Recent progress in the discovery of inhibitors targeting coronavirus proteases

Inhibitor Recognition Specificity of MERS-CoV Papain-like Protease May Differ from That of SARS-CoV

(2015) Hyun Lee et al.   ACS Chemical Biology

The SARS-coronavirus papain-like protease: Structure, function and inhibition by designed antiviral compounds

(2015) Yahira M. Báez-Santos et al.   ANTIVIRAL RESEARCH

Fused-ring structure of decahydroisoquinolin as a novel scaffold for SARS 3CL protease inhibitors

(2015) Yasuhiro Shimamoto et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Targeting zoonotic viruses: Structure-based inhibition of the 3C-like protease from bat coronavirus HKU4—The likely reservoir host to the human coronavirus that causes Middle East Respiratory Syndrome (MERS)

(2015) Sarah E. St. John et al.   BIOORGANIC & MEDICINAL CHEMISTRY

X-ray Structural and Functional Studies of the Three Tandemly Linked Domains of Non-structural Protein 3 (nsp3) from Murine Hepatitis Virus Reveal Conserved Functions

(2015) Yafang Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Broad-Spectrum Inhibitors against 3C-Like Proteases of Feline Coronaviruses and Feline Caliciviruses

(2015) Yunjeong Kim et al.   JOURNAL OF VIROLOGY

Bat-to-human: spike features determining ‘host jump’ of coronaviruses SARS-CoV, MERS-CoV, and beyond

(2015) Guangwen Lu et al.   TRENDS IN MICROBIOLOGY

Evidence for Substrate Binding-Induced Zwitterion Formation in the Catalytic Cys-His Dyad of the SARS-CoV Main Protease

(2014) Alexander Paasche et al.   BIOCHEMISTRY

X-ray Structural and Biological Evaluation of a Series of Potent and Highly Selective Inhibitors of Human Coronavirus Papain-like Proteases

(2014) Yahira M. Báez-Santos et al.   JOURNAL OF MEDICINAL CHEMISTRY

Antiviral drugs specific for coronaviruses in preclinical development

(2014) Adeyemi O Adedeji et al.   Current Opinion in Virology

Geranylated flavonoids displaying SARS-CoV papain-like protease inhibition from the fruits of Paulownia tomentosa

(2013) Jung Keun Cho et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis, modification and docking studies of 5-sulfonyl isatin derivatives as SARS-CoV 3C-like protease inhibitors

(2013) Wei Liu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor

(2013) Xing-Yi Ge et al.   NATURE

Interspecies transmission and emergence of novel viruses: lessons from bats and birds

(2013) Jasper Fuk-Woo Chan et al.   TRENDS IN MICROBIOLOGY

Diarylheptanoids from Alnus japonica Inhibit Papain-Like Protease of Severe Acute Respiratory Syndrome Coronavirus

(2012) Ji-Young Park et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Tanshinones as selective and slow-binding inhibitors for SARS-CoV cysteine proteases

(2012) Ji-Young Park et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Discovery of Seven Novel Mammalian and Avian Coronaviruses in the Genus Deltacoronavirus Supports Bat Coronaviruses as the Gene Source of Alphacoronavirus and Betacoronavirus and Avian Coronaviruses as the Gene Source of Gammacoronavirus and Deltacoronavirus

(2012) P. C. Y. Woo et al.   JOURNAL OF VIROLOGY

Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia

(2012) Ali M. Zaki et al.   NEW ENGLAND JOURNAL OF MEDICINE

Coronavirus Papain-like Proteases Negatively Regulate Antiviral Innate Immune Response through Disruption of STING-Mediated Signaling

(2012) Li Sun et al.   PLoS One

Inhibitors of SARS-3CLpro: Virtual Screening, Biological Evaluation, and Molecular Dynamics Simulation Studies

(2011) Prasenjit Mukherjee et al.   Journal of Chemical Information and Modeling

The SARS-coronavirus nsp7+nsp8 complex is a unique multimeric RNA polymerase capable of both de novo initiation and primer extension

(2011) Aartjan J.W. te Velthuis et al.   NUCLEIC ACIDS RESEARCH

Synthesis, docking studies, and evaluation of pyrimidines as inhibitors of SARS-CoV 3CL protease

(2010) R. Ramajayam et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Severe Acute Respiratory Syndrome Coronavirus Papain-like Novel Protease Inhibitors: Design, Synthesis, Protein−Ligand X-ray Structure and Biological Evaluation

(2010) Arun K. Ghosh et al.   JOURNAL OF MEDICINAL CHEMISTRY

Coronavirus Diversity, Phylogeny and Interspecies Jumping

(2009) Patrick C. Y. Woo et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Structure-Based Design, Synthesis, and Biological Evaluation of a Series of Novel and Reversible Inhibitors for the Severe Acute Respiratory Syndrome−Coronavirus Papain-Like Protease

(2009) Arun K. Ghosh et al.   JOURNAL OF MEDICINAL CHEMISTRY

Severe Acute Respiratory Syndrome Coronavirus Nonstructural Protein 2 Interacts with a Host Protein Complex Involved in Mitochondrial Biogenesis and Intracellular Signaling

(2009) C. T. Cornillez-Ty et al.   JOURNAL OF VIROLOGY

Structure-based virtual screening against SARS-3CLpro to identify novel non-peptidic hits

(2008) Prasenjit Mukherjee et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design, synthesis, and evaluation of trifluoromethyl ketones as inhibitors of SARS-CoV 3CL protease

(2008) Yi-Ming Shao et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Mechanism for Controlling the Dimer-Monomer Switch and Coupling Dimerization to Catalysis of the Severe Acute Respiratory Syndrome Coronavirus 3C-Like Protease

(2008) J. Shi et al.   JOURNAL OF VIROLOGY

Severe Acute Respiratory Syndrome Coronavirus nsp1 Suppresses Host Gene Expression, Including That of Type I Interferon, in Infected Cells

(2008) K. Narayanan et al.   JOURNAL OF VIROLOGY

A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication

(2008) K. Ratia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA