Photoredox-catalyzed deuteration and tritiation of pharmaceutical compounds

Selective sp3 C–H alkylation via polarity-match-based cross-coupling

(2017) Chip Le et al.   NATURE

Structural basis for the cooperative allosteric activation of the free fatty acid receptor GPR40

(2017) Jun Lu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Design and Synthesis of Novel, Selective GPR40 AgoPAMs

(2017) Christopher W. Plummer et al.   ACS Medicinal Chemistry Letters

Structural basis for the cooperative allosteric activation of the free fatty acid receptor GPR40

(2017) Jun Lu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A General Small-Scale Reactor To Enable Standardization and Acceleration of Photocatalytic Reactions

(2017) Chi “Chip” Le et al.   ACS Central Science

Development of a scintillation proximity binding assay for high-throughput screening of hematopoietic prostaglandin D2 synthase

(2016) Cesar Meleza et al.   ANALYTICAL BIOCHEMISTRY

Photochemical Approaches to Complex Chemotypes: Applications in Natural Product Synthesis

(2016) Markus D. Kärkäs et al.   CHEMICAL REVIEWS

Photoredox Catalysis in Organic Chemistry

(2016) Megan H. Shaw et al.   JOURNAL OF ORGANIC CHEMISTRY

Stereoretentive Deuteration of α-Chiral Amines with D2O

(2016) Lillian V. A. Hale et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Iron-catalysed tritiation of pharmaceuticals

(2016) Renyuan Pony Yu et al.   NATURE

Donor–Acceptor Fluorophores for Visible-Light-Promoted Organic Synthesis: Photoredox/Ni Dual Catalytic C(sp3)–C(sp2) Cross-Coupling

(2016) Jian Luo et al.   ACS Catalysis

Isotope chemistry; a useful tool in the drug discovery arsenal

(2015) Charles S. Elmore et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Quantum-Chemical Predictions of pKa’s of Thiols in DMSO

(2014) Hai-Zhu Yu et al.   JOURNAL OF PHYSICAL CHEMISTRY A

Photoredox α-Vinylation of α-Amino Acids and N-Aryl Amines

(2014) Adam Noble et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Amine α-heteroarylation via photoredox catalysis: a homolytic aromatic substitution pathway

(2014) Christopher K. Prier et al.   Chemical Science

Regioselective and Stereospecific Deuteration of Bioactive Aza Compounds by the Use of Ruthenium Nanoparticles

(2013) Grégory Pieters et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Visible Light Photoredox Catalysis with Transition Metal Complexes: Applications in Organic Synthesis

(2013) Christopher K. Prier et al.   CHEMICAL REVIEWS

Use of Radiolabeled Compounds in Drug Metabolism and Pharmacokinetic Studies

(2012) Emre M. Isin et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Tritium: a coming of age for drug discovery and development ADME studies

(2012) W. J. S. Lockley et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Ruthenium-Catalyzed Selective α,β-Deuteration of Bioactive Amines

(2012) Lorenz Neubert et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Discovery of an  -Amino C-H Arylation Reaction Using the Strategy of Accelerated Serendipity

(2011) A. McNally et al.   SCIENCE

Ligand binding assays at equilibrium: validation and interpretation

(2010) Edward C. Hulme et al.   BRITISH JOURNAL OF PHARMACOLOGY

A Graphical Journey of Innovative Organic Architectures That Have Improved Our Lives

(2010) Nicholas A. McGrath et al.   JOURNAL OF CHEMICAL EDUCATION

Rhodium- and ruthenium-catalysed hydrogen isotope exchange

(2010) W. J. S. Lockley et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Metal-catalysed isotopic exchange labelling: 30 years of experience in pharmaceutical R&D

(2010) Paul H. Allen et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Structure−Activity Relationships for a Novel Series of Citalopram (1-(3-(Dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile) Analogues at Monoamine Transporters

(2010) Peng Zhang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Hydrogen-Deuterium Exchange Reactions of Aromatic Compounds and Heterocycles by NaBD4-Activated Rhodium, Platinum and Palladium Catalysts

(2009) Volker Derdau et al.   CHEMISTRY-A EUROPEAN JOURNAL

Using chemical probes to investigate the sub-inhibitory effects of azithromycin

(2008) Freija G. Glansdorp et al.   ORGANIC & BIOMOLECULAR CHEMISTRY