CF2DSO2Na: An Effective Precursor Reagent for Deuteriodifluoromethylthiolation and Deuteriodifluoromethylation

Base-Catalyzed H/D Exchange Reaction of Difluoromethylarenes

(2021) Linwei Huang et al.   JOURNAL OF ORGANIC CHEMISTRY

Full-Spectrum Fluoromethyl Sulfonation via Modularized Multicomponent Coupling

(2021) Kejie Li et al.   CCS Chemistry

Direct C–H difluoromethylation of heterocycles via organic photoredox catalysis

(2020) Wei Zhang et al.   Nature Communications

Base-Promoted Radical Azofluoromethylation of Unactivated Alkenes

(2020) Zhichao Lu et al.   ORGANIC LETTERS

Deuteriodifluoromethylation and gem ‐Difluoroalkenylation of Aldehydes Using ClCF 2 H in Continuous Flow

(2020) Wai Chung Fu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Applications of deuterium in medicinal chemistry

(2019) Tracey Pirali et al.   JOURNAL OF MEDICINAL CHEMISTRY

Electrochemically Promoted Fluoroalkylation–Distal Functionalization of Unactivated Alkenes

(2019) Zhenlei Zou et al.   ORGANIC LETTERS

From heavy water to heavy aldehydes

(2019) Sarah M. Anthony et al.   Nature Catalysis

Deuterium- and Tritium-Labelled Compounds: Applications in the Life Sciences

(2018) Jens Atzrodt et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Redox-neutral tri-/difluoromethylation of para-quinone methides with sodium sulfinates

(2018) Qing-Yan Wu et al.   Organic Chemistry Frontiers

Visible-Light- and Oxygen-Promoted Direct Csp2-H Radical Difluoromethylation of Coumarins and Antifungal Activities

(2018) Peng Dai et al.   ORGANIC LETTERS

Silver-catalyzed fluoroalkylation of thiols using fluoroalkanesulfinates

(2017) Jing-jing Ma et al.   JOURNAL OF FLUORINE CHEMISTRY

First deuterated drug approved

(2017) Charles Schmidt   NATURE BIOTECHNOLOGY

Difluoromethylthiolation of Phenols and Related Compounds with a HF2CSO2Na/Ph2PCl/Me3SiCl System

(2017) Zhongyan Huang et al.   ORGANIC LETTERS

Sodium difluoromethanesulfinate—A difluoromethylating agent toward protonated heterocyclic bases

(2017) M. A. Lytkina et al.   RUSSIAN JOURNAL OF ORGANIC CHEMISTRY

Conversion of methyl ketones and methyl sulfones into α-deutero-α,α-difluoromethyl ketones and α-deutero-α,α-difluoromethyl sulfones in three synthetic steps

(2017) Munia F. Sowaileh et al.   TETRAHEDRON LETTERS

Direct Electrophilic (Benzenesulfonyl)Difluoromethylthiolation with a Shelf-Stable Reagent

(2016) Ermal Ismalaj et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Sulfur Containing Scaffolds in Drugs: Synthesis and Application in Medicinal Chemistry

(2016) Minghao Feng et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Isotope chemistry; a useful tool in the drug discovery arsenal

(2015) Charles S. Elmore et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Fluoroalkylative Aryl Migration of Conjugated N-Arylsulfonylated Amides Using Easily Accessible Sodium Di- and Monofluoroalkanesulfinates

(2015) Zhengbiao He et al.   ORGANIC LETTERS

Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)

(2013) Jiang Wang et al.   CHEMICAL REVIEWS

Using Deuterium in Drug Discovery: Leaving the Label in the Drug

(2013) Thomas G. Gant   JOURNAL OF MEDICINAL CHEMISTRY

Copper-Mediated Difluoromethylation of Aryl and Vinyl Iodides

(2012) Patrick S. Fier et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

New trends in the chemistry of α-fluorinated ethers, thioethers, amines and phosphines

(2009) Baptiste Manteau et al.   JOURNAL OF FLUORINE CHEMISTRY

N-Tosyl-S-difluoromethyl-S-phenylsulfoximine: A New Difluoromethylation Reagent for S-, N-, and C-Nucleophiles

(2009) Wei Zhang et al.   ORGANIC LETTERS

Understanding organofluorine chemistry. An introduction to the C–F bond

(2007) David O'Hagan   CHEMICAL SOCIETY REVIEWS

Fluorine in medicinal chemistry

(2007) Sophie Purser et al.   CHEMICAL SOCIETY REVIEWS