A primer of deuterium in drug design

Applications of deuterium in medicinal chemistry

(2019) Tracey Pirali et al.   JOURNAL OF MEDICINAL CHEMISTRY

A rapid MS/MS method to assess the deuterium kinetic isotope effect and associated improvement in the metabolic stability of deuterated biological and pharmacological molecules as applied to an imaging agent

(2019) Rhys B. Murphy et al.   ANALYTICA CHIMICA ACTA

New clues to ancient water on Itokawa

(2019) Ziliang Jin et al.   Science Advances

Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design

(2018) Nicholas A. Meanwell   JOURNAL OF MEDICINAL CHEMISTRY

Randomized, clinical trial of RT001: Early signals of efficacy in Friedreich's ataxia

(2018) Theresa Zesiewicz et al.   MOVEMENT DISORDERS

The Progression of Geographic Atrophy Secondary to Age-Related Macular Degeneration

(2018) Monika Fleckenstein et al.   OPHTHALMOLOGY

Phase 2 Trial of Selective Tyrosine Kinase 2 Inhibition in Psoriasis

(2018) Kim Papp et al.   NEW ENGLAND JOURNAL OF MEDICINE

Evaluation of Deuterium-Labeled JNJ38877605: Pharmacokinetic, Metabolic, and in Vivo Antitumor Profiles

(2018) Zhengsheng Zhan et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Effect of N -methyl deuteration on pharmacokinetics and pharmacodynamics of enzalutamide

(2017) Xuehai Pang et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

First deuterated drug approved

(2017) Charles Schmidt   NATURE BIOTECHNOLOGY

Effect of N-methyl deuteration on metabolism and pharmacokinetics of enzalutamide

(2016) Jinfang Jiang et al.   Drug Design Development and Therapy

Using Deuterium in Drug Discovery: Leaving the Label in the Drug

(2013) Thomas G. Gant   JOURNAL OF MEDICINAL CHEMISTRY

Increased Survival with Enzalutamide in Prostate Cancer after Chemotherapy

(2012) Howard I. Scher et al.   NEW ENGLAND JOURNAL OF MEDICINE

Deuterium Enrichment of Vitamin A at the C20 Position Slows the Formation of Detrimental Vitamin A Dimers in Wild-type Rodents

(2010) Yardana Kaufman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aurora Kinase Inhibitors Based on the Imidazo[1,2-a]pyrazine Core: Fluorine and Deuterium Incorporation Improve Oral Absorption and Exposure

(2010) Angela D. Kerekes et al.   JOURNAL OF MEDICINAL CHEMISTRY