Mutations in the SARS-CoV-2 RNA dependent RNA polymerase confer resistance to remdesivir by distinct mechanisms
出版年份 2022 全文链接
标题
Mutations in the SARS-CoV-2 RNA dependent RNA polymerase confer resistance to remdesivir by distinct mechanisms
作者
关键词
-
出版物
Science Translational Medicine
Volume -, Issue -, Pages -
出版商
American Association for the Advancement of Science (AAAS)
发表日期
2022-04-29
DOI
10.1126/scitranslmed.abo0718
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Mechanism of SARS-CoV-2 polymerase stalling by remdesivir
- (2021) Goran Kokic et al. Nature Communications
- Twelve years of SAMtools and BCFtools
- (2021) Petr Danecek et al. GigaScience
- Prodrugs of a 1′-CN-4-Aza-7,9-dideazaadenosine C-Nucleoside Leading to the Discovery of Remdesivir (GS-5734) as a Potent Inhibitor of Respiratory Syncytial Virus with Efficacy in the African Green Monkey Model of RSV
- (2021) Richard L. Mackman et al. JOURNAL OF MEDICINAL CHEMISTRY
- Remdesivir is a delayed translocation inhibitor of SARS-CoV-2 replication
- (2021) Jack P.K. Bravo et al. MOLECULAR CELL
- Report of the National Institutes of Health SARS-CoV-2 Antiviral Therapeutics Summit
- (2021) Matthew D Hall et al. JOURNAL OF INFECTIOUS DISEASES
- Prevention and therapy of SARS-CoV-2 and the B.1.351 variant in mice
- (2021) David R. Martinez et al. Cell Reports
- In vitro selection of Remdesivir resistance suggests evolutionary predictability of SARS-CoV-2
- (2021) Agnieszka M. Szemiel et al. PLoS Pathogens
- Efficient incorporation and template-dependent polymerase inhibition are major determinants for the broad-spectrum antiviral activity of remdesivir
- (2021) Calvin J. Gordon et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Early Remdesivir to Prevent Progression to Severe Covid-19 in Outpatients
- (2021) Robert L. Gottlieb et al. NEW ENGLAND JOURNAL OF MEDICINE
- Inhibition of SARS-CoV-2 polymerase by nucleotide analogs from a single-molecule perspective
- (2021) Mona Seifert et al. eLife
- The antiviral compound remdesivir potently inhibits RNA-dependent RNA polymerase from Middle East respiratory syndrome coronavirus
- (2020) Calvin J Gordon et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Prophylactic and therapeutic remdesivir (GS-5734) treatment in the rhesus macaque model of MERS-CoV infection
- (2020) Emmie de Wit et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV
- (2020) Timothy P. Sheahan et al. Nature Communications
- Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency
- (2020) Calvin J. Gordon et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Emerging SARS-CoV-2 mutation hot spots include a novel RNA-dependent-RNA polymerase variant
- (2020) Maria Pachetti et al. Journal of Translational Medicine
- Remdesivir for the Treatment of Covid-19 — Preliminary Report
- (2020) John H. Beigel et al. NEW ENGLAND JOURNAL OF MEDICINE
- An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice
- (2020) Timothy P. Sheahan et al. Science Translational Medicine
- Structural Basis for Helicase-Polymerase Coupling in the SARS-CoV-2 Replication-Transcription Complex
- (2020) James Chen et al. CELL
- Remdesivir Inhibits SARS-CoV-2 in Human Lung Cells and Chimeric SARS-CoV Expressing the SARS-CoV-2 RNA Polymerase in Mice
- (2020) Andrea J. Pruijssers et al. Cell Reports
- Remdesivir failure with SARS-CoV-2 RNA-dependent RNA-polymerase mutation in a B-cell immunodeficient patient with protracted Covid-19
- (2020) Martin Martinot et al. CLINICAL INFECTIOUS DISEASES
- Effect of Remdesivir vs Standard Care on Clinical Status at 11 Days in Patients With Moderate COVID-19
- (2020) Christoph D. Spinner et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Template-dependent inhibition of coronavirus RNA-dependent RNA polymerase by remdesivir reveals a second mechanism of action
- (2020) Egor P Tchesnokov et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Remdesivir Is Effective in Combating COVID-19 because It Is a Better Substrate than ATP for the Viral RNA-Dependent RNA Polymerase
- (2020) Tyler L. Dangerfield et al. iScience
- Broad spectrum antiviral remdesivir inhibits human endemic and zoonotic deltacoronaviruses with a highly divergent RNA dependent RNA polymerase
- (2019) Ariane J. Brown et al. ANTIVIRAL RESEARCH
- Small-Molecule Antiviral β-D-N4-Hydroxycytidine Inhibits a Proofreading-Intact Coronavirus with a High Genetic Barrier to Resistance
- (2019) Maria L. Agostini et al. JOURNAL OF VIROLOGY
- Minimap2: pairwise alignment for nucleotide sequences
- (2018) Heng Li BIOINFORMATICS
- Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease
- (2018) Maria L. Agostini et al. mBio
- Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses
- (2017) Timothy P. Sheahan et al. Science Translational Medicine
- Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys
- (2016) Travis K. Warren et al. NATURE
- A complete bacterial genome assembled de novo using only nanopore sequencing data
- (2015) Nicholas J Loman et al. NATURE METHODS
- Structural basis for RNA replication by the hepatitis C virus polymerase
- (2015) T. C. Appleby et al. SCIENCE
- The Lysine 65 Residue in HIV-1 Reverse Transcriptase Function and in Nucleoside Analog Drug Resistance
- (2014) Scott Garforth et al. Viruses-Basel
- Coronaviruses Lacking Exoribonuclease Activity Are Susceptible to Lethal Mutagenesis: Evidence for Proofreading and Potential Therapeutics
- (2013) Everett Clinton Smith et al. PLoS Pathogens
- Motif D of Viral RNA-Dependent RNA Polymerases Determines Efficiency and Fidelity of Nucleotide Addition
- (2012) Xiaorong Yang et al. STRUCTURE
- Structural basis for active site closure by the poliovirus RNA-dependent RNA polymerase
- (2010) P. Gong et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structural Insights into Mechanisms of Catalysis and Inhibition in Norwalk Virus Polymerase
- (2008) Dmitry F. Zamyatkin et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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