An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice

Coronavirus Infections—More Than Just the Common Cold

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Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China

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Receptor recognition by novel coronavirus from Wuhan: An analysis based on decade-long structural studies of SARS

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Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV

(2020) Timothy P. Sheahan et al.   Nature Communications

Virological assessment of hospitalized patients with COVID-2019

(2020) Roman Wölfel et al.   NATURE

A Trial of Lopinavir–Ritonavir in Adults Hospitalized with Severe Covid-19

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A systematic review on the efficacy and safety of chloroquine for the treatment of COVID-19

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Clinical and virological data of the first cases of COVID-19 in Europe: a case series

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Mechanism of Inhibition of Ebola Virus RNA-Dependent RNA Polymerase by Remdesivir

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Structure of the SARS-CoV nsp12 polymerase bound to nsp7 and nsp8 co-factors

(2019) Robert N. Kirchdoerfer et al.   Nature Communications

Broad spectrum antiviral remdesivir inhibits human endemic and zoonotic deltacoronaviruses with a highly divergent RNA dependent RNA polymerase

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Small-Molecule Antiviral β-D-N4-Hydroxycytidine Inhibits a Proofreading-Intact Coronavirus with a High Genetic Barrier to Resistance

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Characterization of orally efficacious influenza drug with high resistance barrier in ferrets and human airway epithelia

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Orally Efficacious Broad-Spectrum Ribonucleoside Analog Inhibitor of Influenza and Respiratory Syncytial Viruses

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Adaptive evolution influences the infectious dose of MERS-CoV necessary to achieve severe respiratory disease

(2018) Madeline G. Douglas et al.   VIROLOGY

Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease

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Initiation, extension, and termination of RNA synthesis by a paramyxovirus polymerase

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Memory CD8 T cells mediate severe immunopathology following respiratory syncytial virus infection

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Fatal swine acute diarrhoea syndrome caused by an HKU2-related coronavirus of bat origin

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β-D- N 4 -Hydroxycytidine Is a Potent Anti-alphavirus Compound That Induces a High Level of Mutations in the Viral Genome

(2017) Nadya Urakova et al.   JOURNAL OF VIROLOGY

Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses

(2017) Timothy P. Sheahan et al.   Science Translational Medicine

Further Evidence for Bats as the Evolutionary Source of Middle East Respiratory Syndrome Coronavirus

(2017) S. J. Anthony et al.   mBio

GS-5734 and its parent nucleoside analog inhibit Filo-, Pneumo- and Paramyxoviruses

(2017) Michael K. Lo et al.   Scientific Reports

Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys

(2016) Travis K. Warren et al.   NATURE

Coronaviruses — drug discovery and therapeutic options

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SARS and MERS: recent insights into emerging coronaviruses

(2016) Emmie de Wit et al.   NATURE REVIEWS MICROBIOLOGY

Viral Load Kinetics of MERS Coronavirus Infection

(2016) Myoung-don Oh et al.   NEW ENGLAND JOURNAL OF MEDICINE

ConSurf 2016: an improved methodology to estimate and visualize evolutionary conservation in macromolecules

(2016) Haim Ashkenazy et al.   NUCLEIC ACIDS RESEARCH

SARS-like WIV1-CoV poised for human emergence

(2016) Vineet D. Menachery et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A mouse model for MERS coronavirus-induced acute respiratory distress syndrome

(2016) Adam S. Cockrell et al.   Nature Microbiology

Primer ID Validates Template Sampling Depth and Greatly Reduces the Error Rate of Next-Generation Sequencing of HIV-1 Genomic RNA Populations

(2015) Shuntai Zhou et al.   JOURNAL OF VIROLOGY

A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence

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Bat origin of human coronaviruses

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Identification of a New Ribonucleoside Inhibitor of Ebola Virus Replication

(2015) Olivier Reynard et al.   Viruses-Basel

New Metrics for Evaluating Viral Respiratory Pathogenesis

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Emerging Viral Diseases: Confronting Threats with New Technologies

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A Mouse Model for Betacoronavirus Subgroup 2c Using a Bat Coronavirus Strain HKU5 Variant

(2014) S. Agnihothram et al.   mBio

Middle East respiratory syndrome coronavirus (MERS-CoV) causes transient lower respiratory tract infection in rhesus macaques

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Reverse genetics with a full-length infectious cDNA of the Middle East respiratory syndrome coronavirus

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Engineering a Replication-Competent, Propagation-Defective Middle East Respiratory Syndrome Coronavirus as a Vaccine Candidate

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Coronaviruses Lacking Exoribonuclease Activity Are Susceptible to Lethal Mutagenesis: Evidence for Proofreading and Potential Therapeutics

(2013) Everett Clinton Smith et al.   PLoS Pathogens

Evidence Supporting a Zoonotic Origin of Human Coronavirus Strain NL63

(2012) J. Huynh et al.   JOURNAL OF VIROLOGY

Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia

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An Official American Thoracic Society Workshop Report: Features and Measurements of Experimental Acute Lung Injury in Animals

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Risk Factors for Severe Illness with 2009 Pandemic Influenza A (H1N1) Virus Infection in China

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Serial Histopathological Examination of the Lungs of Mice Infected with Influenza A Virus PR8 Strain

(2011) Masaya Fukushi et al.   PLoS One

Accurate sampling and deep sequencing of the HIV-1 protease gene using a Primer ID

(2011) C. B. Jabara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Successful Vaccination Strategies That Protect Aged Mice from Lethal Challenge from Influenza Virus and Heterologous Severe Acute Respiratory Syndrome Coronavirus

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Synthetic recombinant bat SARS-like coronavirus is infectious in cultured cells and in mice

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