Deuteriodifluoromethylation and gem ‐Difluoroalkenylation of Aldehydes Using ClCF 2 H in Continuous Flow
出版年份 2020 全文链接
标题
Deuteriodifluoromethylation and
gem
‐Difluoroalkenylation of Aldehydes Using ClCF
2
H in Continuous Flow
作者
关键词
-
出版物
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 59, Issue 33, Pages 13885-13890
出版商
Wiley
发表日期
2020-06-04
DOI
10.1002/anie.202004260
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Difluorodiazoethane (CF2HCHN2): a new reagent for the introduction of the difluoromethyl group
- (2019) Pavel Mykhailiuk et al. CHEMISTRY-A EUROPEAN JOURNAL
- Facile synthesis of unsymmetrical 2,5-disubstituted 1,3,4-oxadiazoles by the cyclization of gem-difluoroalkenes with acyl hydrazides
- (2019) Xuxue Zhang et al. Asian Journal of Organic Chemistry
- Application of deuterated THENA for assigning the absolute configuration of chiral secondary alcohols
- (2019) Jakapun Soponpong et al. TETRAHEDRON LETTERS
- Regio- and Enantioselective C–H Cyclization of Pyridines with Alkenes Enabled by a Nickel/N-Heterocyclic Carbene Catalysis
- (2019) Wu-Bin Zhang et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Photocatalyzed Cyanodifluoromethylation of Alkenes
- (2019) Min Zhang et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Modular Continuous Flow Synthesis of Imatinib and Analogues
- (2019) Wai Chung Fu et al. ORGANIC LETTERS
- Utilizing o-Quinone Methide Chemistry: Synthesis of d9-Ivacaftor
- (2019) Adam R. Looker et al. JOURNAL OF ORGANIC CHEMISTRY
- Deuterium- and Tritium-Labelled Compounds: Applications in the Life Sciences
- (2018) Jens Atzrodt et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Utilization of fluoroform for difluoromethylation in continuous flow: a concise synthesis of α-difluoromethyl-amino acids
- (2018) Manuel Köckinger et al. GREEN CHEMISTRY
- Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design
- (2018) Nicholas A. Meanwell JOURNAL OF MEDICINAL CHEMISTRY
- Difluoromethylation of (hetero)aryl chlorides with chlorodifluoromethane catalyzed by nickel
- (2018) Chang Xu et al. Nature Communications
- Scalable Continuous Flow Process for the Synthesis of Eflornithine Using Fluoroform as Difluoromethyl Source
- (2018) Manuel Köckinger et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- Selective Late-Stage Hydrodefluorination of Trifluoromethylarenes: A Facile Access to Difluoromethylarenes
- (2017) Socrates B. Munoz et al. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
- Synthesis, properties and application of electronically-tuned tetraarylarsonium salts as phase transfer catalysts (PTC) for the synthesis of gem -difluorocyclopropanes
- (2017) Krzysztof Grudzień et al. JOURNAL OF FLUORINE CHEMISTRY
- Difluoromethyl Bioisostere: Examining the “Lipophilic Hydrogen Bond Donor” Concept
- (2017) Yossi Zafrani et al. JOURNAL OF MEDICINAL CHEMISTRY
- CF2H, a Hydrogen Bond Donor
- (2017) Chanan D. Sessler et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Direct β-Selective Hydrocarboxylation of Styrenes with CO2 Enabled by Continuous Flow Photoredox Catalysis
- (2017) Hyowon Seo et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- First deuterated drug approved
- (2017) Charles Schmidt NATURE BIOTECHNOLOGY
- Chlorodifluoromethane-triggered formation of difluoromethylated arenes catalysed by palladium
- (2017) Zhang Feng et al. Nature Chemistry
- The Direct C–H Difluoromethylation of Heteroarenes Based on the Photolysis of Hypervalent Iodine(III) Reagents That Contain Difluoroacetoxy Ligands
- (2017) Ryu Sakamoto et al. ORGANIC LETTERS
- Conversion of methyl ketones and methyl sulfones into α-deutero-α,α-difluoromethyl ketones and α-deutero-α,α-difluoromethyl sulfones in three synthetic steps
- (2017) Munia F. Sowaileh et al. TETRAHEDRON LETTERS
- Recent advances in the synthesis and CF functionalization of gem-difluoroalkenes
- (2017) Xuxue Zhang et al. TETRAHEDRON LETTERS
- Continuous-flow difluoromethylation with chlorodifluoromethane under biphasic conditions
- (2017) Bernhard Gutmann et al. Journal of Flow Chemistry
- Real-Time Spectroscopic Analysis Enabling Quantitative and Safe Consumption of Fluoroform during Nucleophilic Trifluoromethylation in Flow
- (2017) Biagia Musio et al. ACS Sustainable Chemistry & Engineering
- Metal-Catalyzed Direct Difluoromethylation Reactions
- (2017) Jian Rong et al. Asian Journal of Organic Chemistry
- Direct Electrophilic (Benzenesulfonyl)Difluoromethylthiolation with a Shelf-Stable Reagent
- (2016) Ermal Ismalaj et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Deuteration enhances catalyst lifetime in palladium-catalysed alcohol oxidation
- (2016) Nicola Armenise et al. CHEMICAL COMMUNICATIONS
- Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas
- (2016) Yu Zhou et al. CHEMICAL REVIEWS
- The Mechanism of Phosphonium Ylide Alcoholysis and Hydrolysis: Concerted Addition of the O−H Bond Across the P=C Bond
- (2016) Peter A. Byrne et al. CHEMISTRY-A EUROPEAN JOURNAL
- Direct Difluoromethylenation of Carbonyl Compounds by Using TMSCF3: The Right Conditions
- (2016) Sankarganesh Krishnamoorthy et al. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
- Effect of Deutetrabenazine on Chorea Among Patients With Huntington Disease
- (2016) et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Direct Difluoromethylation of Aryl Halides via Base Metal Catalysis at Room Temperature
- (2016) Long Xu et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Photoredox activation of carbon dioxide for amino acid synthesis in continuous flow
- (2016) Hyowon Seo et al. Nature Chemistry
- Direct Nucleophilic Difluoromethylation of Carbonyl Compounds
- (2016) Zuyong Deng et al. ORGANIC LETTERS
- Visible-Light-Induced Hydrodifluoromethylation of Alkenes with a Bromodifluoromethylphosphonium Bromide
- (2015) Qing-Yu Lin et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- First ever observation of the intermediate of phosphonium salt and ylide hydrolysis: P-hydroxytetraorganophosphorane
- (2015) Peter A. Byrne et al. CHEMICAL COMMUNICATIONS
- Oxydifluoromethylation of Alkenes by Photoredox Catalysis: Simple Synthesis of CF2 H-Containing Alcohols
- (2015) Yusuke Arai et al. CHEMISTRY-A EUROPEAN JOURNAL
- Fluorine in Drug Design: A Case Study with Fluoroanisoles
- (2015) Li Xing et al. ChemMedChem
- Applications of Fluorine in Medicinal Chemistry
- (2015) Eric P. Gillis et al. JOURNAL OF MEDICINAL CHEMISTRY
- Analysis of Past and Present Synthetic Methodologies on Medicinal Chemistry: Where Have All the New Reactions Gone?
- (2015) Dean G. Brown et al. JOURNAL OF MEDICINAL CHEMISTRY
- Well-Defined, Shelf-Stable (NHC)Ag(CF2H) Complexes for Difluoromethylation
- (2015) Yang Gu et al. ORGANOMETALLICS
- A Three-Minute Synthesis and Purification of Ibuprofen: Pushing the Limits of Continuous-Flow Processing
- (2014) David R. Snead et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Deoxygenativegem-difluoroolefination of carbonyl compounds with (chlorodifluoromethyl)trimethylsilane and triphenylphosphine
- (2014) Fei Wang et al. Beilstein Journal of Organic Chemistry
- gem-Difluoroolefination of Diaryl Ketones and Enolizable Aldehydes with Difluoromethyl 2-Pyridyl Sulfone: New Insights into the Julia-Kocienski Reaction
- (2014) Bing Gao et al. CHEMISTRY-A EUROPEAN JOURNAL
- Decarboxylative Julia-Kocienskigem-Difluoro-Olefination of 2-Pyridinyl Sulfonyldifluoroacetate
- (2014) Xiao-Ping Wang et al. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
- Difluoromethylene Phosphabetaine as an Equivalent of Difluoromethyl Carbanion
- (2014) Vitalij V. Levin et al. ORGANIC LETTERS
- Synthesis ofgem-Difluorocyclopropa(e)nes and O-, S-, N-, and P-Difluoromethylated Compounds with TMSCF2Br
- (2013) Lingchun Li et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Synthesis and decarboxylative Wittig reaction of difluoromethylene phosphobetaine
- (2013) Jian Zheng et al. CHEMICAL COMMUNICATIONS
- Conversion between Difluorocarbene and Difluoromethylene Ylide
- (2013) Jian Zheng et al. CHEMISTRY-A EUROPEAN JOURNAL
- Investigations on the Operation of Stereochemical Drift in the Wittig Reaction by NMR and Variable-Temperature NMR Spectroscopy of Oxaphosphetane Intermediates and Their Quench Products
- (2013) Peter A. Byrne et al. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
- The use of methyl 2,2-difluoro-2-(fluorosulfonyl)acetate as the difluorocarbene source to generate an in situ source of difluoromethylene triphenylphosphonium ylide
- (2013) Charles S. Thomoson et al. JOURNAL OF FLUORINE CHEMISTRY
- Using Deuterium in Drug Discovery: Leaving the Label in the Drug
- (2013) Thomas G. Gant JOURNAL OF MEDICINAL CHEMISTRY
- Use of Fluoroform as a Source of Difluorocarbene in the Synthesis of Difluoromethoxy- and Difluorothiomethoxyarenes
- (2013) Charles S. Thomoson et al. JOURNAL OF ORGANIC CHEMISTRY
- End-to-end continuous flow synthesis and purification of diphenhydramine hydrochloride featuring atom economy, in-line separation, and flow of molten ammonium salts
- (2013) David R. Snead et al. Chemical Science
- On the Interpretation of Deuterium Kinetic Isotope Effects in CH Bond Functionalizations by Transition-Metal Complexes
- (2012) Eric M. Simmons et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Copper-Mediated Difluoromethylation of (Hetero)aryl Iodides and β-Styryl Halides with Tributyl(difluoromethyl)stannane
- (2012) G. K. Surya Prakash et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Unequivocal Experimental Evidence for a Unified Lithium Salt-Free Wittig Reaction Mechanism for All Phosphonium Ylide Types: Reactions with β-Heteroatom-Substituted Aldehydes Are Consistently Selective for cis-Oxaphosphetane-Derived Products
- (2012) Peter A. Byrne et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Copper-Mediated Difluoromethylation of Aryl and Vinyl Iodides
- (2012) Patrick S. Fier et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- The Microwave-to-Flow Paradigm: Translating High-Temperature Batch Microwave Chemistry to Scalable Continuous-Flow Processes
- (2011) Toma N. Glasnov et al. CHEMISTRY-A EUROPEAN JOURNAL
- Synthesis of Annulated Pyridines by Intramolecular Inverse-Electron-Demand Hetero-Diels-Alder Reaction under Superheated Continuous Flow Conditions
- (2011) Rainer E. Martin et al. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
- Continuous flow reactors: a perspective
- (2011) Charlotte Wiles et al. GREEN CHEMISTRY
- Synopsis of Some Recent Tactical Application of Bioisosteres in Drug Design
- (2011) Nicholas A. Meanwell JOURNAL OF MEDICINAL CHEMISTRY
- On the Elucidation of the Mechanism ofVincaAlkaloid Fluorination in Superacidic Medium
- (2011) Emerson Giovanelli et al. ORGANIC LETTERS
- Efficient and Direct Nucleophilic Difluoromethylation of Carbonyl Compounds and Imines with Me3SiCF2H at Ambient or Low Temperature
- (2011) Yanchuan Zhao et al. ORGANIC LETTERS
- Green and Sustainable Chemical Synthesis Using Flow Microreactors
- (2010) Jun-ichi Yoshida et al. ChemSusChem
- Pd- and Pt-catalyzed H/D exchange methods and their application for internal MS standard preparation from a Sanofi-Aventis perspective
- (2010) Jens Atzrodt et al. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
- Aurora Kinase Inhibitors Based on the Imidazo[1,2-a]pyrazine Core: Fluorine and Deuterium Incorporation Improve Oral Absorption and Exposure
- (2010) Angela D. Kerekes et al. JOURNAL OF MEDICINAL CHEMISTRY
- Difluoromethyl 2-Pyridyl Sulfone: A Newgem-Difluoroolefination Reagent for Aldehydes and Ketones
- (2010) Yanchuan Zhao et al. ORGANIC LETTERS
- N-Tosyl-S-difluoromethyl-S-phenylsulfoximine: A New Difluoromethylation Reagent for S-, N-, and C-Nucleophiles
- (2009) Wei Zhang et al. ORGANIC LETTERS
- Direct Vinylation and Difluorovinylation of Arylboronic Acids Using Vinyl- and 2,2-Difluorovinyl Tosylates via the Suzuki−Miyaura Cross Coupling
- (2008) Thomas M. Gøgsig et al. JOURNAL OF ORGANIC CHEMISTRY
- Investigations into the effectiveness of deuterium as a “protecting group” for C–H bonds in radical reactions involving hydrogen atom transfer
- (2008) Mark E. Wood et al. ORGANIC & BIOMOLECULAR CHEMISTRY
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