Proteases and protease inhibitors in infectious diseases

Systematic review: current concepts and challenges for the direct-acting antiviral era in hepatitis C cirrhosis

(2016) A. Majumdar et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

New directions for protease inhibitors directed drug discovery

(2016) Yoshio Hamada et al.   BIOPOLYMERS

GS-9857 in patients with chronic hepatitis C virus genotype 1-4 infection: a randomized, double-blind, dose-ranging phase 1 study

(2016) M. Rodriguez-Torres et al.   JOURNAL OF VIRAL HEPATITIS

Crystal structure of Zika virus NS2B-NS3 protease in complex with a boronate inhibitor

(2016) Jian Lei et al.   SCIENCE

Structural Insights into the Allosteric Operation of the Lon AAA+ Protease

(2016) Chien-Chu Lin et al.   STRUCTURE

Triazole resistance mediated by mutations of a conserved active site tyrosine in fungal lanosterol 14α-demethylase

(2016) Alia A. Sagatova et al.   Scientific Reports

Combating HIV resistance – focus on darunavir

(2016) Cecile Tremblay   Therapeutics and Clinical Risk Management

Potent Antiviral Activities of the Direct-Acting Antivirals ABT-493 and ABT-530 with Three-Day Monotherapy for Hepatitis C Virus Genotype 1 Infection

(2015) Eric J. Lawitz et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The flavivirus NS2B–NS3 protease–helicase as a target for antiviral drug development

(2015) Dahai Luo et al.   ANTIVIRAL RESEARCH

Access to hepatitis C medicines

(2015) Danny J Edwards et al.   BULLETIN OF THE WORLD HEALTH ORGANIZATION

Molecular principles behind Boceprevir resistance due to mutations in hepatitis C NS3/4A protease

(2015) Neha Nagpal et al.   GENE

Serine Proteases of Parasitic Helminths

(2015) Yong Yang et al.   KOREAN JOURNAL OF PARASITOLOGY

Ombitasvir plus paritaprevir plus ritonavir with or without ribavirin in treatment-naive and treatment-experienced patients with genotype 4 chronic hepatitis C virus infection (PEARL-I): a randomised, open-label trial

(2015) Christophe Hézode et al.   LANCET

The A, B, Cs of Herpesvirus Capsids

(2015) Ritesh Tandon et al.   Viruses-Basel

The sheddase ADAM10 is a potent modulator of prion disease

(2015) Hermann C Altmeppen et al.   eLife

Biochemistry and Medicinal Chemistry of the Dengue Virus Protease

(2014) Christoph Nitsche et al.   CHEMICAL REVIEWS

Lassomycin, a Ribosomally Synthesized Cyclic Peptide, Kills Mycobacterium tuberculosis by Targeting the ATP-Dependent Protease ClpC1P1P2

(2014) Ekaterina Gavrish et al.   CHEMISTRY & BIOLOGY

A perspective on targeting non-structural proteins to combat neglected tropical diseases: Dengue, West Nile and Chikungunya viruses

(2014) Soumendranath Bhakat et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

ABT-450, Ritonavir, Ombitasvir, and Dasabuvir Achieves 97% and 100% Sustained Virologic Response With or Without Ribavirin in Treatment-Experienced Patients With HCV Genotype 1b Infection

(2014) Pietro Andreone et al.   GASTROENTEROLOGY

Global distribution and prevalence of hepatitis C virus genotypes

(2014) Jane P. Messina et al.   HEPATOLOGY

Key Binding and Susceptibility of NS3/4A Serine Protease Inhibitors against Hepatitis C Virus

(2014) Arthitaya Meeprasert et al.   Journal of Chemical Information and Modeling

The Discovery of Asunaprevir (BMS-650032), An Orally Efficacious NS3 Protease Inhibitor for the Treatment of Hepatitis C Virus Infection

(2014) Paul M. Scola et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery and Development of Simeprevir (TMC435), a HCV NS3/4A Protease Inhibitor

(2014) Åsa Rosenquist et al.   JOURNAL OF MEDICINAL CHEMISTRY

Global numbers of infection and disease burden of soil transmitted helminth infections in 2010

(2014) Rachel L Pullan et al.   Parasites & Vectors

Independent Expansion of Zincin Metalloproteinases in Onygenales Fungi May Be Associated with Their Pathogenicity

(2014) Juan Li et al.   PLoS One

In vitro ANTIGIARDIAL ACTIVITY OF THE CYSTEINE PROTEASE INHIBITOR E-64

(2014) Thais Batista de Carvalho et al.   REVISTA DO INSTITUTO DE MEDICINA TROPICAL DE SAO PAULO

Inhibiting Helicobacter pylori HtrA protease by addressing a computationally predicted allosteric ligand binding site

(2014) Anna Maria Perna et al.   Chemical Science

Invasion of the Central Nervous System by Cryptococcus neoformans Requires a Secreted Fungal Metalloprotease

(2014) K. Vu et al.   mBio

Trypsin- and Chymotrypsin-Like Serine Proteases in Schistosoma mansoni – ‘The Undiscovered Country’

(2014) Martin Horn et al.   PLoS Neglected Tropical Diseases

Post-Translational Regulation via Clp Protease Is Critical for Survival of Mycobacterium tuberculosis

(2014) Ravikiran M. Raju et al.   PLoS Pathogens

A functional and structural study of the major metalloprotease secreted by the pathogenic fungusAspergillus fumigatus

(2013) Daniel Fernández et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Advances in MRSA drug discovery: where are we and where do we need to be?

(2013) Michio Kurosu et al.   Expert Opinion on Drug Discovery

Candida albicans secreted aspartic proteases 4–6 induce apoptosis of epithelial cells by a novel Trojan horse mechanism

(2013) Hao Wu et al.   FASEB JOURNAL

Roles of endoproteolytic α-cleavage and shedding of the prion protein in neurodegeneration

(2013) Hermann C. Altmeppen et al.   FEBS Journal

Discovery of Danoprevir (ITMN-191/R7227), a Highly Selective and Potent Inhibitor of Hepatitis C Virus (HCV) NS3/4A Protease

(2013) Yutong Jiang et al.   JOURNAL OF MEDICINAL CHEMISTRY

New therapeutic strategies in HCV: second-generation protease inhibitors

(2013) Virginia C. Clark et al.   LIVER INTERNATIONAL

Identification of a serine protease inhibitor which causes inclusion vacuole reduction and is lethal toChlamydia trachomatis

(2013) Sarina Gloeckl et al.   MOLECULAR MICROBIOLOGY

Hepatitis C Virus NS3 Inhibitors: Current and Future Perspectives

(2013) Kazi Abdus Salam et al.   Biomed Research International

The first wave: HCV NS3 protease inhibitors telaprevir and boceprevir

(2012) Kristen M Marks et al.   ANTIVIRAL THERAPY

Recent development of 3C and 3CL protease inhibitors for anti-coronavirus and anti-picornavirus drug discovery

(2012) R. Ramajayam et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The tip of the iceberg: RNA-binding proteins with prion-like domains in neurodegenerative disease

(2012) Oliver D. King et al.   BRAIN RESEARCH

Falcipain inhibitors as potential therapeutics for resistant strains of malaria: a patent review

(2012) Uttam Rajaram Mane et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Hepatitis C virus NS2 protease inhibits host cell antiviral response by inhibiting IKKε and TBK1 functions

(2012) Pasi Kaukinen et al.   JOURNAL OF MEDICAL VIROLOGY

Filoviruses Require Endosomal Cysteine Proteases for Entry but Exhibit Distinct Protease Preferences

(2012) J. Misasi et al.   JOURNAL OF VIROLOGY

Bacterial proteolytic complexes as therapeutic targets

(2012) Ravikiran M. Raju et al.   NATURE REVIEWS DRUG DISCOVERY

Serine protease inhibitors of parasitic helminths

(2012) ADEBAYO J. MOLEHIN et al.   PARASITOLOGY

The Safety, Effectiveness and Concentrations of Adjusted Lopinavir/Ritonavir in HIV-Infected Adults on Rifampicin-Based Antitubercular Therapy

(2012) Eric H. Decloedt et al.   PLoS One

Continuous Production of Prions after Infectious Particles Are Eliminated: Implications for Alzheimer’s Disease

(2012) Kohtaro Miyazawa et al.   PLoS One

Azithromycin antimicrobial resistance and genitalChlamydia trachomatisinfection: duration of therapy may be the key to improving efficacy

(2012) Paddy J Horner   SEXUALLY TRANSMITTED INFECTIONS

Inhibition of the keratinolytic subtilisin protease Sub3 from Microsporum canis by its propeptide (proSub3) and evaluation of the capacity of proSub3 to inhibit fungal adherence to feline epidermis

(2012) A. Baldo et al.   VETERINARY MICROBIOLOGY

Discovery of MK-5172, a Macrocyclic Hepatitis C Virus NS3/4a Protease Inhibitor

(2012) Steven Harper et al.   ACS Medicinal Chemistry Letters

Investigation of the Proteolytic Functions of an Expanded Cercarial Elastase Gene Family in Schistosoma mansoni

(2012) Jessica R. Ingram et al.   PLoS Neglected Tropical Diseases

Mycobacterium tuberculosis ClpP1 and ClpP2 Function Together in Protein Degradation and Are Required for Viability in vitro and During Infection

(2012) Ravikiran M. Raju et al.   PLoS Pathogens

Co-Occurrence of Types 1 and 2 PrP res in Sporadic Creutzfeldt-Jakob Disease MM1

(2011) Atsushi Kobayashi et al.   AMERICAN JOURNAL OF PATHOLOGY

Discovery of GS-9256: A novel phosphinic acid derived inhibitor of the hepatitis C virus NS3/4A protease with potent clinical activity

(2011) X. Christopher Sheng et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Validation of the Essential ClpP Protease in Mycobacterium tuberculosis as a Novel Drug Target

(2011) J. Ollinger et al.   JOURNAL OF BACTERIOLOGY

Independent Subtilases Expansions in Fungi Associated with Animals

(2011) A. Muszewska et al.   MOLECULAR BIOLOGY AND EVOLUTION

Discovery and development of telaprevir: an NS3-4A protease inhibitor for treating genotype 1 chronic hepatitis C virus

(2011) Ann D Kwong et al.   NATURE BIOTECHNOLOGY

Inhibitors of Helicobacter pylori Protease HtrA Found by ‘Virtual Ligand’ Screening Combat Bacterial Invasion of Epithelia

(2011) Martin Löwer et al.   PLoS One

Unique Residues Involved in Activation of the Multitasking Protease/Chaperone HtrA from Chlamydia trachomatis

(2011) Wilhelmina M. Huston et al.   PLoS One

Rapid induction of IgE responses to a worm cysteine protease during murine pre-patent schistosome infection

(2010) Lucia A de Oliveira Fraga et al.   BMC IMMUNOLOGY

Helicobacter pylori and Gastric Cancer: Factors That Modulate Disease Risk

(2010) L. E. Wroblewski et al.   CLINICAL MICROBIOLOGY REVIEWS

Helicobacter pylori HtrA is a new secreted virulence factor that cleaves E-cadherin to disrupt intercellular adhesion

(2010) Benjamin Hoy et al.   EMBO REPORTS

Bacterial proteases from the intracellular vacuole niche; protease conservation and adaptation for pathogenic advantage

(2010) Wilhelmina M. Huston   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Secreted Aspergillus fumigatus Protease Alp1 Degrades Human Complement Proteins C3, C4, and C5

(2010) J. Behnsen et al.   INFECTION AND IMMUNITY

Hepatitis C virus replication cycle

(2010) Ralf Bartenschlager et al.   JOURNAL OF HEPATOLOGY

Discovery of a Potent and Selective Noncovalent Linear Inhibitor of the Hepatitis C Virus NS3 Protease (BI 201335)

(2010) Montse Llinàs-Brunet et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Vaniprevir (MK-7009), a Macrocyclic Hepatitis C Virus NS3/4a Protease Inhibitor

(2010) John A. McCauley et al.   JOURNAL OF MEDICINAL CHEMISTRY

Crucial Role for Prion Protein Membrane Anchoring in the Neuroinvasion and Neural Spread of Prion Infection

(2010) M. Klingeborn et al.   JOURNAL OF VIROLOGY

Structures of ClpP in complex with acyldepsipeptide antibiotics reveal its activation mechanism

(2010) Byung-Gil Lee et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

HtrA proteases have a conserved activation mechanism that can be triggered by distinct molecular cues

(2010) Tobias Krojer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Drug resistance against HCV NS3/4A inhibitors is defined by the balance of substrate recognition versus inhibitor binding

(2010) K. P. Romano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of a secreted aspartic protease from C. albicans complexed with a potent inhibitor: Implications for the design of antifungal agents

(2010) Cele Abad-Zapatero et al.   PROTEIN SCIENCE

Exploitation of the Ubiquitin System by Invading Bacteria

(2010) Olivia Steele-Mortimer   TRAFFIC

The Hepatitis C Virus Nonstructural Protein 2 (NS2): An Up-and-Coming Antiviral Drug Target

(2010) Ivo C. Lorenz   Viruses-Basel

Comparative Studies on Retroviral Proteases: Substrate Specificity

(2010) József Tözsér   Viruses-Basel

Discovery of Narlaprevir (SCH 900518): A Potent, Second Generation HCV NS3 Serine Protease Inhibitor

(2010) Ashok Arasappan et al.   ACS Medicinal Chemistry Letters

Getting a Grip on Prions: Oligomers, Amyloids, and Pathological Membrane Interactions

(2009) Byron Caughey et al.   Annual Review of Biochemistry

Regulation and Cellular Roles of Ubiquitin-Specific Deubiquitinating Enzymes

(2009) Francisca E. Reyes-Turcu et al.   Annual Review of Biochemistry

The antibiotic ADEP reprogrammes ClpP, switching it from a regulated to an uncontrolled protease

(2009) Janine Kirstein et al.   EMBO Molecular Medicine

HIV protease inhibitors: recent clinical trials and recommendations on use

(2009) José Vicente Fernández-Montero et al.   EXPERT OPINION ON PHARMACOTHERAPY

The Mycobacterium tuberculosis proteasome: more than just a barrel-shaped protease

(2009) Francisca Cerda-Maira et al.   MICROBES AND INFECTION

Helminth immunoregulation: The role of parasite secreted proteins in modulating host immunity

(2009) James P. Hewitson et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Role of DegP for two-partner secretion inBordetella

(2009) C. Baud et al.   MOLECULAR MICROBIOLOGY

Inhibitors selective for mycobacterial versus human proteasomes

(2009) Gang Lin et al.   NATURE

Inhibition of a viral enzyme by a small-molecule dimer disruptor

(2009) Tina Shahian et al.   Nature Chemical Biology

The crystal structure of apo-FtsH reveals domain movements necessary for substrate unfolding and translocation

(2009) C. Bieniossek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteases in bacterial pathogenesis

(2009) Hanne Ingmer et al.   RESEARCH IN MICROBIOLOGY

Current and Novel Inhibitors of HIV Protease

(2009) Jana Pokorná et al.   Viruses-Basel

The order Herpesvirales

(2008) Andrew J. Davison et al.   ARCHIVES OF VIROLOGY

Crystal Structures of Highly Constrained Substrate and Hydrolysis Products Bound to HIV-1 Protease. Implications for the Catalytic Mechanism†

(2008) Joel D. A. Tyndall et al.   BIOCHEMISTRY

Chlamydia trachomatis responds to heat shock, penicillin induced persistence, and IFN-gamma persistence by altering levels of the extracytoplasmic stress response protease HtrA

(2008) Wilhelmina M Huston et al.   BMC MICROBIOLOGY

Inhibition of HIV-2 Protease by HIV-1 Protease Inhibitors in Clinical Use

(2008) Evan T. Brower et al.   Chemical Biology & Drug Design

West Nile Virus NS2B/NS3 Protease As An Antiviral Target

(2008) K. Chappell et al.   CURRENT MEDICINAL CHEMISTRY

Tipranavir

(2008) Jennifer S Orman et al.   DRUGS

Identification of the Major Cysteine Protease ofGiardiaand Its Role in Encystation

(2008) Kelly N. DuBois et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PL-100, a novel HIV-1 protease inhibitor displaying a high genetic barrier to resistance: An in vitro selection study

(2008) Serge Dandache et al.   JOURNAL OF MEDICAL VIROLOGY

HIV-1 Protease Inhibitors from Inverse Design in the Substrate Envelope Exhibit Subnanomolar Binding to Drug-Resistant Variants

(2008) Michael D. Altman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

β-Lactones as Specific Inhibitors of ClpP Attenuate the Production of Extracellular Virulence Factors ofStaphylococcus aureus

(2008) Thomas Böttcher et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Secreted aspartic proteases are not required for invasion of reconstituted human epithelia by Candida albicans

(2008) Ulrich Lermann et al.   MICROBIOLOGY-SGM

Unraveling prion strains with cell biology and organic chemistry

(2008) A. Aguzzi   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tipranavir analogous 3-sulfonylanilidotetronic acids: new synthesis and structure-dependent anti-HIV activity

(2008) Rainer Schobert et al.   TETRAHEDRON

An expanded family of fungalysin extracellular metallopeptidases of Coprinopsis cinerea

(2008) Walt W. Lilly et al.