Metabolic Heterogeneity of Cancer Cells: An Interplay between HIF-1, GLUTs, and AMPK

Metabolism of pancreatic cancer: paving the way to better anticancer strategies

(2020) Cheng Qin et al.   Molecular Cancer

Acetate supplementation restores chromatin accessibility and promotes tumor cell differentiation under hypoxia

(2020) Yang Li et al.   Cell Death & Disease

Is Lactate an Oncometabolite? Evidence Supporting a Role for Lactate in the Regulation of Transcriptional Activity of Cancer-Related Genes in MCF7 Breast Cancer Cells

(2020) Iñigo San-Millán et al.   Frontiers in Oncology

Spatiotemporal regulation of clonogenicity in colorectal cancer xenografts

(2019) Maartje van der Heijden et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Elucidating cancer metabolic plasticity by coupling gene regulation with metabolic pathways

(2019) Dongya Jia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Follicle-stimulating hormone promoted pyruvate kinase isozyme type M2-induced glycolysis and proliferation of ovarian cancer cells

(2019) Shuangdi Li et al.   ARCHIVES OF GYNECOLOGY AND OBSTETRICS

AMP ‐activated protein kinase regulates cancer cell growth and metabolism via nuclear and mitochondria events

(2019) Shanshan Jiang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Pyruvate kinase M2 contributes to cell growth in gastric cancer via aerobic glycolysis

(2019) He Li et al.   PATHOLOGY RESEARCH AND PRACTICE

Oncogenic KRAS Reduces Expression of FGF21 in Acinar Cells to Promote Pancreatic Tumorigenesis in Mice on a High-Fat Diet

(2019) Yongde Luo et al.   GASTROENTEROLOGY

Hypoxia-induced switch in SNAT2/SLC38A2 regulation generates endocrine resistance in breast cancer

(2019) Matteo Morotti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Correlation and expression analysis of hypoxia‑inducible factor�1α, glucose transporter 1 and lactate dehydrogenase�5 in human gastric cancer

(2019) Lang‑Song Hao et al.   Oncology Letters

Effects and significance of formononetin on expression levels of HIF‑1α and VEGF in mouse cervical cancer tissue

(2019) Yue Zhang et al.   Oncology Letters

Oncometabolites: A new insight for oncology

(2019) Fatemeh Khatami et al.   Molecular Genetics & Genomic Medicine

UCP2 regulates cholangiocarcinoma cell plasticity via mitochondria-to-AMPK signals

(2019) Jianhua Yu et al.   BIOCHEMICAL PHARMACOLOGY

6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase-2 Regulates TP53-Dependent Paclitaxel Sensitivity in Ovarian and Breast Cancers

(2019) Hailing Yang et al.   CLINICAL CANCER RESEARCH

Expression of Alpha-Enolase (ENO1), Myc Promoter-Binding Protein-1 (MBP-1) and Matrix Metalloproteinases (MMP-2 and MMP-9) Reflect the Nature and Aggressiveness of Breast Tumors

(2019) Patrizia Cancemi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

HIF-transcribed p53 chaperones HIF-1α

(2019) Esha Madan et al.   NUCLEIC ACIDS RESEARCH

ROS/KRAS/AMPK Signaling Contributes to Gemcitabine-Induced Stem-like Cell Properties in Pancreatic Cancer

(2019) Hengqiang Zhao et al.   Molecular Therapy-Oncolytics

Metabolic Abnormalities in Glioblastoma and Metabolic Strategies to Overcome Treatment Resistance

(2019) Weihua Zhou et al.   Cancers

Non‐enzymatic reaction of carnosine and glyceraldehyde‐3‐phosphate accompanies metabolic changes of the pentose phosphate pathway

(2019) Henry Oppermann et al.   CELL PROLIFERATION

1-Hydroxy-8-methoxy-anthraquinon reverses cisplatin resistance by inhibiting 6PGD in cancer cells

(2019) Huamin Zhang et al.   Open Life Sciences

Isorhamnetin Induces Cell Cycle Arrest and Apoptosis Via Reactive Oxygen Species-Mediated AMP-Activated Protein Kinase Signaling Pathway Activation in Human Bladder Cancer Cells

(2019) Park et al.   Cancers

Tumor Microenvironment: A Metabolic Player that Shapes the Immune Response

(2019) Shamir Cassim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Advances in Hypoxia-Inducible Factor Biology

(2018) Hani Choudhry et al.   Cell Metabolism

Metformin in cancer

(2018) Ritwika Mallik et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Glucose transporters in cancer - from tumor cells to the tumor microenvironment

(2018) Pierre-Benoit Ancey et al.   FEBS Journal

ROS and RNS signalling: adaptive redox switches through oxidative/nitrosative protein modifications

(2018) N. T. Moldogazieva et al.   FREE RADICAL RESEARCH

Aldolase A as a prognostic factor and mediator of progression via inducing epithelial-mesenchymal transition in gastric cancer

(2018) Zhonghua Jiang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Phosphorylation of Acetyl-CoA Carboxylase by AMPK Reduces Renal Fibrosis and Is Essential for the Anti-Fibrotic Effect of Metformin

(2018) Mardiana Lee et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Knockdown of KLF5 suppresses hypoxia-induced resistance to cisplatin in NSCLC cells by regulating HIF-1α-dependent glycolysis through inactivation of the PI3K/Akt/mTOR pathway

(2018) Tianxiao Gong et al.   Journal of Translational Medicine

The phosphoglycerate kinase 1 variants found in carcinoma cells display different catalytic activity and conformational stability compared to the native enzyme

(2018) Annarita Fiorillo et al.   PLoS One

Inhibition of Glucose-6-Phosphate Dehydrogenase Reverses Cisplatin Resistance in Lung Cancer Cells via the Redox System

(2018) Weipeng Hong et al.   Frontiers in Pharmacology

Elucidating the Metabolic Plasticity of Cancer: Mitochondrial Reprogramming and Hybrid Metabolic States

(2018) Dongya Jia et al.   Cells

Fatty acid oxidation: An emerging facet of metabolic transformation in cancer

(2018) Yibao Ma et al.   CANCER LETTERS

SIRT3 Overexpression Inhibits Growth of Kidney Tumor Cells and Enhances Mitochondrial Biogenesis

(2018) Huan Liu et al.   JOURNAL OF PROTEOME RESEARCH

Ragulator and SLC38A9 activate the Rag GTPases through noncanonical GEF mechanisms

(2018) Kuang Shen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epigenetic-Transcriptional Regulation of Fatty Acid Metabolism and Its Alterations in Leukaemia

(2018) Michael Maher et al.   Frontiers in Genetics

Fructose 2,6-Bisphosphate in Cancer Cell Metabolism

(2018) Ramon Bartrons et al.   Frontiers in Oncology

Reactive Oxygen and Nitrogen Species–Induced Protein Modifications: Implication in Carcinogenesis and Anticancer Therapy

(2018) Nurbubu T. Moldogazieva et al.   CANCER RESEARCH

AKT and AMP-activated protein kinase regulate TBC1D1 through phosphorylation and its interaction with the cytosolic tail of insulin-regulated aminopeptidase IRAP

(2018) Samaneh Mafakheri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Defining Physiological Normoxia for Improved Translation of Cell Physiology to Animal Models and Humans

(2018) Thomas P. Keeley et al.   PHYSIOLOGICAL REVIEWS

SIRT3 deacetylates and promotes degradation of P53 in PTEN-defective non-small cell lung cancer

(2017) Yanlu Xiong et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK

(2017) Chen-Song Zhang et al.   NATURE

Glucose feeds the TCA cycle via circulating lactate

(2017) Sheng Hui et al.   NATURE

AMPK: guardian of metabolism and mitochondrial homeostasis

(2017) Sébastien Herzig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Hodgkin lymphoma: A complex metabolic ecosystem with glycolytic reprogramming of the tumor microenvironment

(2017) Lekha Mikkilineni et al.   SEMINARS IN ONCOLOGY

Glucose-6-phosphate dehydrogenase and transketolase modulate breast cancer cell metabolic reprogramming and correlate with poor patient outcome

(2017) Adrián Benito et al.   Oncotarget

The emerging role and targetability of the TCA cycle in cancer metabolism

(2017) Nicole M. Anderson et al.   Protein & Cell

Inhibition of 6-phosphogluconate Dehydrogenase Reverses Cisplatin Resistance in Ovarian and Lung Cancer

(2017) Wujian Zheng et al.   Frontiers in Pharmacology

Maintenance of redox homeostasis by hypoxia-inducible factors

(2017) Debangshu Samanta et al.   Redox Biology

Redox signaling during hypoxia in mammalian cells

(2017) Kimberly A. Smith et al.   Redox Biology

Lipid Metabolism and Lipid Droplets in Pancreatic Cancer and Stellate Cells

(2017) Yoshiaki Sunami et al.   Cancers

Mitochondrial Akt Regulation of Hypoxic Tumor Reprogramming

(2016) Young Chan Chae et al.   CANCER CELL

Reexamining cancer metabolism: lactate production for carcinogenesis could be the purpose and explanation of the Warburg Effect

(2016) Iñigo San-Millán et al.   CARCINOGENESIS

Mitochondrial generation of superoxide and hydrogen peroxide as the source of mitochondrial redox signaling

(2016) Martin D. Brand   FREE RADICAL BIOLOGY AND MEDICINE

Epigenetic regulation of the glucose transporter geneSlc2a1by β-hydroxybutyrate underlies preferential glucose supply to the brain of fasted mice

(2016) Kosuke Tanegashima et al.   GENES TO CELLS

PHD3 Loss in Cancer Enables Metabolic Reliance on Fatty Acid Oxidation via Deactivation of ACC2

(2016) Natalie J. German et al.   MOLECULAR CELL

Targeting renal cell carcinoma with a HIF-2 antagonist

(2016) Wenfang Chen et al.   NATURE

Inhibition of fatty acid oxidation as a therapy for MYC-overexpressing triple-negative breast cancer

(2016) Roman Camarda et al.   NATURE MEDICINE

Fatty acid oxidation is required for the respiration and proliferation of malignant glioma cells

(2016) Hua Lin et al.   NEURO-ONCOLOGY

Fatty acid oxidation and carnitine palmitoyltransferase I: emerging therapeutic targets in cancer

(2016) Q Qu et al.   Cell Death & Disease

Lactic acidosis switches cancer cells from aerobic glycolysis back to dominant oxidative phosphorylation

(2016) Hao Wu et al.   Oncotarget

HBx regulates fatty acid oxidation to promote hepatocellular carcinoma survival during metabolic stress

(2016) Ming-Da Wang et al.   Oncotarget

Mitochondrial dysfunction and oxidative stress in aging and cancer

(2016) Anna V. Kudryavtseva et al.   Oncotarget

Fatty Acid Oxidation Mediated by Acyl-CoA Synthetase Long Chain 3 Is Required for Mutant KRAS Lung Tumorigenesis

(2016) Mahesh S. Padanad et al.   Cell Reports

ATP-Citrate Lyase Controls a Glucose-to-Acetate Metabolic Switch

(2016) Steven Zhao et al.   Cell Reports

Breast Cancer-Derived Lung Metastases Show Increased Pyruvate Carboxylase-Dependent Anaplerosis

(2016) Stefan Christen et al.   Cell Reports

Fatty Acid Oxidation-Driven Src Links Mitochondrial Energy Reprogramming and Oncogenic Properties in Triple-Negative Breast Cancer

(2016) Jun Hyoung Park et al.   Cell Reports

Transketolase Serves a Poor Prognosticator in Esophageal Cancer by Promoting Cell Invasion via Epithelial-Mesenchymal Transition

(2016) Yin-Kai Chao et al.   Journal of Cancer

Fundamentals of cancer metabolism

(2016) R. J. DeBerardinis et al.   Science Advances

Proton channels and exchangers in cancer

(2015) Enrico Pierluigi Spugnini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Targeting metabolic plasticity in breast cancer cells via mitochondrial complex I modulation

(2015) Qijin Xu et al.   BREAST CANCER RESEARCH AND TREATMENT

Acetyl-CoA Synthetase 2 Promotes Acetate Utilization and Maintains Cancer Cell Growth under Metabolic Stress

(2015) Zachary T. Schug et al.   CANCER CELL

Acetate/acetyl-CoA metabolism associated with cancer fatty acid synthesis: Overview and application

(2015) Yukie Yoshii et al.   CANCER LETTERS

Tumors and Mitochondrial Respiration: A Neglected Connection

(2015) Andrea Viale et al.   CANCER RESEARCH

Identification of AMPK Phosphorylation Sites Reveals a Network of Proteins Involved in Cell Invasion and Facilitates Large-Scale Substrate Prediction

(2015) Bethany E. Schaffer et al.   Cell Metabolism

Motif affinity and mass spectrometry proteomic approach for the discovery of cellular AMPK targets: Identification of mitochondrial fission factor as a new AMPK substrate

(2015) Serge Ducommun et al.   CELLULAR SIGNALLING

SIRT1/PGC1 -Dependent Increase in Oxidative Phosphorylation Supports Chemotherapy Resistance of Colon Cancer

(2015) T. T. Vellinga et al.   CLINICAL CANCER RESEARCH

Molecular Pathways: Mitochondrial Reprogramming in Tumor Progression and Therapy

(2015) M. C. Caino et al.   CLINICAL CANCER RESEARCH

Hypoxia and free radicals: Role in tumor progression and the use of engineering-based platforms to address these relationships

(2015) Abigail Hielscher et al.   FREE RADICAL BIOLOGY AND MEDICINE

Emerging roles of hypoxia-inducible factors and reactive oxygen species in cancer and pluripotent stem cells

(2015) Shigeo Saito et al.   KAOHSIUNG JOURNAL OF MEDICAL SCIENCES

6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1–AMPK signalling

(2015) Ruiting Lin et al.   NATURE CELL BIOLOGY

Cholesterol uptake disruption, in association with chemotherapy, is a promising combined metabolic therapy for pancreatic adenocarcinoma

(2015) Fabienne Guillaumond et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pyruvate kinase: Function, regulation and role in cancer

(2015) William J. Israelsen et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

MYC, Metabolism, and Cancer

(2015) Z. E. Stine et al.   Cancer Discovery

Tumor Heterogeneity and Lesion-Specific Response to Targeted Therapy in Colorectal Cancer

(2015) M. Russo et al.   Cancer Discovery

Hypoxia-inducible factor 1α (HIF-1α) and reactive oxygen species (ROS) mediates radiation-induced invasiveness through the SDF-1α/CXCR4 pathway in non-small cell lung carcinoma cells

(2015) Qing Gu et al.   Oncotarget

Inactivation of SDH and FH cause loss of 5hmC and increased H3K9me3 in paraganglioma/pheochromocytoma and smooth muscle tumors

(2015) Attje S. Hoekstra et al.   Oncotarget

Metabolomic profile of glycolysis and the pentose phosphate pathway identifies the central role of glucose-6-phosphate dehydrogenase in clear cell-renal cell carcinoma

(2015) Giuseppe Lucarelli et al.   Oncotarget

Carnitine palmitoyltransferase 1A functions to repress FoxO transcription factors to allow cell cycle progression in ovarian cancer

(2015) Huanjie Shao et al.   Oncotarget

Mitochondrial biogenesis is required for the anchorage-independent survival and propagation of stem-like cancer cells

(2015) Arianna De Luca et al.   Oncotarget

Hypoxia-Inducible Factor-1α Protects Cervical Carcinoma Cells from Apoptosis Induced by Radiation via Modulation of Vascular Endothelial Growth Factor and p53 under Hypoxia

(2015) Fengmei Wang   MEDICAL SCIENCE MONITOR

Inhibition of Aerobic Glycolysis Represses Akt/mTOR/HIF-1α Axis and Restores Tamoxifen Sensitivity in Antiestrogen-Resistant Breast Cancer Cells

(2015) Yu Mi Woo et al.   PLoS One

Melatonin Cytotoxicity Is Associated to Warburg Effect Inhibition in Ewing Sarcoma Cells

(2015) Ana M. Sanchez-Sanchez et al.   PLoS One

Cancer stem cells from epithelial ovarian cancer patients privilege oxidative phosphorylation, and resist glucose deprivation

(2015) Anna Pastò et al.   Oncotarget

Specific monoclonal antibodies against IDH1/2 mutations as diagnostic tools for gliomas

(2014) Yukinari Kato   Brain Tumor Pathology

Defining normoxia, physoxia and hypoxia in tumours—implications for treatment response

(2014) S R McKeown   BRITISH JOURNAL OF RADIOLOGY

Acetate Is a Bioenergetic Substrate for Human Glioblastoma and Brain Metastases

(2014) Tomoyuki Mashimo et al.   CELL

Oncogene-induced reactive oxygen species fuel hyperproliferation and DNA damage response activation

(2014) M Ogrunc et al.   CELL DEATH AND DIFFERENTIATION

Hypoxic Regulation of Glutamine Metabolism through HIF1 and SIAH2 Supports Lipid Synthesis that Is Necessary for Tumor Growth

(2014) Ramon C. Sun et al.   Cell Metabolism

The mTORC1/S6K1 Pathway Regulates Glutamine Metabolism through the eIF4B-Dependent Control of c-Myc Translation

(2014) Alfredo Csibi et al.   CURRENT BIOLOGY

Evidence for Heightened Hexokinase II Immunoexpression in Hepatocyte Dysplasia and Hepatocellular Carcinoma

(2014) Grace Guzman et al.   DIGESTIVE DISEASES AND SCIENCES

Sirt1 induction confers resistance to etoposide-induced genotoxic apoptosis in thyroid cancers

(2014) KI HWAN KWEON et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Body-mass index and risk of 22 specific cancers: a population-based cohort study of 5·24 million UK adults

(2014) Krishnan Bhaskaran et al.   LANCET

Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function

(2014) Andrea Viale et al.   NATURE

Metabolic reprogramming during TGFβ1-induced epithelial-to-mesenchymal transition

(2014) L Jiang et al.   ONCOGENE

Tumor Microenvironment and Metabolic Synergy in Breast Cancers: Critical Importance of Mitochondrial Fuels and Function

(2014) Ubaldo Martinez-Outschoorn et al.   SEMINARS IN ONCOLOGY

A Mitochondrial Switch Promotes Tumor Metastasis

(2014) Paolo E. Porporato et al.   Cell Reports

Oxygen Sensing, Hypoxia-Inducible Factors, and Disease Pathophysiology

(2013) Gregg L. Semenza   Annual Review of Pathology-Mechanisms of Disease

Rheb and Rags come together at the lysosome to activate mTORC1: Figure 1

(2013) Marlous J. Groenewoud et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

ROS generation and multiple forms of mammalian mitochondrial glycerol-3-phosphate dehydrogenase

(2013) Tomáš Mráček et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Overcoming Intrinsic Multidrug Resistance in Melanoma by Blocking the Mitochondrial Respiratory Chain of Slow-Cycling JARID1Bhigh Cells

(2013) Alexander Roesch et al.   CANCER CELL

Acidic extracellular microenvironment and cancer

(2013) Yasumasa Kato et al.   Cancer Cell International

The mTORC1 Pathway Stimulates Glutamine Metabolism and Cell Proliferation by Repressing SIRT4

(2013) Alfred Csibi et al.   CELL

Cancer metabolism, stemness and tumor recurrence

(2013) Joseph M. Curry et al.   CELL CYCLE

Metabolic regulation of Sirtuins upon fasting and the implication for cancer

(2013) Yueming Zhu et al.   CURRENT OPINION IN ONCOLOGY

A High-Fat Diet Activates Oncogenic Kras and COX2 to Induce Development of Pancreatic Ductal Adenocarcinoma in Mice

(2013) Bincy Philip et al.   GASTROENTEROLOGY

Tumor-Derived Lactate Modifies Antitumor Immune Response: Effect on Myeloid-Derived Suppressor Cells and NK Cells

(2013) Z. Husain et al.   JOURNAL OF IMMUNOLOGY

AMPK-Dependent Degradation of TXNIP upon Energy Stress Leads to Enhanced Glucose Uptake via GLUT1

(2013) Ning Wu et al.   MOLECULAR CELL

Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence

(2013) Peng Jiang et al.   NATURE

Rare insights into cancer biology

(2013) J Adam et al.   ONCOGENE

Relevance of Mitochondrial Genetics and Metabolism in Cancer Development

(2013) G. Gasparre et al.   Cold Spring Harbor Perspectives in Biology

Gamma rays induce a p53-independent mitochondrial biogenesis that is counter-regulated by HIF1α

(2013) A Bartoletti-Stella et al.   Cell Death & Disease

Pyruvate uptake is increased in highly invasive ovarian cancer cells under anoikis conditions for anaplerosis, mitochondrial function, and migration

(2012) Christine A. Caneba et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Analysis of Tumor Metabolism Reveals Mitochondrial Glucose Oxidation in Genetically Diverse Human Glioblastomas in the Mouse Brain In Vivo

(2012) Isaac Marin-Valencia et al.   Cell Metabolism

c-Myc and Cancer Metabolism

(2012) D. M. Miller et al.   CLINICAL CANCER RESEARCH

Expression of hypoxia-related glucose transporters GLUT1 and GLUT3 in benign, malignant and non-neoplastic thyroid lesions

(2012) PAWEŁ JÓźWIAK et al.   Molecular Medicine Reports

Metabolism of [U-13C]glucose in human brain tumorsin vivo

(2012) Elizabeth A. Maher et al.   NMR IN BIOMEDICINE

Expression of GLUT1 and GLUT3 Glucose Transporters in Endometrial and Breast Cancers

(2012) Anna Krzeslak et al.   PATHOLOGY & ONCOLOGY RESEARCH

TKTL-1 expression in lung cancer

(2012) Peter Fritz et al.   PATHOLOGY RESEARCH AND PRACTICE

Glutamine-fueled mitochondrial metabolism is decoupled from glycolysis in melanoma

(2012) Fabian V. Filipp et al.   Pigment Cell & Melanoma Research

Low SIRT3 Expression Correlates with Poor Differentiation and Unfavorable Prognosis in Primary Hepatocellular Carcinoma

(2012) Chris Zhiyi Zhang et al.   PLoS One

Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYC

(2012) W. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AMPK functions as an adenylate charge-regulated protein kinase

(2012) Jonathan S. Oakhill et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Metabolic reprogramming by class I and II histone deacetylases

(2012) Maria M. Mihaylova et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Metabolic regulation by SIRT3: implications for tumorigenesis

(2012) Lydia W.S. Finley et al.   TRENDS IN MOLECULAR MEDICINE

The emerging role of fumarate as an oncometabolite

(2012) Ming Yang et al.   Frontiers in Oncology

AMPK and mTOR in Cellular Energy Homeostasis and Drug Targets

(2011) Ken Inoki et al.   Annual Review of Pharmacology and Toxicology

Establishing a relationship between prolactin and altered fatty acid β-Oxidation via carnitine palmitoyl transferase 1 in breast cancer cells

(2011) Katja Linher-Melville et al.   BMC CANCER

Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases

(2011) Wei Xu et al.   CANCER CELL

SIRT3 Opposes Reprogramming of Cancer Cell Metabolism through HIF1α Destabilization

(2011) Lydia W.S. Finley et al.   CANCER CELL

Hyperactivation of oxidative mitochondrial metabolism in epithelial cancer cells in situ

(2011) Diana Whitaker-Menezes et al.   CELL CYCLE

Activation of AMP-kinase by AICAR induces apoptosis of DU-145 prostate cancer cells through generation of reactive oxygen species and activation of c-Jun N-terminal kinase

(2011) Heinrich Sauer   INTERNATIONAL JOURNAL OF ONCOLOGY

Comparative Metabolic Flux Profiling of Melanoma Cell Lines

(2011) David A. Scott et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Why is the partial oxygen pressure of human tissues a crucial parameter? Small molecules and hypoxia

(2011) Aude Carreau et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

(2011) Maria M. Mihaylova et al.   NATURE CELL BIOLOGY

Identification of additional IDH mutations associated with oncometabolite R(−)-2-hydroxyglutarate production

(2011) P S Ward et al.   ONCOGENE

Reduced Expression of Fumarate Hydratase in Clear Cell Renal Cancer Mediates HIF-2α Accumulation and Promotes Migration and Invasion

(2011) Sunil Sudarshan et al.   PLoS One

Transketolase-Like 1 Expression Is Modulated during Colorectal Cancer Progression and Metastasis Formation

(2011) Santiago Diaz-Moralli et al.   PLoS One

Pyruvate carboxylase is required for glutamine-independent growth of tumor cells

(2011) T. Cheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth

(2011) Q. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondria in cancer: at the crossroads of life and death

(2011) Vanessa C. Fogg et al.   Chinese Journal of Cancer

Hypoxia and mitochondrial oxidative metabolism

(2010) Giancarlo Solaini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

The electron transfer flavoprotein: Ubiquinone oxidoreductases

(2010) Nicholas J. Watmough et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Oxidative phosphorylation in cancer cells

(2010) Giancarlo Solaini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Glutaminolysis: Supplying carbon or nitrogen or both for cancer cells?

(2010) Chi V. Dang   CELL CYCLE

TKTL1 Is Activated by Promoter Hypomethylation and Contributes to Head and Neck Squamous Cell Carcinoma Carcinogenesis through Increased Aerobic Glycolysis and HIF1  Stabilization

(2010) W. Sun et al.   CLINICAL CANCER RESEARCH

TBC1D1 Regulates Insulin- and Contraction-Induced Glucose Transport in Mouse Skeletal Muscle

(2010) D. An et al.   DIABETES

Waves of gene regulation suppress and then restore oxidative phosphorylation in cancer cells

(2010) Katarína Smolková et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

pH control mechanisms of tumor survival and growth

(2010) Scott K. Parks et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The causes of cancer revisited: “Mitochondrial malignancy” and ROS-induced oncogenic transformation – Why mitochondria are targets for cancer therapy

(2010) Stephen J. Ralph et al.   MOLECULAR ASPECTS OF MEDICINE

Oncogenic KRAS modulates mitochondrial metabolism in human colon cancer cells by inducing HIF-1a and HIF-2a target genes

(2010) Sang Y Chun et al.   Molecular Cancer

LKB1 and AMP-activated protein kinase control of mTOR signalling and growth

(2009) R. J. Shaw   Acta Physiologica

Mitochondrial Metabolism and Cancer

(2009) Frank Weinberg et al.   Annals of the New York Academy of Sciences

Tumor heterogeneity: Causes and consequences

(2009) Andriy Marusyk et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Novel Lipogenic Enzyme ELOVL7 Is Involved in Prostate Cancer Growth through Saturated Long-Chain Fatty Acid Metabolism

(2009) K. Tamura et al.   CANCER RESEARCH

Cell-cell and intracellular lactate shuttles

(2009) George A. Brooks   JOURNAL OF PHYSIOLOGY-LONDON

Glucose Deprivation Contributes to the Development of KRAS Pathway Mutations in Tumor Cells

(2009) J. Yun et al.   SCIENCE

ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation

(2009) K. E. Wellen et al.   SCIENCE

The TSC1–TSC2 complex: a molecular switchboard controlling cell growth

(2008) Jingxiang Huang et al.   BIOCHEMICAL JOURNAL

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

The mitochondrial p53 pathway

(2008) Angelina V. Vaseva et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Glucose avidity of carcinomas

(2008) Álvaro D. Ortega et al.   CANCER LETTERS

Hypoxia-Inducible Carbonic Anhydrase IX and XII Promote Tumor Cell Growth by Counteracting Acidosis through the Regulation of the Intracellular pH

(2008) J. Chiche et al.   CANCER RESEARCH

Induction of HIF-1α expression by intermittent hypoxia: Involvement of NADPH oxidase, Ca2+signaling, prolyl hydroxylases, and mTOR

(2008) Guoxiang Yuan et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice

(2008) Pierre Sonveaux et al.   JOURNAL OF CLINICAL INVESTIGATION

Tumour glycolysis: The many faces of HIF

(2008) Catherine Kelly et al.   JOURNAL OF THEORETICAL BIOLOGY

Ras oncogenes: split personalities

(2008) Antoine E. Karnoub et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Subclonal phylogenetic structures in cancer revealed by ultra-deep sequencing

(2008) P. J. Campbell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PHDs overactivation during chronic hypoxia "desensitizes" HIF  and protects cells from necrosis

(2008) A. Ginouves et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA