Hypoxia-Induced Cancer Cell Responses Driving Radioresistance of Hypoxic Tumors: Approaches to Targeting and Radiosensitizing
出版年份 2021 全文链接
标题
Hypoxia-Induced Cancer Cell Responses Driving Radioresistance of Hypoxic Tumors: Approaches to Targeting and Radiosensitizing
作者
关键词
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出版物
Cancers
Volume 13, Issue 5, Pages 1102
出版商
MDPI AG
发表日期
2021-03-05
DOI
10.3390/cancers13051102
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Roles of HIF and 2-Oxoglutarate-Dependent Dioxygenases in Controlling Gene Expression in Hypoxia
- (2021) Julianty Frost et al. Cancers
- Overcoming Radioresistance in Tumor Therapy by Alleviating Hypoxia and Using the HIF-1 Inhibitor
- (2020) Xingguo Zhou et al. ACS Applied Materials & Interfaces
- Histone deacetylase (HDAC) inhibitors in cancer: a patent review (2017-present)
- (2020) Chunlong Zhao et al. EXPERT OPINION ON THERAPEUTIC PATENTS
- Ku80-targeted pH-sensitive peptide-PNA conjugates are tumor selective and sensitize cancer cells to ionizing radiation
- (2020) Alanna R Kaplan et al. MOLECULAR CANCER RESEARCH
- Circular RNA circRNF20 promotes breast cancer tumorigenesis and Warburg effect through miR-487a/HIF-1α/HK2
- (2020) Lili Cao et al. Cell Death & Disease
- Acetate supplementation restores chromatin accessibility and promotes tumor cell differentiation under hypoxia
- (2020) Yang Li et al. Cell Death & Disease
- LncRNA RUNX1-IT1 which is downregulated by hypoxia-driven histone deacetylase 3 represses proliferation and cancer stem-like properties in hepatocellular carcinoma cells
- (2020) Liankang Sun et al. Cell Death & Disease
- Modulation of Mitochondrial Metabolic Reprogramming and Oxidative Stress to Overcome Chemoresistance in Cancer
- (2020) Rosario Avolio et al. Biomolecules
- YC-1 sensitizes the antitumor effects of boron neutron capture therapy in hypoxic tumor cells
- (2020) Takaomi Harada et al. JOURNAL OF RADIATION RESEARCH
- Estimation of the oxygen enhancement ratio for charged particle radiation
- (2020) David Robert Grimes PHYSICS IN MEDICINE AND BIOLOGY
- Effects of Hypoxia and Radiation-Induced Exosomes on Migration of Lung Cancer Cells and Angiogenesis of Umbilical Vein Endothelial Cells
- (2020) Fang Mo et al. RADIATION RESEARCH
- Transcriptional regulation of HSPB1 by Friend leukemia integration-1 factor modulates radiation and temozolomide resistance in glioblastoma
- (2020) Yetirajam Rajesh et al. Oncotarget
- LncRNA HOTAIR enhances breast cancer radioresistance through facilitating HSPA1A expression via sequestering miR ‐449b‐5p
- (2020) Shuqin Zhang et al. Thoracic Cancer
- Metabolic Heterogeneity of Cancer Cells: An Interplay between HIF-1, GLUTs, and AMPK
- (2020) Nurbubu T. Moldogazieva et al. Cancers
- Inhibition of HIF-1α by Atorvastatin During 131I-RTX Therapy in Burkitt’s Lymphoma Model
- (2020) Eun-Ho Kim et al. Cancers
- Elevated PDK1 Expression Drives PI3K/AKT/MTOR Signaling Promotes Radiation-Resistant and Dedifferentiated Phenotype of Hepatocellular Carcinoma
- (2020) Oluwaseun Adebayo Bamodu et al. Cells
- Molecular Chaperones in Cancer Stem Cells: Determinants of Stemness and Potential Targets for Antitumor Therapy
- (2020) Alexander Kabakov et al. Cells
- Knockdown of Circ_0081143 Mitigates Hypoxia-Induced Migration, Invasion, and EMT in Gastric Cancer Cells Through the miR-497-5p/EGFR Axis
- (2020) Jianjun Tang et al. CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS
- Circle RNA circABCB10 Modulates PFN2 to Promote Breast Cancer Progression, as Well as Aggravate Radioresistance Through Facilitating Glycolytic Metabolism Via miR-223-3p
- (2020) Yue Zhao et al. CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS
- Exosome-transmitted lncRNA PCGEM1 promotes invasive and metastasis in gastric cancer by maintaining the stability of SNAI1
- (2020) H.-y. Piao et al. Clinical & Translational Oncology
- Hypoxia, metabolism, and the circadian clock: new links to overcome radiation resistance in high-grade gliomas
- (2020) Han Shen et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- HSP27 regulates viability and migration of cancer cell lines following irradiation
- (2020) Benjamin Philipp Ernst et al. Journal of Proteomics
- New insights into molecular chaperone TRAP1 as a feasible target for future cancer treatments
- (2020) Xiao-Tong Li et al. LIFE SCIENCES
- Exosomal miR‐1255b‐5p targets human telomerase reverse transcriptase in colorectal cancer cells to suppress epithelial‐to‐mesenchymal transition
- (2020) Xue Zhang et al. Molecular Oncology
- Targeting Stem Cells with Hyperthermia: Translational Relevance in Cancer Patients
- (2020) Michele Ammendola et al. ONCOLOGY
- Integrating Loco-Regional Hyperthermia Into the Current Oncology Practice: SWOT and TOWS Analyses
- (2020) Niloy R. Datta et al. Frontiers in Oncology
- Chloroquine combined with concurrent radiotherapy and temozolomide for newly diagnosed glioblastoma: a phase IB trial
- (2020) Inge Compter et al. Autophagy
- ALDH-1-positive cells exhibited a radioresistant phenotype that was enhanced with hypoxia in cervical cancer
- (2020) Tingting Yao et al. BMC CANCER
- Targeting tumor hypoxia and mitochondrial metabolism with anti-parasitic drugs to improve radiation response in high-grade gliomas
- (2020) Faiqa Mudassar et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Glioma Stem-Like Cells Can Be Targeted in Boron Neutron Capture Therapy with Boronophenylalanine
- (2020) Natsuko Kondo et al. Cancers
- Cyclic Hypoxia: An Update on Its Characteristics, Methods to Measure It and Biological Implications in Cancer
- (2020) Samuel B. Bader et al. Cancers
- Cancer Stem Cells: The Architects of the Tumor Ecosystem
- (2019) Briana C. Prager et al. Cell Stem Cell
- HIF-1-Dependent Reprogramming of Glucose Metabolic Pathway of Cancer Cells and Its Therapeutic Significance
- (2019) Ayako Nagao et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Histone Deacetylase Inhibitors and Phenotypical Transformation of Cancer Cells
- (2019) Anna Wawruszak et al. Cancers
- Extracellular Vesicles as Transmitters of Hypoxia Tolerance in Solid Cancers
- (2019) Marijke Zonneveld et al. Cancers
- Baicalein Suppresses Stem Cell-Like Characteristics in Radio- and Chemoresistant MDA-MB-231 Human Breast Cancer Cells through Up-Regulation of IFIT2
- (2019) So Koh et al. Nutrients
- HIF Inhibitors: Status of Current Clinical Development
- (2019) Jaleh Fallah et al. Current Oncology Reports
- Induction of HSP27 and HSP70 by constitutive overexpression of Redd1 confers resistance of lung cancer cells to ionizing radiation
- (2019) Hyeon‑Ok Jin et al. ONCOLOGY REPORTS
- The Warburg effect: essential part of metabolic reprogramming and central contributor to cancer progression
- (2019) Peter Vaupel et al. INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
- Hypoxia Induced ER Stress Response as an Adaptive Mechanism in Cancer
- (2019) Sandhya Chipurupalli et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Overcoming Radioresistance: Small Molecule Radiosensitisers and Hypoxia-activated Prodrugs
- (2019) R.K. Jackson et al. CLINICAL ONCOLOGY
- Autophagy and cancer stem cells: molecular mechanisms and therapeutic applications
- (2019) Francesca Nazio et al. CELL DEATH AND DIFFERENTIATION
- Regulation of pH by Carbonic Anhydrase 9 Mediates Survival of Pancreatic Cancer Cells With Activated KRAS in Response to Hypoxia
- (2019) Paul C. McDonald et al. GASTROENTEROLOGY
- HDAC1,2 Knock-Out and HDACi Induced Cell Apoptosis in Imatinib-Resistant K562 Cells
- (2019) Shu-Huey Chen et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Silencing of heat shock protein 27 increases the radiosensitivity of non‑small cell lung carcinoma cells
- (2019) Liping Xu et al. Molecular Medicine Reports
- Extracellular Acidosis Modulates the Expression of Epithelial-Mesenchymal Transition (EMT) Markers and Adhesion of Epithelial and Tumor Cells
- (2019) Anne Riemann et al. NEOPLASIA
- ROS Production and Distribution: A New Paradigm to Explain the Differential Effects of X-ray and Carbon Ion Irradiation on Cancer Stem Cell Migration and Invasion
- (2019) Anne-Sophie Wozny et al. Cancers
- The lncRNA PVT1 regulates nasopharyngeal carcinoma cell proliferation via activating the KAT2A acetyltransferase and stabilizing HIF-1α
- (2019) Ying Wang et al. CELL DEATH AND DIFFERENTIATION
- The Role of SIRT1 on DNA Damage Response and Epigenetic Alterations in Cancer
- (2019) Débora Kristina Alves-Fernandes et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Hypoxic glioma cells-secreted exosomal miR-301a activates the Wnt/β-catenin signaling and promotes radiation resistance by targeting TCEAL7
- (2019) Xiao Yue et al. MOLECULAR THERAPY
- The Hsp70 chaperone network
- (2019) Rina Rosenzweig et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Hypoxia- and MicroRNA-Induced Metabolic Reprogramming of Tumor-Initiating Cells
- (2019) Pit Ullmann et al. Cells
- Targeting cancer stem cells: protons versus photons
- (2019) Valentina Dini et al. BRITISH JOURNAL OF RADIOLOGY
- RadiationGeneSigDB: a database of oxic and hypoxic radiation response gene signatures and their utility in pre-clinical research
- (2019) Venkata SK Manem et al. BRITISH JOURNAL OF RADIOLOGY
- Knockdown of cZNF292 suppressed hypoxic human hepatoma SMMC7721 cell proliferation, vasculogenic mimicry, and radioresistance
- (2019) Wei Yang et al. CELLULAR SIGNALLING
- Hypoxia-induced exosomes promote hepatocellular carcinoma proliferation and metastasis via miR-1273f transfer
- (2019) You Yu et al. EXPERIMENTAL CELL RESEARCH
- Approaches to combat hypoxia in cancer therapy and the potential for in silico models in their evaluation
- (2019) Jake C. Forster et al. Physica Medica-European Journal of Medical Physics
- Targeting Heat Shock Protein 27 in Cancer: A Druggable Target for Cancer Treatment?
- (2019) Choi et al. Cancers
- Anti-Tumor Drug-Loaded Oxygen Nanobubbles for the Degradation of HIF-1α and the Upregulation of Reactive Oxygen Species in Tumor Cells
- (2019) Muhammad Saad Khan et al. Cancers
- Cancer Stem Cells and Targeting Strategies
- (2019) Luisa Barbato et al. Cells
- DNA-PKcs is activated under nutrient starvation and activates Akt, MST1, FoxO3a, and NDR1
- (2019) Soichiro Shiga et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Phase 1 dose‐finding study of metformin in combination with concurrent cisplatin and radiotherapy in patients with locally advanced head and neck squamous cell cancer
- (2019) Shuchi Gulati et al. CANCER
- Therapeutic Potential of the microRNA-ATM Axis in the Management of Tumor Radioresistance
- (2019) George A Calin et al. CANCER RESEARCH
- ΗΙF1α, EGR1 and SP1 co-regulate the erythropoietin receptor expression under hypoxia: an essential role in the growth of non-small cell lung cancer cells
- (2019) Tianhong Su et al. Cell Communication and Signaling
- HSF1Base: A Comprehensive Database of HSF1 (Heat Shock Factor 1) Target Genes
- (2019) Kovács et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Enhancing Radiotherapeutic Effect With Nanoparticle-Mediated Radiosensitizer Delivery Guided By Focused Gamma Rays In Lewis Lung Carcinoma-Bearing Mouse Brain Tumor Models
- (2019) Sa-Hoe Lim et al. International Journal of Nanomedicine
- Heat Shock Protein 90 Inhibitors: An Update on Achievements, Challenges, and Future Directions
- (2019) Li Li et al. JOURNAL OF MEDICINAL CHEMISTRY
- Celecoxib enhances the sensitivity of non-small-cell lung cancer cells to radiation-induced apoptosis through downregulation of the Akt/mTOR signaling pathway and COX-2 expression
- (2019) Pan Zhang et al. PLoS One
- The Critical Role of Hypoxic Microenvironment and Epigenetic Deregulation in Esophageal Cancer Radioresistance
- (2019) Catarina Macedo-Silva et al. Genes
- Hadrontherapy Interactions in Molecular and Cellular Biology
- (2019) Juliette Thariat et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Targeting signalling pathways and the immune microenvironment of cancer stem cells — a clinical update
- (2019) Joseph A. Clara et al. Nature Reviews Clinical Oncology
- Inhibiting Heat Shock Factor 1 in Cancer: A Unique Therapeutic Opportunity
- (2019) Bushu Dong et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- microRNA: The Impact on Cancer Stemness and Therapeutic Resistance
- (2019) Xueqiao Jiao et al. Cells
- Heat Shock Proteins: Agents of Cancer Development and Therapeutic Targets in Anti-Cancer Therapy
- (2019) Chul Won Yun et al. Cells
- Pachymic Acid Sensitizes Gastric Cancer Cells to Radiation Therapy by Upregulating Bax through Hypoxia
- (2018) Chunwei Lu et al. AMERICAN JOURNAL OF CHINESE MEDICINE
- EGFRvIII expression triggers a metabolic dependency and therapeutic vulnerability sensitive to autophagy inhibition
- (2018) Barry Jutten et al. Autophagy
- ROS mediated EGFR/MEK/ERK/HIF-1α Loop Regulates Glucose metabolism in pancreatic cancer
- (2018) Gang Wang et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Knockdown of AMPKα decreases ATM expression and increases radiosensitivity under hypoxia and nutrient starvation in an SV40-transformed human fibroblast cell line, LM217
- (2018) Yasuhiko Murata et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Development and MPI tracking of novel hypoxia-targeted theranostic exosomes
- (2018) Kyung Oh Jung et al. BIOMATERIALS
- Targeting autophagy in cancer
- (2018) Angelique V. Onorati et al. CANCER
- Nuclear translocation of PKM2/AMPK complex sustains cancer stem cell populations under glucose restriction stress
- (2018) Yi-Chieh Yang et al. CANCER LETTERS
- Advances in Hypoxia-Inducible Factor Biology
- (2018) Hani Choudhry et al. Cell Metabolism
- Essential roles of telomerase reverse transcriptase hTERT in cancer stemness and metastasis
- (2018) Ricarda Hannen et al. FEBS LETTERS
- β‑catenin nuclear translocation induced by HIF‑1α overexpression leads to the radioresistance of prostate cancer
- (2018) Yong Luo et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Development of single nanometer-sized ultrafine oxygen bubbles to overcome the hypoxia-induced resistance to radiation therapy via the suppression of hypoxia-inducible factor‑1α
- (2018) Misaki Iijima et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Introducing a simple model system for binding studies of known and novel inhibitors of AMPK: a therapeutic target for prostate cancer
- (2018) Rakesh Kumar et al. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
- AMP-activated protein kinase promotes epithelial-mesenchymal transition in cancer cells by Twist1 upregulation
- (2018) Meera Saxena et al. JOURNAL OF CELL SCIENCE
- HSP27 associates with epithelial-mesenchymal transition, stemness and radioresistance of salivary adenoid cystic carcinoma
- (2018) Wei Chen et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- The role of HGF-MET pathway and CCDC66 cirRNA expression in EGFR resistance and epithelial-to-mesenchymal transition of lung adenocarcinoma cells
- (2018) Nithila A. Joseph et al. Journal of Hematology & Oncology
- 18F-HX4 Hypoxia PET Holds Promise as a Prognostic and Predictive Imaging Biomarker in a Lung Cancer Xenograft Model Treated with Metformin and Radiotherapy
- (2018) Sven De Bruycker et al. JOURNAL OF NUCLEAR MEDICINE
- AMP kinase promotes glioblastoma bioenergetics and tumour growth
- (2018) Rishi Raj Chhipa et al. NATURE CELL BIOLOGY
- Hypoxia induced EMT: A review on the mechanism of tumor progression and metastasis in OSCC
- (2018) Joel P. Joseph et al. ORAL ONCOLOGY
- HOXA9 inhibits HIF-1α-mediated glycolysis through interacting with CRIP2 to repress cutaneous squamous cell carcinoma development
- (2018) Liang Zhou et al. Nature Communications
- Cancer epigenetics: Moving forward
- (2018) Angela Nebbioso et al. PLoS Genetics
- Radiosensitizing effects of miR-18a-5p on lung cancer stem-like cells via downregulating both ATM and HIF-1α
- (2018) Xu Chen et al. Cancer Medicine
- TRAP1 Regulation of Cancer Metabolism: Dual Role as Oncogene or Tumor Suppressor
- (2018) Danilo Matassa et al. Genes
- Targeting SLC25A10 alleviates improved antioxidant capacity and associated radioresistance of cancer cells induced by chronic-cycling hypoxia
- (2018) Julian Hlouschek et al. CANCER LETTERS
- Hypoxia-inducible TAGLN2 selects EMT and γ-radiation resistant subtypes via FAK-associated IGF1R activation in NSCLC cells
- (2018) In-Gyu Kim et al. CANCER SCIENCE
- Salinomycin suppresses cancer cell stemness and attenuates TGF-β-induced epithelial-mesenchymal transition of renal cell carcinoma cells
- (2018) Lei Liu et al. CHEMICO-BIOLOGICAL INTERACTIONS
- Hypoxia-induced autophagy promotes EGFR loss in specific cell contexts, which leads to cell death and enhanced radiosensitivity
- (2018) Baocai Liu et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Gene Suppression of Transketolase-Like Protein 1 (TKTL1) Sensitizes Glioma Cells to Hypoxia and Ionizing Radiation
- (2018) Sonja Heller et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Knockdown of USP28 enhances the radiosensitivity of esophageal cancer cells via the c-Myc/hypoxia-inducible factor-1 alpha pathway
- (2018) Zhang Weili et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Role of hypoxia-induced exosomes in tumor biology
- (2018) Chuchu Shao et al. Molecular Cancer
- The Reciprocity between Radiotherapy and Cancer Immunotherapy
- (2018) Yifan Wang et al. CLINICAL CANCER RESEARCH
- HSF1 as a Cancer Biomarker and Therapeutic Target
- (2018) Richard L. Carpenter et al. CURRENT CANCER DRUG TARGETS
- Epithelial-mesenchymal Transition and Cancer Stem Cells: At the Crossroads of Differentiation and Dedifferentiation
- (2018) Hanmin Wang et al. DEVELOPMENTAL DYNAMICS
- Autophagy induced by ionizing radiation promotes cell death over survival in human colorectal cancer cells
- (2018) Fabian Classen et al. EXPERIMENTAL CELL RESEARCH
- Overcoming tumor hypoxia as a barrier to radiotherapy, chemotherapy and immunotherapy in cancer treatment
- (2018) Kaitlin Graham et al. International Journal of Nanomedicine
- AHIF promotes glioblastoma progression and radioresistance via exosomes
- (2018) Xuejun Dai et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- New insights into the mechanisms of epithelial–mesenchymal transition and implications for cancer
- (2018) Anushka Dongre et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Overexpression of HOTAIR leads to radioresistance of human cervical cancer via promoting HIF-1α expression
- (2018) Ning Li et al. Radiation Oncology
- Enhancement of radiotherapy efficacy by silver nanoparticles in hypoxic glioma cells
- (2018) Zhujun Liu et al. Artificial Cells Nanomedicine and Biotechnology
- Antidiabetic Biguanides Radiosensitize Hypoxic Colorectal Cancer Cells Through a Decrease in Oxygen Consumption
- (2018) Sven de Mey et al. Frontiers in Pharmacology
- Hypoxia-Induced Upregulation of HE4 Is Responsible for Resistance to Radiation Therapy of Gastric Cancer
- (2018) Chunwei Peng et al. Molecular Therapy-Oncolytics
- Upregulated AHIF-mediated radioresistance in glioblastoma
- (2018) Keman Liao et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- LincRNA-p21 knockdown enhances radiosensitivity of hypoxic tumor cells by reducing autophagy through HIF-1/Akt/mTOR/P70S6K pathway
- (2017) Yueming Shen et al. EXPERIMENTAL CELL RESEARCH
- Requirement of Hsp105 in CoCl 2 -induced HIF-1α accumulation and transcriptional activation
- (2017) Hiroki Mikami et al. EXPERIMENTAL CELL RESEARCH
- Regulation of the mammalian heat shock factor 1
- (2017) Sharadha Dayalan Naidu et al. FEBS Journal
- SENP1 promotes hypoxia-induced cancer stemness by HIF-1α deSUMOylation and SENP1/HIF-1α positive feedback loop
- (2017) Chun-Ping Cui et al. GUT
- Targeting therapy-resistant cancer stem cells by hyperthermia
- (2017) A. L. Oei et al. INTERNATIONAL JOURNAL OF HYPERTHERMIA
- Engineering Exosomes for Cancer Therapy
- (2017) et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Histone Deacetylase Inhibitors as Anticancer Drugs
- (2017) Tomas Eckschlager et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- 2-Methoxyestradiol enhances radiosensitivity in radioresistant melanoma MDA-MB-435R cells by regulating glycolysis via HIF-1α/PDK1 axis
- (2017) Hong Zhao et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Autophagy enhanced the radioresistance of non-small cell lung cancer by regulating ROS level under hypoxia condition
- (2017) Xiaoyan Chen et al. INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
- Clinical Advances of Hypoxia-Activated Prodrugs in Combination With Radiation Therapy
- (2017) Ishna N. Mistry et al. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
- Role of autophagy in regulating the radiosensitivity of tumor cells
- (2017) Yong Xin et al. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
- Oleuropein enhances radiation sensitivity of nasopharyngeal carcinoma by downregulating PDRG1 through HIF1α-repressed microRNA-519d
- (2017) Ting Xu et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Epigenetics in cancer stem cells
- (2017) Tan Boon Toh et al. Molecular Cancer
- The HSP90 chaperone machinery
- (2017) Florian H. Schopf et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- AMPK: guardian of metabolism and mitochondrial homeostasis
- (2017) Sébastien Herzig et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Hypoxic lung cancer-secreted exosomal miR-23a increased angiogenesis and vascular permeability by targeting prolyl hydroxylase and tight junction protein ZO-1
- (2017) Y-L Hsu et al. ONCOGENE
- The heat-shock, or HSF1-mediated proteotoxic stress, response in cancer: from proteomic stability to oncogenesis
- (2017) Chengkai Dai PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
- Opposite response to hypoxia by breast cancer cells between cell proliferation and cell migration: A clue from microRNA expression profile
- (2017) Ming Zhang et al. Oncology Letters
- Oleuropein represses the radiation resistance of ovarian cancer by inhibiting hypoxia and microRNA-299-targetted heparanase expression
- (2017) Yubai Xing et al. Food & Function
- microRNA-33a-5p increases radiosensitivity by inhibiting glycolysis in melanoma
- (2017) Ke Cao et al. Oncotarget
- The miR-125a/HK2 axis regulates cancer cell energy metabolism reprogramming in hepatocellular carcinoma
- (2017) Fangfang Jin et al. Scientific Reports
- Mutual Regulation of MiR-199a-5p and HIF-1α Modulates the Warburg Effect in Hepatocellular Carcinoma
- (2017) Binkui Li et al. Journal of Cancer
- Twist1 Enhances Hypoxia Induced Radioresistance in Cervical Cancer Cells by Promoting Nuclear EGFR Localization
- (2017) Hua Xiong et al. Journal of Cancer
- The role of hypoxia on the acquisition of epithelial-mesenchymal transition and cancer stemness: a possible link to epigenetic regulation
- (2017) Chang Dong Yeo et al. KOREAN JOURNAL OF INTERNAL MEDICINE
- Targeting Prostate Cancer Stem Cells with Alpha-Particle Therapy
- (2017) Jens Ceder et al. Frontiers in Oncology
- Induction of Hsp70 in tumor cells treated with inhibitors of the Hsp90 activity: A predictive marker and promising target for radiosensitization
- (2017) Vladimir A. Kudryavtsev et al. PLoS One
- Hypoxia-induced angiotensin II by the lactate-chymase-dependent mechanism mediates radioresistance of hypoxic tumor cells
- (2017) Guozhu Xie et al. Scientific Reports
- UCHL1-HIF-1 axis-mediated antioxidant property of cancer cells as a therapeutic target for radiosensitization
- (2017) Ryota Nakashima et al. Scientific Reports
- Identification of Targets of the HIF-1 Inhibitor IDF-11774 Using Alkyne-Conjugated Photoaffinity Probes
- (2016) Hyun Seung Ban et al. BIOCONJUGATE CHEMISTRY
- Hypoxia-independent gene expression signature associated with radiosensitisation of prostate cancer cell lines by histone deacetylase inhibition
- (2016) Marte Jonsson et al. BRITISH JOURNAL OF CANCER
- Inhibition of Glut1 by WZB117 sensitizes radioresistant breast cancer cells to irradiation
- (2016) Fei Zhao et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- The human HSP70 family of chaperones: where do we stand?
- (2016) Jürgen Radons CELL STRESS & CHAPERONES
- Protein quality control at the endoplasmic reticulum
- (2016) K. McCaffrey et al. Essays in Biochemistry
- The resveratrol analog HS-1793 enhances radiosensitivity of mouse-derived breast cancer cells under hypoxic conditions
- (2016) Yoo Jin Choi et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Fructose-bisphosphate aldolase A is a key regulator of hypoxic adaptation in colorectal cancer cells and involved in treatment resistance and poor prognosis
- (2016) Kenji Kawai et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Tumor Cells Surviving Exposure to Proton or Photon Radiation Share a Common Immunogenic Modulation Signature, Rendering Them More Sensitive to T Cell–Mediated Killing
- (2016) Sofia R. Gameiro et al. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
- Mortalin-mediated and ERK-controlled targeting of HIF-1α to mitochondria confers resistance to apoptosis under hypoxia
- (2016) Ilias Mylonis et al. JOURNAL OF CELL SCIENCE
- Hypoxia-inducible factor 1–mediated characteristic features of cancer cells for tumor radioresistance
- (2016) Hiroshi Harada JOURNAL OF RADIATION RESEARCH
- PU-H71, a novel Hsp90 inhibitor, as a potential cancer-specific sensitizer to carbon-ion beam therapy
- (2016) Huizi Keiko Li et al. JOURNAL OF RADIATION RESEARCH
- Bortezomib sensitizes esophageal squamous cancer cells to radiotherapy by suppressing the expression of HIF-1α and apoptosis proteins
- (2016) Di Wang et al. Journal of X-Ray Science and Technology
- MicroRNA-21 modulates radiation resistance through upregulation of hypoxia-inducible factor-1α-promoted glycolysis in non-small cell lung cancer cells
- (2016) SHUMEI JIANG et al. Molecular Medicine Reports
- Radiosensitizing effect of irisquinone on glioma through the downregulation of HIF-1α evaluated by 18F-FDG and 18F-FMISO PET/CT
- (2016) Hui Wang et al. NUCLEAR MEDICINE COMMUNICATIONS
- Ursolic acid inhibits proliferation and reverses drug resistance of ovarian cancer stem cells by downregulating ABCG2 through suppressing the expression of hypoxia-inducible factor-1α in vitro
- (2016) WEN-JING WANG et al. ONCOLOGY REPORTS
- 2-Methoxyestradiol inhibits the proliferation and migration and reduces the radioresistance of nasopharyngeal carcinoma CNE-2 stem cells via NF-κB/HIF-1 signaling pathway inactivation and EMT reversal
- (2016) Shun-Long Wu et al. ONCOLOGY REPORTS
- The purine scaffold Hsp90 inhibitor PU-H71 sensitizes cancer cells to heavy ion radiation by inhibiting DNA repair by homologous recombination and non-homologous end joining
- (2016) Younghyun Lee et al. RADIOTHERAPY AND ONCOLOGY
- To live or let die: Unclear task of autophagy in the radiosensitization battle
- (2016) Martin Ondrej et al. RADIOTHERAPY AND ONCOLOGY
- MiR-21 modulates radiosensitivity of cervical cancer through inhibiting autophagy via the PTEN/Akt/HIF-1α feedback loop and the Akt-mTOR signaling pathway
- (2016) Lili Song et al. TUMOR BIOLOGY
- The Natural Compound Gambogic Acid Radiosensitizes Nasopharyngeal Carcinoma Cells under Hypoxic Conditions
- (2016) Meilin Yang et al. TUMORI
- Ursolic acid sensitizes radioresistant NSCLC cells expressing HIF-1α through reducing endogenous GSH and inhibiting HIF-1α
- (2016) Bing Song et al. Oncology Letters
- ARD1-mediated Hsp70 acetylation balances stress-induced protein refolding and degradation
- (2016) Ji Hae Seo et al. Nature Communications
- miRNA Deregulation in Cancer Cells and the Tumor Microenvironment
- (2016) R. Rupaimoole et al. Cancer Discovery
- Carbon ion irradiation withstands cancer stem cells’ migration/invasion process in Head and Neck Squamous Cell Carcinoma (HNSCC)
- (2016) Coralie Moncharmont et al. Oncotarget
- In silico modelling of a cancer stem cell-targeting agent and its effects on tumour control during radiotherapy
- (2016) Loredana G. Marcu et al. Scientific Reports
- The Long Non-coding RNA HIF1A-AS2 Facilitates the Maintenance of Mesenchymal Glioblastoma Stem-like Cells in Hypoxic Niches
- (2016) Marco Mineo et al. Cell Reports
- Hypoxia-Responsive Mir-301a and Mir-301b Promote Radioresistance of Prostate Cancer Cells via Downregulating NDRG2
- (2016) Wei Wang et al. MEDICAL SCIENCE MONITOR
- Hypoxia-responsive miR-124 and miR-144 reduce hypoxia-induced autophagy and enhance radiosensitivity of prostate cancer cells via suppressing PIM1
- (2016) Hao Gu et al. Cancer Medicine
- The Natural Compound Gambogic Acid Radiosensitizes Nasopharyngeal Carcinoma Cells under Hypoxic Conditions
- (2016) Meilin Yang et al. TUMORI JOURNAL
- Identification of known drugs targeting the endoplasmic reticulum stress response
- (2015) Kun Bi et al. ANALYTICAL AND BIOANALYTICAL CHEMISTRY
- SIRT1 deacetylates and stabilizes hypoxia-inducible factor-1α (HIF-1α) via direct interactions during hypoxia
- (2015) Hyun-Yoo Joo et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Cell type-dependent modulation of the gene encoding heat shock protein HSPA2 by hypoxia-inducible factor HIF-1: Down-regulation in keratinocytes and up-regulation in HeLa cells
- (2015) Anna Habryka et al. Biochimica et Biophysica Acta-Gene Regulatory Mechanisms
- Sensitizing tumor cells to radiation by targeting the heat shock response
- (2015) Daniela Schilling et al. CANCER LETTERS
- AMPK-HDAC5 pathway facilitates nuclear accumulation of HIF-1α and functional activation of HIF-1 by deacetylating Hsp70 in the cytosol
- (2015) Shuyang Chen et al. CELL CYCLE
- Hsp27 Acts as a Master Molecular Chaperone and Plays an Essential Role in Hepatocellular Carcinoma Progression
- (2015) Jun Cheng et al. DIGESTION
- PI3K/mTOR pathway inhibition overcomes radioresistance via suppression of the HIF1-α/VEGF pathway in endometrial cancer
- (2015) Aki Miyasaka et al. GYNECOLOGIC ONCOLOGY
- The Role of Hypoxia-Induced miR-210 in Cancer Progression
- (2015) Kyvan Dang et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Naphthazarin enhances ionizing radiation-induced cell cycle arrest and apoptosis in human breast cancer cells
- (2015) MIN YOUNG KIM et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Radio-sensitization effect of an mTOR inhibitor, temsirolimus, on lung adenocarcinoma A549 cells under normoxic and hypoxic conditions
- (2015) Hiroki Ushijima et al. JOURNAL OF RADIATION RESEARCH
- Direct Quantification and Comparison of Intratumoral Hypoxia following Transcatheter Arterial Embolization of VX2 Liver Tumors with Different Diameter Microspheres
- (2015) Elliot B. Levy et al. JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
- Paclitaxel pretreatment overcomes hypoxia inducible factor-1α-induced radioresistance acquisition of human hepatoma and lung adenocarcinoma cells
- (2015) Kun-Goung Lai et al. LIFE SCIENCES
- Sensitization of Glioblastoma Cells to Irradiation by Modulating the Glucose Metabolism
- (2015) H. Shen et al. MOLECULAR CANCER THERAPEUTICS
- Effect of proton and gamma irradiation on human lung carcinoma cells: Gene expression, cell cycle, cell death, epithelial–mesenchymal transition and cancer-stem cell trait as biological end points
- (2015) Himanshi Narang et al. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
- Ionizing radiation improves glioma-specific targeting of superparamagnetic iron oxide nanoparticles conjugated with cmHsp70.1 monoclonal antibodies (SPION–cmHsp70.1)
- (2015) Maxim A. Shevtsov et al. Nanoscale
- Opportunities and challenges of radiotherapy for treating cancer
- (2015) Dörthe Schaue et al. Nature Reviews Clinical Oncology
- Cancer stem cells: The potential of carbon ion beam radiation and new radiosensitizers (Review)
- (2015) SUNG-JAE BAEK et al. ONCOLOGY REPORTS
- Emodin attenuates radioresistance induced by hypoxia in HepG2 cells via the enhancement of PARP1 cleavage and inhibition of JMJD2B
- (2015) SANG YOUN HWANG et al. ONCOLOGY REPORTS
- Inhibiting GLUT-1 expression and PI3K/Akt signaling using apigenin improves the radiosensitivity of laryngeal carcinoma in vivo
- (2015) YANG-YANG BAO et al. ONCOLOGY REPORTS
- HIF-1 regulates CD47 expression in breast cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells
- (2015) Huimin Zhang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Sunitinib reduces tumor hypoxia and angiogenesis, and radiosensitizes prostate cancer stem-like cells
- (2015) Roque Diaz et al. PROSTATE
- Role of membrane Hsp70 in radiation sensitivity of tumor cells
- (2015) Naoya Murakami et al. Radiation Oncology
- AMPK-independent autophagy promotes radioresistance of human tumor cells under clinical relevant hypoxia in vitro
- (2015) Hassan Chaachouay et al. RADIOTHERAPY AND ONCOLOGY
- The role of hypoxia-inducible factor-1α in radiation-induced autophagic cell death in breast cancer cells
- (2015) Rui Zhong et al. TUMOR BIOLOGY
- Multifaceted roles of HSF1 in cancer
- (2015) Sufang Jiang et al. TUMOR BIOLOGY
- Inhibition of Hypoxia-inducible Factor-1 Alpha Radiosensitized MG-63 Human Osteosarcoma Cells in Vitro
- (2015) Zhu Jin et al. TUMORI
- TAT-ODD-p53 enhances the radiosensitivity of hypoxic breast cancer cells by inhibiting Parkin-mediated mitophagy
- (2015) Rong Zheng et al. Oncotarget
- Hypoxia-Inducible Factor-1α Protects Cervical Carcinoma Cells from Apoptosis Induced by Radiation via Modulation of Vascular Endothelial Growth Factor and p53 under Hypoxia
- (2015) Fengmei Wang MEDICAL SCIENCE MONITOR
- Inhibition of Hypoxia-inducible Factor-1 Alpha Radiosensitized MG-63 Human Osteosarcoma Cells in Vitro
- (2015) Zhu Jin et al. TUMORI JOURNAL
- Silencing erythropoietin receptor on glioma cells reinforces efficacy of temozolomide and X-rays through senescence and mitotic catastrophe
- (2015) Elodie A. Pérès et al. Oncotarget
- Saikosaponin-D Enhances Radiosensitivity of Hepatoma Cells under Hypoxic Conditions by Inhibiting Hypoxia-Inducible Factor-1a
- (2014) Bao-Feng Wang et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- Upregulation of HIF-2α induced by sorafenib contributes to the resistance by activating the TGF-α/EGFR pathway in hepatocellular carcinoma cells
- (2014) Dali Zhao et al. CELLULAR SIGNALLING
- Livin Contributes to Tumor Hypoxia-Induced Resistance to Cytotoxic Therapies in Glioblastoma Multiforme
- (2014) C.-H. Hsieh et al. CLINICAL CANCER RESEARCH
- Berberine inhibits the expression of hypoxia induction factor-1alpha and increases the radiosensitivity of prostate cancer
- (2014) Qu Zhang et al. Diagnostic Pathology
- Expression of hypoxic signaling markers in head and neck squamous cell carcinoma and its clinical significance
- (2014) Hyo Geun Choi et al. EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
- Knockdown of miR-210 decreases hypoxic glioma stem cells stemness and radioresistance
- (2014) Wei Yang et al. EXPERIMENTAL CELL RESEARCH
- Heat-shock protein 27 (HSP27, HSPB1) is up-regulated by MET kinase inhibitors and confers resistance to MET-targeted therapy
- (2014) Daniele Musiani et al. FASEB JOURNAL
- MicroRNA control of epithelial-mesenchymal transition in cancer stem cells
- (2014) Jin Hao et al. INTERNATIONAL JOURNAL OF CANCER
- Hypoxia-induced autophagy reduces radiosensitivity by the HIF-1α/miR-210/Bcl-2 pathway in colon cancer cells
- (2014) YONG SUN et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Hypoxia sustains glioblastoma radioresistance through ERKs/DNA-PKcs/HIF-1α functional interplay
- (2014) FRANCESCO MARAMPON et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Hypoxia-induced autophagy contributes to radioresistance via c-Jun-mediated Beclin1 expression in lung cancer cells
- (2014) Yan-mei Zou et al. Journal of Huazhong University of Science and Technology-Medical Sciences
- 2,4-Bis(4-hydroxybenzyl)phenol Inhibits Heat Shock Transcription Factor 1 and Sensitizes Lung Cancer Cells to Conventional Anticancer Modalities
- (2014) Taesook Yoon et al. JOURNAL OF NATURAL PRODUCTS
- STAT3 inhibitor NSC74859 radiosensitizes esophageal cancer via the downregulation of HIF-1α
- (2014) Chi Zhang et al. TUMOR BIOLOGY
- Melittin enhances radiosensitivity of hypoxic head and neck squamous cell carcinoma by suppressing HIF-1α
- (2014) Xi Yang et al. TUMOR BIOLOGY
- Effect of celecoxib on inhibiting tumor repopulation during radiotherapy in human FaDu squamous cell carcinoma
- (2014) Jia Yang et al. Wspolczesna Onkologia-Contemporary Oncology
- Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER
- (2014) Twan van den Beucken et al. Nature Communications
- Berberine radiosensitizes human nasopharyngeal carcinoma by suppressing hypoxia-inducible factor-1α expression
- (2013) Chi Zhang et al. ACTA OTO-LARYNGOLOGICA
- Hsp90 inhibition by NVP-AUY922 and NVP-BEP800 decreases migration and invasion of irradiated normoxic and hypoxic tumor cell lines
- (2013) Susanne Hartmann et al. CANCER LETTERS
- The Mitochondrial Chaperone TRAP1 Promotes Neoplastic Growth by Inhibiting Succinate Dehydrogenase
- (2013) Marco Sciacovelli et al. Cell Metabolism
- Heat shock protein 70 expression and effect of combined transcatheter arterial embolization and radiofrequency ablation in the rabbit VX2 liver tumour model
- (2013) X. Duan et al. CLINICAL RADIOLOGY
- Resveratrol Impedes the Stemness, Epithelial-Mesenchymal Transition, and Metabolic Reprogramming of Cancer Stem Cells in Nasopharyngeal Carcinoma through p53 Activation
- (2013) Yao-An Shen et al. Evidence-based Complementary and Alternative Medicine
- Hypoxia promotes radioresistance of CD133-positive Hep-2 human laryngeal squamous carcinoma cells in vitro
- (2013) MAOXIN WANG et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Inhibition of Hsp27 Radiosensitizes Head-and-Neck Cancer by Modulating Deoxyribonucleic Acid Repair
- (2013) David M. Guttmann et al. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
- Hypoxia-Inducible Factor Pathway Inhibition Resolves Tumor Hypoxia and Improves Local Tumor Control After Single-Dose Irradiation
- (2013) Linda Helbig et al. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
- Targeting by cmHsp70.1-antibody coated and survivin miRNA plasmid loaded nanoparticles to radiosensitize glioblastoma cells
- (2013) Sebastian Gaca et al. JOURNAL OF CONTROLLED RELEASE
- Therapy-Resistant Cancer Stem Cells Have Differing Sensitivity to Photon versus Proton Beam Radiation
- (2013) Xiaochun Zhang et al. Journal of Thoracic Oncology
- Exosomes secreted under hypoxia enhance invasiveness and stemness of prostate cancer cells by targeting adherens junction molecules
- (2013) Anand Ramteke et al. MOLECULAR CARCINOGENESIS
- Celecoxib enhances radiosensitivity of hypoxic glioblastoma cells through endoplasmic reticulum stress
- (2013) Kenshi Suzuki et al. NEURO-ONCOLOGY
- The combination of sorafenib and radiation preferentially inhibits breast cancer stem cells by suppressing HIF-1α expression
- (2013) JAE HO LEE et al. ONCOLOGY REPORTS
- Hypoxia-Induced Autophagy Confers Resistance of Breast Cancer Cells to Ionizing Radiation
- (2013) Wen-Shan He et al. ONCOLOGY RESEARCH
- PERK/eIF2 signaling protects therapy resistant hypoxic cells through induction of glutathione synthesis and protection against ROS
- (2013) K. M. Rouschop et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The PERK/ATF4/LAMP3-arm of the unfolded protein response affects radioresistance by interfering with the DNA damage response
- (2013) Anika Nagelkerke et al. RADIOTHERAPY AND ONCOLOGY
- Targeting Head and Neck Cancer Stem Cells to Overcome Resistance to Photon and Carbon Ion Radiation
- (2013) Gérald Bertrand et al. Stem Cell Reviews and Reports
- MiR-210 promotes a hypoxic phenotype and increases radioresistance in human lung cancer cell lines
- (2013) S Grosso et al. Cell Death & Disease
- Landscape of the mitochondrial Hsp90 metabolome in tumours
- (2013) Young Chan Chae et al. Nature Communications
- KNK437, abrogates hypoxia-induced radioresistance by dual targeting of the AKT and HIF-1α survival pathways
- (2012) Deepu Oommen et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Histone demethylase JMJD2B-mediated cell proliferation regulated by hypoxia and radiation in gastric cancer cell
- (2012) Joong-Gook Kim et al. Biochimica et Biophysica Acta-Gene Regulatory Mechanisms
- Hsp90 inhibitor NVP-AUY922 enhances radiation sensitivity of tumor cell lines under hypoxia
- (2012) Cholpon S. Djuzenova et al. CANCER BIOLOGY & THERAPY
- Cancer stem cells, the epithelial to mesenchymal transition (EMT) and radioresistance: Potential role of hypoxia
- (2012) Delphine Tamara Marie-Egyptienne et al. CANCER LETTERS
- Hypoxia-Induced Autophagy Promotes Tumor Cell Survival and Adaptation to Antiangiogenic Treatment in Glioblastoma
- (2012) Y.-L. Hu et al. CANCER RESEARCH
- SirT1 regulates radiosensitivity of hepatoma cells differently under normoxic and hypoxic conditions
- (2012) Yuexia Xie et al. CANCER SCIENCE
- Radiosensitization of wildtype p53 cancer cells by the MDM2-inhibitor PXN727 is associated with altered heat shock protein 70 (Hsp70) levels
- (2012) Daniela Schilling et al. CELL STRESS & CHAPERONES
- Molecular Parameters of Hyperthermia for Radiosensitization
- (2012) Tej K. Pandita et al. CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION
- Downregulation of miR-210 expression inhibits proliferation, induces apoptosis and enhances radiosensitivity in hypoxic human hepatoma cells in vitro
- (2012) Wei Yang et al. EXPERIMENTAL CELL RESEARCH
- Salinomycin as a Drug for Targeting Human Cancer Stem Cells
- (2012) Cord Naujokat et al. JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY
- Identification of heat shock protein 27 as a radioresistance-related protein in nasopharyngeal carcinoma cells
- (2012) Bin Zhang et al. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
- SirT1 Confers Hypoxia-induced Radioresistance via the Modulation of c-Myc Stabilization on Hepatoma Cells
- (2012) Yuexia XIE et al. JOURNAL OF RADIATION RESEARCH
- Heat Shock Transcription Factor Hsf1 Is Involved in Tumor Progression via Regulation of Hypoxia-Inducible Factor 1 and RNA-Binding Protein HuR
- (2012) V. L. Gabai et al. MOLECULAR AND CELLULAR BIOLOGY
- Oxygen Levels Do Not Determine Radiation Survival of Breast Cancer Stem Cells
- (2012) Chann Lagadec et al. PLoS One
- Radiosensitization of Normoxic and Hypoxic H1339 Lung Tumor Cells by Heat Shock Protein 90 Inhibition Is Independent of Hypoxia Inducible Factor-1α
- (2012) Daniela Schilling et al. PLoS One
- Survival of Cancer Stem Cells under Hypoxia and Serum Depletion via Decrease in PP2A Activity and Activation of p38-MAPKAPK2-Hsp27
- (2012) Shih-Pei Lin et al. PLoS One
- Targeting the Unfolded Protein Response in Glioblastoma Cells with the Fusion Protein EGF-SubA
- (2012) Antony Prabhu et al. PLoS One
- Radiosensitization by the histone deacetylase inhibitor vorinostat under hypoxia and with capecitabine in experimental colorectal carcinoma
- (2012) Marie Saelen et al. Radiation Oncology
- Radiation protective effect of Hypoxia-inducible factor-1 (HIF-1 ) on human oral squamous cell carcinoma cell lines
- (2012) Y. Hosokawa et al. RADIATION PROTECTION DOSIMETRY
- Radiosensitization of renal cell carcinoma in vitro through the induction of autophagy
- (2012) Selvakumar Anbalagan et al. RADIOTHERAPY AND ONCOLOGY
- Exposure to hypoxia following irradiation increases radioresistance in prostate cancer cells
- (2012) Derek Hennessey et al. UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
- Cancer cells that survive radiation therapy acquire HIF-1 activity and translocate towards tumour blood vessels
- (2012) Hiroshi Harada et al. Nature Communications
- Inhibition of aldehyde dehydrogenase (ALDH) activity reduces chemotherapy and radiation resistance of stem-like ALDHhiCD44+ human breast cancer cells
- (2011) Alysha K. Croker et al. BREAST CANCER RESEARCH AND TREATMENT
- Inhibition of hypoxia-induced miR-155 radiosensitizes hypoxic lung cancer cells
- (2011) Imran A. Babar et al. CANCER BIOLOGY & THERAPY
- In Vivo Profiling of Hypoxic Gene Expression in Gliomas Using the Hypoxia Marker EF5 and Laser-capture Microdissection
- (2011) D. Marotta et al. CANCER RESEARCH
- Altered Cross-Linking of HSP27 by Zerumbone as a Novel Strategy for Overcoming HSP27-Mediated Radioresistance
- (2011) Seo-Hyun Choi et al. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
- Heat Shock Protein 27-Targeted Heptapeptide of the PKCΔ Catalytic V5 Region Sensitizes Tumors With Radio- and Chemoresistance
- (2011) Hae-June Lee et al. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
- Soy Isoflavones Augment Radiation Effect by Inhibiting APE1/Ref-1 DNA Repair Activity in Non-small Cell Lung Cancer
- (2011) Vinita Singh-Gupta et al. Journal of Thoracic Oncology
- Loss of HSF1 Results in Defective Radiation-Induced G2Arrest and DNA Repair
- (2011) Qiang Li et al. RADIATION RESEARCH
- E-Cadherin loss associated with EMT promotes radioresistance in human tumor cells
- (2011) Jan Theys et al. RADIOTHERAPY AND ONCOLOGY
- HIF-1α inhibition by siRNA or chetomin in human malignant glioma cells: effects on hypoxic radioresistance and monitoring via CA9 expression
- (2010) Jacqueline Kessler et al. BMC CANCER
- JNK1 Mediates Degradation HIF-1 by a VHL-Independent Mechanism that Involves the Chaperones Hsp90/Hsp70
- (2010) D. Zhang et al. CANCER RESEARCH
- HIF-1 and NDRG2 contribute to hypoxia-induced radioresistance of cervical cancer Hela cells
- (2010) Junye Liu et al. EXPERIMENTAL CELL RESEARCH
- Celecoxib and radioresistant glioblastoma-derived CD133+ cells: improvement in radiotherapeutic effects
- (2010) Hsin-I Ma et al. JOURNAL OF NEUROSURGERY
- HSP72 depletion suppresses γH2AX activation by genotoxic stresses via p53/p21 signaling
- (2010) V L Gabai et al. ONCOGENE
- Treatment regimen determines whether an HIF-1 inhibitor enhances or inhibits the effect of radiation therapy
- (2009) H Harada et al. BRITISH JOURNAL OF CANCER
- Targeting Heat Shock Protein 90 Overrides the Resistance of Lung Cancer Cells by Blocking Radiation-Induced Stabilization of Hypoxia-Inducible Factor-1α
- (2009) Woo-Young Kim et al. CANCER RESEARCH
- Silencing of Heat Shock Protein 70 Expression Enhances Radiotherapy Efficacy and Inhibits Cell Invasion in Endometrial Cancer Cell Line
- (2009) Xue-lian Du et al. CROATIAN MEDICAL JOURNAL
- Binding of heat shock protein 70 to extracellular phosphatidylserine promotes killing of normoxic and hypoxic tumor cells
- (2009) Daniela Schilling et al. FASEB JOURNAL
- Tumour oxygenation is increased by hyperthermia at mild temperatures
- (2009) C. W. Song et al. INTERNATIONAL JOURNAL OF HYPERTHERMIA
- Hsp70 and CHIP Selectively Mediate Ubiquitination and Degradation of Hypoxia-inducible Factor (HIF)-1α but Not HIF-2α
- (2009) Weibo Luo et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Clinical studies for improving radiotherapy with 2-deoxy-D-glucose: Present status and future prospects
- (2009) BS Dwarakanath et al. Journal of Cancer Research and Therapeutics
- Heat Shock Protein 27 as a New Therapeutic Target for Radiation Sensitization of Head and Neck Squamous Cell Carcinoma
- (2009) Elie Hadchity et al. MOLECULAR THERAPY
- Using YC-1 to overcome the radioresistance of hypoxic cancer cells
- (2009) So Young Moon et al. ORAL ONCOLOGY
- Epigenetic modulation of radiation response in human cancer cells with activated EGFR or HER-2 signaling: Potential role of histone deacetylase 6
- (2009) In Ah Kim et al. RADIOTHERAPY AND ONCOLOGY
- Insulin-like growth factor stimulation increases radiosensitivity of a pancreatic cancer cell line through endoplasmic reticulum stress under hypoxic conditions
- (2008) Fumiaki Isohashi et al. CANCER SCIENCE
- DNA-dependent protein kinase is involved in heat shock protein-mediated accumulation of hypoxia-inducible factor-1α in hypoxic preconditioned HepG2 cells
- (2008) Moon Jung Kang et al. FEBS Journal
- PX-478, an inhibitor of hypoxia-inducible factor-1α, enhances radiosensitivity of prostate carcinoma cells
- (2008) Sanjeewani T. Palayoor et al. INTERNATIONAL JOURNAL OF CANCER
- Radiation-induced HIF-1α cell survival pathway is inhibited by soy isoflavones in prostate cancer cells
- (2008) Vinita Singh-Gupta et al. INTERNATIONAL JOURNAL OF CANCER
- Transcriptional upregulation of HSP70-2 by HIF-1 in cancer cells in response to hypoxia
- (2008) Wen-Jie Huang et al. INTERNATIONAL JOURNAL OF CANCER
- Protective Role of Hsp27 Protein Against Gamma Radiation–Induced Apoptosis and Radiosensitization Effects of Hsp27 Gene Silencing in Different Human Tumor Cells
- (2008) Marie-Thérèse Aloy et al. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
- Erythropoietin Augments Survival of Glioma Cells After Radiation and Temozolomide
- (2008) Imam Hassouna et al. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
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