, Nannan Cao, Pingping Xu, Mengxiao Yu, Xin Xiong, Xiangping Tan, Qi Deng, Junhua Yan
Summary: Changes in litter quality and above-ground biomass during vegetation restoration have significant impacts on soil properties, but their effects on soil microbial metabolic limitations are still unclear.
SOIL ECOLOGY LETTERS
(2023)
Article
Biotechnology & Applied Microbiology
Peng Cheng, Liqun Jiang, Rui Shan, Zhen Fang, Nianfang Ma, Lianwu Deng, Yaoquan Lu, Xiangping Tan, Weijun Shen, Rongrong Liu
Summary: This study comprehensively investigated the use of forced ventilation to reduce nitrogen loss during composting. The addition of 10% coral sand and the implementation of forced ventilation were found to effectively prolong the thermophilic phase, accelerate substrate decomposition, and reduce nitrogen loss.
FERMENTATION-BASEL
(2022)
