Comprehensive fitness landscape of SARS-CoV-2 Mpro reveals insights into viral resistance mechanisms
出版年份 2022 全文链接
标题
Comprehensive fitness landscape of SARS-CoV-2 Mpro reveals insights into viral resistance mechanisms
作者
关键词
-
出版物
eLife
Volume 11, Issue -, Pages -
出版商
eLife Sciences Publications, Ltd
发表日期
2022-06-20
DOI
10.7554/elife.77433
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Targeting allosteric pockets of SARS-CoV-2 main protease Mpro
- (2021) Zahoor Ahmad Bhat et al. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
- Molecular dynamics and in silico mutagenesis on the reversible inhibitor-bound SARS-CoV-2 main protease complexes reveal the role of lateral pocket in enhancing the ligand affinity
- (2021) Ying Li Weng et al. Scientific Reports
- Dynamic Profiling of β-Coronavirus 3CL Mpro Protease Ligand-Binding Sites
- (2021) Eunice Cho et al. Journal of Chemical Information and Modeling
- De novo Design of SARS-CoV-2 Main Protease Inhibitors
- (2021) Dirk Trauner et al. SYNLETT
- Characterising proteolysis during SARS-CoV-2 infection identifies viral cleavage sites and cellular targets with therapeutic potential
- (2021) Bjoern Meyer et al. Nature Communications
- Recognition of Divergent Viral Substrates by the SARS-CoV-2 Main Protease
- (2021) Elizabeth A. MacDonald et al. ACS Infectious Diseases
- Screening a Library of FDA-Approved and Bioactive Compounds for Antiviral Activity against SARS-CoV-2
- (2021) Scott B. Biering et al. ACS Infectious Diseases
- An oral SARS-CoV-2 M pro inhibitor clinical candidate for the treatment of COVID-19
- (2021) Dafydd R. Owen et al. SCIENCE
- Crystal structure of SARS-CoV-2 main protease in complex with protease inhibitor PF-07321332
- (2021) Yao Zhao et al. Protein & Cell
- A Genetic Trap in Yeast for Inhibitors of SARS-CoV-2 Main Protease
- (2021) Hanna Alalam et al. mSystems
- PremPLI: a machine learning model for predicting the effects of missense mutations on protein-ligand interactions
- (2021) Tingting Sun et al. Communications Biology
- Structural and Evolutionary Analysis Indicate That the SARS-CoV-2 Mpro Is a Challenging Target for Small-Molecule Inhibitor Design
- (2020) Maria Bzówka et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors
- (2020) Zhenming Jin et al. NATURE
- Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors
- (2020) Linlin Zhang et al. SCIENCE
- Topological analysis of SARS CoV-2 main protease
- (2020) Ernesto Estrada CHAOS
- Structural plasticity of SARS-CoV-2 3CL Mpro active site cavity revealed by room temperature X-ray crystallography
- (2020) Daniel W. Kneller et al. Nature Communications
- Swine acute diarrhea syndrome coronavirus replication in primary human cells reveals potential susceptibility to infection
- (2020) Caitlin E. Edwards et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Quantifying and understanding the fitness effects of protein mutations: Laboratory versus nature
- (2019) Jeffrey I. Boucher et al. PROTEIN SCIENCE
- CRISPR-Cas9–mediated saturated mutagenesis screen predicts clinical drug resistance with improved accuracy
- (2017) Leyuan Ma et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- ConSurf 2016: an improved methodology to estimate and visualize evolutionary conservation in macromolecules
- (2016) Haim Ashkenazy et al. NUCLEIC ACIDS RESEARCH
- Systematic Mutant Analyses Elucidate General and Client-Specific Aspects of Hsp90 Function
- (2016) Parul Mishra et al. Cell Reports
- A Comprehensive, High-Resolution Map of a Gene’s Fitness Landscape
- (2014) Elad Firnberg et al. MOLECULAR BIOLOGY AND EVOLUTION
- Deep mutational scanning: a new style of protein science
- (2014) Douglas M Fowler et al. NATURE METHODS
- Inducible, tightly regulated and growth condition-independent transcription factor in Saccharomyces cerevisiae
- (2014) Diana S.M. Ottoz et al. NUCLEIC ACIDS RESEARCH
- Analyses of the Effects of All Ubiquitin Point Mutants on Yeast Growth Rate
- (2013) Benjamin P. Roscoe et al. JOURNAL OF MOLECULAR BIOLOGY
- Identification of PLX4032-resistance mechanisms and implications for novel RAF inhibitors
- (2013) Jaehyuk Choi et al. Pigment Cell & Melanoma Research
- Activity-enhancing mutations in an E3 ubiquitin ligase identified by high-throughput mutagenesis
- (2013) L. M. Starita et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Deep mutational scanning of an RRM domain of the Saccharomyces cerevisiae poly(A)-binding protein
- (2013) D. Melamed et al. RNA
- Latent Effects of Hsp90 Mutants Revealed at Reduced Expression Levels
- (2013) Li Jiang et al. PLoS Genetics
- Deep Sequencing of Systematic Combinatorial Libraries Reveals β-Lactamase Sequence Constraints at High Resolution
- (2012) Zhifeng Deng et al. JOURNAL OF MOLECULAR BIOLOGY
- Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia
- (2012) Ali M. Zaki et al. NEW ENGLAND JOURNAL OF MEDICINE
- The resurgence of covalent drugs
- (2011) Juswinder Singh et al. NATURE REVIEWS DRUG DISCOVERY
- Experimental illumination of a fitness landscape
- (2011) R. T. Hietpas et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mutation of Glu-166 Blocks the Substrate-Induced Dimerization of SARS Coronavirus Main Protease
- (2010) Shu-Chun Cheng et al. BIOPHYSICAL JOURNAL
- Correlation between dissociation and catalysis of SARS-CoV main protease
- (2008) Pei-Ying Lin et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started