Harnessing ynamide activation to access deuterated carbonyls

Chemoselective Alpha‐Deuteration of Amides Via Retro‐ene Reaction

(2020) Vincent Porte et al.   CHEMISTRY-A EUROPEAN JOURNAL

Development of a Scalable Synthesis of Mevidalen (LY3154207), an Orally Available Positive Allosteric Modulator of the Human Dopamine D1 Receptor

(2020) Jeffery Richardson et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Applications of deuterium in medicinal chemistry

(2019) Tracey Pirali et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of α-Fluorinated Imides via Direct Fluorohydroxylation of Ynamides

(2019) Ji-Lin Li et al.   ORGANIC LETTERS

Reversal of Regioselectivity in Ynamide Chemistry

(2019) Bo Zhou et al.   ACS Catalysis

A Domino 10-Step Total Synthesis of FR252921 and Its Analogues, Complex Macrocyclic Immunosuppressants

(2019) Yong Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Unified Approach to the Chemoselective α-Functionalization of Amides with Heteroatom Nucleophiles

(2019) Carlos R. Gonçalves et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Highly Selective Directed Iridium-Catalyzed Hydrogen Isotope Exchange Reactions of Aliphatic Amides

(2018) Mégane Valero et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

C−H Functionalisation for Hydrogen Isotope Exchange

(2018) Jens Atzrodt et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A General Strategy for Site-Selective Incorporation of Deuterium and Tritium into Pyridines, Diazines, and Pharmaceuticals

(2018) J. Luke Koniarczyk et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Broadly Applicable Ytterbium-Catalyzed Esterification, Hydrolysis, and Amidation of Imides

(2018) Céline Guissart et al.   ORGANIC LETTERS

Stereodivergent synthesis of 1,4-dicarbonyls by traceless charge–accelerated sulfonium rearrangement

(2018) Dainis Kaldre et al.   SCIENCE

Deoxygenative Deuteration of Carboxylic Acids with D2 O

(2018) Muliang Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Direct Lewis Acid Catalyzed Conversion of Enantioenriched N-Acyloxazolidinones to Chiral Esters, Amides, and Acids

(2018) Jason M. Stevens et al.   JOURNAL OF ORGANIC CHEMISTRY

On the formation of seven-membered rings by arene-ynamide cyclization

(2018) Bogdan R. Brutiu et al.   MONATSHEFTE FUR CHEMIE

Lithium Hexamethyldisilazide-Mediated Enolization of Acylated Oxazolidinones: Solvent, Cosolvent, and Isotope Effects on Competing Monomer- and Dimer-Based Pathways

(2017) Gabriel J. Reyes-Rodríguez et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Radical Deuteration with D2O: Catalysis and Mechanistic Insights

(2017) Valentin Soulard et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

First deuterated drug approved

(2017) Charles Schmidt   NATURE BIOTECHNOLOGY

Photoredox-catalyzed deuteration and tritiation of pharmaceutical compounds

(2017) Yong Yao Loh et al.   SCIENCE

A Journey in the Chemistry of Ynamides: From Synthesis to Applications

(2016) Gwilherm Evano et al.   CHEMISTRY LETTERS

Isotope chemistry; a useful tool in the drug discovery arsenal

(2015) Charles S. Elmore et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A Brønsted Acid Catalyzed Redox Arylation

(2014) Bo Peng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A simple method forα-position deuterated carbonyl compounds with pyrrolidine as catalyst

(2014) Miao Zhan et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Ynamides in Ring Forming Transformations

(2013) Xiao-Na Wang et al.   ACCOUNTS OF CHEMICAL RESEARCH

Using Deuterium in Drug Discovery: Leaving the Label in the Drug

(2013) Thomas G. Gant   JOURNAL OF MEDICINAL CHEMISTRY

Coupled Methyl Group Epimerization and Reduction by Polyketide Synthase Ketoreductase Domains. Ketoreductase-Catalyzed Equilibrium Isotope Exchange

(2013) Ashish Garg et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Kinetic Isotope Effects in the Study of Organometallic Reaction Mechanisms

(2011) Mar Gómez-Gallego et al.   CHEMICAL REVIEWS

Synthesis of deuterium-labeled pregabalin

(2011) Zucheng Shen et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Once-daily treatment of ADHD with guanfacine: patient implications

(2011) Brandon Strange   Neuropsychiatric Disease and Treatment

Ynamides: Versatile Tools in Organic Synthesis

(2010) Gwilherm Evano et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ynamides: A Modern Functional Group for the New Millennium

(2010) Kyle A. DeKorver et al.   CHEMICAL REVIEWS

Metal-catalysed hydrogen isotope exchange labelling: a brief overview

(2010) William J. S. Lockley et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Rhodium-catalyzed carbometalation of ynamides with organoboron reagents

(2010) Benoit Gourdet et al.   TETRAHEDRON

Optimization of Azoles as Anti-Human Immunodeficiency Virus Agents Guided by Free-Energy Calculations

(2008) Jacob G. Zeevaart et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biosynthesis of (−)-(1S,2R)-Allocoronamic Acyl Thioester by an FeII-Dependent Halogenase and a Cyclopropane-Forming Flavoprotein

(2008) Christopher S. Neumann et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis and use of isotope-labelled substrates for a mechanistic study on human α-methylacyl-CoA racemase 1A (AMACR; P504S)

(2008) Daniel J. Darley et al.   ORGANIC & BIOMOLECULAR CHEMISTRY